Infertility

Lupron question

Hi ladies,

So, I've never officially intro'd, because honestly I never know quite what to say.  Most of my pertinent info is in my siggy, but I'm 34, DH is 33, and we're prepping for our first FET from IVF #2 in March. 

I just started my 10 units subq Lupron last night (I was supposed to start on saturday, but Quest labs MASSIVELY screwed up my blood work.) But anyway. I injected around 8pm, and then around 4am, I woke up in severe pain. My entire pelvis and the tops of my thighs felt like they were on fire. Now, I have an 19-year history of endometriosis. When I'm not on the pill, I rupture a cyst every damned month. So I'm definitely accustomed to a certain amount of pain. But this was very different, and I'm having a terrible time getting it under control. 

I went to my OBGYN last week so he could make sure I didn't have any endometriomas before started prep, and we learned then that I had a lot of free fluid and blood around my uterus, as well as the usual multiple small cysts. 

This pain didn't feel like a typical rupture... honestly, it was worse. So my question is, has anyone else ever experienced this? Severe pelvic pain following Lupron injection? Google seems to be somewhat hazy on whether or not this is a side effect. I do have a call into my doctor, but I haven't heard back yet.

As a side note: I've been dirty-lurking here since last September, and I just wanted to wish everyone good luck in their upcoming cycles. It's always so wonderful to see someone graduate from this board.
Me: 34 / DH: 33
19-year history of endometriosis. Multiple surgeries and cyst removals. Forced directly into IVF due to blocked tubes and severe adhesions.
IVF w/ICSI and CCS #1 - Dec 2013 - Only 1 normal. Ended in CP
IVF w/ICSI and CCS #2, at CCRM - March 2014!
14R, 12 ICSI'd, 11F, 6 for CCS, 5 healthy blasts frozen!
Two 5BB blasts transferred 9/10; First beta 9/19: 109; second beta 9/22: 550!
EDD: 5/29/15

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BabyFetus Ticker

Re: Lupron question

  • pblgepblge member
    Yikes! No idea, but I hope it's nothing serious. Let us know what the doc says! ((hugs))
    **********************siggy/ticker warning**********************

    ***Losses mentioned.*** TTC #1 since May 2012. Me: 37, OH: 41. Ectopic August 2012 => tubal damage. :'(  Stage 1 endo removed June 2013. IVF #1 Oct/Nov 2013: Long Lupron with Gonal-F. 7R, 7M, 7F. 2 txfer@3d. Nothing frozen.  => M/C @ 8 wks. :'( Selected RPL panel all normal. Very hyper and brittle response to stims. IVF #2 (antagonist protocol) Feb 2014 => Converted to IUI (Perfect conditions). BFN. IVF #2.1 w/ new RE June 2014: Antagonist protocol. 33R, 31M, 30F, 19 blasts to test!!! I made it through without crashing!! :) Hats off to Dr. Fancypants!! ET of one 5AB blast. BFN. 13 10 CCS'ed snowflakes! FET #1 PUPO as of 7/29 Betas: 8/7@24, 8/9@97, 8/11@334 (etc.) Two sacs on 8/15, one seen on 8/18 after a bleed. U/s 8/25 (6+3) "perfect": 5.9 mm + HB@120bpm! U/s 9/4 (7+6): 15.9 mm + HB@172 bpm! Please, PLEASE stick this time!!!!
    http://i955.photobucket.com/albums/ae39/catfreeburg/866da40f5178fed79efe23fc8a4e8a_zps4498a9cc.jpgimageimageimageimage
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  • Loading the player...
  • Thanks, I appreciate it. I really wish he'd call me back... I'm really miserable. 
    Me: 34 / DH: 33
    19-year history of endometriosis. Multiple surgeries and cyst removals. Forced directly into IVF due to blocked tubes and severe adhesions.
    IVF w/ICSI and CCS #1 - Dec 2013 - Only 1 normal. Ended in CP
    IVF w/ICSI and CCS #2, at CCRM - March 2014!
    14R, 12 ICSI'd, 11F, 6 for CCS, 5 healthy blasts frozen!
    Two 5BB blasts transferred 9/10; First beta 9/19: 109; second beta 9/22: 550!
    EDD: 5/29/15

    imageimage


    BabyFetus Ticker
  • Tea+Tea+ member
    I didn't have Lupron during Stims but I did use it monthly 3mths before. I had horrible joint pain. Not burning sensation but pain. Hips & elbow mostly. It did eventually calm but even now I have residual hip pain. Good luck at the docs!
    TTC Since 2012
    Me: Endo Stage IV (20+yrs) (who knew? Not me)
    MyLove: Pretty Ok. Low #s (i think) 
    IVF#1: No Eggs to Retrieve
    Taking time to ourselves
     Poor Responder will add COQ10 & DHEA next cycle
    **All Welcome**


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  • pjpahelpjpahel member
    I hope that your doctor calls you back.  It seems like an odd side effect, particularly after one dose, but anything is possible.  

    Pamela
    *~*Signature Warning*~*
    Me: 35 Healthy
     DH: 44 vasectomy with failed reversal. 
    IVF #1: Follistim/Ganirelix: 10 retrieved, 4 perfect embies. 2 transferred, 2 frosties = BFN
     IVF #2: Follistim/Ganirelix: 11 retrieved, 1 perfect embie transferred = BFP Willow 4/14/11 
    FET #1: 2 frosties, neither survived the thaw
     IVF #3 Bravelle/Menopur/Ganirelix 4 retrieved, 1 perfect embie transferred = BFN 
    IVF #4 Microdose Lupron/Bravelle/Menopur: 8 retrieved, 6 fertilized, 2 transferred, 2 Frozen: Beta 1: 63, #2: 51, #3:148 #4: 537 #5 2204.  US #1: very small gestational sac.  US#2: Empty sac 

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  • My RE's office finally called; she said it was more likely endo or cyst-related, and the timing was just a coincidence. She told me to go to the ER if it doesn't improve (my RE is out of state, so they can't see me). I'm going to give it until tomorrow morning, which is my usual MO for this kind of thing.

    We'll see how things go after the second shot tonight. Thanks for the advice, everyone, I appreciate it.
    Me: 34 / DH: 33
    19-year history of endometriosis. Multiple surgeries and cyst removals. Forced directly into IVF due to blocked tubes and severe adhesions.
    IVF w/ICSI and CCS #1 - Dec 2013 - Only 1 normal. Ended in CP
    IVF w/ICSI and CCS #2, at CCRM - March 2014!
    14R, 12 ICSI'd, 11F, 6 for CCS, 5 healthy blasts frozen!
    Two 5BB blasts transferred 9/10; First beta 9/19: 109; second beta 9/22: 550!
    EDD: 5/29/15

    imageimage


    BabyFetus Ticker
  • I've heard of people having an allergic reaction to lupron and taking Benadryl nightly with the shot. I'm not sure that would cause the severe pain though. I'm sorry you are dealing with that!FX that it goes away soon!



    ********Siggy/Ticker Warning***********



    Me (35) no known issues DH (37) MFI. TTC 21 months (24 cycles)
    Dx MFI with low to normal count, low motility, morphology 3%
    HSG normal, ultrasound and labs on me all normal. 

    1 cycle of Clomid 50mg and TI, unmonitored by OBGYN= BFN
    1 cycle of Clomid 50mg and IUI, unmonitored by OBGYN= BFN
    Started seeing an RE!!
    2 more cycles of clomid 50mg (great response), with IUI and Pregnyl trigger (4.8-8 mil good ones after wash) = all BFN
    1 cycle of clomid 50mg (3-7) followed by Follistim 75iu (7-11) + IUI = BFN
    December 2013 DH saw urologist and is taking Anastrozole, CoQ10, and L-Carnitine
    IUI #5 natural cycle (needed a med break) = BFN
    IUI #6 Follistim 75iu (CD3-10) + Pregnyl (CD11) + IUI (final count after wash 300K) = BFN
    IUI #7 Follistim 75iu (CD3-9) + Pregnyl (CD11) + IUI on 2/20 (post wash count 12.5 million)= BFN
    IUI cancelled (DH OOT) Clomid 50mg (CD3-7) 1 follicle +(not well timed) TI = BFN
    IUI #8 and last one!! Clomid 100mg (CD3-7) +OPK before US + IUI 4/17 (post wash 8.5 mil)= BFN

    Pre-IVF testing complete! SHG great and measurements taken! Labs for infectious diseases completed, FSH (5.4), TSH (1.6), Prolactin (11), AMH (2.6), Estradiol (40).

    Started BCP 5/29 and Lupron 6/11 prep for IVF #1! Started follistim 225u/day on 6/28. Monitoring on 7/2 >15 follicles measuring 11-14, E2 758. Monitoring on 7/5 all ready to go!! Great follicle sizes and lining is at 9. Tigger 7/5, ER 7/7 16R 9M 3F. Stimmed too fast in just 7 days. 7/10 3dt of 2 8-cell grade 2 & 4. 7/14 P4 >60.
    Holy crap BFP!!!
    Beta #1 (14dpo) 7/21 112 Beta #2 (16dpo) 7/23 286 a Beta #3 (18dpo) 7/25 761 Beta #4 (21dpo) 2631!!! Hold on tight little embies!!
      First Ultrasound 8/7- 1 perfect little bean with a beating heart 117bpm!! EDD 3/30.
    Second ultrasound 9/2 Little bean measuring a few days ahead with a heart rate of 161!



    PAIF/SAIF/All Welcome!

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    March 15 Siggy Challenge: You had one job

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