Trouble TTC

Holy CRAZY cycle vent...iui girls come in please!

So, this has been a completely ridiculous cycle...first I was not responding to the 75 iu gonal f, like no follicular action period for about a week. They bumped up to 100, then 150 iu with little response. Talk of possibly cancelling cycle ensued. Then I finally seemed to be responding (slowly) as that e2 creeped up, and LH went down. After 12 days of stims I finally had an ultrasound and there was one little 10mm follie. The next day it was 11mm, then 13, then today....12??? and surprise, another little 10 popped up! How did that first one get SMALLER? So I'm thinking, well at least there's two targets now...then I got my monitoring email this afternoon and it says my LH went from 13 yesterday to 30 today...wtf is that? They said "you have started your ovulation surge even though your follicles are still small". I didn't even know this was possible! I'm assuming when I go tomorrow they will cancel the iui, but does anyone have experience with this? An LH surge with no mature follicles/eggs? Is there any way I had a hiding mature follicle or is that even crazier? My e2 level today was 919 (Canadian measurement) which seems high for two follies that small....arrrrgh. I don't even know what to make of this crazy cycle :-S

Me: 37 | DH: 41
TTC Since 2011 DX: Unexplained 
IUI's #1 - 3 = BFN
IVF August 2014: FSH 4.1, PRL 15.3, TSH 2.1, W/ AFC 8.
 08/03 ER 5R, 4M, 3F. 08/08 5DT of 1-3AA0, 2 frozen :) bfp @9dp5dt. Beta on 08/20 = 414.
So excited to have one little bean on the way!!
 
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Re: Holy CRAZY cycle vent...iui girls come in please!

  • For anyone who read all that, I just did the e2 conversion and it's actually only 250 in the American measurement....

    Me: 37 | DH: 41
    TTC Since 2011 DX: Unexplained 
    IUI's #1 - 3 = BFN
    IVF August 2014: FSH 4.1, PRL 15.3, TSH 2.1, W/ AFC 8.
     08/03 ER 5R, 4M, 3F. 08/08 5DT of 1-3AA0, 2 frozen :) bfp @9dp5dt. Beta on 08/20 = 414.
    So excited to have one little bean on the way!!
     
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  • I'm not completely sure of how all that works, but last month I was all of a sudden not really responding to Letrozole the way I did the previous times. I did have an 11mm follie at u/s 1. At u/s 2 the 11 was gone and nothing else worth counting, and then at u/s 3 I had already ovulated. So looks like when the 11 disappeared maybe it's because it was getting ready to ovulate? So in this case I guess I, too, ovulated without a nature follie. But I have no idea how that works! I'm sorry. :(

    Me: 32  DH: 33  Married: March 2004

    July 2006: started TTC
    2008: HSG (normal), couple rounds of clomid through gyno
    2008 - 2010: dragging my feet out of fear and procrastination
    October 2010: first consultation with RE, dx PCOS and fibroids (DH slightly low count/motility)
    Oct. 2010 - Dec. 2012:  In DENIAL! avoided the issue because I was scared of surgery
    January 2013: returned to RE, fibroids grew significantly
    February 2013: second HSG, fibroids pushed on tubes which blocked them somewhat
    March 2013: MRI to determine what type of surgery may be necessary

    July 29, 2013: fibroids (5) removed via robotic laparascopy
    August 2013 - Nov 2013 : benched due to recent surgery

    IUI #1, Dec. 24, 2013, BFN 
    IUI #2, Jan. 25, 2014, BFN
    IUI #3, Feb. 25, 2014  BFN
    IUI #4 canceled due to lack of response to letrozole
    IUI #4.1 April 28, 2014, BFN

    May 16, 2014: wtf consult, start prepping for IVF in June and add injects for one last IUI in the meantime
    IUI #5 started letrozole and bravelle but canceled after HSG led to new diagnosis

    May 21, 2014: third HSG, tubes blocked, one at the beginning, one hydrosalpinx??
    June 11, 2014: consult, approved to move on to IVF because the hydro is not completely blocked therefore allowing fluid to move through slowly rather than backwards
    IVF #1 August 8, 2014 - 3dt of 2 embryos, BFN
    September 17, 2014 - 4th HSG, the right tube is very patent (open!!) dye went straight through this time. Weird!
    October 2, 2014 - started metformin treatment
    November 14, 2014 - blood work, brought A1C down from 5.8 to 5.5

    November 26, 2014 - RE finally back from vaca and reviewed my chart, no more IVFs for rest of calendar year
    December 1, 2014 - Right after Thanksgiving, I called a new clinic and got in right away! Plan for IVF
    December 17, 2014 - ER! 29 retrieved (!!), 16 mature, all 16 fertilized (ICSI)

    IVF #2 December 20, 2014 - 3dt of 3 embryos, BFN

    We are done with treatment unsuccessfully. :(


    PAIF/SAIF/All Welcome!

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  • There is some error in those measurements so the 13 vs 12 could be the same one.  

    My RE cancelled previous IUI for 12mm follicles.  FX yours will have increased in size by tomorrow!
  • I have no advice or insight, but wanted to say good luck! :)

    DH: 34  
    Aug 2013 - SA: Counts & Motility = great, Morph = 1%; RE didn't seem too concerned

    Me: 26
    Jan. 2014 - Blood work ordered by obgyn:  Prolactin = high & AMH = low (0.73)
    Feb. 6, 2014 - Repeat blood work ordered by obgyn:  Prolactin = normal & AMH = low (0.9)
    Feb.  20, 2014 - First appointment with RE
    Feb. 24, 2014 - HSG scheduled;  DX:  one tube definitely open & one tube could be blocked
    Mar. 7, 2014 - CD 21 Blood work for Progesterone; DX:  Progesterone level at 5.2; shows I ovulated but was low
    Mar. 28, 2014 - Laparoscopy; DX:  Tubes open.  Found some endometriosis and had that removed.
     
    History:
    Started TTC:  June 2012
    June 2012 - March 2013:  When it Happens/it happens method = BFN
    March 2013:  Started using Fertility Friend
    Cycles 1 - 15 with Fertility Friend = BFN
    Cycle 16 - Benched due to Laparoscopy
    Cycle 17 - Natural Cycle = BFN
    Cycle 18 - Natural Cycle = BFN
    Cycle 19 - Natural Cycle = BFN
     

    Current Cycle:
    Cycle 20 = Natural Cycle


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  • I have no advice on that, but I just wanted to say that I am so sorry for your difficult stimming! I never heard of that happening, but it sounds really frustrating. :(
    January 3T Siggy Challenge - New Year's Resolutions
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    Me (29), DH (30) TTC actively 54 55+ cycles | All BFNs
    MFI (low everything) | Endo Stage 1 & Stenotic Cervix (treated) | PCO
    Married - July 2008 | Started TTC - Jan 2009RE Visit #1 - Mar 2014 
    IUI #1 ICI #1 - June | IUI #1.1 Laparoscopy - Aug
    IUIs #1.2, 2, 3 - Sept, Oct, Nov (Letrozole) - BFNs 
    IUI #4 - Dec (Bravelle) | IUI #5 - Dec/Jan (Bravelle) - 5 follies + TI - BFNs
    IUI #5.1 - Jan (Bravelle) Cancelled 
    Planning to start IVF in March!
    ***All Welcome***
  • I've never heard of having an LH surge before follicles were mature either. Maybe that's what "weak ovulation" is? That term always confuses me some. 
    **siggy warning**  **everyone welcome**

    ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~
    DS- 11.07.02
    DSS- 6.26.04
    Married- 6.29.13
    TTC Again- Sept. 2013
    ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~
    Test Results/Diagnosis- HSG & SA totally normal
    DX: 3/2014 Prolactinoma/Hyperprolactinemia- Started cabergoline 2/2014
    5/2014 Possible mild PCOS in addition to hyperprolactinemia??
    7/2014 Adding probable tubal factor to the diagnosis list
    9/2014 And now adding hypothyroid to the list- Started synthroid 9/2014
    Cycles 1-4 - Sept.-March- All Anovulatory 
    IUI #1 March/April-  Clomid 50mg + Clomid 100mg +Trigger + IUI #1 = BFN
     IUI #2 April/May-Clomid 100mg + Clomid 150mg + Trigger + IUI #2 + Endometrin=BFN
    IUI #3- June- Follistim 75iu + Trigger + IUI #3  Benched due to a 40 mm cyst. :-(
    IUI #3- July- Follistim 75iu + Trigger + IUI #3 + Endometrin = BFP! on 7/25/14
    Slowly rising betas - Ectopic suspected on 8/8/14 & confirmed on 8/11/14
    Methotrexate on 8/12/14 -HCG negative on 9/2/14
    IVF #1- November- Antagonist protocol: 11/1: start stims, 200iu of Follistim; 11/12 ER 17R/14M/14F; 11/17 5 day transfer of two blasts, 2 blasts and 2 expanding morulas frozen; 11/22 BFP!! (On FRER at 5dp5dt)
    Betas: 9dp5dt 205, 11dp5dt 497, 14dp5dt 1,709
    u/s at 5w0d- 1 sac; u/s at 6w0d 1 baby with heartbeat, another sac without a heartbeat
    image


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