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Low dose HCG question

Marissa6609Marissa6609 member
in Infertility

My IVF protocol uses low dose HCG with follistim (I don't see many other people that have this protocol on here). The issue is, the pharmacy did not tell me to refrigerate the low dose HCG, nor did they give it to me cold/ refrigerated, so I have been using it for a week at room temperature. I mentioned to my RE that I had read online that this med should be refrigerated, but the pharmacy told me that was not necessary - he immediately ordered a new batch for me for the last couple of days on stims. I am really just curious what this would impact - the quality, quantity, rate of growth of the follicles?  Thanks!





** Losses Mentioned **
Me(32) - Low AMH (0.46) and DH(33) - All good!
May 2014 - IUI (Follistim) = BFP! Ectopic. Surgery June 2014.
August/Sept 2014 - IVF #1. BFP! Chemical Pregnancy.
November 2014 - IVF #2; ER only - PGS testing 3 Frosties.
December 2014 - FET #1 - Beta on 12/17!  BFP  *It's TWINS*

image        image      image  
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Re: Low dose HCG question

  • gsanchogsancho member
    edited September 2014
    Were the HCG shots pre-mixed?  I've only heard that you should refrigerate after mixing/prepping the solution and powder.  So I got mine non-refrigerated and only refrigerated the times when I prepped in the morning and didn't do the shot until a little later.

    Most of what I've read regarding refrigerating fertility meds, it's important to help prolong potency, but it's not necessarily a crisis if they are at room temperature.  It just means the potency of the drug will lessen faster.  However, if you did your stims relatively soon after getting the meds, I think it's fine.  My RE only seemed concerned when I had meds from a few months back that I wanted to use for my latest cycle.

    It won't affect the quality of the follicles.  If the potency was low and you weren't responding as quickly as they wanted you to, they are getting you new meds anyways to get you back on track.  I think you're good.


    Me 33, DH 37 -- TTC since Jan'12 -- Low AMH (0.78) & endo, SA w/ low motility
    IUI's 1-3 = BFN, IVF converted to IUI 4/13 = BFN
    IVF 1.2: 8R 6M 4F -- 2 blastocysts frozen, FET 8/15 = BFP!!
    Beta #s = 445;1,098; 9,545  -- EDD 5/2 -- Team Pink!
    Camila Josephine arrived 4/30 :)
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  • Marissa6609Marissa6609 member

    It was premixed by the pharmacy. Starting off, when its premixed it only has a 9 day shelf life. So I am guessing that by keeping it room temp, it cut the shelf life down, so there were a couple of days I was probably not benefiting from it. Time will tell :)  Thanks for the info!





    ** Losses Mentioned **
    Me(32) - Low AMH (0.46) and DH(33) - All good!
    May 2014 - IUI (Follistim) = BFP! Ectopic. Surgery June 2014.
    August/Sept 2014 - IVF #1. BFP! Chemical Pregnancy.
    November 2014 - IVF #2; ER only - PGS testing 3 Frosties.
    December 2014 - FET #1 - Beta on 12/17!  BFP  *It's TWINS*

    image        image      image  
    Report Reply
  • Marissa6609Marissa6609 member
    I have felt fine. I am a low responder... triggering tonight with 7 follicles and hoping for the best. I didn't notice any cramping. I was on 25 iu/day (very small dosage) and then 200 ius my last two days of stims. Definately refrigerate it :) Good luck!!




    ** Losses Mentioned **
    Me(32) - Low AMH (0.46) and DH(33) - All good!
    May 2014 - IUI (Follistim) = BFP! Ectopic. Surgery June 2014.
    August/Sept 2014 - IVF #1. BFP! Chemical Pregnancy.
    November 2014 - IVF #2; ER only - PGS testing 3 Frosties.
    December 2014 - FET #1 - Beta on 12/17!  BFP  *It's TWINS*

    image        image      image  
    Report Reply
  • ddvj79ddvj79 member
    I'm also a low responder & will be on the same protocol for ER...once I AF starts!

    I hope you have eggs in all 7 & get your BFP! Good luck!!!

    DH :  36, has Chronic Kidney Disease, on dialysis & is waiting on the transplant list (average wait for B+ is 5 years)

    Me:   36, Hypothyroidism, PCOS, BMI 32, need to be done with "child bearing" ASAP so that I can be a Kidney donor (was fun realizing we didn't as much time as we thought :-/ )

    We're TTC#1

    IUI #1 : 5mcg Letrozole (CD 3-7) + Ovidrel Trigger + Had the one follicle = BFN  (March 2014)

    IUI #2 : 5mcg Letrozole (CD 3-7) + 150 iu Bravelle on CD9 (after much begging!) + Had the one follicle = BFN (April 2014)

    7th May 2014 - changed REs, this one seems to care (we think....)

    IUI #3 : 7mcg Letrozole (CD 3- 7) + 75 iu Bravelle (CD 8-12) + CD12 Scan 5/16 + Had 3 follicles (2 under 15mm) = BFN(May 2014)

    IUI #4 : 7mcg Letrozole (CD 3- 7) + 75 iu Bravelle (CD 8-12) + CD12 Scan 5/16 + Had 1 follicle + DH gave best sample so far = BFN(June 2014)

    IVF#1 -  ER Only Cycle Sept-Oct 2014, 17  eggs Retrieved, 14 mature, 10 fertilized, 6 made it to Blast & post PGS  5 were not viable due to chromosomal abnormalities
    Not sure where we go from here...

    We're parents to two very adorable, bratty, affectionate & goofy Bernese Mountain Dog pups who would very much like a 2 legged baby brother or sister of their own!

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