Recurrent M/C and PCOS — The Bump
Secondary IF

Recurrent M/C and PCOS

Trying to decide how to best approach my doctor about this and what to ask questions about...Metformin, HCG shots, Progesterone suppositories, Clomid...first pregnancy in Jan 2011 was a chem. pregnancy loss, my DD is a Clomid baby, but since I've had another chemical pregnancy loss since DD's birth, I am wondering if maybe I should incorporate one or more of these others in with the Clomid this time. Anyone had any experience/success with a combination of the above mentioned therapies?
ME: 24 with PCOS and a HX of Endo (rem. 04/12) 
DH: 24 with Low Motility 
TTC since 11/09
M/C 01/11 at >2w, chemical pregnancy
50mg Clomid 02/12, -OPK
100mg Clomid 03/12, -OPK
Surgery to remove endo. and check tubes 04/04/12
10d Provera & 150mg Clomid 05/12, 1st positive OPK!
BFP 06/12
DD born 01/30/13!!! 
TTC #2 since 09/13
Last Normal Cycle 12/16/13
Neg OPKs in 01/14
Neg Prog. in 01/14
10d Provera started 01/21/14
ER Visit 02/15/14, u/s showed empty uterus, BHCG = 111 
M/C 02/16/14, chemical pregnancy...M/C was confirmed 2/18/14, BHCG = 28

05/12/2014 Started 50 mg Clomid
05/16/2014 Ended 50 mg Clomid

05/28/2014 Negative "Day 21" progesterone bloodwork
06/06/2014 BFP!!!
06/09/2014, beta HCG 75
06/12/2014 beta HCG 242!
06/20/2014 beta HCG 2823!
06/26/2014 m/c at 6w1d
07/21/2014 diagnosed with APS (Lupus Anticoagulant), Factor V, and MTHFR mutation in addition to PCOS and HX of Endometriosis
10/27/2014 repeat Lupus Anticoagulant tested negative

Re: Recurrent M/C and PCOS

  • Clomid never worked for me, but Clomid plus trigger could help a lot if your issue is releasing eggs that aren't quite mature- that could (potentially) explain the CPs. Just make sure they are monitoring you closely with this combo- you don't want to be the next octomom! 

    Progesterone never hurts anything. Idk about the metformin.

    Good luck! 

    Spontaneous pregnancy #1
    DD1 July 31, 2011

    Trying for #2 since Oct 11
    732973 Clomid Cycles
    2 IUIs 
    3 Fresh IVFs= 1 Ectopic treated with MTX
    Spontaneous pregnancy #2= Ectopic #2= lost left tube
    Spontaneous pregnancy #3= DD2 January 29, 2016
    Spontaneous pregnancy #4= Ectopic #3
    Spontaneous pregnancy #5= Baby #3 is a BOY!!! 

    BabyFruit Ticker
  • I agree with PP. And please correct me if I'm wrong about this, but I seem to remember being told that its a common thing for PCOSers to have progesterone deficiency/ luteal phase defect issues.
    Me: 30 Dh: 33   Married: 10 yrs.

    BFP #1: 1/04  [email protected] wks  D&C 4/22/04

    DX w/PCOS 1/05, met RE 6/05, HSG 7/05

    BFP#2 8/05 w/Clomid 100mg, trigger shot, IUI  (Metformin, Progesterone, Heparin during PG) DD born 5/06

    BFP #3 8/09 DS born 4/10

    BFP #4: 7/16/13     D&C 8/19/13

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  • I think you should be on metformin now.  If you have PCOS, taking metformin will address the root cause and help get your body ready and balanced BEFORE you become pregnant.  You want your body at its best before you become pg so that it's ready to receive the fertilized egg.  

    As far as clomid and/or trigger, it sounds like you had success before and I would try it again if I were in your place.  Clomid made my lining too thin, so it's not an option for me. But I wish it were!  I would probably be doing it now if I thought it would help me!

    I would also push for progesterone if I were in your shoes.  I took it for the first 10 weeks with my son even though I didn't use other medical interventions to conceive him.  I think it's better safe than sorry.
    Happily Mrs. C 
    image  image

    image Image and video hosting by TinyPicimage image
    Baby Birthday Ticker Ticker 
    start ttc #1 in Jan 2009
    dx PCOS in May 2010, begin metformin
    Two failed clomid cycles (made lining too thin)
    Started acupuncture while saving for IVF in Sept 2011
    Add herbal infusions to the mix in Dec 2011
    Hoping holistic approach works!!!

    BFP on April 2012 at 11dpo
    Meepy Man born on Jan 2013 - Hip Hip Hurray!

    Ready to start ttc #2 April 2013, but plan to be an extended BF'er
    Back on metformin Aug 2013
    Restart herbal infusions Sept 2013 - currently drinking nettle, oatstraw, and red raspberry leaf
    DS weaned in April 2014
    Taking a break from herbs and just riding the healthy train.  
    Planning medicated cycle end of summer.  FX I get KU before then!!!
  • The way my RE phrased it the progesterone suppositories won't hurt. Just do the research and bring it up, clomid didnt work for me, now I'm on femera.
    Lilypie Third Birthday tickers Lilypie Pregnancy tickers
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