Infertility

Egg quality

Hello, My name is Kelly and I have been TTC for over a year and a half. I have poor egg quantity and I just learned quality too. We just did one round of IVF with ICSI and ended with 1 embryo and after the PGD testing it came back abnormal.  We are set to do another round of IVF in the near future. I am new to forums so hope I am doing this right but I am looking for support and advice. Does anyone have any ideas of ways to improve egg quality? Anyone try a gluten and dairy free diet to help with egg quality? Thanks so much!!

Re: Egg quality

  • Welcome and I'm sorry you are here. Some of us are on supplements for egg quality. I was recommended by my RE to take CoQ10, DHEA, and melatonin. I would ask your RE before taking anything though.
    I believe gluten-free helps lessen inflammation. I am going gluten free to help with implantation. Not really sure if it does anything for quality.
    You should ask to get your vitamin d levels checked. Sometimes if you are low, your AMH could be reading low and it may go up a small amount if you start taking supplements.
    Good luck!
    ***WARNING***

    TTC Since 12/2008;  DH: 32, Azoospermia     me: 33, DX during IVF #4: Low AMH (Normal FSH) / SER due 
    to IVF Meds (causing failure to fertilize) Recent DX: Hashimoto's, Lupus Anticoagulant, White Blood Cell Disorder 
    High ANA, ATA, & APA, PAI-1 Heterozygous= blood clotting disorder; connective tissue disorder 
    IVF w/ ICSI #1 2/2011     IVF w/ ICSI #2 5/2011    IVF w/ ICSI #3 12/2012   *New RE* IVF w/ ICSI #4  5/2013
    IVF w/ ICSI #5 8/2013 (Natural Cycle- No drugs)- One follicle->one blast. CCS normal. FET 9/10- 6BB blast. m/c @ 5w
    IUI #1 12/23- BFN  IUI #2 Cancelled (ovulated during AF)  Prep:CoQ10 (300 mg); DHEA (25 mg); Melatonin (3 mg), Folgard 2.2, Metformin 500 2x, Levothyroxine 50mcg, Aspirin 81mg w/ calcium, B12,  Vit. D 4000 & Prenate Elite Daily; Cabergoline 1/2 pill 2x week-  Cycling: Estrace Priming; Prednisone 10mg, Lovenox 40mg 2x,  Femera & Menopur   
    IUI #2.1 6/30 & 7/1. 1st Beta: 90 (7/15); 2nd Beta: 226 (7/17); 3rd Beta: 766   EDD: 3/23/2015

       **ALL WELCOME**                                    My Blog 
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  • I'm on 600mg ubiquinol CoQ10 daily as well as 1000iu of Vitamin D.  I will be taking dexamethasone for inflammation during IVF#2 as well as adding in HGH this time around to see if it helps improve quality (studies have shown it can help AMA ladies).  

    TTC since July 2009. Dx MFI & LPD. 
    IUI#1&2&3 (2011 & 2012) BFN
    IUI#4 1/23/13 on 75iu x9 Follistim = BFP then chem preg m/c (Feb 2013)
    IUI#5 BFN (April 2013)
    IVF w/ICSI Oct. 2, 2012 - 13R, 11M, 7F, 1 frozen blast 4BB grade - - - FET Nov 15, 2013
    BFP! Beta 1:104 @ 10dp6dt, Beta 2:178 @ 12dp6dt,  beta 3:366 @ 14dp6dt
    Saw heartbeat twice before missed M/C at 8w3d on 12/27/13, missing my little angel boy
    JUNE 2014 IVF#2;  5R, 2M, 1F Three day transfer 6/7.  Beta 6/18 - BFN
    Child Free Now?
    S/PAIFW , S/PALW

    My Blog

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  • as PP said CoQ10 - in preliminary studies has shown very positive results with egg quality.  But i agree with @poohniki talk to your RE before starting anything new

    Good luck!!

    imageimageimage
    ***Siggy Warning***
    TTC Since Feb 2011 - HSG Aug 2012 opened 1 tube - Lap Nov 2012 confirmed Endo. 
    May 2013 both tubes blocked by hydrosalpinx. Nov 2013 Essure Placed permanently blocking both tubes

    IVF #1 - Jan/Feb 2014 Patch Protocol - 3 day 5 blasts Frosties - transferred 1 blast BFN 
    FET #1 - May 15 transferred 1 blast - HPT May 22 BFP - Beta #1 May 26 - 578 - Beta #2 May 28 1707
    U/S #1 June 9 6w4d hb 111 - U/S #2 June 17 7w5d HB 156 - EDD Jan 29, 2015


  • **BFP mentioned**


    My first IVF resulted in 29 eggs retrieved, but only 11 were mature and only 5 fertilized.  We ended up transferring one 4BB and froze one 4BB and got a BFN.  Though I don't have egg quantity issues, my RE believes that I may have quality issues.  For IVF #2, I was put on CoQ10, Saizen (HGH), and dexamethasone in addition to the same antagonist protocol for IVF #1.  IVF #2 resulted in 20 eggs retrieved, 10 mature, but all 10 fertilized.  It also resulted in better quality embryos, we transferred two 4AB, and had two 4BB to freeze.  I haven't had my beta yet, but got a BFP on a HPT on Sunday.  No matter what happens, this cycle has already been way better than the first.  Not sure whether it's a fluke or if it's attributable to the Saizen, CoQ10, and dex.

    Good luck!
    TTC since 5/2012
    12/12: c/p
    4/13: c/p

    8/13: Started seeing RE; DX: Unexplained IF, RPL testing normal, SA perfect.
    Oct - Dec '13: Clomid 25 mg + Ovidrel + IUI = BFN
    2/14: IVF #1 Gonal F + Menopur + Ganirilex + Lupron trigger w/ HCG boost= 28R, 11M, 5F. 5dt 4BB, 1 frozen 4BB
    . BFN
    4/14: IVF #2 Saizen, Gonal F, Menopur, Ganirilex = 20R, 10M, 10F.  5dt of 2 4AB, 2 frozen 4BB.  +HPT 4dp5dt, Beta 4/26

  • Thank you all for the advice! I am taking 600 mg of COQ10,  75 mg of micronized DHEA, and 2000 mg of Vit D daily. I am also taking royal jelly and L'Arginine.  I will ask more about melatonin. I was told with IVF #2 I will get HGH too. Thanks again! I really appreciate your help!
  • I recommend a book called "It starts with the egg" by Rebecca Fett. You can purchase it off of Amazon.
    Someone recommended it here not long ago and I just finished it yesterday. It was very helpful for me. I, too, took royal jelly and l-arginine and there is contradicting studies for those two things in there. Worth the read for sure!

    Good luck!
    Me: 31 DH: 31
    TTC#1 since Sept. 2011
    March 2012-June 2012 - IUI's- BFN

    Sept 2012= IVF #1- 14 eggs, 9 fert, no frosties. 2 blasts 5dt=BFN
    Oct/Nov 2012= IVF #2- 20 eggs, 14 fert, no frosties. 2 blasts transferred despite mild OHSS=BFN
    Nov 2012= hubby got transferred, moving to new state, time for a break until summer!
    Feb 2013= Natural BFP!! Valentine's day surprise! 
    Mar 2013= m/c @ 7.5 weeks :(

    *New RE*
    July 2013= ER for a freeze all cycle. 21 eggs, 9 fert, freeze all day 1.
    Lab is closed in August! (Of course!) 
    Sept 2013= FET #1 - transferred 3 not so great quality day 3 embies=BFN
    Oct 2013= FET #2- transferred 4! 3 good, 1 poor= BFP! On hubby's birthday :)
    Started bleeding at 5w5d. ER trip confirms one gest sac, one yolk sac, no fetal pole. 6w u/s showed nothing. Levels drop from 4,500 to 250. 
    Nov.2013=meet with RE to discuss where to go from here.
           *Tests showed PCOS-ish. High testosterone. Start Metformin 1500 mg.
    February 2014- CLomid, IUI, Trigger. 4 juicy and ripe follies (24,25, 28 and 34!) 111 million post wash sperm count. BFFN!!!! WTH?
    March 2014- Over my RE. Year of fun for us and looking into RMANJ.
  • Thank you! Now I am wondering if I should stop taking royal jelly and l'arginine. I will check out book!
  • Make sure you are taking the ubiquinol form of CoQ10!

    TTC since April 2012

    BFP #1, 10/03/2012 - EDD 6/15/2013 - MMC 11/15/2012 - D&C 01/04/2013

    BFP #2, 04/06/2013 - EDD 12/17/2013 - MC 04/19/2013

    6/12/2013 Diagnosed with Balanced Translocation (12 & 16)

    IVF #1 with PGS: 10/2013: Canceled 9/27/2013 for issues with genetic lab

    IVF #1.5 with PGS: 11/16/2013: Canceled. 11 eggs retrieved, 9 mature & 9 fertilized, all unhealthy embryos

    IVF #2: 1/22/14: Canceled. 16 eggs retrieved, 14 mature, 7 fertilized, all unhealthy embryos

    IVF #3 with PGS: 5/10/2014: Switched to FET in July. 10 eggs retrieved, 9 mature, 8 fertilized, 2 healthy embryos!

    FET #1: 7/31/2014: Transferred 2 nearly perfect (6AA, 6BA) healthy embryos- BFFN

    Laproscopy: 10/2014: Healthy uterus

    IVF #4: 12/8/2014: Canceled. 17 eggs retrieved, 15 mature, 10 fertilized, all unhealthy embryos



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  • How do you know if you are? I am taking the one from Costco that are the Kirkland Brand. I don't see it on there so assume I am not then. 
  • COQ10 and Pycnogenol are what my RE suggested. 

    I also used HGH (human growth hormone) this IVF. 

    Welcome and best of luck!
    ***SIGGY WARNING***

    DX: Unexplained
    6 Failed IUIs (Clomid and Gonal F).  
    IVF #1 began August 2013- BC, 4 days of Estrace, stimmed with Gonal F and Menopur, Ganirelix, 9R 5M 5F, Medrol and Doxycycline, 5 day transfer of 2 early blastocysts- good quality, Progesterone, Estrace, and baby aspirin, BETA on 9/20 BFN,   IVF #2 began September 2013, stimming with Gonal F (higher dose) and Menopur, Ganirelix, 18R 14M 9F with ICSI, 5 day transfer of 2 BBs one was starting to hatch, 2 frosties: 1  BB and 1 AC, BETA on 10/21, BFN BETA was a 5- chemical 
    Getting some more testing and trying to figure out what the issue is before FET in December, started acupuncture on 11/10, RLP and some other BW nothing major to report except slightly high Prolactin. Prolactin was slightly high when I started with my RE and I already had an MRI which was Neg.  Endo biopsy=negative.  WTF is wrong with us???
    12/18/13 FET of 1 BB and 1 AC.  Hoping for a miracle.  Beta 12/26 Low BETA-8 2nd BETA 5- chemical
    After 3 failed transfers IDK where to go from here.  Still no real answers as to why this isn't working.  Getting a second opinion in February and looking into immune testing.  
    2/14- NEW RE- Immune testing showed a partial dq alpha match with DH- On prednisone and did intralipids prior to transfer.  3/14 Lupron, gonal f, menopur, HGH.  ER 15 mature all 15 fertilized!  5dt of an early blast grade 1 and an expanded blast grade 2.  BETA on 4/21.  1 grade 2 embryo frozen
    BETA #1 59 BETA #2 148 BETA #3 283 BETA #4 2,783! US at 6w2d shows 1 bean measuring right on track! HR 121.  US at 8w3d measuring on track HR 177. Released form my RE.  EDD 12/28


    All Welcome
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