ME:46 MH:44 DE IVF 2014
Met with RE 4/11.
2 IUI's BFN. DE best option. Switched clinics to do
"shared" program.
Had to retake all tests and a mamm that put me behind and then on a DE waiting list for 12 months.
Picked a donor!! (10/13/13) Got matched. Estimated transfer in December. After 2.5 years of patiently waiting I will finally cycle....can hardly believe it. DE cycle got cancelled. One of her tests came back positive. Waiting for another donor. Donor picked!! (1/18/14)
DE IVF #1 (4/26) BFN DE FET #1 (6/4) BFP! Beta 1=339 Beta 2=852 Beta 3=9957 EDD 2/22/15!!
Re: FET Plan...sound right?
DOR and AMA
2/12-5/12: 4 IUI cycles = all BFN;
7/12: DE IVF # 1 (with ICSI)- 20R, 16M, 14F, 5DT of 2 blasts; 6 frosties = BFN;
Lupus anticoagulant initially high, then found to be normal on hematology consult;
Follow up testing in September all clear;
Started synthroid for "high normal" TSH;
FET # 1- late October 2012- BFP on FRER; beta # 1- 21(low), beta # 2- 48 (still low), beta # 3- 132, beta # 4- 1,293; beta # 5- 5,606; last beta- over 100,000. First u/s 11/21- heard heartbeat
12/12- Officially an OB patient!
Level 2 ultrasound at 20 weeks shows vasa previa and VCI
Referral to MFM and mandatory c section for delivery
Beautiful baby girl born at 34 weeks
Finally home after 15 day NICU stay!
Trying for sibling: FET # 2- May 2014; beta 5/31, BFN
FET #3, early July 2014; beta 7/14, BFN
DE IVF # 2- August 2014; 14R, 13M, 11F, 5dt of 2 blasts (3 AA), 5 frosties = BFN
FET #4- December 2014, yet another BFN
Dr. KK work up shows borderline uterine blood flow, elevated NK cells, and MTHFR mutation (homozygous for c677t)
Added baby aspirin, prednisone, supplements, Metanx, and intralipids
Switched to large clinic for final attempt; had endometrial receptivity testing in January; FET March 2015 = yet another BFN
Likely OAD- NBC
Me: Diagnosed with ovarian cancer in 2013, underwent fertility sparing surgery which left low ovarian reserve, no tubes, partial ovary | DH: perfectly normal
BFP: 5/30/2014 via donor eggs | EDD: 2/6/2015
@chicagobride_07 the biopsy is to confirm that the estrogen and progesterone on my uterine mining is sufficient to expect that implantation can occur. Is that what its used for @Jessarab? Ugh I'm clueless. My e2 was low from the beginning.
No to immune testing. I know others have gone above and beyond and spent a good amount of $ to try/have their baby. Sadly that is not us. This is our stopping point. I would do AH but hate the thought of biopsy. Not sure what is wrong with me. Just freaking out I guess.
Well I guess if we are not going to go with what is recommended or just do AH then it's no ones fault but ours in the end. They said it's up too us. Thanks ladies. I'm pathetic
ME:46 MH:44 DE IVF 2014
Met with RE 4/11. 2 IUI's BFN. DE best option. Switched clinics to do "shared" program. Had to retake all tests and a mamm that put me behind and then on a DE waiting list for 12 months. Picked a donor!! (10/13/13) Got matched. Estimated transfer in December. After 2.5 years of patiently waiting I will finally cycle....can hardly believe it. DE cycle got cancelled. One of her tests came back positive. Waiting for another donor. Donor picked!! (1/18/14)
DE IVF #1 (4/26) BFN DE FET #1 (6/4) BFP! Beta 1=339 Beta 2=852 Beta 3=9957 EDD 2/22/15!!
Oh now I'm wondering about my grammer with all those grammer pet peeves discussion we just had!!
ME:46 MH:44 DE IVF 2014
Met with RE 4/11. 2 IUI's BFN. DE best option. Switched clinics to do "shared" program. Had to retake all tests and a mamm that put me behind and then on a DE waiting list for 12 months. Picked a donor!! (10/13/13) Got matched. Estimated transfer in December. After 2.5 years of patiently waiting I will finally cycle....can hardly believe it. DE cycle got cancelled. One of her tests came back positive. Waiting for another donor. Donor picked!! (1/18/14)
DE IVF #1 (4/26) BFN DE FET #1 (6/4) BFP! Beta 1=339 Beta 2=852 Beta 3=9957 EDD 2/22/15!!
As others have said, you want to make sure you have no regrets. While I'm tempted to tell you to pull out all the stops for this final transfer, you (and DH) have to feel comfortable with the plan.
FWIW, I've done the endo biopsy several times, but ironically not before this last (successful) cycle. The actual procedure didn't bother me, but if it's causing you this much stress, I would say to go with your gut and not do it. However, in my own humble opinion, I think it would be best to transfer two this time and to go for the added cost of AH. Again, only you and DH can decide whether you are OK with transferring two. I just know that I've always transferred two and never had more than one stick....but everyone is different...and we've seen other AMA ladies wind up with twins, so it's hard to say what is the best choice.
Finally, I just wanted to ask for clarification....when you said you didn't sign up for any testing, what were you referring to? I thought you had at least done the required testing for an IVF cycle (saline sono, HSG, etc.)? Forgive me for asking, but I just wanted to make sure I understand that your tubes, uterus are OK and that you're not missing these kinds of tests.
(((HUGS))) again as you decide on how to proceed with the FET. I hope you and DH can get on the same page.
Me: AMA, DOR, undetectable AMH, carrier of SMA, MTHFR homozygous C677T, high cytokines, low IGg B cells, Factor XIII V34l mutation, High Anti-Phosphatidylethanolmine, borderline hypothyroid and mildly insulin resistant.
MH: No known issues, aside from MTHFR.
Recommendations from RI: LIT, Humira, IVIG, Lovenox, Baby Aspirin, Folic Acid, Low-dose synthroid and Metformin.
Currently taking: Pre-Natal vitamins, Foltanx, Low-dose synthroid and Metformin.
When cycling also taking: Baby Aspirin, Lovenox, Humira and IVIG.
TTC since 7/11/09..with medical intervention starting in 2010, including 4 failed IVF's and 6 failed IUI's...only "success" was a chemical pregnancy in 11/2012 (credited to use of DE).
FET #1 (11th cycle) on 8/23/13 = BFN.
FET #2 (12th cycle) Transfer of last two (day 6) donor egg blasts on 1/22/14 = BFP, EDD = 10/10/14 (please stick little BOY!)
My favorite breed:
***PAIF/SAIF always welcome***
Hope all is well with you!!
ME:46 MH:44 DE IVF 2014
Met with RE 4/11. 2 IUI's BFN. DE best option. Switched clinics to do "shared" program. Had to retake all tests and a mamm that put me behind and then on a DE waiting list for 12 months. Picked a donor!! (10/13/13) Got matched. Estimated transfer in December. After 2.5 years of patiently waiting I will finally cycle....can hardly believe it. DE cycle got cancelled. One of her tests came back positive. Waiting for another donor. Donor picked!! (1/18/14)
DE IVF #1 (4/26) BFN DE FET #1 (6/4) BFP! Beta 1=339 Beta 2=852 Beta 3=9957 EDD 2/22/15!!
Awww big squishy ((((HUGS))))). I get where you are coming from, we did only basic test (HSG, SA, etc) to save cost, and we never had anything come across saying we SHOULD do more test. So it is a shocker to try and add in the extra cost and makes these decisions even harder.
So I say take a deep breath and if you feel comfortable with just going for it one last try, then I say go for it and I will send you all the sticky vibes possible.
ETA: Also, my RE has me take progesterone vaginally, so no shots, could you ask your RE about that? From what I found there was no difference in out comes one way or the other.
April 2013 DE IVF= BFN
September 2013 DE IVF (Fingers Crossed) = BFFFN! again...
October 2013 FET of our last 2 = Beta Hellzz for 6-7 Weeks. M/C
ME:46 MH:44 DE IVF 2014
Met with RE 4/11. 2 IUI's BFN. DE best option. Switched clinics to do "shared" program. Had to retake all tests and a mamm that put me behind and then on a DE waiting list for 12 months. Picked a donor!! (10/13/13) Got matched. Estimated transfer in December. After 2.5 years of patiently waiting I will finally cycle....can hardly believe it. DE cycle got cancelled. One of her tests came back positive. Waiting for another donor. Donor picked!! (1/18/14)
DE IVF #1 (4/26) BFN DE FET #1 (6/4) BFP! Beta 1=339 Beta 2=852 Beta 3=9957 EDD 2/22/15!!
Your RE only wants what is best for you and wants to do whatever will give you your best chance of getting pregnant.
I apologize in advance if you've already answered this, but why have you decided this will be your final transfer? It just seems like you have waited so very long and my experience has been that FETs are so much easier than fresh cycles. (Timing and scheduling wise, no synchronizing with the donor, no waiting for donor testing, less medications and less appointments and less stress because you know ahead of time the quality and quantity of the embryos. (although I know there is the possibility of thawing issues))
Assuming you and your husband are firm on this being your last transfer, are you comfortable with transferring 2?
Yes, the testing your RE is recommending is usually only done after multiple failures, but I think he is just trying to give you all your options so you can make a fully informed decision.
After this most recent failed cycle, my RE recommended another sonohystogram and biopsy. I just had both of these done in October. I've had at least 6 different sonohystograms and 1 hysteroscopy. I flat out refused. I feel that because all of them have always been normal, it is a waste of time.
My RE was totally fine with it and just explained that this was really all he could offer to me at this point. I've had the RPL panel and every other test he can offer to me. He explained he can't alter the embryos, they are what they are and just wanted to give me the option.
My point is, if you don't want to do it you absolutely don't have to. Honestly, if I had only had 1 failed transfer of 1 day 3 embryo, I wouldn't do it.
I've had 2 biopsies done, 1 was awful and my last one was not bad at all! Ask your RE if he can have you cough really hard during the actual biopsy, this has really helped me with the pain. I just did this when I had lidocaine injected into my cervix for my stitch on Monday and it makes a HUGE difference. Also, I had 10mg of Valium.
I hope this is helpful. Sorry for the novel. I just wanted to offer you 1 more piece of advice, I hope you don't mind.
Even if you are 100% sure this is your last transfer, I wouldn't discard your remaining embryos yet. If you do get pregnant and god forbid, I hate to even type this, but miscarry, you might be kicking yourself and want to try again.
And if again, god forbid, you aren't successful with this transfer, I can tell you from personal experience it will hit you hard. It will literally feel like your world has fallen apart. You might want nothing more than to try 1 last time and regret discarding your remaining frosties.
I know this process is expensive and scary, I just don't want you to limit your options while you're in the middle of this awful process. You have a really good chance at your take home baby with the frosties you have.
Best of luck, no matter what you decide.
>:D< >:D< >:D< >:D<
Me (32) DOR, elevated NK Cells/ 2 copies of MTHFR mutation/ MH (35) azoo/high DFI (TTC#1 since 2009)
IVFs#1-4: (4/10-2/12) all BFN
Surprise Bfp (9/11) - c/p
DS IUI#1-2 (9/12, 10/12) - BFN
DS IVF: (11/12) - BFN
DE/DS IVF#1: (10/13) - 2 day 3 embies transferred-BFFN
FET of 2 day 6 blasts: (12/13) - c/p
DE/DS IVF #2: (4/14) - 1 day 5 blast transferred...BFFN...again.
FET 5/14: 1 day 5 hatching blast transferred...another BFFN
Repeat SHG 6/14-normal / Endometrial Receptivity Array biopsy 7/14-Receptive Uterus
New RE, additional testing reveals elevated NK Cells
FET of 1 day 5 blast (RE recommends transferring 1 due to elevated NK cells) with lovenox, steroids & intralipids in October
I will not discard remaining 2 frosties. Like you said you just never know what can happen or if we change our mind months down the road but with my age I'm not sure.
MH is just comfortable transferring one. I asked coordinator how effective AH is and she said they really are not sure if it helps for donor eggs but they are just offering us best options. I'm not doing biopsy.
Why last try? Honestly I think we are just lost on this process. MH did say we would try one last time before he knew my boss was helping us with some costs for FET. I think he is scared and wants me to know there has to be a stopping point. Even though it's just another small chunk of change for a 2nd FET he is just not comfortable in spending more $ for maybe a baby. I havent had a raise in 6 years. He barely gets them. It's just what we feel comfortable in doing. Can he change his mind? Of course. I don't think we know WHAT were doing. When talking to the coordinator it was her idea to tell Dr this was "probably" our last try just by seeing how upset I was.
You all probably think we are psychotic!
ME:46 MH:44 DE IVF 2014
Met with RE 4/11. 2 IUI's BFN. DE best option. Switched clinics to do "shared" program. Had to retake all tests and a mamm that put me behind and then on a DE waiting list for 12 months. Picked a donor!! (10/13/13) Got matched. Estimated transfer in December. After 2.5 years of patiently waiting I will finally cycle....can hardly believe it. DE cycle got cancelled. One of her tests came back positive. Waiting for another donor. Donor picked!! (1/18/14)
DE IVF #1 (4/26) BFN DE FET #1 (6/4) BFP! Beta 1=339 Beta 2=852 Beta 3=9957 EDD 2/22/15!!
Becky all I can say is a big FU to IF. When my DH I started we talked about one try and done and well, as you know that did not happen. BUT. We did have a serious talk about our next try being the last try once and for all, which is scary to think about but we all have our limits, emotionally and financially.
Again (((HUGS))) and honestly this stuff does/can drive you to the loony bin with all the different emotions that we go through, so your not alone ;-)
April 2013 DE IVF= BFN
September 2013 DE IVF (Fingers Crossed) = BFFFN! again...
October 2013 FET of our last 2 = Beta Hellzz for 6-7 Weeks. M/C
You really made me think about the when is enough, enough. Limits isn't something we have really discussed but I can see the importance of it now - so thank you
As long as you do what is best for you & hubby, no one can ask more than that!
Me: Diagnosed with ovarian cancer in 2013, underwent fertility sparing surgery which left low ovarian reserve, no tubes, partial ovary | DH: perfectly normal
BFP: 5/30/2014 via donor eggs | EDD: 2/6/2015
IUI#1 w/ Clomid, Trigger, and Crinone: BFP 9/12/12, EDD 5/24/13, mm/c 10/13/12, Testing done = Trisomy 16
IUI#2-8 (injectables): BFN
IVF #1- April 2013: Only 1 follicle on max stims- Converted to IUI: BFN
DE IVF#1: BFP!! EDD 11/20/14
Praying unceasingly for a miracle. ALL welcome!
IVF#1 Oct 2009 (CCRM) - BFN
IVF#2 March 2010 - Poor response/cancelled
DE IVF#1 Aug 2010 - BFN
DE IVF#2 Dec 2010 - Transferred 1, 2 frozen - BFP!
TTC#2 FET Jan 2013 - Transferred 1 - BFP!
Me: 33 (Mosaic Turner's Syndrome/POF)