Immuno Testing — The Bump
Trouble TTC

Immuno Testing

100 Comments 25 Love Its Name Dropper
edited February 2014 in Trouble TTC
Hi everyone,  

I would like to ask my RE to run some immuno tests NK cells, haplotypes, etc.
I do get hives for no reason occasionally, so I am worried it might be causing problems? Idk...

At what point did you have yours done and was it something you suggested or your RE did?


Re: Immuno Testing

  • Sorry I don't have an answer for you. This is something we're just starting to explore for me but we're not doing any official testing yet. I did get a Kenalog shot and I'm on Dexamethason this month with my Clomid. If we have another failure then we'll look into testing since he thinks there's something more going on.

    I also have hives constantly. I was on an OTC antihistamine for 2 years just to manage the hives and got fed up. So we went for the Kenalog and it's been a life saver so far! No more hives!

    I don't think it would be inappropriate to start talking to your doc about possibilities. Good luck!!
    PAIF/SAIF/etc welcome!

    TTC #1 since Aug. 2010

    OB/GYN: DH SA (Sept. 2011): Normal -- Round 1 (11/27/11): 50mg Clomid = BFN -- Round 2 (12/27/11): 50mg Clomid = BFN

    Hormone specialist: CD 21 b/w (May 2012): Normal -- Thyroid: slightly low

    RE: CD 2 b/w (Oct 2012): Normal -- HSG (Oct 2012) - normal (for the most part), Retroverted/Retroflexed Uterus. Otherwise normal shape and no tubal blockages.
    **Unexplained Infertility**

    Second opinion (12/16/13):
    DH: Excellent SA
    Me: Slightly elevated AMH, slightly low FSH, low thyroid, extremely low DHEA,
    Jan 2, 2014: Clomid cycle (100mg), 2 great follies at 28mm and 31mm (no cysts so far), great lining and fantastic timing = BFN
    Jan 30, 2014: Clomid cycle (100mg) + .5mg Dexamethason + 81mg Aspirin = BFN

    Testosterone level was 20Estradiol & Progesterone also low. Hormone pellets for 1 year + Progesterone. Numbers looked great while on pellets. After pellets, Testosterone down to 5! Taking a break from all the bloodwork & hormones.

    Looking at possible Th1 & Th2 elevations. Requesting laparoscopy.
    Currently taking Pregnitude, "Female Balance" herbs, DHEA.
     Daisypath Anniversary tickers

  • It doesn't hurt to ask. My doc never brought up autoimmune testing. I brought it up in our WTF appointment after IVF #2 failed, but he wasn't into it. Then we consulted with four other REs in the area. One of the four wanted to do the testing. It seems to be something that is not done by all clinics.

    Me: 32 DH: 35  TTC#1 since March 2012
    Dx: Poor Embryo Quality, Arcuate Uterus, Poor Uterine Blood Flow, Mild Endo, 
           Protein S Deficiency, Sjorgen's Syndrome 

    IUI #1-5: BFN
    Laparoscopy & Hysteroscopy: minimal endo, partial septoplasty
    IVF #1: 10R/6M/6F ~ Day 3 ET = BFN
    IVF #2: 14R/9M/5F ~ transfer canceled ~ all embryos arrested at 1-2 cell stage
    IVF #3: 9R/5M/5F ~ 1 frosty!
    IVF #4 (FET #1): BFN

    IVF #5 (DE IVF #1 with Dr. KK protocol): Currently PREGNANT!!!!!!
    Synthroid + Prednisone + Metformin + Baby Aspirin + Supplements Galore = 15+ pills a day
    Lupron + Lovenox + Delestrogen + IVIG + B/W = 2-5 pokes a day
    19R, 17M, 17F - transferred two Grade A blasts 11/16, four frosties!!!
    Beta #1 11/24 (13dpo/8dp5dt) = 367 ~ Beta #2 11/26 (15dpo/10dp5dt) = 709
    Beta #3 11/29 (18dpo/13dp5dt) = 1,997 ~ Beta #4 12/1 (20dpo/15dp5dt) = 3,403


    My Blog: Running and Dreaming for Two ~ All are Welcome!
  • I just had mine done after we'd been trying for 2 years, seeing an RE for 9 months, and had exhausted literally every other explanation for why I'm not getting pregnant.  I had to ask though.  I asked for autoimmune and she ended up ordering autoimmune, clotting, and thyroid tests.  They drew 6 tubes of blood to do all of these.  I asked about NK cell and she said she doesn't order it because it really doesn't give any useful information.  I asked DH about it (since he tests his patients for autoimmune disorders all the time) and he said no one ever orders it because it's really non-specific and not particularly useful.

    The other test I originally asked for and which didn't get relayed to her was androgens, even though I show no signs of PCOS.  She just ordered that on Friday and I'll get the results in a week.

    Here's what I had done (all of which were normal):
    Thyroid peroxidase antibody
    Antinuclear antibody screen
    Anti-cardiolipin antibody
    Beta-2 glycoprotein antibodies
    Lupus anticoagulant
    Thyroglobulin antibody
    PT and PTT 
    Antiphospholipid antibody
    Baby girl N born 10/29/14!

    **Follow your heart, but take your brain with you**

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