UPDATE: Got a partial answer after 2nd tri missed MC?

GummiBearJ

Hi everyone.

Yesterday we found out that my baby girl, who we lost at 16 weeks, had trisomy 21 (Downs). I'm not sure what to do with the news. We don't know yet if it was because I passed on a translocation - I had my blood drawn after we got the results so we can find out. Of course I'm very nervous that this will be the case, but also very hopeful that this will turn out to have been a random mutation and I am "normal." If that happens, then our next pregnancy will have a low risk of 1% of this happening again. If I do have the translocation, I guess I have a 10-15% chance that this will happen again and might need to consider PGD and IVF.

Does anyone have any experience with a MC from trisomy 21, or any information on the odds of it being random vs. a translocation? I've been reading a lot about it online but with all the medical jargon, sometimes it's hard to distinguish the facts.

Thank you.

KingLED

APA has some good information HERE.

And depending how much you like to read THIS is another great resource.

Spring78

I lost my baby girl at nearly 12 weeks due to Trisomy 21. Ours was the random variety, and my doctor said that the vast majority are random (I forget the actual statistic she used). I am very sorry for your loss and the stress you are going through now. I hope they are able to gve you some answers (and reassurance) soon.

[Deleted User]

I am sorry for your loss.  While I did not have a loss (that I know of) from T21 (I have never had my babies tested for the cause of my miscarriages), I do have a child with T21.  She has the most common one...the random kind.  95% of babies have this kind, about 4% have translocation T21 and it is usually from the mother.  The other 1% have mosaic T21.  I hope you get some assurning news.

GummiBearJ

Thank you all for this information and I'm so sorry for your losses. @squirmworms, thank you for sharing the stats you've learned! 

This is pretty reassuring. Having a 2nd tri missed miscarriage really knocked my confidence as it was so unlikely, unfortunately it's hard to be reassured. I am trying to stay positive and be optimistic that ultimately all will be well no matter what the result.

GummiBearJ

Hi everyone, I just wanted to let you all know that my doctor called yesterday because she got my blood test results back early, and it was NOT a translocation. I'm not sure I've ever felt so relieved. My little daughter's Trisomy 21 was totally random and after my next cycle, I can start trying again without fearing that this will be a repetitive problem. I think I needed to hear this to really be able to start moving on. I feel like I can breathe again.

I want to thank you all for your support. This is an incredible group of strong, resilient women and while I'm heartbroken that I've had to join a community about miscarriage, I'm grateful to have this forum.

ctk181

@gummibearJ - I am so happy your got the results you were hoping for and there was no translocation! GL as you TTC again!

GummiBearJ

@ctk181 Thank you very much!