Infertility

WTF tomorrow - Questions?

Hello, ladies.  My first IVF cycle ended in a D&C last week, and I have my WTF appointment tomorrow.
The details should be in my signature, but here's a quick run down: 28 retrieved; 7 mature; 3 fertilized; 2 cleaved & transferred on day 3  (1 @ 6 cells and 1 @ 4 cells); BFP - but slow development on 1st U/S, overlarge yolk sack, undersized fetal pole, and eventually, end of heartbeat at 6wpt.

We did not opt for genetic testing after the D&C, but we are planning on ICSI for round 2.
Are there any questions I should be asking at this stage?  I went through 12 days of stims before retrieval using Gonal F and Menopur, then Cetrotide at the end.

Any suggestions would be appreciated.  We have the non-diagnosis of unexplained infertility, which feels a lot like taking your car to the mechanic again and again, and never quite figuring out what's causing that strange noise.  :P

*** Ticker Warning ***

Me: 37, DH: 39, TTC 5 yrs

2013 summary: Diagnosed with Hypothyroid; Cervical polyp removed (benign); 
2 rounds ovidrel with timed intercourse (no result): 3 rounds IUI with clomid + ovidrel (no result)
2014 summary (to date):
IVF cycle 1 - ER: 4/17 (28 follicles, 3 fertilized, 2 survived to day 3);
ET: 4/20 (3rd day, 2 embryos - 1 @ 6 cells & 1 @ 4 cells); Beta 5/1 - BFP!; 
1st scan 5/13 - development behind, no heartbeat detected; D&C 6/2; WTF 6/13
IVF cycle 2 - BCP begun 7/12; stims w/ HGH begun 7/26; 
ER: 8/6, 12 follicles, 7 fertilized w/ ICSI; ET: 8/11, 3 blastocysts left, 2 transferred, 3rd arrested 8/12 - none to freeze :'(
1st beta 8/19 - BFP! 294; 2nd beta 8/26 - 4976; 1st u/s 9/2; 2nd u/s 9/9 - two little heartbeats at 140 each!!! 
EDD: 29-April-2015
Other Meds: Synthroid 100 mcg/daily

  imageimageimage
Pregnancy Ticker

Re: WTF tomorrow - Questions?

  • @HollowBerry - Thanks for the ideas.  I'm going to read up on CCS and PGD tonight, so I can formulate my questions.
    And the day 5 vs day 3 debate is a good topic too - especially since my eggs seemed so slow to develop.  (4 cells on day 3 is not the norm, or so I'm told).

    *** Ticker Warning ***

    Me: 37, DH: 39, TTC 5 yrs

    2013 summary: Diagnosed with Hypothyroid; Cervical polyp removed (benign); 
    2 rounds ovidrel with timed intercourse (no result): 3 rounds IUI with clomid + ovidrel (no result)
    2014 summary (to date):
    IVF cycle 1 - ER: 4/17 (28 follicles, 3 fertilized, 2 survived to day 3);
    ET: 4/20 (3rd day, 2 embryos - 1 @ 6 cells & 1 @ 4 cells); Beta 5/1 - BFP!; 
    1st scan 5/13 - development behind, no heartbeat detected; D&C 6/2; WTF 6/13
    IVF cycle 2 - BCP begun 7/12; stims w/ HGH begun 7/26; 
    ER: 8/6, 12 follicles, 7 fertilized w/ ICSI; ET: 8/11, 3 blastocysts left, 2 transferred, 3rd arrested 8/12 - none to freeze :'(
    1st beta 8/19 - BFP! 294; 2nd beta 8/26 - 4976; 1st u/s 9/2; 2nd u/s 9/9 - two little heartbeats at 140 each!!! 
    EDD: 29-April-2015
    Other Meds: Synthroid 100 mcg/daily

      imageimageimage
    Pregnancy Ticker
  • pblgepblge member
    WTF are very personalized, so there's no set list of questions. An obvious one in your case is why there were so few mature eggs, especially given a good number retrieved. Your doc should definitely address that issue!

    The threads I've posted recently on CCS were very helpful for me. Here, here, and and here were the best ones.

    I would also consider asking about the RPL panel. I had it done after my IVF #1 resulted in a m/c. They didn't find anything, but others have discovered problems that would prevent success in future pregnancies.

    Those would be my biggest questions. And do know that lots of ladies seek out a second opinion at this point (ahem...trying to say that gently ;-) I'm feeling extraordinarily pro-second opinion right now.).

    Good luck!
    **********************siggy/ticker warning**********************

    ***Losses mentioned.*** TTC #1 since May 2012. Me: 37, OH: 41. Ectopic August 2012 => tubal damage. :'(  Stage 1 endo removed June 2013. IVF #1 Oct/Nov 2013: Long Lupron with Gonal-F. 7R, 7M, 7F. 2 txfer@3d. Nothing frozen.  => M/C @ 8 wks. :'( Selected RPL panel all normal. Very hyper and brittle response to stims. IVF #2 (antagonist protocol) Feb 2014 => Converted to IUI (Perfect conditions). BFN. IVF #2.1 w/ new RE June 2014: Antagonist protocol. 33R, 31M, 30F, 19 blasts to test!!! I made it through without crashing!! :) Hats off to Dr. Fancypants!! ET of one 5AB blast. BFN. 13 10 CCS'ed snowflakes! FET #1 PUPO as of 7/29 Betas: 8/7@24, 8/9@97, 8/11@334 (etc.) Two sacs on 8/15, one seen on 8/18 after a bleed. U/s 8/25 (6+3) "perfect": 5.9 mm + HB@120bpm! U/s 9/4 (7+6): 15.9 mm + HB@172 bpm! Please, PLEASE stick this time!!!!
    http://i955.photobucket.com/albums/ae39/catfreeburg/866da40f5178fed79efe23fc8a4e8a_zps4498a9cc.jpgimageimageimageimage
    image
  • Loading the player...
  • pblgepblge member
    ...Not that there's necessarily anything wrong with your doctor! It's just a time that lots of ladies seek a second opinion!

    Whew, I'm paranoid now! LOL!
    **********************siggy/ticker warning**********************

    ***Losses mentioned.*** TTC #1 since May 2012. Me: 37, OH: 41. Ectopic August 2012 => tubal damage. :'(  Stage 1 endo removed June 2013. IVF #1 Oct/Nov 2013: Long Lupron with Gonal-F. 7R, 7M, 7F. 2 txfer@3d. Nothing frozen.  => M/C @ 8 wks. :'( Selected RPL panel all normal. Very hyper and brittle response to stims. IVF #2 (antagonist protocol) Feb 2014 => Converted to IUI (Perfect conditions). BFN. IVF #2.1 w/ new RE June 2014: Antagonist protocol. 33R, 31M, 30F, 19 blasts to test!!! I made it through without crashing!! :) Hats off to Dr. Fancypants!! ET of one 5AB blast. BFN. 13 10 CCS'ed snowflakes! FET #1 PUPO as of 7/29 Betas: 8/7@24, 8/9@97, 8/11@334 (etc.) Two sacs on 8/15, one seen on 8/18 after a bleed. U/s 8/25 (6+3) "perfect": 5.9 mm + HB@120bpm! U/s 9/4 (7+6): 15.9 mm + HB@172 bpm! Please, PLEASE stick this time!!!!
    http://i955.photobucket.com/albums/ae39/catfreeburg/866da40f5178fed79efe23fc8a4e8a_zps4498a9cc.jpgimageimageimageimage
    image
  • @pblge - Thanks for the links to all those relevant threads.  I'm probably leaning toward your line of thinking now - I'd like to test, but that will be dependent on the number of embryos created.

    I also appreciate your feedback about the 2nd opinion (no worries here - I took no offense).  Frankly, I would be very unlikely to come to this decision myself as I'm very shy about these kinds of things.  (Which might explain why I ignored my IF for years until I finally was old enough to be high risk before seeking any help at all).  I need to be told things like that, so that I can at least consider whether this is the right move for me.

    *** Ticker Warning ***

    Me: 37, DH: 39, TTC 5 yrs

    2013 summary: Diagnosed with Hypothyroid; Cervical polyp removed (benign); 
    2 rounds ovidrel with timed intercourse (no result): 3 rounds IUI with clomid + ovidrel (no result)
    2014 summary (to date):
    IVF cycle 1 - ER: 4/17 (28 follicles, 3 fertilized, 2 survived to day 3);
    ET: 4/20 (3rd day, 2 embryos - 1 @ 6 cells & 1 @ 4 cells); Beta 5/1 - BFP!; 
    1st scan 5/13 - development behind, no heartbeat detected; D&C 6/2; WTF 6/13
    IVF cycle 2 - BCP begun 7/12; stims w/ HGH begun 7/26; 
    ER: 8/6, 12 follicles, 7 fertilized w/ ICSI; ET: 8/11, 3 blastocysts left, 2 transferred, 3rd arrested 8/12 - none to freeze :'(
    1st beta 8/19 - BFP! 294; 2nd beta 8/26 - 4976; 1st u/s 9/2; 2nd u/s 9/9 - two little heartbeats at 140 each!!! 
    EDD: 29-April-2015
    Other Meds: Synthroid 100 mcg/daily

      imageimageimage
    Pregnancy Ticker
  • vibeeevibeee member
    If you can afford it please look into PGD/CCS.  It will give you a piece of mind.  I woudl rather be left with 1-2 healthy blasts then 6-8 unknown quality ones.

    I hope all goes well!  
    TTC since 2007; Unexplained; 8PG: 4CP, 2EP, 2MC w/HB at 8-9 weeks
    Getting ready for DIVF #1 - Transfer 12/16! 
  • AMSharkAMShark member
    edited June 2014
    @vibeee - Thanks for your opinion.  Would you still test if you only had 2 fertilized eggs?  That was our situation last time by day 2, and I understand that the testing may have some potential to cause damage.

    So, I guess the question is, would you rather have 0 healthy blasts, the 1-2 unknown quality ones?
    I really hope we're not facing the same situation this round, but I am preparing myself for that, just in case.

    *** Ticker Warning ***

    Me: 37, DH: 39, TTC 5 yrs

    2013 summary: Diagnosed with Hypothyroid; Cervical polyp removed (benign); 
    2 rounds ovidrel with timed intercourse (no result): 3 rounds IUI with clomid + ovidrel (no result)
    2014 summary (to date):
    IVF cycle 1 - ER: 4/17 (28 follicles, 3 fertilized, 2 survived to day 3);
    ET: 4/20 (3rd day, 2 embryos - 1 @ 6 cells & 1 @ 4 cells); Beta 5/1 - BFP!; 
    1st scan 5/13 - development behind, no heartbeat detected; D&C 6/2; WTF 6/13
    IVF cycle 2 - BCP begun 7/12; stims w/ HGH begun 7/26; 
    ER: 8/6, 12 follicles, 7 fertilized w/ ICSI; ET: 8/11, 3 blastocysts left, 2 transferred, 3rd arrested 8/12 - none to freeze :'(
    1st beta 8/19 - BFP! 294; 2nd beta 8/26 - 4976; 1st u/s 9/2; 2nd u/s 9/9 - two little heartbeats at 140 each!!! 
    EDD: 29-April-2015
    Other Meds: Synthroid 100 mcg/daily

      imageimageimage
    Pregnancy Ticker
  • After 12 days of stims I would wonder how many of those 28 were over mature and how your RE plans to address that in the future. Good luck!
    Me: 30 DH: 30 ~ TTC #1 Since August 2011 
    BFP #1 2/28/13, Ectopic, Tubal surgery 3/25 
    Began RE testing 8/8, Dx Unexplained, 
    IUI #1 11/1=BFN Moving on to IVF 
    IVF #1 12/2 ER 8R 7M 4 fertilized
    12/7 Transferred 2 "perfect" little blasts 12/17 BFN
    New DX= DOR, I fu*kng hate IF
    1/14 Hysteroscopy, new clean uterus!
    IVF #2: bcp, Lupron, follistim 300, menopur 225. 2/21 8R 4M 3F. 3dt of 2 perfect embryos. 1 little penguin 
     3/10 BFFN
    Regrouping. Seeing reproductive immunologist Dr. Kwak Kim 6/10 
    Kwak Kim protocol: Metformin 1000mg, vitamin D 4000iu, vitamin E 400iu, baby aspirin, Metanx, levothyroxine 75mcgs 
     Surprise BFP 9/21!!! Beta #1 247, Beta #2 630. Miscarried 10/13

  • @missmarypoppins - Thanks.  I was under the impression that all but 7 were under mature - but I never actually confirmed that.  That will be a good question to ask.

    *** Ticker Warning ***

    Me: 37, DH: 39, TTC 5 yrs

    2013 summary: Diagnosed with Hypothyroid; Cervical polyp removed (benign); 
    2 rounds ovidrel with timed intercourse (no result): 3 rounds IUI with clomid + ovidrel (no result)
    2014 summary (to date):
    IVF cycle 1 - ER: 4/17 (28 follicles, 3 fertilized, 2 survived to day 3);
    ET: 4/20 (3rd day, 2 embryos - 1 @ 6 cells & 1 @ 4 cells); Beta 5/1 - BFP!; 
    1st scan 5/13 - development behind, no heartbeat detected; D&C 6/2; WTF 6/13
    IVF cycle 2 - BCP begun 7/12; stims w/ HGH begun 7/26; 
    ER: 8/6, 12 follicles, 7 fertilized w/ ICSI; ET: 8/11, 3 blastocysts left, 2 transferred, 3rd arrested 8/12 - none to freeze :'(
    1st beta 8/19 - BFP! 294; 2nd beta 8/26 - 4976; 1st u/s 9/2; 2nd u/s 9/9 - two little heartbeats at 140 each!!! 
    EDD: 29-April-2015
    Other Meds: Synthroid 100 mcg/daily

      imageimageimage
    Pregnancy Ticker
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