Infertility

PGD vs DNA testing for inheritable diseases

For those of you doing PGD, I was wondering if that was your choice, or something your clinic routinely does.  My clinic suggested DNA genetic testing on us before we started the IVF process, but has not mentioned PGD.  Does anyone know if it's usually one test or the other, or both, or any other info on this is appreciated. 

Thanks!
First natural BFP June 2013
Ectopic July 2012 with fallopian tube and ovary removal :(

First IVF (after 1 cancelled cycle) Jan 2014, 
ER 1/16
ET 1/21
Beta 1/31 BFP!
Beta 2: 400
Beta 3: 700
Beta 4: 11,000  
Beta 5: 45,000
1st US 2/18:  TWINS!!!  :)
EDD: 10/10/14
Delivered via c section 9/17/14, B/G twins


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Re: PGD vs DNA testing for inheritable diseases

  • I believe many with PGD recommended have either an already known issue found through DNA testing, or repeat loss (with having had genetic testing on the losses showing genetic abnormalities).
    For example we did genetic testing on our recent loss to determine if we should have pgd moving forward. If you have no known history of loss or genetic disorders that most REs don't recommend it for IVF.

    TTC since July 2009. Dx MFI & LPD. 
    IUI#1&2&3 (2011 & 2012) BFN
    IUI#4 1/23/13 on 75iu x9 Follistim = BFP then chem preg m/c (Feb 2013)
    IUI#5 BFN (April 2013)
    IVF w/ICSI Oct. 2, 2012 - 13R, 11M, 7F, 1 frozen blast 4BB grade - - - FET Nov 15, 2013
    BFP! Beta 1:104 @ 10dp6dt, Beta 2:178 @ 12dp6dt,  beta 3:366 @ 14dp6dt
    Saw heartbeat twice before missed M/C at 8w3d on 12/27/13, missing my little angel boy
    JUNE 2014 IVF#2;  5R, 2M, 1F Three day transfer 6/7.  Beta 6/18 - BFN
    Child Free Now?
    S/PAIFW , S/PALW

    My Blog

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  • Our RE recommended it due to recurrent loss and no real issues found in the RPL testing. It is quite expensive but we are hoping to avoid future losses.

     image

    BFP #1: 1/4/13, EDD 9/8/13, Missed M/C confirmed 2/8/13, Misoprostol

    2013: Three CPs w/ EDDs: EDD 2/10/14, EDD 3/24/14, EDD 6/24/14

    IVF/ICSI #1 (Antagonist) - Jan 2014- 19R, 14M, 11F, 3 penguins (6BB, 4BB, 6BC)  PGD tested- All Normal!

    IVF/ICSI #2 (Antagonist) - Feb 2014 - 23R, 11M, 10F, 1 penguin (3BB) - Another Normal!

    FET #1 - March 26, BFN

    FET #2- Beta #1 (9dp5dt) -332, Beta #2 (11dp5dt) -1027, EDD 1/30/2015, Missed M/C, D&C 6/19/14

    IVF/ICSI #3 (Lupron Down Reg) - Oct 2014 - 38R, 28M, 27F, 20 frozen on day 5, 16 normal penguins!!

    FET#3 - February 1, 2015, Prep begins 1/13

    All Welcome!

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  • I apologize for bringing up this sensitive subject, but thank you for the info.
    First natural BFP June 2013
    Ectopic July 2012 with fallopian tube and ovary removal :(

    First IVF (after 1 cancelled cycle) Jan 2014, 
    ER 1/16
    ET 1/21
    Beta 1/31 BFP!
    Beta 2: 400
    Beta 3: 700
    Beta 4: 11,000  
    Beta 5: 45,000
    1st US 2/18:  TWINS!!!  :)
    EDD: 10/10/14
    Delivered via c section 9/17/14, B/G twins


    image 


  • Lurking from PAIF...

    We had to undergo DNA testing before starting IVF but did not do PGD. I ended up being a carrier for 3 weird super rare mutations but DH came back completely normal so we decided not to pursue PGD.

    Good luck!

    ***SIGGY/TICKER WARNING***

    TTC since September 2012 ~ DH(32): Non-obstructive azoospermia, Me(32): Normal

    10/13 - TESE found sperm!! ~ 11/13 - IVF w/ ICSI #1 ~ ER 11/23/13 ~ 10 R, 9 M, 8 F

    ET 11/29/13 ~ Transferred 2 beautiful hatching blasts, 5 frosties

    12/5/13 -  BFP!!! Beta #1 (12/7/13) - 189  Beta #2 (12/9/13) - 401 Beta #3 5871

    12/16/13 U/S #1 - TWINS!! EDD - August 16, 2014 ~ 7/19/14 - Our beautiful baby girls joined the world!

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