Question from a desperate IFV

mm29

Hi Ladies,

This question has been on my mind. I wasn't going to ask until we decided to cycle again, but I cannot stop thinking about it. Some of you may remember my disastrous DE cycle, 30 ER, 21M, 15F, 4 (day 6) blasts, 1 normal which ended in a Chemical pregnancy.

This cycle was the first with my current RE, and she didn't have much to compare to with the cycles involving my OE’s. However, in reviewing my medical records, and comparing with our DE cycle she feels our issue may be more of a sperm issue than my eggs. The tentative plan after having a lap next month is to do a few DS IUI’s and incorporating intralipid infusions.
Is there anyone on this board who has both DOR and MFI, who found success with DS IUI’s or DS IVF? If so, was there anything special you did that helped you find success, such as a specific protocol, supplements, etc.? TIA!!

Mr. & Mrs. Woodtick

I have no advice but wanted to wish you GL when you cycle again!

kbeach82

On iPad so please excuse lack of formatting...We have a dx of both DOR and MFI, but we have 3 LOs from IVF cycles using my eggs and DH's sperm. Our first cycle (prior to my DOR diagnosis, we thought we were only dealing with MFI at the time) was a Long Lupron. We had 5 ER, 4M, 3 fertilize normally via ICSI, and transferred 2 embryos in a 3dt (the remaining embryo didn't make it to freeze). That cycle brought us DS1. We did a Microdose Lupron Flare protocol when TTC #2 and had 6 ER, 5M, and 4 fertilize normally via ICSI. We did a 5dt of 2 embryos and 1 made it to freeze. Our twins from that cycle turn 1 next week. Did you do ICSI with your cycles after IVF #1 and how long ago was your DH's most recent SA?

mm29

kbeach82 said:

On iPad so please excuse lack of formatting...We have a dx of both DOR and MFI, but we have 3 LOs from IVF cycles using my eggs and DH's sperm. Our first cycle (prior to my DOR diagnosis, we thought we were only dealing with MFI at the time) was a Long Lupron. We had 5 ER, 4M, 3 fertilize normally via ICSI, and transferred 2 embryos in a 3dt (the remaining embryo didn't make it to freeze). That cycle brought us DS1. We did a Microdose Lupron Flare protocol when TTC #2 and had 6 ER, 5M, and 4 fertilize normally via ICSI. We did a 5dt of 2 embryos and 1 made it to freeze. Our twins from that cycle turn 1 next week. Did you do ICSI with your cycles after IVF #1 and how long ago was your DH's most recent SA?

I have severe DOR. AMH is <0.16, and our MFI is unique.  DH has a balanced translocation, his SA is perfect, and his DNA fragmentation is normal as well.  However, with our recent donor egg cycle (using a proven donor), and using DH's sperm our embryos fell behind day 4 an 5 which indicates a sperm problem, maybe it's just the BT that affected our embryo, we have no idea for sure. We did PGD and only had one normal embryo. There is no way we can use my egg and DH's sperm.  If we use DH's sperm we need a lot of eggs. If we use my eggs we need sperm that does not carry a Balanced translocation,because BT carries have issues with chromosomally abnormal embryos.  We tried DE w/DH's sperm and it was a BFFN, so we are ready to try DS and my egg. If that doesn't work we will need to consider other options.  

PurpleIris30

Just wanted to send you a hug.

blueberries8

No advice here, just wanted to say that the plan sounds reasonable and I am thinking of you and hoping for the best!

kbeach82

mm29 said:

kbeach82 said:

On iPad so please excuse lack of formatting...We have a dx of both DOR and MFI, but we have 3 LOs from IVF cycles using my eggs and DH's sperm. Our first cycle (prior to my DOR diagnosis, we thought we were only dealing with MFI at the time) was a Long Lupron. We had 5 ER, 4M, 3 fertilize normally via ICSI, and transferred 2 embryos in a 3dt (the remaining embryo didn't make it to freeze). That cycle brought us DS1. We did a Microdose Lupron Flare protocol when TTC #2 and had 6 ER, 5M, and 4 fertilize normally via ICSI. We did a 5dt of 2 embryos and 1 made it to freeze. Our twins from that cycle turn 1 next week. Did you do ICSI with your cycles after IVF #1 and how long ago was your DH's most recent SA?

I have severe DOR. AMH is <0.16, and our MFI is unique.  DH has a balanced translocation, his SA is perfect, and his DNA fragmentation is normal as well.  However, with our recent donor egg cycle (using a proven donor), and using DH's sperm our embryos fell behind day 4 an 5 which indicates a sperm problem, maybe it's just the BT that affected our embryo, we have no idea for sure. We did PGD and only had one normal embryo. There is no way we can use my egg and DH's sperm.  If we use DH's sperm we need a lot of eggs. If we use my eggs we need sperm that does not carry a Balanced translocation,because BT carries have issues with chromosomally abnormal embryos.  We tried DE w/DH's sperm and it was a BFFN, so we are ready to try DS and my egg. If that doesn't work we will need to consider other options.  

I do not have any experience with BT. I hope there are other ladies here with experiences that are better aligned with your own that can offer you suggestions or advice. I wish you the very best of luck in your future efforts and I am sorry I can't be of more help :-(

STL34

((HUGS))  I am wishing you the best!!

I don't have a similar situation, my husband has slightly low morph but nothing ICSI doesn't fix.  Our problem is primarily my DOR.  Our only successful cycle was with AH (we also had some experimental immune treatments so we can't be 100% on which worked).  We intend to do an IVF cycle without immune treatments but with ICSI and AH.  I really think my DOR causes my embryos not to be able to hatch on their own.  It would make sense since that is a problem sometimes seen in older women.  Good luck moving forward.  I hope you find success with DS IUIs.  But, if you go back to IVF, I would ask about AH.

mm29

STL34 said:

((HUGS))  I am wishing you the best!!

I don't have a similar situation, my husband has slightly low morph but nothing ICSI doesn't fix.  Our problem is primarily my DOR.  Our only successful cycle was with AH (we also had some experimental immune treatments so we can't be 100% on which worked).  We intend to do an IVF cycle without immune treatments but with ICSI and AH.  I really think my DOR causes my embryos not to be able to hatch on their own.  It would make sense since that is a problem sometimes seen in older women.  Good luck moving forward.  I hope you find success with DS IUIs.  But, if you go back to IVF, I would ask about AH.

Thank you for your advice. The last IVF with my eggs we did not do AH, but I know they kind of did it with my DE cycle, because they had biopsied the embryo for pgd. I just wish I knew if DS IUI would work, I'm guessing it won't. If it doesn't I'm not sure if it's worth doing IVF with my OE's, it may be a waste of money and I should skip it all and do DE/DS or embryo adoption.  

Whales124

I can't speak to the DS, and I'm not classified DOR technically, my RE said I am headed there though, but I did do intralipid treatments. I had one infusion before transfer, and after. I definitely think it helped. That was after a lupron flare fresh cycle. I didn't have success with my long lupron cycle with my fresh or frozen embies. I also had lovenox on my successful cycle because my estrogen was so high, but since it worked I would be inclined to want it again. Good luck and huge hugs!