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Letrozole (femara) side effects

jencity9jencity9 member
in Trouble TTC
Maybe I'm just having a bad IF day but I am just feeling so moody and depressed and not sure why. I've also had horrible headaches. I think I've been eating for comfort a lot lately too and am feeling so bloated and fat. Really I feel like I'm PMSing. I'm guessing this is all from Letrozole and I'm just in one of those moods that I feel so frustrated at dealing with all this. Today's the last day of Letrozole but then I have more symptoms to look forward to when I start progesterone in probably another week or so! Just whining over here! :)

Me: 32  DH: 33  Married: March 2004

July 2006: started TTC
2008: HSG (normal), couple rounds of clomid through gyno
2008 - 2010: dragging my feet out of fear and procrastination
October 2010: first consultation with RE, dx PCOS and fibroids (DH slightly low count/motility)
Oct. 2010 - Dec. 2012:  In DENIAL! avoided the issue because I was scared of surgery
January 2013: returned to RE, fibroids grew significantly
February 2013: second HSG, fibroids pushed on tubes which blocked them somewhat
March 2013: MRI to determine what type of surgery may be necessary
July 29, 2013: fibroids (5) removed via robotic laparascopy
August 2013 - Nov 2013 : benched due to recent surgery

IUI #1, Dec. 24, 2013, BFN 
IUI #2, Jan. 25, 2014, BFN
IUI #3, Feb. 25, 2014  BFN
IUI #4 canceled due to lack of response to letrozole
IUI #4.1 April 28, 2014, BFN
May 16, 2014: wtf consult, start prepping for IVF in June and add injects for one last IUI in the meantime
IUI #5 started letrozole and bravelle but canceled after HSG led to new diagnosis
May 21, 2014: third HSG, tubes blocked, one at the beginning, one hydrosalpinx??
June 11, 2014: consult, approved to move on to IVF because the hydro is not completely blocked therefore allowing fluid to move through slowly rather than backwards
IVF #1 August 8, 2014 - 3dt of 2 embryos, BFN
September 17, 2014 - 4th HSG, the right tube is very patent (open!!) dye went straight through this time. Weird!
October 2, 2014 - started metformin treatment
November 14, 2014 - blood work, brought A1C down from 5.8 to 5.5
November 26, 2014 - RE finally back from vaca and reviewed my chart, no more IVFs for rest of calendar year
December 1, 2014 - Right after Thanksgiving, I called a new clinic and got in right away! Plan for IVF
December 17, 2014 - ER! 29 retrieved (!!), 16 mature, all 16 fertilized (ICSI)
IVF #2 December 20, 2014 - 3dt of 3 embryos, BFN

We are done with treatment unsuccessfully. :(


PAIF/SAIF/All Welcome!

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Re: Letrozole (femara) side effects

  • pmpknbridepmpknbride member
    edited February 2014
    I have had some moodiness with Femara, but I can't complain because it pales in comparison to the deep depression I felt with Clomid. I think I only ever had one headache with Femara, but I always sleep longer when taking it, about 9 hours per night vs. my normal 7.5ish
    *** SIGGY WARNING ***

    Happily Married Since 10.2006  •  TTC since 07.2012
    HSG Good & SA mostly Normal  •  DX lean PCOS
    MAR - NOV 2013  •  5 Cycles Clomid + TI = 2 Late O's/BFN & 3 Big Fat FAILS
    DEC 2013 - FEB 2014  •  IUI #1-3  •  Femara 5mg + Trigger = 3 BFNs
    MAR 2014  •  IUI #4  •  Follistim + Trigger + Crinone = BFN
    APR 2014  •  Benched  •  BCPs to clear up Cysts

    MAY 2014  •  IUI #5  •  Follistim + Ganirelix + Trigger = BFP
    E.D.D. 2/18/2015
    6/11 +HPT • 6/13 BETA 447 • 6/16 BETA 1535
    6/23 U/S Adorable Little Bean • 6/30 U/S Beautiful Strong Heartbeat

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  • ReneeJ2011ReneeJ2011 member
    calindi said I have felt like my ovaries are crampy since taking the Femara but I had my U/S today and it was OK so I don't know what all that is about..                          
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  • RNCrystalRNCrystal member
    I just finished my first cycle of ferama and also experienced side effects-although I never took clomid so I can't compare. I felt tired but had a hard time sleeping at times, had several headaches throughout the day as well . I also felt bloated but that could have been poor food choices- overall I just felt a little "off" but it it works it will all be worth it!
    Married July 2 2011
    Not trying Not preventing since 2011
    Me: Ovulate on my own (but poorly) DH: Low count and poor motility
    Oct 2013 Uterine polyp removed
    Feb 2014 First round Ferama, trigger and IUI...BFN
    March 2014 Second round Ferama, trigger and iui
    Waiting....
    Trying to Conceive Ticker
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  • PurpleDaisy923PurpleDaisy923 member
    The only side effect that I have had while on letrozole was mild depression. I cry over the littlest things. It is only during the 5 days that I am taking it though. It wears off pretty quickly.
    ********Siggy Warning********

    Me: 25 DH: 29
    Married 9/23/2012, TTC since 3/2013
    Dx: PCOS, Anovulation/Amenorrhea
    HSG: All clear, SA: Normal 
    Oct 2013: 1st consult with RE
    Nov 2013-Dec 2013: Letrozole + Trigger + TI = BFN
    Jan 2014-May 2014: IUI#1-4: Letrozole + Trigger + Progesterone= All BFN
    Sept 2014: IVF#1: 24R/13M/11F
    Transferred 2 embryos on 9/24, 2 frosties = BFP!!
    Beta#1: 8dp5dt: 188, Beta#2: 12dp5dt: 822
    Beta#3: 15dp5dt: 1965
    1st u/s 10/13: TWINS!!
    u/s 12/23: TEAM PURPLE!!
    All Welcome! 
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    Lilypie Pregnancy tickers
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  • kaynix21kaynix21 member
    I had some serious cramping on the right side on CD5. And then aches on CD6 and 7...I thought it was my appendix or something but it went away.

    I also had weird neck pain, like a pulled muscle but IDK if that was just a coincidence or not.

    Lilypie Angel and Memorial tickers

    TTC: Started May 2012
    Bloodwork - potential ovulation issue which seemed to be fixed by clomid.
    SA - Mot (36%) and count low 9.3 mil (updated) 
    HSG - Oct 16 2013 - came back clear
    Clomid #1 - Nov. 2013 - BFN
    BFP#1 =  Clomid #2, Dec. 2013 - EDD 9.9.14 Loss Jan 9
    Femara #1 + Trigger (2/21) Feb. 2014 +ruptured ovarian cyst - BFN
    SIS clear
    April 2014: 50IU Follistim CD3-CD9 + 25IU CD10-CD13+CD13 trigger 1 mature follie= BFN
    IUI #1: May 2014 50IU Follistim + trigger + IUI = BFN
    IUI #2: June 2014 50IU Follistim + IUI (3 mil sperm)=  BFN
    TI #2: June 2014 50IU Follistim  + Trigger = BFN
    BFP#2 = IUI# 3: Aug 2014 75IU Follistim+ Trigger + IUI (2 mil sperm) EDD May 15

    BabyFruit Ticker


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     Love bugs unite!
    Daisypath Anniversary tickers

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  • LadyiebrnLadyiebrn member
    I have headaches that go away in a few hours. I am also very sensitive. I want to cry over everything. 
    Report Reply
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