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letrozole/femara experience

Steph1673Steph1673 member
edited June 2014 in Secondary IF
I took my first dose of letrozole this morning: 5.0mg per day (2.5mg am/pm) CD3-CD7. My RE said most women have far less side effects with it than with chlomid, but I was just curious of the side effects that some of you have felt so I know what to expect. 

ETA: Correct dosage :-) Was missing the decimal points.
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Re: letrozole/femara experience

  • designer303designer303 member
    letrazole was fairly easy for me, I had more ovulation cramping and pain but that was due to a huge follie

    TTC#1 May 2009- July 2010 on our own with no luck

    Started with RE in August 2010, dx with unexplained IF and then finally our 3rd IUI cycle using Follistim and Trigger resulted in our wonderful little man.  Born 12/2/11

    TTC#2 Never really prevented, but were careful early on as Dr. reccomended

    Surprise BFP 12/16/13, started progesterone immediately as first numbers came back low, but betas were good.  Progesterone wasnt enough. Natural MC 12/24/13.

    Back with RE as of January 2014...

    5/27/14- Chemical Pregnancy :(

    April 2015 IVF#1

    5/13/15- BFP, please stick LO!

    Oh and I'm a major Harry Potter Nerd :)

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  • MrsLaurenandDanMrsLaurenandDan member
    I was really weepy on it. But are you sure of that dosage? I feel like mine was 7.5mg.
    TTC #1 June 2010
    1/3/11 S/A - Count 45; Motility 32; Morph 4.3 - 2/10/11 - S/A Count 17mil; Motility 39; Morph 7.9
    1/5/11 Femara Cycle #1 = BFN  2/4/11 Femara Cycle #2 = BFP: 3/4/11 - Starting Progesterone suppositories 
    Beta#1 15DPO = 108; Beta#2 17DPO = 179; Beta#3 18DPO = 259; Beta 4# 20DPO =659!!
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    TTC#2 Pulled goalie 5/12, PPAF 3/13, BFP 6/27 Beta 15DPO=248! 
    Dx Severe Hydrocephalus and severe Dandy Walker Cyst.   Stillborn 10/19/13
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    TTC#3 - (No preventing, TTC+progesterone starting 12/13)
    4/7/14 CD3 BW - FSH 5.6; AMH 0.469 - 4/11/14 S/A Count 35, Motility 47, Morph 1.5
    4/16/14 - Cycle 6 - Natural IUI - Beta 12DPIUI = 3; Beta 13DPIUI=4.  15DPIUI=6. 17DPIU=4. Chemical Pregnancy  
    TTC #4
    5/5/14 Dx MTHFR homozygous A1298C, Benched 1 cycle HSG 5/14 both tubes open w/scarring on the left   
    5/28/14 Starting clomid 6/8/14 IUI #2 1 dominant follicle 31mm Beta 11DPIUI =4, 15DPIUI = 74, 17DPIUI = 165 
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  • Steph1673Steph1673 member
    MrsLaurenandDan said:
    But are you sure of that dosage? I feel like mine was 7.5mg.
    Oops, I'm missing decimal points. 5.0MG and 2.5MG. I'm going to edit original post :-)
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  • Bananappeal145Bananappeal145 member
    Clomid was awful and gave me rage and migraines. Femara was/is much better. I get a few hot flashes while I'm actually taking it but nothing much after that. Good luck!
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  • FrenchteachermamaFrenchteachermama member
    I took 5.0 mg at night each night CD 3-7 for the past 3 cycles and have had no side effects.



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    My FF Chart:
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    TTC #3 since June 2013
    BFP #1 7/21/2013--EDD 3/30/14--D&C 9/24/13
    BFP #2 1/28/14--MC 2/7/14
    IUI #1 5mg Femara + trigger = BFN
    IUI #2 5mg Femara + trigger = BFN
    IUI #3 5mg Femara + trigger = BFN
    IVF #1, Stimmed for 12 days, ER 8/22/14, 9 retrieved, 7M, 7F!!  Freeze all due to fluid in uterus.
    FET end of October 2014 cancelled due to fluid in uterus due to possible c-scar defect
    Surgery scheduled 12/12/14 to fix possible isthmocele
    3/26/15 transferred one 8 cell grade 4 embryo and one 6 cell grade 3 embryo = slow rising betas for 2+ weeks = ectopic MTX shot 4/29/15
    Repeat c-scar surgery June 2015
    2nd and last IVF cycle August 2015, stimmed for 12 days, 2 egg retrieved, both mature and both fertilized.  Transferred both 8-cell embryos on Day 3, beta 9/5/15 = BFFN
    MOVING TO ADOPTION!  


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  • zsharkyzsharky member
    I think I was on 2.5 mg and I didn't have any side effects. It was so much better for me than Clomid, which made me ragey. I got pregnant with my son on cycle 2 of Femara, so it worked well for me. I only took it once a day, at night, I think. It was almost 4 years ago so I don't know how reliable my memory is.
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  • lupineauralupineaura member
    Thanks for asking- this thread is very interesting to me as well; I'll be switching from Clomid to Letrozol soon. 
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  • Steph1673Steph1673 member
    I'm on my last day taking Letrozle this cycle (CD7), 5th day on it) so I thought I'd report back...

    Fairly symptom-free outside of one night (CD5, 3rd day on it) feeling a little "weepy" as PP called it and waking up with a pretty bad hot flash that same night/early the next morning.
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