Hi Girls, I'm feeling a little discouraged at the moment. I just made an appointment with Dr. KK for August 20th with my follow up on September 29th... so far away! I'm just having a hard time believing that this is going to help. Our issue is poor embryo quality most likely due to my eggs. My most recent doctor said that it was a metabolic issue, and that the egg is producing too much mitochondria. Something about my eggs not having enough energy, so the mitochondria is trying to compensate. I seem to hear most of the fuss with Dr. KK about MTHFR and NK cells... I just wonder if she's going to have anything worthwhile for me... Any thoughts on this?
She runs a battery of tests. If you have insulin imbalances or testosterone imbalances that could affect egg quality.
Only you can decide if it's worth the wait. I wish I would have seen her earlier than I did but I have egg quality issues and RPL so my story is a little different.
TTC#1 since April 2011 IVF#1 July 2012 5R, 3 made it to blast, sET c/p FET#1 Aug 2012 2 blasts transferred BFN IVF#2 Oct 2012 16R/6M/6F/2-8 cell grade 1 transfer Beta 1-237.9, Beta 2-566, Beta 3-8657 US 6w3d shows one baby w/ HB 115 US 7w1d no more heartbeat/ D&C 11/30/12 normal karyotype IVF#3 Mar 2013 6R/4M/4F 1 compacting and 2-8 cell transfer ectopic pg MTX given 3 month break from TTC
IVF#4 Sept 2013--BFN IVF#5-7 Apr 2014, Jun 2014 and Aug 2014 banking embryos for CCS testing. Praying for normals!
Natural cycle Dec 2010 BFP M/C 6 1/2 Weeks, D&E Jan 2011 1 Clomid/Ovidrel BFN May 2011 Natural cycle Aug 2011 BFP M/C 4 Weeks 1 IUI Sept 2011 BFP M/c 7 weeks Provera Dec 2011 BFP M/C 3 Weeks
DQ ALPHA HLA MATCH, High NK Cells Diagnosed Dec 2011 IVF March 2012 BFP m/c 4weeks 5 days (IL, Prednisone) IVF#2w/DS July 2012 MEGA FAILURE BFN (IL, Dexamethasone) Diagnosed No real HLA Match, DQ Beta Triad, High TNF, Low NK Cells Oct 2012 Natural Cycle m/c 4wks (Lovenox, Prednisone) Went to Beer Center- high tnf, low lad, implantation failure
Nov/Dec 2012 LIT Treatment
Dec 12 Humira Jan 2013 BFP Humira,LIT,Prednisone, Lovenox, IVIG, Baby Aspirin Miracle Born August 2013 Premature
It seems as though we have a very similar 'diagnosis'.. To me it's the diagnosis of exclusion when they can't find anything else. I have no advice with dr kk, as I am stuck and don't know what to do either, but if you already have the appointment you may as well go I would say. Enjoy the summer and wait and it'll be here in no time. Good luck to you.
Me: 37, DH: 38: ttc 7 years, dx: unknown 10/11: after 2 years, saw a RE, FSH 5.4 11/11: BFP! (surprise after thyroid & normal hsg), 12/11: missed m/c after 7 week u/s, 1/12: D&C 6/12 IUI#1-IUI #3: clomid = BFP!, C/P IVF #1(10/12) FSH 5.4, AFC: 16 long Lupron, 5R/5M/4F, all 4 made it to 5dt, 1 blast/1-8 cell transferred=BFN IVF #2(12/12)AFC 21, MD lupron, 4R/4M/3F, 5dt of 1 blast and 2-8cell. BFN. IVF#3(4/13) Natural start antagon protocol, 12R,11F. one PGS normal at day 6 transfer. BFN. IVF#4 (11/13) C.CRM (ODW.U normal 8/13 Still no Diagnosis) EPP/antagonist. ER 13R/7M/6F. Only 1 made it to freeze. Abnormal.
Looking into options of DE, Fresh vs frozen. 10/14 new local RE to look into what's next. CD3 FSH 4.7, AMH 0.9. Met with DE agencies and exploring options for feb/march 2015. Surprise natural bfp (4 days before donor is signed). Beta #1 at 9dpo: 51.8, 2nd beta: 195 (25 hours doubling) @11dpo. 3rd beta (12/15): 516 (35 hrs doubling) 4th beta(12/17): 895 (58 hours doubling) 5th beta(12/19): 2120. U/S at 5w0d(12/22): one gestational sac with yolk sac. U/S #2 (6w0d)12/29. One little bean measuring 6w0d with HR 124. 3rd u/s(1/4)7w0d: baby measuring 7w2d. HR 134. 3/30: A/S at MFM went great except for low lying placenta. Verifi results are normal! Team Blue!
Please send any positive thoughts our way! EDD:8/24/2015
Baby Will born 8/18. He's perfect.
I'm sorry you feel discouraged!! I was going to make an appointment with her, but then decided against it since my RE suggested intralipids with my next cycle. If my next cycle does not work I am definitely going to make the call.
It's hard to wait when all you want is a baby! I say keep the appointment. I have seen so many women move on to PAIF/SAIF after seeing a RI. Good luck sweetie!!
::: Married June 2003::: TTC #1 since: Aug. 2008 Me: 34, DOR, MTHFR-A1298C (heterozygous), decreased blood flow to uterus, Mild Endo DH: 38, Balanced translocation 5&10, unexplained MFI, normal SA and SCSA Tx History: IUI 1&2= BFN IVF# 1 W/ICSI= BFN IVF# 2: cancelled d/t no response IVF# 3= 1 egg retrieved=immature/not viable IVF# 4= c/p ***CCRM ODWU*** Found DHs BT and Me-decreased blood flow to uterus Recommended DE IVF w/PGD, incorporate electro-acupuncture. Decided to cycle locally ***New RE*** DE IVF# 1(cycle #6) w/pgd, (freeze all): 30R, 23M, 15F, slow/poor embryo development, 4 biopsied, 1 Normal "Norm"; DE IVF w/PGD, incorporate electro-acupuncture. IVF# 6: (OE/DS) cancelled IVF# 7: (OE/DS) 1R, 1M, 1F, arrested day 5 Plan-DE IVF# 2 (cycle #8): DE/DS in May 2015
Thanks ladies. I am very much on the emotional roller coaster - there are so many options that we are considering and it is overwhelming at times! I go back and forth every day about the RI. One day I'm like, 'heck yeah, it'll be worth it even if she finds nothing worth treating. At least it'll give us the kick we need to move onto donor eggs' and the next day I'm like, 'everything is bad! Nothing is ever going to work! Woe is me!' I hate all of this so much!!! But complaining about it isn't going to change it, so I have to try to work it out. I appreciate your opinions and input! Thank you for chiming in
I hope the time flies by - I know when we took our treatment break from July-January, it was awful at first, but I felt like I normal human being for a little while. Then when we started up, I felt way more dedicated to it and doing everything possible. WIth this cycle, I'm not even thinking about it really at all. I'm doing what I need to be doing, but I don't feel as focused. I really hope she finds something!
****************SIGGY WARNING****************
TTC since 2011
DH: 29, Severe MFI; grade III varicocele; surgery postponed till KU
Me: 30, POF/DOR, factor II hetero, MTHFR homo
5 IVF's, LLP, EEP, MDLF all BFN
IVF 6 using DEB USA frozen eggs
developed bilateral PE's from BCP, cancelled/delayed 6 mths, taking lovenox
I did see egg quality improvement when I was in treatment with her, but I had issues like hmz described. Our re had suggested considering donor eggs but agreed to let us try one last cycle because we had seen such improvement in my labs while with kk. It was the only cycle we had embies good enough to freeze as well as our only bfp. I know I have a biased opinion, but to me the wait is worth it.
"Everything will be alright in the end. So if it's not alright, it is not yet the end." Me:29 DH:29 TTC since 1/11 Dx: unexplained IF/early DOR/immune issues
Feb'12- July'12-testing(all clear minus slight arcuate ute), 3 IUI with clomid all BFN 8/30IVF#1 Antagonist protocol- ER 9/11-8R, 7M, 5F.
ET 9/14 2 embies transferred. 1 10cell Grade 4, 1 8cell Grade 4. No frosties. BFN IVF#2 Antagonist protocol plus baby aspirin- ER 12/5-16R, 12M, 8F! ET 12/10 5dt! 1 fully expanded blast & 1 early blast. No frosties. BFN 3/13 hysteroscopy & polypectomy, Consulted w Dr. Kwak-Kim.
DX: High NK cells, cytokines, DHEAs& PAI1; hypothyroid, +APA, restricted bloodflow
7/13 IVF#3 Long lupron protocol with PIO, Crinone, Prometrium, and vivelle
(plus synthroid, metformin, baby asa, metanx, PNV, Vit E, D, calcium, fish oil, CoQ10, IVIg infusions and lovenox per Dr. Kwak-kim) ER 7/19 14R, 11M, 9F(4 natural fert, 5 with ICSI) ET 5dt 7/24 2 fully expanded blasts. SURPRISE 3 FROSTIES!!! Beta #1 8/2 335!!!! Beta #2 829!!! 1st u/s 8/14 showed TWINS!!!!!
11/11: TEAM PURPLE!!!!! 3/21/14-L&W born at 37w via csection Here Comes the Sun Blog PAIF/SAIF welcome!
@megs3084, THANK YOU for sharing your story. I can see from your siggy that Dr. KK found some things to work with and wow did she ever work her magic! Congratulations on your twins. What a blessing
Thank you! I see you found my blog and I'm glad its helped. Please let me know if you have any questions as things progress with her! Good luck!!
"Everything will be alright in the end. So if it's not alright, it is not yet the end." Me:29 DH:29 TTC since 1/11 Dx: unexplained IF/early DOR/immune issues
Feb'12- July'12-testing(all clear minus slight arcuate ute), 3 IUI with clomid all BFN 8/30IVF#1 Antagonist protocol- ER 9/11-8R, 7M, 5F.
ET 9/14 2 embies transferred. 1 10cell Grade 4, 1 8cell Grade 4. No frosties. BFN IVF#2 Antagonist protocol plus baby aspirin- ER 12/5-16R, 12M, 8F! ET 12/10 5dt! 1 fully expanded blast & 1 early blast. No frosties. BFN 3/13 hysteroscopy & polypectomy, Consulted w Dr. Kwak-Kim.
DX: High NK cells, cytokines, DHEAs& PAI1; hypothyroid, +APA, restricted bloodflow
7/13 IVF#3 Long lupron protocol with PIO, Crinone, Prometrium, and vivelle
(plus synthroid, metformin, baby asa, metanx, PNV, Vit E, D, calcium, fish oil, CoQ10, IVIg infusions and lovenox per Dr. Kwak-kim) ER 7/19 14R, 11M, 9F(4 natural fert, 5 with ICSI) ET 5dt 7/24 2 fully expanded blasts. SURPRISE 3 FROSTIES!!! Beta #1 8/2 335!!!! Beta #2 829!!! 1st u/s 8/14 showed TWINS!!!!!
11/11: TEAM PURPLE!!!!! 3/21/14-L&W born at 37w via csection Here Comes the Sun Blog PAIF/SAIF welcome!
Re: Dr. KK for improving egg quality??
Only you can decide if it's worth the wait. I wish I would have seen her earlier than I did but I have egg quality issues and RPL so my story is a little different.
TTC#1 since April 2011
IVF#1 July 2012 5R, 3 made it to blast, sET c/p
FET#1 Aug 2012 2 blasts transferred BFN
IVF#2 Oct 2012
16R/6M/6F/2-8 cell grade 1 transfer
Beta 1-237.9, Beta 2-566, Beta 3-8657
US 6w3d shows one baby w/ HB 115
US 7w1d no more heartbeat/ D&C 11/30/12 normal karyotype
IVF#3 Mar 2013
6R/4M/4F 1 compacting and 2-8 cell transfer
ectopic pg MTX given 3 month break from TTC
IVF#4 Sept 2013--BFN
http://i61.tinypic.com/34zll06IVF#5-7 Apr 2014, Jun 2014 and Aug 2014 banking embryos for CCS testing. Praying for normals!
Anovulatory cycles, increased Synthroid Diagnosed Sep 2010
1 Clomid/Ovidrel BFN May 2011
Natural cycle Aug 2011 BFP M/C 4 Weeks
1 IUI Sept 2011 BFP M/c 7 weeks
Provera Dec 2011 BFP M/C 3 Weeks
IVF March 2012 BFP m/c 4weeks 5 days (IL, Prednisone)
IVF#2w/DS July 2012 MEGA FAILURE BFN (IL, Dexamethasone)
Diagnosed No real HLA Match, DQ Beta Triad, High TNF, Low NK Cells
Oct 2012 Natural Cycle m/c 4wks (Lovenox, Prednisone)
Went to Beer Center- high tnf, low lad, implantation failure
Jan 2013 BFP
Humira,LIT,Prednisone, Lovenox, IVIG, Baby Aspirin
Miracle Born August 2013 Premature
Yours doesn't have to be a sad story
10/11: after 2 years, saw a RE, FSH 5.4
11/11: BFP! (surprise after thyroid & normal hsg),
12/11: missed m/c after 7 week u/s, 1/12: D&C
6/12 IUI#1-IUI #3: clomid = BFP!, C/P
IVF #1(10/12) FSH 5.4, AFC: 16 long Lupron, 5R/5M/4F, all 4 made it to 5dt, 1 blast/1-8 cell transferred=BFN
IVF #2(12/12)AFC 21, MD lupron, 4R/4M/3F, 5dt of 1 blast and 2-8cell. BFN.
IVF#3(4/13) Natural start antagon protocol, 12R,11F. one PGS normal at day 6 transfer. BFN.
IVF#4 (11/13) C.CRM (ODW.U normal 8/13 Still no Diagnosis) EPP/antagonist. ER 13R/7M/6F. Only 1 made it to freeze. Abnormal. Looking into options of DE, Fresh vs frozen.
10/14 new local RE to look into what's next. CD3 FSH 4.7, AMH 0.9. Met with DE agencies and exploring options for feb/march 2015.
Surprise natural bfp (4 days before donor is signed). Beta #1 at 9dpo: 51.8, 2nd beta: 195 (25 hours doubling) @11dpo. 3rd beta (12/15): 516 (35 hrs doubling) 4th beta(12/17): 895 (58 hours doubling) 5th beta(12/19): 2120. U/S at 5w0d(12/22): one gestational sac with yolk sac. U/S #2 (6w0d)12/29. One little bean measuring 6w0d with HR 124. 3rd u/s(1/4)7w0d: baby measuring 7w2d. HR 134. 3/30: A/S at MFM went great except for low lying placenta. Verifi results are normal! Team Blue! Please send any positive thoughts our way! EDD:8/24/2015
Baby Will born 8/18. He's perfect.
I'm sorry you feel discouraged!! I was going to make an appointment with her, but then decided against it since my RE suggested intralipids with my next cycle. If my next cycle does not work I am definitely going to make the call.
It's hard to wait when all you want is a baby! I say keep the appointment. I have seen so many women move on to PAIF/SAIF after seeing a RI. Good luck sweetie!!
::: Married June 2003:::
TTC #1 since: Aug. 2008
Me: 34, DOR, MTHFR-A1298C (heterozygous), decreased blood flow to uterus, Mild Endo
DH: 38, Balanced translocation 5&10, unexplained MFI, normal SA and SCSA
Tx History: IUI 1&2= BFN
IVF# 1 W/ICSI= BFN
IVF# 2: cancelled d/t no response
IVF# 3= 1 egg retrieved=immature/not viable
IVF# 4= c/p
***CCRM ODWU***
Found DHs BT and Me-decreased blood flow to uterus
Recommended DE IVF w/PGD, incorporate electro-acupuncture. Decided to cycle locally
***New RE***
DE IVF# 1(cycle #6) w/pgd, (freeze all): 30R, 23M, 15F, slow/poor embryo development, 4 biopsied, 1 Normal "Norm"; DE IVF w/PGD, incorporate electro-acupuncture.
IVF# 6: (OE/DS) cancelled
IVF# 7: (OE/DS) 1R, 1M, 1F, arrested day 5
Plan-DE IVF# 2 (cycle #8): DE/DS in May 2015
http://icanhazbabyz.blogspot.com/
Me:29 DH:29 TTC since 1/11 Dx: unexplained IF/early DOR/immune issues
8/30IVF#1 Antagonist protocol- ER 9/11-8R, 7M, 5F.
IVF#2 Antagonist protocol plus baby aspirin- ER 12/5-16R, 12M, 8F!
ET 12/10 5dt! 1 fully expanded blast & 1 early blast. No frosties. BFN
3/13 hysteroscopy & polypectomy, Consulted w Dr. Kwak-Kim.
ER 7/19 14R, 11M, 9F(4 natural fert, 5 with ICSI)
ET 5dt 7/24 2 fully expanded blasts. SURPRISE 3 FROSTIES!!!
Beta #1 8/2 335!!!! Beta #2 829!!! 1st u/s 8/14 showed TWINS!!!!!
3/21/14-L&W born at 37w via csection
Here Comes the Sun Blog
PAIF/SAIF welcome!
Me:29 DH:29 TTC since 1/11 Dx: unexplained IF/early DOR/immune issues
8/30IVF#1 Antagonist protocol- ER 9/11-8R, 7M, 5F.
IVF#2 Antagonist protocol plus baby aspirin- ER 12/5-16R, 12M, 8F!
ET 12/10 5dt! 1 fully expanded blast & 1 early blast. No frosties. BFN
3/13 hysteroscopy & polypectomy, Consulted w Dr. Kwak-Kim.
ER 7/19 14R, 11M, 9F(4 natural fert, 5 with ICSI)
ET 5dt 7/24 2 fully expanded blasts. SURPRISE 3 FROSTIES!!!
Beta #1 8/2 335!!!! Beta #2 829!!! 1st u/s 8/14 showed TWINS!!!!!
3/21/14-L&W born at 37w via csection
Here Comes the Sun Blog
PAIF/SAIF welcome!