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Estrace

indianaalumindianaalum member
in Infertility
Anyone else have to do some priming with Estrace? I am unclear why I have to do that. Anyone know the answer? what type of side effects could I expect from that one?
===siggy warning====
Me: 40, DH: 42
Diagnosis: PCOS
TTC: May 2013
TX: IUI #1 with Follistim. Canceled due to too many follicles (10 + that were large); BENCHED
IVF #1 March 6. 14 eggs retrieved, 10 fertilized. 
March 11, 4 eggs transferred.
March 21 BFP  :) Beta #1 457, Beta #2 1350, Beta #3 9619. 
Due Date November 27, 2014
TEAM BLUE

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Re: Estrace

  • Ham113Ham113 member
    I can't offer any feedback on the why it's being used for priming, but I was on it post-IUI and didn't really have any side effects besides the telltale blue discharge.

    Did you go to IU Bloomington? 
    TTC since 5/2012
    12/12: c/p
    4/13: c/p
    8/13: Started seeing RE; DX: Unexplained IF, RPL testing normal, SA perfect.
    Oct - Dec '13: Clomid 25 mg + Ovidrel + IUI = BFN
    2/14: IVF #1 Gonal F + Menopur + Ganirilex + Lupron trigger w/ HCG boost= 28R, 11M, 5F. 5dt 4BB, 1 frozen 4BB    . BFN
    4/14: IVF #2 Saizen, Gonal F, Menopur, Ganirilex = 20R, 10M, 10F.  5dt of 2 4AB, 2 frozen 4BB.  +HPT 4dp5dt, Beta 4/26

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  • overwhelmed29overwhelmed29 member
    I used it before my FET and am still using it. Its estrogen support and I believe it helps thicken your lining. It makes me super hungry, I'm bloated and my boobs are huge, sore and veiny!

    ******Siggy Warning**************

    Me 29 - no known issues ( Highest FSH 10.1??) 
    DH- 36 - quite the perfect man!
    TTC since 1/2011
    IUI #1 March 2012 
    BETA #1  BFP
    B/O at 6 weeks D&C @ 10 weeks 
    IUI #2-7 (2012)= BFN
    IVF  Jan 14 - Follistim, Ganirelix
    22R, 8M, 8F
    ET  (1-14-14) - 1 Grade A 8 cell = BFN
    FET (2-18-14)  1 grade A 12 cell and one early morula!
    BETA #1 (3-3-14) =1,389  p4 17.4
    BETA #2  (3-5-14) = 4,553 u/s showed one small g sac
    U/S #2      (3-17-14) Shows two little beans with heartbeats!!! TWINS!! 
                                       Heartbeats were 119 & 120 beans measured (6 weeks 1 day) (6 weeks 2 days)
    found out at 20 weeks that baby B went to heaven
    11/12/14 Baby girl arrived :)
    FET (1-24-16) Grade A early morula 
    BETA #1 300 p4. 11.1 
    BETA#2 1300
    u/s d 1 tiny babe :)
    10/7/16 another sweet baby girl
    4/18 SURPRISE + HPT 
    Beta #1 6 weeks 16,202 p4. 13.2




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  • STBMrsMillerSTBMrsMiller member
    I used it in one of my IVF cycles to prep and was told it helps coat the ovaries so they will be more responsive.
    Pregnancy Ticker

    TTC #1 since June 2012
    Me (28) - DOR (AFC <10, undetectable AMH, >10 FSH), homozygous E429A MTHFR
    DH (29) - MFI low count and morphology

    September 2013 IUI#1 - Clomid + Trigger + IUI = BFN
    October 2013 IUI#2 - Letrozole + Menopur + Trigger + IUI = BFN

    Nov 2013 IVF/ICSI #1 - Protocol: BCP prep, high doses Menopur and Bravelle (12 days), ganirelex
    Results: 5 retrieved / mature, 4 fertilized, 1 arrested and 3 complex abnormal after day 3 PGS = Cancelled after ER
    Jan/Feb 2014 IVF/ICSI #2 - Protocol: Estrogen priming, high doses Menopur and Bravelle (11 days), microdose lupron
    Results: Cancelled after 11 days of stims due to low response and E2 levels
    Feb 2014 IVF/ICSI #3 - Protocol: No prep, low dose Menopur (6 days), ganirelex, Bravelle booster with trigger
    Results: 1 retrieved / 0 mature = Cancelled after ER

    Officially moving on to embryo adoption! We used and love Embryo Adoption Services of Cedar Park
    October 2014 FET #1 - BCP/Lupron/Estrace/Prometrium, transferred 2 of 4 from match #1, BFN
    December 2014 FET #2 - BCP/Lupron/Estrace/Prometrium, transferred 2 of 4 from match #1, BFN
    March 2015 FET #3 - BCP/Lupron/Estrace/Prometrium, transferred 2 of 6 from match #2, BFN
    May 2015 FET #4 - BCP/Lupron/Estrace/Prometrium, lost 2 to thaw, transferred 2 of 6 from match #2, BFN
    October 2015 FET #5 - Natural cycle, lost 1 from match #3 and 1 from clinic backup to thaw, transferred 1 backup, BFN
    February 2016 FET #6 - Natural cycle, transferred 1 from match #4, B FREAKING P!
    Beta 1 = 162, Beta 2 = 316, doubling just over 48 hours

     

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  • keziah23keziah23 member
    I am in an estrogen priming cycle now, didn't use estrace but used two other estrogen supplements, Estridol Varilate shots and Estrogen suppositories. My doctor said it makes the ovaries "listen" to the stimming meds and respond better. 
    Me 39, DH 40
    Male Factor (severe oligospermia) 
    IVF#1-December 2013: Conversion Protocol @ SIRM, Canceled on day 10 of stims due to poor response
    IVF#2- February 2014:  Estrogen Priming Conversion Protocol @ SIRM (ER 2/22: (9R, 7M, 4F, All arrested, nothing to trasnfer)
    IUI#1-May 28, 2014- 100mg clomid, HCG Trigger, 100mg progesterone oral--BFN
    IUI#2-June 24, 2014- non medicated, HCG 2,500mg x 4 doses (over a week), Endometrium- BFN
    Suprise BFP- September 1, 2014- miscarriage at 5 weeks. 

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  • RunCC37RunCC37 member
    I did estrogen priming for IVF #2 and was told it would "bathe the ovaries in estrogen" and that "they like that."

    I took my Estrace orally, so no smurf vag as some call it ;) But it always does make my skin break out. And I get a tad (read: extremely) emotional.

    Good luck!
    **SIGGY WARNING**

    Me: 32 DH: 35  TTC#1 since March 2012
    Dx: Poor Embryo Quality, Arcuate Uterus, Poor Uterine Blood Flow, Mild Endo, 
           Protein S Deficiency, Sjorgen's Syndrome 

    IUI #1-5: BFN
    Laparoscopy & Hysteroscopy: minimal endo, partial septoplasty
    IVF #1: 10R/6M/6F ~ Day 3 ET = BFN
    IVF #2: 14R/9M/5F ~ transfer canceled ~ all embryos arrested at 1-2 cell stage
    IVF #3: 9R/5M/5F ~ 1 frosty!
    IVF #4 (FET #1): BFN

    IVF #5 (DE IVF #1 with Dr. KK protocol): Currently PREGNANT!!!!!!
    Synthroid + Prednisone + Metformin + Baby Aspirin + Supplements Galore = 15+ pills a day
    Lupron + Lovenox + Delestrogen + IVIG + B/W = 2-5 pokes a day
    19R, 17M, 17F - transferred two Grade A blasts 11/16, four frosties!!!
    Beta #1 11/24 (13dpo/8dp5dt) = 367 ~ Beta #2 11/26 (15dpo/10dp5dt) = 709
    Beta #3 11/29 (18dpo/13dp5dt) = 1,997 ~ Beta #4 12/1 (20dpo/15dp5dt) = 3,403

    imageimageimage

    My Blog: Running and Dreaming for Two ~ All are Welcome!
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  • kz's_girlygirlkz's_girlygirl member
    I'm doing estrogen priming as well- my Re said it helps prepare the ovaries so they respond to the stimulation drugs better. In past cycles I have had a low response despite normal levels, so the estrogen will hopefully remedy that. GL as you continue!
    Image and video hosting by TinyPic
    Anniversary

    TTC since 2008
    Dh:34, no issues.  Me:31, Endo, slightly hypothyroid, deformed ovary, paracentric inversion.
    4 Gonal-F, Cetrotide, HcG, Crinone +TI cycles= all BFN
    Lap in 2012 to remove large unresolving cyst discovered endo and double lobed ovary.
     6 Gonal-F, Cetrotide, HcG, Crinone IUI cycles= All BFN,
    1st IVF w/ICSI- June '13 Antagonist: Gonal-F, Menopur, Ganirelix, HcG, Estradiol, Crinone= 7 retrieved, 4 mature, 1 unfertilized, 2 abnormally fertilized, 1 normally fertilized.  2DT of only embryo and our miracle BFP.
    Our beloved baby boy was born sleeping Oct. 13, 2013 due to pROM/IC/Uterine infection.
    2nd IVF w/ICSI- Feb. '14 EPP/lupron/antagonist: Estrace, lupron, HGH, Gonal-F, Menopur, HcG, PIO, lovenox, doxy/dex.=21 retrieved, 16 mature, 15 fertilized!!  5dt of 1 blast/ 6 frozen. BFP!  Beta 1 9dp5dt:83.9  Beta 2: 11dp5dt: 145.2  Beta 3  14dp5dt: 497  Please be our sticky rainbow baby!

    Image and video hosting by TinyPic

    Lilypie Angel and Memorial tickers


    imageimage
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  • MrsC430MrsC430 member
    I'm also taking it for our FET to help thicken my lining. I get headaches and mood swings off and on. Nothing too crazy though. GL!

    It's twin girls!! Born on 11-2-14!
    image
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  • indianaalumindianaalum member
    RunCC37 said:
    I did estrogen priming for IVF #2 and was told it would "bathe the ovaries in estrogen" and that "they like that."

    I took my Estrace orally, so no smurf vag as some call it ;) But it always does make my skin break out. And I get a tad (read: extremely) emotional.

    Good luck!

    RunCC37 said:
    I did estrogen priming for IVF #2 and was told it would "bathe the ovaries in estrogen" and that "they like that."

    I took my Estrace orally, so no smurf vag as some call it ;) But it always does make my skin break out. And I get a tad (read: extremely) emotional.

    Good luck!
    Great..moody and pimply..Just what I wanted! LOL
    ===siggy warning====
    Me: 40, DH: 42
    Diagnosis: PCOS
    TTC: May 2013
    TX: IUI #1 with Follistim. Canceled due to too many follicles (10 + that were large); BENCHED
    IVF #1 March 6. 14 eggs retrieved, 10 fertilized. 
    March 11, 4 eggs transferred.
    March 21 BFP  :) Beta #1 457, Beta #2 1350, Beta #3 9619. 
    Due Date November 27, 2014
    TEAM BLUE

    Report Reply
  • indianaalumindianaalum member
    Thanks everyone for answering. It makes more sense now :)

    I didn't truly understand before as my estrogen levels always seemed normal.
    ===siggy warning====
    Me: 40, DH: 42
    Diagnosis: PCOS
    TTC: May 2013
    TX: IUI #1 with Follistim. Canceled due to too many follicles (10 + that were large); BENCHED
    IVF #1 March 6. 14 eggs retrieved, 10 fertilized. 
    March 11, 4 eggs transferred.
    March 21 BFP  :) Beta #1 457, Beta #2 1350, Beta #3 9619. 
    Due Date November 27, 2014
    TEAM BLUE

    Report Reply
  • janet1206janet1206 member
    I've researched this and also discussed it w my dr. It helps line up all the antral follicles prior to the beginning of your cycle so there isn't a dominant follicle that leads when you start stim meds. In other words, it keeps them quiet and all the same size so they all respond at the same rate. This is how they achieve many dominant follicles for ivf.
    Married September 5, 2009
    TTC #1 since December 2010
    DH (33): Perfect
    Me (33): All tests normal; Unexplained IF
    IUI #1 July 2012 - Chemical :(
    IUI #2 - #6 - All BFN
    IVF #1 (New RE) March 2014 - Antagonist Protocol - 15R, 6F, transferred 2 5day embies -BFN
    image

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