Infertility

Day 1 fertilization report WTH!

Yesterday they retrieved 8 eggs.  I got the call this morning that of the 8 they were only able to inject 4 and of the 4 only 2 fertilized.  What happened??????
TTC 2007
Me-OK DH- MFI
2010 IUI 1-3 Femara + Ovidrill BFN
Change DR 5/12 IUI 4-5 Natural Cycle BFN
5/13 DH diagnosed with b1/b3 microdeletion of Y chromosome
IVF #1 July  Started Lupron 7/5 AF 7/14
ER 8/1 7R 5M 3F W/ICSI ET 8/6 Moved to 8/7 due to no blast 
Transferred our UNO embryo Beta #1 27 Beta #2 33 Beta #3 29 CP :(
IVF #2 Started Lupron 2/14 
Protocol 10U Lupron, 150 Bravelle, 150 Menopur, HGH for 4 days, Dexamethesone, 
Supplements 6000mg CoQ10, 100mg DHEA, Vitamin D, Folic Acid, 
ER 3/12 8R 4 able to be injected 2f with ICSI ET 3/15 2 "perfect" textbook Embryos
2 crinone, estrace, dexamethesone, doxycycline
BETA #1 3/26 201  BETA #2 3/28 524  BETA #3 4/5 9,876  Ultrasound April 7 Showed TWINs
April 18 ultrasound Baby A HB 147   Baby B HB 146  Both measuring 7w1d
WE ARE TEAM BLUE X2!
Jonathan Daniel received his angel wings July 23, 2014 :( born 9/20/14
Jackson Thomas was born October 31, 2014 @ 35w 5d
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Re: Day 1 fertilization report WTH!

  • Sorry you didn't get great news. I'm guessing the other 4 weren't mature?




    dx:  Unexplained IF
     TTC since May 2011, 1 year trying, and then 3 TI, 2 IUI = BFN
    IVF #1 (May 2013):  Antagonist Protocol: 
    24R, 18M, 15F w/ICSI; 5dt of 2 early blasts, no frosties = BFN
    IVF #2 (August 2013):  Lupron Stop Protocol: 
    28R, 23M, 15F w/ICSI; 5dt of 1 partially hatched blast, 7 frosties = BFP
    EDD 5/23/14, blighted ovum (6w6d), D&C (8w6d)
    FET #1 (April 2014):  transferred 2 5d blasts = BFP
    C.J. born 01/09/15


  • I'm sorry you got this news this morning. Ditto on the PP about maturity. For this cycle I had 2 that weren't mature but they matured overnight & then the ICSI'ed them the following day & they fertilized. Perhaps they may be able to do the same with your remaining 4 eggs.

    I've had low retrival rates both IVFs, in my clinic they will do a 2 day transfer in cases like this if there are only 2 & that's what you were planning on transferring. They go with the theory of they are better in the uterus than in the lab waiting until day 3 or 5. Is this an option the discussed with you? It's something to think about. It makes for a longer more difficult 2WW though.

    Hugs, so sorry you are delaing with this! :-(

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  • Sorry you didn't get better news. My results were similair to yours. I would assume the other were not mature enough or they were over mature. I hope at least one of those two is you're lucky one!
    Me: 30 DH: 30 ~ TTC #1 Since August 2011 
    BFP #1 2/28/13, Ectopic, Tubal surgery 3/25 
    Began RE testing 8/8, Dx Unexplained, 
    IUI #1 11/1=BFN Moving on to IVF 
    IVF #1 12/2 ER 8R 7M 4 fertilized
    12/7 Transferred 2 "perfect" little blasts 12/17 BFN
    New DX= DOR, I fu*kng hate IF
    1/14 Hysteroscopy, new clean uterus!
    IVF #2: bcp, Lupron, follistim 300, menopur 225. 2/21 8R 4M 3F. 3dt of 2 perfect embryos. 1 little penguin 
     3/10 BFFN
    Regrouping. Seeing reproductive immunologist Dr. Kwak Kim 6/10 
    Kwak Kim protocol: Metformin 1000mg, vitamin D 4000iu, vitamin E 400iu, baby aspirin, Metanx, levothyroxine 75mcgs 
     Surprise BFP 9/21!!! Beta #1 247, Beta #2 630. Miscarried 10/13

  • cls78cls78 member
    Sorry. Hope your other 2 are ok.
    TTC since May/June 2012 
    Sept 2013 testing:
    SA #1 Low motility (17%) 
    SA #2 Lower sperm count, but much higher motility
    CD 3 Bloodwork and ultrasound - Normal HSG - Clear tubes 
    Oct/Nov 2013 Cycle 1 with RE 50 mg Clomid + Ovidrel + IUI BFN  
    Nov/Dec 2013 Cycle 2 with RE 50 mg Clomid + Ovidrel + IUI BFN 
    Jan/Feb 2014 Cycle 3 with RE 50 mg Clomid + Ovidrel + IUI BFN 
    2/20/14 Follow up consult RE recommends IVF with ICSI 
    3/10/14 New patient consult with RMA NJ 
    3/11/14 AMH and other Bloodwork to prep for IVF with ICSI at RMA NJ
    3/28/14 Saline Sonogram - All good
    March/April 2014 IVF #1 Antagonist Protocol
    BCP/Bravelle/Menopur/Ganirelix
    4/16/14 ER 26 Retrieved!!!
    4/17/14 Fert Report 22 Mature 21 Fertilized w/ ICSI
    4/22/14 Report #2 15 BLASTS
    5/24/14 FET!!!  (Transferring 2 snowflakes)
    6/2/14 Beta #1 575!!! :)
    6/4/14 Beta #2 2060!!! :)
    6/11/14 1st Ultrasound...Saw 2 Gestational Sacs!!  Beta #3 34,312!!! 
    6/18/14 2nd Ultrasound...Heartbeats!! Baby A 112bpm Baby B 117bmp <3 Beta #4 172,080!!!
    6/25/14 3rd Ultrasound...Heartbeats!! Baby A 150bpm Baby B 158bpm <3 Beta #5 232,134!!! 
    7/3/14 4th Ultrasound...Heartbeats!! Baby A 173bpm Baby B 162bpm <3 Beta #6 269,228!!!
    Graduated from RMA!!  First appt with OB 7/8/14

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    BabyFruit Ticker

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  • one of our cycles was similar, our only issue is severe MFI.  they did a 2 day transfer of 2 of the embryos, I got my BFP but it sadly ended in a cp - good luck it really does only take 1 :)
  • Fingers crossed for your 2!

    f/k/a/ Kari3629

    Me: 40/DH: 34

    Unexplained IF

    IVF #1 - 9/2013 8ER/5M/4EF/4ET = BFN

    IVF #2 - 2/2014 - Fingers crossed this is the one!

    4ER/3EF/3 "beautiful embryos" transferred - Beta March 7 = BFN :(

    Everyone Welcome!

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  • I'm so sorry. I'm dealing with disappointing numbers, too. I know it's hard to stay positive but sending prayers that your two fertilized grow into strong, healthy embryos.

    ***************************Loss Mentioned***************************


    Me 37 y/o, DH 45 y/o; DH vasectomy reversal (his 2nd marriage) 11/8/12; TTC since 12/8/12. IVF due to MFI. DOR diagnosis April 2015.

     

    IVF #1 BCPs/Antagonist w/ICSI Jan 2014 = BFN

    IVF #2 MDL w/PICSI March 2014 = BFN

    IVF #3 EPP/Antagonist w/PICSI May/June 2014 = BFP!; MMC 6w4d

    IVF #4 No suppression/Antagonist Nov 2014/Converted to IUI #1 = BFN
    IVF #4.1 Feb 2015 = cancelled
    IVF #4.2 April 2015 - Lupron Stop Protocol with ICSI = PGD testing of embryo indicated it was abnormal
    IVF #5 June 2015 EPP with Antagonist 

     

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    Everyone welcome!

  • This is really similar to my fert report with IVF#1.  We had 7 retrieved, but only 4 were able to be ICSI'd (mature) and only 1 fertilized normally. 

    Of the 3 that weren't able to be injected, 1 wasn't mature, and the other two deteriorated almost immediately which I'm told is due to quality issues. 

    Of the 3 that were mature but didn't fertilize normally- we are blaming that on my chromosomal issue which makes fertilization possible, but further division impossible/severely slowed.  In your siggy I see that your DH has a microdeletion- could that have had something to do with low fertilization rates? 

    Also, to ech what PP said- since we only had 1 embryo, we did a 2dt, bc really, why not.  There's still hope, and I will be thinking of you and crossing my fingers that you can do a transfer and get good news in a couple of weeks!!
    Image and video hosting by TinyPic
    Anniversary

    TTC since 2008
    Dh:34, no issues.  Me:31, Endo, slightly hypothyroid, deformed ovary, paracentric inversion.
    4 Gonal-F, Cetrotide, HcG, Crinone +TI cycles= all BFN
    Lap in 2012 to remove large unresolving cyst discovered endo and double lobed ovary.
     6 Gonal-F, Cetrotide, HcG, Crinone IUI cycles= All BFN,
    1st IVF w/ICSI- June '13 Antagonist: Gonal-F, Menopur, Ganirelix, HcG, Estradiol, Crinone= 7 retrieved, 4 mature, 1 unfertilized, 2 abnormally fertilized, 1 normally fertilized.  2DT of only embryo and our miracle BFP.
    Our beloved baby boy was born sleeping Oct. 13, 2013 due to pROM/IC/Uterine infection.
    2nd IVF w/ICSI- Feb. '14 EPP/lupron/antagonist: Estrace, lupron, HGH, Gonal-F, Menopur, HcG, PIO, lovenox, doxy/dex.=21 retrieved, 16 mature, 15 fertilized!!  5dt of 1 blast/ 6 frozen. BFP!  Beta 1 9dp5dt:83.9  Beta 2: 11dp5dt: 145.2  Beta 3  14dp5dt: 497  Please be our sticky rainbow baby!

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    Lilypie Angel and Memorial tickers


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  • This positively sucks!! I am so sorry...however, you have two awesome one so good luck!!
  • I'm so sorry. I dealt with this too. I had 15 retrieved and only 5 fertilized normally...I was very shocked, upset and worried. Many were still immature. But 6 made it to day 5 as morulas, in which i transferred 2 of the best. Only 1 made it freeze the day after which was also disappointing but at least theres one. Just try to stay positive. I know how you are feeling. I couldn't sleep and was a mess until the day of transfer. You still have a good chance. FX for you.
    Married September 5, 2009
    TTC #1 since December 2010
    DH (33): Perfect
    Me (33): All tests normal; Unexplained IF
    IUI #1 July 2012 - Chemical :(
    IUI #2 - #6 - All BFN
    IVF #1 (New RE) March 2014 - Antagonist Protocol - 15R, 6F, transferred 2 5day embies -BFN
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  • Fingers crossed your 2 fertilized continue to grow! Best wishes
    *~*~*~*~*~*~*~*~*~*~*~*~*~*~*~*~*~*~*~*~*~*~*~*~*~*~*~*~*~*~*~*~*~*~*~*~*~*~*~*~*~*~*~*~*~*~
    Waited a long time, tried a lot of stuff, science made me a mom.
     Loss and IF veteran. Current mom of DS 5.5, DD 2, and sometimes DH 40. Due June 2021 with TWINS
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