Third-Party Reproduction

Is it ok to intro and to ask a ? here/*child mentioned*

Hi Ladies,

This will be our 4th (and final IVF). We are looking at doing an IVF cycle sometime in October/November. I have already met with our RE and have our protocol and plan in place. I will be doing an antagonist protocol. Gonal-F and Menopur. No bcp's. Plus other meds like baby aspirin, pnv and DHEA. I will start the DHEA in September. RE wants me to take it for 2-3 months prior to starting stims. I also will have to have b/w and saline sono done. 
The reason I am intro'ing and posting here is that I have DOR and endo and usually only have 2-3 eggs max at retrieval. RE is giving us the choice to use my eggs or donor eggs. I've been thinking ALOT about donor eggs. Reading books, forums, etc. RE says my chances are 50/50 with my eggs IF I can make it to retrieval or 70% chance with donor eggs.
*child mentioned*








We have a 2 year old from our 3rd IVF. Back in 2011 my FSH was 10.7. My AMH in March of this year was 0.16 and my FSH was 19. Like a lot of people, we are out of pocket though we did get approved for the Compassionate Care program for med help. Just wondering what you think about the numbers and if I should try own eggs one last time or go for donor eggs?
Thanks for reading and I hope I did the warning correctly.
Many failed IUI's (medicated and unmedicated) IVF#1-Micro-dose Lupron protocol: BFN IVF#2-Antagonist Protocol-transferred 1 8-cell grade A embryo: BFP! Missed Miscarriage- D&C 4/2011 IVF#3-Antagonist protocol again but no bcp's: August 2011 DOR, endo and cervical stenosis ER 8/16/11 3 er 3 fert w/icsi ET 8/19/11-assisted hatching- transferred (2) 8 cell embryos! 9/1/11=Beta#1=824 9/6/11=Beta#2=7337


Re: Is it ok to intro and to ask a ? here/*child mentioned*

  • Unfortunately, it would depend on the financials at this point. Just looking at the numbers you posted here, I really think that a 50% success rate is overshooting the odds by a bit. With more normal numbers (FSH< 10, AMH 3, etc..) the rates for ivf are only about 40%. I would think odds for OE ivf with numbers like you mentioned are more like 15-20% per cycle.. I'm not trying to dissuade you at all, do whatever is in your heart, I just question the 50/50 odds. Whatever y choose, good luck!
    Me: 37, DH: 38: ttc 7 years, dx: unknown
    10/11: after 2 years, saw a RE, FSH 5.4
    11/11: BFP! (surprise after thyroid & normal hsg),
    12/11: missed m/c after 7 week u/s, 1/12: D&C
    6/12 IUI#1-IUI #3: clomid = BFP!, C/P
    IVF #1(10/12) FSH 5.4, AFC: 16 long Lupron, 5R/5M/4F, all 4 made it to 5dt, 1 blast/1-8 cell transferred=BFN
    IVF #2(12/12)AFC 21, MD lupron, 4R/4M/3F, 5dt of 1 blast and 2-8cell. BFN.
    IVF#3(4/13) Natural start antagon protocol, 12R,11F. one PGS normal at day 6 transfer. BFN.
    IVF#4 (11/13) C.CRM (ODW.U normal 8/13 Still no Diagnosis) EPP/antagonist. ER 13R/7M/6F. Only 1 made it to freeze. Abnormal. Looking into options of DE, Fresh vs frozen.
    10/14 new local RE to look into what's next. CD3 FSH 4.7, AMH 0.9. Met with DE agencies and exploring options for feb/march 2015.
    Surprise natural bfp (4 days before donor is signed). Beta #1 at 9dpo: 51.8, 2nd beta: 195 (25 hours doubling) @11dpo. 3rd beta (12/15): 516 (35 hrs doubling) 4th beta(12/17): 895 (58 hours doubling) 5th beta(12/19): 2120. U/S at 5w0d(12/22): one gestational sac with yolk sac. U/S #2 (6w0d)12/29. One little bean measuring 6w0d with HR 124. 3rd u/s(1/4)7w0d: baby measuring 7w2d. HR 134. 3/30: A/S at MFM went great except for low lying placenta. Verifi results are normal! Team Blue! Please send any positive thoughts our way! EDD:8/24/2015
    Baby Will born 8/18. He's perfect.
  • jej05jej05 member
    edited July 2014
    J&D2007 said:
    Unfortunately, it would depend on the financials at this point. Just looking at the numbers you posted here, I really think that a 50% success rate is overshooting the odds by a bit. With more normal numbers (FSH< 10, AMH 3, etc..) the rates for ivf are only about 40%. I would think odds for OE ivf with numbers like you mentioned are more like 15-20% per cycle.. I'm not trying to dissuade you at all, do whatever is in your heart, I just question the 50/50 odds. Whatever y choose, good luck!
    Thank you for responding, J&D2007. I should have been more specific when I said 50/50. RE said that there is a 50% chance I make it to retrieval. She said once I get to retrieval I tend to do ok it's just being able to make it there in the first place. I'll think about it some more. If we are going to use my eggs then I start the DHEA soon so we have to decide.
    Many failed IUI's (medicated and unmedicated) IVF#1-Micro-dose Lupron protocol: BFN IVF#2-Antagonist Protocol-transferred 1 8-cell grade A embryo: BFP! Missed Miscarriage- D&C 4/2011 IVF#3-Antagonist protocol again but no bcp's: August 2011 DOR, endo and cervical stenosis ER 8/16/11 3 er 3 fert w/icsi ET 8/19/11-assisted hatching- transferred (2) 8 cell embryos! 9/1/11=Beta#1=824 9/6/11=Beta#2=7337


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  • How old are you? I also am DOR (FSH mid 20's, AMH undetectable). Only got 7 eggs over 4 retrievals. But my egg quality was also crap. But I was 37 when we started. If you are early 30s etc, you have a better chance, especially since your eggs worked once.

    TTC #1 since 8/1/10; Me:41 and BRCA1+, DH:46
    DOR (FSH 24.3)/ terrible egg quality ; homozygous MTHFR c677t
    5 IUI's: 2/11 to 6/11 and 1/12= BFN
    OE IVF#1-4 8/11-6/12= all BFN
    DE IVF#1 11/12 bad embryos= BFN
    DE IVF #2 2/13 BFP/Beta hell: m/c 5w6d
    CFNBC 7 months, not doing well; decided on guarantee program at RBA w/frozen DE
    DE IVF #3 1/14  ET 4BB; BFP;M/C 5w1d, incomplete m/c; MVA extraction in ER 7w1d

    DE FET#1 ET 3/1714; BFP, beta 1 3/27= 197, beta 2 3/31= 1586, beta 3 4/7= 13879!!
    First u/s= Twins with HBs at 6w2d! We are Team Pink x 2!!

    K & K born 11/21/14 at 38wks 4 days

    imageimage

    SAIF/PAIF Welcome


    http://waitingforraintostop.wordpress.com

  • jej05jej05 member

    How old are you? I also am DOR (FSH mid 20's, AMH undetectable). Only got 7 eggs over 4 retrievals. But my egg quality was also crap. But I was 37 when we started. If you are early 30s etc, you have a better chance, especially since your eggs worked once.
    I'll be 39 in November. I was 36 going on 37 when we did IVF#3. They say once they get my eggs and they fertilize (we do AH and ICSI) they are pretty good quality. It's just getting them :(  IVF#3 was twins but one stopped growing around 7 weeks. That's the cycle from our 2 year old. Honestly, back after IVF#1 failed we've gotten the donor egg talk. I didn't want to hear it at first but over the years and most recently I have become ok with it. My DH is ok with whatever I want to do.
    Many failed IUI's (medicated and unmedicated) IVF#1-Micro-dose Lupron protocol: BFN IVF#2-Antagonist Protocol-transferred 1 8-cell grade A embryo: BFP! Missed Miscarriage- D&C 4/2011 IVF#3-Antagonist protocol again but no bcp's: August 2011 DOR, endo and cervical stenosis ER 8/16/11 3 er 3 fert w/icsi ET 8/19/11-assisted hatching- transferred (2) 8 cell embryos! 9/1/11=Beta#1=824 9/6/11=Beta#2=7337


  • Like pp said, a lot of this will depend on age and finances. My last AMH was .23, FSH was 11. I did not have success with IUIs and am over 40. We did not have coverage for IVF at the time, and my RE was not optimistic for success with my OE. We went straight to DE. As you can see from my siggy, even DE is not a 100 percent guarantee. Sometimes that can take multiple cycles so if you are OOP, something to plan for. GL!

    image
    DOR and AMA
    2/12-5/12: 4 IUI cycles = all BFN;
    7/12: DE IVF # 1 (with ICSI)- 20R, 16M, 14F, 5DT of 2 blasts; 6 frosties = BFN;
    Lupus anticoagulant initially high, then found to be normal on hematology consult;
    Follow up testing in September all clear;
    Started synthroid for "high normal" TSH;
    FET # 1- late October 2012- BFP on FRER; beta # 1- 21(low), beta # 2- 48 (still low), beta # 3- 132, beta # 4- 1,293; beta # 5- 5,606; last beta- over 100,000. First u/s 11/21- heard heartbeat
    12/12- Officially an OB patient!
    Level 2 ultrasound at 20 weeks shows vasa previa and VCI
    Referral to MFM and mandatory c section for delivery
    Beautiful baby girl born at 34 weeks
    Finally home after 15 day NICU stay!
    Trying for sibling: FET # 2- May 2014; beta 5/31, BFN
    FET #3, early July 2014; beta 7/14, BFN
    DE IVF # 2- August 2014; 14R, 13M, 11F, 5dt of 2 blasts (3 AA), 5 frosties = BFN
    FET #4- December 2014, yet another BFN

    Dr. KK work up shows borderline uterine blood flow, elevated NK cells, and MTHFR mutation (homozygous for c677t)

    Added baby aspirin, prednisone, supplements, Metanx, and intralipids

    Switched to large clinic for final attempt; had endometrial receptivity testing in January; FET March 2015 = yet another BFN

    Likely OAD- NBC

  • It's a difficult decision that only you can make. The only thing I can say is that DE will be still there after if you decide to try once more with OE. The finances part is the difficult one. Also as PP said, DE is not a guarantee-- it took us 4 tries with DE. FWIw, I did get 3 eggs in my last IVF with worse numbers than you (I was 2 months shy of 39) so I think there's a good chance you will get a few eggs. But it's impossible to know if quality will still be there from 2-3 yrs ago. If my eggs worked once, I may be more likely to try one last time. GL with your decision.

    TTC #1 since 8/1/10; Me:41 and BRCA1+, DH:46
    DOR (FSH 24.3)/ terrible egg quality ; homozygous MTHFR c677t
    5 IUI's: 2/11 to 6/11 and 1/12= BFN
    OE IVF#1-4 8/11-6/12= all BFN
    DE IVF#1 11/12 bad embryos= BFN
    DE IVF #2 2/13 BFP/Beta hell: m/c 5w6d
    CFNBC 7 months, not doing well; decided on guarantee program at RBA w/frozen DE
    DE IVF #3 1/14  ET 4BB; BFP;M/C 5w1d, incomplete m/c; MVA extraction in ER 7w1d

    DE FET#1 ET 3/1714; BFP, beta 1 3/27= 197, beta 2 3/31= 1586, beta 3 4/7= 13879!!
    First u/s= Twins with HBs at 6w2d! We are Team Pink x 2!!

    K & K born 11/21/14 at 38wks 4 days

    imageimage

    SAIF/PAIF Welcome


    http://waitingforraintostop.wordpress.com

  • jej05jej05 member
    Like pp said, a lot of this will depend on age and finances. My last AMH was .23, FSH was 11. I did not have success with IUIs and am over 40. We did not have coverage for IVF at the time, and my RE was not optimistic for success with my OE. We went straight to DE. As you can see from my siggy, even DE is not a 100 percent guarantee. Sometimes that can take multiple cycles so if you are OOP, something to plan for. GL!
    Thanks for your input chicagobride_07. I do see from your siggy that DE is not guaranteed to work on the first try. And yes, we are OOP. Our insurance will only pay for for timed intercourse and meds for timed intercourse. No IUI or IVF. I see you had your little girl at 34 weeks and she was in the NICU. My son was born at 34 weeks and spent time in the NICU as well. Anyway, thanks for your input!
    Many failed IUI's (medicated and unmedicated) IVF#1-Micro-dose Lupron protocol: BFN IVF#2-Antagonist Protocol-transferred 1 8-cell grade A embryo: BFP! Missed Miscarriage- D&C 4/2011 IVF#3-Antagonist protocol again but no bcp's: August 2011 DOR, endo and cervical stenosis ER 8/16/11 3 er 3 fert w/icsi ET 8/19/11-assisted hatching- transferred (2) 8 cell embryos! 9/1/11=Beta#1=824 9/6/11=Beta#2=7337


  • jej05jej05 member
    It's a difficult decision that only you can make. The only thing I can say is that DE will be still there after if you decide to try once more with OE. The finances part is the difficult one. Also as PP said, DE is not a guarantee-- it took us 4 tries with DE. FWIw, I did get 3 eggs in my last IVF with worse numbers than you (I was 2 months shy of 39) so I think there's a good chance you will get a few eggs. But it's impossible to know if quality will still be there from 2-3 yrs ago. If my eggs worked once, I may be more likely to try one last time. GL with your decision.
    Yeah, I know only we can make the decision. It's just so hard!! We've been at this TTC thing off and on since 2005 and I am ready to be done so we can move forward. We have lost a lot of time in between cycles because my DH is military so he is not always around. Thanks for your input and congrats on your girls :)
    Many failed IUI's (medicated and unmedicated) IVF#1-Micro-dose Lupron protocol: BFN IVF#2-Antagonist Protocol-transferred 1 8-cell grade A embryo: BFP! Missed Miscarriage- D&C 4/2011 IVF#3-Antagonist protocol again but no bcp's: August 2011 DOR, endo and cervical stenosis ER 8/16/11 3 er 3 fert w/icsi ET 8/19/11-assisted hatching- transferred (2) 8 cell embryos! 9/1/11=Beta#1=824 9/6/11=Beta#2=7337


  • I agree with pp too.  This is a VERY personal decision but I understand you wanting to talk it out with others that understand, I definitely did the same thing.  I also know the feeling of not wanting to hear about DE at all and then warming up to it.  I've gone through that exact thing.  You really need to look deep inside yourself and make a decision for this one.  Your desire to have ANY child, not just biological will be the determining factor.  It took me a very long time to grieve not having a bio child and I still struggle with it some days.  It's something that no one understands unless it's you.  Plus on top of that, you have to consider your finances and if your cycle fails, would you be able to do DE after?   It's so hard.

    Sorry for my ramble.  I hope that you can come to a decision that you are comfortable with and be able to move forward.
    TTC #1 Since May 2011 ~ Everyone Welcome
    Me (34): DOR d/t chemo/radiation, Immature Endometrial Lining, Hypothyroidism
    DH (35): MFI d/t testicular torsion and removal, Low T, Oligospermia, Anti-Sperm Antibodies, Currently on T supplements
    Sept '11-April '13 ~  Testing, failed multiple MFI treatments, saving & TONS of praying
    January 2014 ~ IVF/ICSI & PGS ~ no response to stims ~ converted to IUI ~ BFN
    February 2014 ~ On to donor embyros ~ 5 blasts!!! 
    March 2014 ~ FET #1 ~ Transferred 2 blasts ~ BFN
    July 2014 ~ Kliman's mock cycle with endometrial function test
    Sample too small for EFT, HE slide showed immature cells
    New protocol planned, saving for another biopsy for EFT
    January 2015 ~ Considering adoption options
    April 2015 ~ Privately arranged adoption of planned pregnancy
    DD#1 ~ Lillyana Violet Marie born 6/15/16, Finalized adoption 12/20/16
    July 13, 2018 ~ BFP....WTF?!?!
    7/16 Beta #1 ~ 466...7/18 Beta #2 ~ 1,077...7/23 Beta #3 ~ 5,291
    7/23 US #1 ~ 1 gestational sac seen and yolk sac
    7/30 US #2 and 1st OB appt ~ 1 perfectly round gestational sac, 1 perfect yolk sac and 1 teeny tiny heart beat seen!!!
    Lilypie Maternity tickers


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