Hi ladies! I hope it's ok that I post over here (from the IF and 2IF boards), I just went through my first IVF cycle and hope that someone might have gone through the same experience that I did. I have been diagnosed with DOR and very low AMH (I'm 36). Throughout my cycle, my RE practice was very disappointed with my response to my drug protocol. We were all shocked to find out last Friday at my egg retrieval that I had 9 eggs hiding in my follicles! On day 2 7 were mature and 7 fertilized. I wasn't able to do a fresh transfer this week because I had a lot of fluid in my uterus so all of my embryos were frozen on day 2. The embryologist said that when I was ready for my FET my embryos would be thawed and hopefully we would have some good growth at that point and be able to transfer 1-2 at that time.
Has anyone else gone through something similar? I was surprised that they didn't let my embryos grow to day 3 or 5 before freezing. DH said I did ask about this (still foggy from the anesthesia) and my RE said that in my situation (freeze all cycle) they want to be able to transfer the "freshest" frozen embryos so it's better if they freeze on day 2 and then allow them to grow to day 3 or 5 before transferring.
IVF #1, Stimmed for 12 days, ER 8/22/14, 9 retrieved, 7M, 7F!! Freeze all due to fluid in uterus.
FET end of October 2014 cancelled due to fluid in uterus due to possible c-scar defect
Surgery scheduled 12/12/14 to fix possible isthmocele
3/26/15 transferred one 8 cell grade 4 embryo and one 6 cell grade 3 embryo = slow rising betas for 2+ weeks = ectopic MTX shot 4/29/15
Repeat c-scar surgery June 2015
2nd and last IVF cycle August 2015, stimmed for 12 days, 2 egg retrieved, both mature and both fertilized. Transferred both 8-cell embryos on Day 3, beta 9/5/15 = BFFN
I did a freeze all, but my embies were grown to 5 day blast before frozen. My clinic does a lot of frozen cycles and only freezes 5 day blast I believe.
Is this a normal protocol of your clinics?
Congrats on a good ER and best of luck to you!
TTC since May/June 2012
Sept 2013 testing:
SA #1 Low motility (17%)
SA #2 Lower sperm count, but much higher motility
CD 3 Bloodwork and ultrasound - Normal
HSG - Clear tubes
Oct/Nov 2013 Cycle 1 with RE
50 mg Clomid + Ovidrel + IUI
BFN
Nov/Dec 2013 Cycle 2 with RE
50 mg Clomid + Ovidrel + IUI
BFN
Jan/Feb 2014 Cycle 3 with RE
50 mg Clomid + Ovidrel + IUI
BFN
2/20/14 Follow up consult RE recommends IVF with ICSI
3/10/14 New patient consult with RMA NJ
3/11/14 AMH and other Bloodwork to prep for IVF with ICSI at RMA NJ
IVF #1, Stimmed for 12 days, ER 8/22/14, 9 retrieved, 7M, 7F!! Freeze all due to fluid in uterus.
FET end of October 2014 cancelled due to fluid in uterus due to possible c-scar defect
Surgery scheduled 12/12/14 to fix possible isthmocele
3/26/15 transferred one 8 cell grade 4 embryo and one 6 cell grade 3 embryo = slow rising betas for 2+ weeks = ectopic MTX shot 4/29/15
Repeat c-scar surgery June 2015
2nd and last IVF cycle August 2015, stimmed for 12 days, 2 egg retrieved, both mature and both fertilized. Transferred both 8-cell embryos on Day 3, beta 9/5/15 = BFFN
When I did my freeze-all cycle, they only froze 5 day blasts. But over the 2 years on the boards, I've learned every RE is different. Did they say what would happen if more than 2 grew to blastocysts? Would they re-freeze them? Or will they thaw them out in batches?
Me 33, DH 37 -- TTC since Jan'12 -- Low AMH (0.78) & endo, SA w/ low motility IUI's 1-3 = BFN, IVF converted to IUI 4/13 = BFN IVF 1.2: 8R 6M 4F -- 2 blastocysts frozen, FET 8/15 = BFP!! Beta #s = 445;1,098; 9,545 -- EDD 5/2 -- Team Pink!
I did a freeze all because of high risk of OHSS, but they waited till day 5 or 6 to freeze. I think every clinic has their own way of doing things, it also depends on the RE. Good luck with your FET cycles! It took us two FETs and a total of 4 frosties to get pregnant with this LO but it's all worth it.
Pregnant with #2
IVF cycle 1 (Nov 2013)- freeze all d/t OHSS FET #1-BFN FET #2-BFP baby girl born Dec 2014 FET #3-Sept 2017 BFP but miscarried at 6 weeks
IVF cycle 2 (Oct 2017)- freeze all again d/t OHSS FET #1 BPF, pregnant with a singleton due Sept 2018
We did a freeze all cycle and they froze one on day 5 and the other on day 6. I've never heard of freezing them on day 2 but we did PGD and had to wait for enough cells to biopsy. What did the gals on IF say?
TTC since 3/2011 Adenomyosis, LPD, hypothyroidism.
BFP on 7/20/12 after 4 cycles Clomid + IUI
2 large subchorionic hematomas & no heartbeat at 7w6d
D&E 8/18/12 Sonohysterography found septum and necrotic tissue.
I did something similar, not due to fluid though. It was hormonal (high progesterone levels). They froze mine on day 3 and I had the same question- why not wait for blasts on day 5? It was really nerve wracking during the frozen cycle.. Not knowing how many will survive the thaw.. Not knowing how many will grow to blasts.. Not knowing how many we'll have to transfer. Honestly I was really stressed out. So I don't have any advice other than find ways to take your mind off it. We did a bunch of date nights and things I wouldn't be able to do pregnant while we waited for the frozen cycle.
---------------Siggy Warning--------------------
Me: 32, DH: 34 / TTC since February 2011 / SA: all normal, HSG: all clear! / on Lovenox for anticardiolipid antibodies 4 IUIs with Clomid, Letrozole, and Menopur. All BFN. 9/12: lap / hysteroscopy: found and removed mild endometriosis, cervical polyp, and 2 para-tubular cysts 5/13 IVF #1: Follistim, Menopur, Ganirelix, 10R/4M/4F, ET of 2, 5 cell and 4 cell, no frosties = BFN 12/13 IVF #2 = November / December 2013. Microdose Lupron Protocol: 15R/6M/6F, Froze all 6 due to high E2 and P4 FET 1: Jan 22, 2014 of one 4AB blast and one 3BB blast (3 blasts on ice!) BFP on HPT 4dp5dt, Beta #1 9dp5dt: 310, Beta #2 11dp5dt: 899 First u/s on 2/17/14: TWINS!!!!! both w/HBs of 114 at 6w3d, HBs 150 and 152 at 7w5d 5/27/2014: Team purple!!!! EDD 10/10/2014 /
Delivered by c-section at 32w0d 8/15/2014 due to preeclampsia/HELLP syndrome Baby Boy 4lbs 1oz, 17 inches Baby Girl 3lbs 5oz, 16 inches
Mine were all frozen on day 5. We also did the PGD/PGS testing on the embryos.
I would see if this is a normal practice for your RE office, and if not, I would ask more questions. Usually they tell you all this before what their plan is and why.
We did a freeze all due to OHSS. They were frozen at day 5. We transferred two back three months later and I'm now nearly 24w. During a previous IVF we had transferred, even though I was on the cusp of OHSS and it ended in a c/p. I think there are a lot of benefits to freezing and doing a FET. Good luck!
Trying to grow our family with both fertility treatments and adoption since March 2009
Re: New to IVF question about freeze all cycle
Is this a normal protocol of your clinics?
Congrats on a good ER and best of luck to you!
TTC #3 since June 2013
BFP #1 7/21/2013--EDD 3/30/14--D&C 9/24/13
BFP #2 1/28/14--MC 2/7/14
IUI #1 5mg Femara + trigger = BFN
IUI #2 5mg Femara + trigger = BFN
IUI #3 5mg Femara + trigger = BFN
Me 33, DH 37 -- TTC since Jan'12 -- Low AMH (0.78) & endo, SA w/ low motility
IUI's 1-3 = BFN, IVF converted to IUI 4/13 = BFN
IVF 1.2: 8R 6M 4F -- 2 blastocysts frozen, FET 8/15 = BFP!!
Beta #s = 445;1,098; 9,545 -- EDD 5/2 -- Team Pink!
TTC Since 12/2008; DH: 32, Azoospermia me: 33, DX during IVF #4: Low AMH (Normal FSH) / SER due
to IVF Meds (causing failure to fertilize) Recent DX: Hashimoto's, Lupus Anticoagulant, White Blood Cell Disorder
High ANA, ATA, & APA, PAI-1 Heterozygous= blood clotting disorder; connective tissue disorder
IVF w/ ICSI #1 2/2011 IVF w/ ICSI #2 5/2011 IVF w/ ICSI #3 12/2012 *New RE* IVF w/ ICSI #4 5/2013
IVF w/ ICSI #5 8/2013 (Natural Cycle- No drugs)- One follicle->one blast. CCS normal. FET 9/10- 6BB blast. m/c @ 5w
IUI #1 12/23- BFN IUI #2 Cancelled (ovulated during AF) Prep:CoQ10 (300 mg); DHEA (25 mg); Melatonin (3 mg), Folgard 2.2, Metformin 500 2x, Levothyroxine 50mcg, Aspirin 81mg w/ calcium, B12, Vit. D 4000 & Prenate Elite Daily; Cabergoline 1/2 pill 2x week- Cycling: Estrace Priming; Prednisone 10mg, Lovenox 40mg 2x, Femera & Menopur
IUI #2.1 6/30 & 7/1. 1st Beta: 90 (7/15); 2nd Beta: 226 (7/17); 3rd Beta: 766 EDD: 3/23/2015
IVF cycle 1 (Nov 2013)- freeze all d/t OHSS
FET #1-BFN
FET #2-BFP baby girl born Dec 2014
FET #3-Sept 2017 BFP but miscarried at 6 weeks
IVF cycle 2 (Oct 2017)- freeze all again d/t OHSS
FET #1 BPF, pregnant with a singleton due Sept 2018
Me: 32, DH: 34 / TTC since February 2011 / SA: all normal, HSG: all clear! / on Lovenox for anticardiolipid antibodies
4 IUIs with Clomid, Letrozole, and Menopur. All BFN.
9/12: lap / hysteroscopy: found and removed mild endometriosis, cervical polyp, and 2 para-tubular cysts
5/13 IVF #1: Follistim, Menopur, Ganirelix, 10R/4M/4F, ET of 2, 5 cell and 4 cell, no frosties = BFN
12/13 IVF #2 = November / December 2013. Microdose Lupron Protocol: 15R/6M/6F, Froze all 6 due to high E2 and P4
FET 1: Jan 22, 2014 of one 4AB blast and one 3BB blast (3 blasts on ice!)
BFP on HPT 4dp5dt, Beta #1 9dp5dt: 310, Beta #2 11dp5dt: 899
First u/s on 2/17/14: TWINS!!!!! both w/HBs of 114 at 6w3d, HBs 150 and 152 at 7w5d
5/27/2014: Team purple!!!! EDD 10/10/2014 /
Baby Boy 4lbs 1oz, 17 inches
Baby Girl 3lbs 5oz, 16 inches
1/7/2015 Twins born @ 34 weeks
TTC #2