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Progesterone crystalizing

Momarazzi007Momarazzi007 member
in Secondary IF
So, over the weekend the 1st bottle of progesterone in oil (ethyl oleate) started to crystalize image
Left bottle
Anyway, I had only maybe three doses left. I didn't feel right about it, talked to my nurse, she was out over weekend but I went ahead and followed my gut and opened second bottle. After yesterday's dose (third one from this bottle) it was still clear but I woke up this morning to find this:image
My nurse told me yesterday to not used crystalized bottle- that there is a way to decrystalize it but she didn't like it (warming it up slowly until crystals dissolve). She went ahead and ordered new (in sesame oil- I don't have the localized reactions with that like I do w the ethyl oleate either). Problem is they won't get here until Thursday at the earliest. So I am trying the good old warming method going on 45 minutes now and they are not dissolving.
My question is- with all the experience and cycles and trauma we have all collectively been through- anyone run across this? I'm seriously losing my mind.
January 2007- Stop BCP! Let's DO this!
June 2010- MFI. BS. IVF! Ectopic. BS. image

November 2010- FAILED FET! BS!
January 2011- BFP FET! TWINS! February 2011- lost twin. BS. image

SEPTEMBER 2011- DD Born! Most awesome girl in the world!
November 2013- FAILED FET! BS! (screw you November FETs)
April Fresh Cycle, FAILED. Frozen embryos frozen for future FETs.
FROZEN CYCLE JUNE! BFP
BABY BOY VINCENT!
image

We can't wait to meet you!
Conception:imageimageimage Potato Love!

BabyFruit Ticker


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Re: Progesterone crystalizing

  • FrenchteachermamaFrenchteachermama member
    Omg! I've only used Progesterone suppositories or Crinone with an applicator. I'm sorry I can't give you any advice!



    imageimageimage
    image
    My FF Chart:
    http://www.fertilityfriend.com/home/490dd7
    TTC #3 since June 2013
    BFP #1 7/21/2013--EDD 3/30/14--D&C 9/24/13
    BFP #2 1/28/14--MC 2/7/14
    IUI #1 5mg Femara + trigger = BFN
    IUI #2 5mg Femara + trigger = BFN
    IUI #3 5mg Femara + trigger = BFN
    IVF #1, Stimmed for 12 days, ER 8/22/14, 9 retrieved, 7M, 7F!!  Freeze all due to fluid in uterus.
    FET end of October 2014 cancelled due to fluid in uterus due to possible c-scar defect
    Surgery scheduled 12/12/14 to fix possible isthmocele
    3/26/15 transferred one 8 cell grade 4 embryo and one 6 cell grade 3 embryo = slow rising betas for 2+ weeks = ectopic MTX shot 4/29/15
    Repeat c-scar surgery June 2015
    2nd and last IVF cycle August 2015, stimmed for 12 days, 2 egg retrieved, both mature and both fertilized.  Transferred both 8-cell embryos on Day 3, beta 9/5/15 = BFFN
    MOVING TO ADOPTION!  


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  • MrsLaurenandDanMrsLaurenandDan member
    I wish I had advice! That is crazy, I'm sorry!
    TTC #1 June 2010
    1/3/11 S/A - Count 45; Motility 32; Morph 4.3 - 2/10/11 - S/A Count 17mil; Motility 39; Morph 7.9
    1/5/11 Femara Cycle #1 = BFN  2/4/11 Femara Cycle #2 = BFP: 3/4/11 - Starting Progesterone suppositories 
    Beta#1 15DPO = 108; Beta#2 17DPO = 179; Beta#3 18DPO = 259; Beta 4# 20DPO =659!!
    Lilypie Premature Baby tickers
    TTC#2 Pulled goalie 5/12, PPAF 3/13, BFP 6/27 Beta 15DPO=248! 
    Dx Severe Hydrocephalus and severe Dandy Walker Cyst.   Stillborn 10/19/13
    Lilypie - Personal pictureLilypie Angel and Memorial tickers 
    TTC#3 - (No preventing, TTC+progesterone starting 12/13)
    4/7/14 CD3 BW - FSH 5.6; AMH 0.469 - 4/11/14 S/A Count 35, Motility 47, Morph 1.5
    4/16/14 - Cycle 6 - Natural IUI - Beta 12DPIUI = 3; Beta 13DPIUI=4.  15DPIUI=6. 17DPIU=4. Chemical Pregnancy  
    TTC #4
    5/5/14 Dx MTHFR homozygous A1298C, Benched 1 cycle HSG 5/14 both tubes open w/scarring on the left   
    5/28/14 Starting clomid 6/8/14 IUI #2 1 dominant follicle 31mm Beta 11DPIUI =4, 15DPIUI = 74, 17DPIUI = 165 
    Lilypie - Personal pictureLilypie Maternity tickers
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  • iheartsippycups2iheartsippycups2 member
    No advice here, but can they give you another form of progesterone in the meantime?
    image
    image

    My History:
    Lots of BFN's & failed IUI's w/clomid and/or femara
    Finally BFP with femara & t.i.- son born 6/17/2010
    Started TTC again around when DS was 3ish
    Lots of BFN's with femara & t.i & ovidrel
    Tubes clear, S.A came back low motility but high count
    About to switch to injectables w/femara, did one last cycle with just femara & an IUI with ovidrel- stupid motility was fantastic in the sample, but count was 700,000 AFTER wash! Had to sign a paper to even still do IUI- BFFP (big fat freaking positive) Go figure!
    1st Beta 13dpiui 54, 2nd beta 48 hours later 115, 3rd beta 48 hours later 310, 4th beta 72 hours later 1748.
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  • Momarazzi007Momarazzi007 member
    It's ok- I appreciate the sentiments. It is a weird thing that happened! Finally got everything sorted- have to take questionable dose today and the new PIO in sesame oil will be here tomorrow. Just have to question everything and panic today!!! Mostly just feeling like Sunday I overdid it chasing around DD bc hubs didn't watch her as much as promised, then yesterday wasn't able to get my shot until late in day (so like 7 hours late) and during weekend travels forgot a dose of my estrace... Now this... It's like everything is lining up for bfN
    January 2007- Stop BCP! Let's DO this!
    June 2010- MFI. BS. IVF! Ectopic. BS. image

    November 2010- FAILED FET! BS!
    January 2011- BFP FET! TWINS!     February 2011- lost twin. BS. image

    SEPTEMBER 2011- DD Born! Most awesome girl in the world!
    November 2013- FAILED FET! BS! (screw you November FETs)
    April Fresh Cycle, FAILED. Frozen embryos frozen for future FETs.
    FROZEN CYCLE JUNE! BFP
    BABY BOY VINCENT!
    image

    We can't wait to meet you!
    Conception:image    imageimage Potato Love!

    BabyFruit Ticker


    Report Reply
  • Momarazzi007Momarazzi007 member
    Oh, and the PIO they have in stock is half dose of what I need (apparently everything but ethyl oleate they only have at 50mg/ml) so two shots or one huge one!
    January 2007- Stop BCP! Let's DO this!
    June 2010- MFI. BS. IVF! Ectopic. BS. image

    November 2010- FAILED FET! BS!
    January 2011- BFP FET! TWINS!     February 2011- lost twin. BS. image

    SEPTEMBER 2011- DD Born! Most awesome girl in the world!
    November 2013- FAILED FET! BS! (screw you November FETs)
    April Fresh Cycle, FAILED. Frozen embryos frozen for future FETs.
    FROZEN CYCLE JUNE! BFP
    BABY BOY VINCENT!
    image

    We can't wait to meet you!
    Conception:image    imageimage Potato Love!

    BabyFruit Ticker


    Report Reply
  • MrsLaurenandDanMrsLaurenandDan member
    Oh man, not what you need. Keeping my fingers crossed for you! When is beta?
    TTC #1 June 2010
    1/3/11 S/A - Count 45; Motility 32; Morph 4.3 - 2/10/11 - S/A Count 17mil; Motility 39; Morph 7.9
    1/5/11 Femara Cycle #1 = BFN  2/4/11 Femara Cycle #2 = BFP: 3/4/11 - Starting Progesterone suppositories 
    Beta#1 15DPO = 108; Beta#2 17DPO = 179; Beta#3 18DPO = 259; Beta 4# 20DPO =659!!
    Lilypie Premature Baby tickers
    TTC#2 Pulled goalie 5/12, PPAF 3/13, BFP 6/27 Beta 15DPO=248! 
    Dx Severe Hydrocephalus and severe Dandy Walker Cyst.   Stillborn 10/19/13
    Lilypie - Personal pictureLilypie Angel and Memorial tickers 
    TTC#3 - (No preventing, TTC+progesterone starting 12/13)
    4/7/14 CD3 BW - FSH 5.6; AMH 0.469 - 4/11/14 S/A Count 35, Motility 47, Morph 1.5
    4/16/14 - Cycle 6 - Natural IUI - Beta 12DPIUI = 3; Beta 13DPIUI=4.  15DPIUI=6. 17DPIU=4. Chemical Pregnancy  
    TTC #4
    5/5/14 Dx MTHFR homozygous A1298C, Benched 1 cycle HSG 5/14 both tubes open w/scarring on the left   
    5/28/14 Starting clomid 6/8/14 IUI #2 1 dominant follicle 31mm Beta 11DPIUI =4, 15DPIUI = 74, 17DPIUI = 165 
    Lilypie - Personal pictureLilypie Maternity tickers
    Report Reply
  • ConstanceGoodspeedConstanceGoodspeed member
    Huh, maybe it is crystallizing in my ass and that is what forms the lumps and bruises (jk).

    At least with the warming-to-dissolve method the pio will be nice and fluid and hopefully go in easy and disperse.
    IVF/ICSI #1 - BFP, DS born Jan 2013
    IVF/ICSI #2 - BFP, DD born Feb 2015
    IVF FET - BFP, due April 2017


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  • Momarazzi007Momarazzi007 member
    Are you ethyl oleate too @ConstanceGoodspeed‌? I think I have a reaction to it, that is why I get the bruising and knots- I do not get them with sesame oil at all! Can you imagine it crystalizing in the butt? That just sounds painful!!!
    January 2007- Stop BCP! Let's DO this!
    June 2010- MFI. BS. IVF! Ectopic. BS. image

    November 2010- FAILED FET! BS!
    January 2011- BFP FET! TWINS!     February 2011- lost twin. BS. image

    SEPTEMBER 2011- DD Born! Most awesome girl in the world!
    November 2013- FAILED FET! BS! (screw you November FETs)
    April Fresh Cycle, FAILED. Frozen embryos frozen for future FETs.
    FROZEN CYCLE JUNE! BFP
    BABY BOY VINCENT!
    image

    We can't wait to meet you!
    Conception:image    imageimage Potato Love!

    BabyFruit Ticker


    Report Reply
  • ConstanceGoodspeedConstanceGoodspeed member
    I asked for a switch this cycle. I forget what I was using before (it was two years ago) but I had terrible itching at the injection site. 

    I am currently using sesame and have no itching but instead minor lumps, bruises and soreness.

    Neither ever crystallized. 
    IVF/ICSI #1 - BFP, DS born Jan 2013
    IVF/ICSI #2 - BFP, DD born Feb 2015
    IVF FET - BFP, due April 2017


    Report Reply
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