Endometrial Receptivity Array??

Km672

Hey ladies,

I need your thoughts. Has anyone heard of the Iviomics endometrial receptivity array? I would post a clicky link, but I don't know how!

My RE called me around 6pm last night to discuss this, given the fact that we have switched everything except for me out of the mix, they are suggesting I have this test done. Basically, from what I understand, this month will be a mock cycle and I will have an endometrial biopsy on the day I would normally have a transfer.

The results will take 2 weeks and will tell us if I was 'receptive' for an embryo to implant, if 'non receptive' it will also suggest when I would likely be 'receptive'... Then another mock cycle with another uterine biopsy on the estimated receptive day to verify that I was receptive.

Then they would use this info to verify the best day for transfer.

I still have my 2nd opinion on Tuesday, but I think we need to try this. I'm running out of options and I only have 2 embryos left, so I am desperate. I hate that this could push the transfer back another month, but I know I would regret it if this fails again and I'd wonder what if?? It's not covered by insurance, $500 per biopsy, so assuming I'll need 2, around $1000.

I'm mostly terrified this test could reveal I'm not ever 'receptive' (the site states this happens in 1% of cases)... For which there is no treatment.

Sorry for the rambling... It's 5am and I'm at work. Anyone have any thoughts/experiences with anything like this??

hmz819

I haven't heard of this test. I've heard of the beta integrin test but this seems different. Good luck!

RunCC37

I haven't heard of this test, but it sounds interesting to me. I can understand your fear, but hope you are not part of the 1%! Personally, I'd want to find out because, like you said, those two embryos are precious. If it's a matter of waiting an extra month or two, I'd think it is worth it! Good luck!

Sophistikitty

****Signature Warning****

The ERA test was suggested to me before my last cycle.  I had previously had the E-tegrity test so I elected to pass with the mindset that if our fresh transfer failed I would do it before proceeding to an FET.  If I remember correctly it seemed to be a much more accurate test than E-tegrity.  

I would probably do it if I were you.  At the very least it would give you peace of mind that you have investigated everything.    

Good luck!

Mrs.McIrish

Is this the Yale test??? If so I've heard of it. At this point, I think you need to do it to rule stuff out.. But I'm still jumping up and down that you need to be on lovenox!!

Km672

@MrsMcIrish - it's not the Yale test. It's supposed to be pretty accurate and should tell me if my uterus is 'prereceptive', 'receptive' or 'postreceptive' at the usual time of transfer... Then the results are verified the next month, assuming the timing was out of sync.

I was told its pretty new, still considered experimental. I think you're right, I have to do everything in my power to figure this out. At this point, it's pretty clear that there is something going undetected/untreated.

I have my medical record now and read through all of it last week (that was depressing!!) but it clearly stated in the lab report that the MTHFR mutations I have A1298C is not associated with any clotting disorders or heart disease... So it's kinda hard for me to convince my RE to try Lovenox... But I will keep trying.

He will be calling me this evening to further discuss the endometrial testing and I will try again. My 2nd opinion is tomorrow, I'm anxious to hear his thoughts. If he will try Lovenox and or steroids, I'm sure I'll switch clinics for the FET after this testing is completed.

It's really hard to advocate for yourself, keep a somewhat open mind and not yell at my RE. I want to shake him and scream 'obviously you're missing something!! Just TRY something different for Christ sake!! This is my last chance! I'm aware medications have side effects and risks, but I'm willing to take that risk.' Ughhhhhh!!!!!

SFOS

I had the ERA biopsy and a biopsy that looks at NK cells done earlier this week and should get the results in the next couple weeks.  We've had 7 failed transfers of a total of 8 seemingly top quality embryos (both day 3 and day 5) over the past year and a half, with one very early chemical pregnancy as the only hint of positive. Our original issue is male factor and it is quite frustrating not knowing why our embryos aren't implanting.  I'll post back once I have updates.  I found another thread on Fertility Thoughts about the ERA biopsy.  Here is a link to another forum entry on the ERA biopsy:
https://www.fertilethoughts.com/forums/questions-for-patient-care-advocates/721349-experience-endometrial-receptivity-array-implantation-window-test.html

SnookA1

So I'm still very new this site & my docs are now suggesting the ERA testing. We've had two failed IVF cycles (1st transferred two fresh embryos & 2nd transferred two frozen embryos). From what I've gathered the ERA testing is kinda like your finger print, your endometrial finger print We are going forward with the testing as soon as we have positive urine Lh! We only have two frozen embryos left & are praying that this is our answer!?! Three times a charm right ~

SFOS

I got the results of my second ERA biopsy back today after the non-receptive/pre-receptive results of my first biopsy at P+5.  My eyes were met with a big, bold, capitalized “RECEPTIVE”. The tears were not long to follow - tears of relief, tears of hope, all mixed in with a dash of apprehension. The recommendation is to proceed with a frozen embryo transfer under the same conditions as my biopsy. So it looks like we’ll be going ahead with a transfer of a 5-day blast on the 8th day of progesterone (P+7) in a hormone replacement cycle. My doctor is on holiday until the end of the week, but I’m scheduled for the first appointment on Monday and hopefully Day 1 will be soon to follow.  I'll check back with news after our next transfer.

Km672

That's great! Congrats on a receptive ute! Wishing you all the best on your next cycle!!