Trouble TTC

Clomid after femara

I posted this in another forum, so sorry if it's repetitive for some of you.
I am switching to 100mg clomid after 2 failed iuis using femara 5mg. The first round was a CP & I didn't respond well the second time (only one little follie).
Has anyone else made such a switch? If so, how did it work out? Also, how many follies should I expect (or hope for) with 100mg clomid?
Thank you all!!
DH & I married 12/17/2012
Me (31)-dx w/PCOS 2007, when married to ex-husband after MC
DH (41)-no MFI
07/2014-Femara 5mg + trigger + IUI= chem preg ;(
08/2014-Femara 5mg + trigger + IUI + 2nd trigger= BFN
09/2014-Clomid 100mg + trigger + IUI + 2nd trigger= BFN
10/2014-benched due to RE out of town, tying naturally!
11/2014-benched due to cyst
12/2014-Femara 5mg + stair step with additional 5 days Femara 5mg + trigger + IUI=BFN
01/2015-Femara 5mg + Gonal F 25 units + trigger (plus additional Gonal F 100 units on trigger night) + IUI= BFP!!! Twins due 10/2015
09/28/2015- Surprise!  Conrad and Hudson born at 35w6d!  

Re: Clomid after femara

  • I'm sorry for your loss.

    I hate that there aren't clear answers to these kind of questions - they're the type that Dr. Google likes to frustrate me about! Unfortunately, what Rumbera said is true - response can be unpredictable. 100 Clomid does sound like an excellent next step if Femara was not successful.
    January 3T Siggy Challenge - New Year's Resolutions
    image
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    Me (29), DH (30) TTC actively 54 55+ cycles | All BFNs
    MFI (low everything) | Endo Stage 1 & Stenotic Cervix (treated) | PCO
    Married - July 2008 | Started TTC - Jan 2009RE Visit #1 - Mar 2014 
    IUI #1 ICI #1 - June | IUI #1.1 Laparoscopy - Aug
    IUIs #1.2, 2, 3 - Sept, Oct, Nov (Letrozole) - BFNs 
    IUI #4 - Dec (Bravelle) | IUI #5 - Dec/Jan (Bravelle) - 5 follies + TI - BFNs
    IUI #5.1 - Jan (Bravelle) Cancelled 
    Planning to start IVF in March!
    ***All Welcome***
  • I'm sorry for your loss.


    I hate that there aren't clear answers to these kind of questions - they're the type that Dr. Google likes to frustrate me about! Unfortunately, what Rumbera said is true - response can be unpredictable. 100 Clomid does sound like an excellent next step if Femara was not successful.
    Thank you for your feedback! It it reassuring to know other women, who are going through the same thing, believe it was a good decision to switch from femara to clomid. I guess I'll see how it goes and can always go back to femara if necessary.

    DH & I married 12/17/2012
    Me (31)-dx w/PCOS 2007, when married to ex-husband after MC
    DH (41)-no MFI
    07/2014-Femara 5mg + trigger + IUI= chem preg ;(
    08/2014-Femara 5mg + trigger + IUI + 2nd trigger= BFN
    09/2014-Clomid 100mg + trigger + IUI + 2nd trigger= BFN
    10/2014-benched due to RE out of town, tying naturally!
    11/2014-benched due to cyst
    12/2014-Femara 5mg + stair step with additional 5 days Femara 5mg + trigger + IUI=BFN
    01/2015-Femara 5mg + Gonal F 25 units + trigger (plus additional Gonal F 100 units on trigger night) + IUI= BFP!!! Twins due 10/2015
    09/28/2015- Surprise!  Conrad and Hudson born at 35w6d!  
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  • Rumbera28 said:

    Welcome, and I'm sorry for your loss.   I've been only on injects for all of my iui's, but I will say that there is no way to predict how many follies that you will get, even when you have the same dosage from cycle to cycle. 

    How many mature follies to hope for really depends on your diagnosis and your age.  For example,  because I am AMA, I am allowed to have up to 6 follies on a given cycle.   They would never allow that with a younger woman.

    Thanks for getting back to me! My RE said if this doesn't work we will add injects next cycle. Problem is, I have a high AMH, dad is frat twin & I'm "skinny PCOS" which puts me at high risk for overstim or high order multiples?! So, yes-she would never allow 6 follies ;)
    Best of luck to you. What round will this be for you?

    DH & I married 12/17/2012
    Me (31)-dx w/PCOS 2007, when married to ex-husband after MC
    DH (41)-no MFI
    07/2014-Femara 5mg + trigger + IUI= chem preg ;(
    08/2014-Femara 5mg + trigger + IUI + 2nd trigger= BFN
    09/2014-Clomid 100mg + trigger + IUI + 2nd trigger= BFN
    10/2014-benched due to RE out of town, tying naturally!
    11/2014-benched due to cyst
    12/2014-Femara 5mg + stair step with additional 5 days Femara 5mg + trigger + IUI=BFN
    01/2015-Femara 5mg + Gonal F 25 units + trigger (plus additional Gonal F 100 units on trigger night) + IUI= BFP!!! Twins due 10/2015
    09/28/2015- Surprise!  Conrad and Hudson born at 35w6d!  
  • I started on clomid and switched to femara...I think everyone reacts differently follicle wise.  I have only had 1-2 on my femara cycles but on 150 mg of clomid I had 4.  good luck!
    Me (29), DH (32)
    Aug 2011  - Married
    Jan 2013   - Started TTC
    Jan 2014   - OB started some testing 
                         - HSG - Normal
                         - Ultrasound - Normal
                         - SA - Normal, but tested positive for Ureaplasma
                         - Both of us on antibiotics to treat ureaplasma
                         - Blood work - progesterone: 15.9, TSH: 0.89, FT4: 1.2, Prolactin: 33.4 
    Feb 2014   - Endometrial Biopsy - Normal
    Mar 2014   - Prolactin: 22.9, referred to RE
    Apr 2014   - First RE appointment, put on medication for high prolactin levels 
                      - Clomid (50 mg) 1 follicle, Trigger shot - BFN
                      - Second SA - All Normal, borderline morph (5%) 
    May 2014   - Clomid (100mg) 2 follicles, Trigger shot - BFN
                      - blood work: Estradiol: 32.7, FSH: 5.3, Prolactin: 14.1
    June 2014  - IUI #1, Clomid (150 mg), 3 follicles, Trigger shot - BFN 
    July 2014   - IUI #2, Clomid (150 mg), 4 follicles, Trigger shot - BFN
    Aug 2014   - IUI #3, Femara 2.5, 3 follicles, Trigger shot (first time done by DH!!) - BFN
                      - Hysteroscopy - Normal
    Sept 2014 - IUI #4 Femara 2.5, 1 follicle, possibility of another one, Trigger shot - BFN
                       -Progesterone test 4 DPIUI - 7.8...started crinone.
    Oct 2014 - IUI #5 Follistim 150 3 possibly 4 follicles - Trigger Shot - BFN
    Oct/Nov 2014 - Follistim 150 with TI & Trigger shot - ???

    **October Siggy Challenge**

    I don't even know what he is supposed to be!
    image


    **EVERYONE WELCOME!! :)**

  • lisa89760 said:

    I started on clomid and switched to femara...I think everyone reacts differently follicle wise.  I have only had 1-2 on my femara cycles but on 150 mg of clomid I had 4.  good luck!

    Thanks for your input! I have heard that femara produces less follicles but they are better quality. I only had one on my last femara cycle :( Best of luck to you too!

    DH & I married 12/17/2012
    Me (31)-dx w/PCOS 2007, when married to ex-husband after MC
    DH (41)-no MFI
    07/2014-Femara 5mg + trigger + IUI= chem preg ;(
    08/2014-Femara 5mg + trigger + IUI + 2nd trigger= BFN
    09/2014-Clomid 100mg + trigger + IUI + 2nd trigger= BFN
    10/2014-benched due to RE out of town, tying naturally!
    11/2014-benched due to cyst
    12/2014-Femara 5mg + stair step with additional 5 days Femara 5mg + trigger + IUI=BFN
    01/2015-Femara 5mg + Gonal F 25 units + trigger (plus additional Gonal F 100 units on trigger night) + IUI= BFP!!! Twins due 10/2015
    09/28/2015- Surprise!  Conrad and Hudson born at 35w6d!  
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