Success after IF

low estradiol - good outcome possible?

My soggy is messed up so quick background: me (33), dh (41).  Diagnosis: severe MFI.  IVF #1 - success.  2 spontaneous healthy pregnancies.  3 girls total :) FET #1 and FET #2 failed.  Onto IVF.

I started at the same dose last Thursday as my first IVF 5 years ago - 150 Gonal-f/75 units Menopur.  Labs on Sunday - Estradiol 42.  New doses - 225 Gonal-F/150 U Menopur.  Labs today - low Estradiol (she didn't tell me the number) and only 11 follicles, 5-10 mm.  New doses- 300 Gonal-F/225 U Menopur.  I'm now doing Gonal-f in the AM and Menopur in the PM.

I am so worried that this cycle is going to be a bust.  When I was younger, I had 22 eggs retrieved!  I'm commuting 185 each way to the REI right now, planning to stay this weekend.  My retrieval was tentatively scheduled for next Tuesday, but I'm still having some bleeding and he said there's still fluid/no lining as of this morning.  I've never had any problems before, all of my labs were normal in my work-up.  I did have issues getting a natural period after I stopped nursing DD#3, and now I am wondering what the heck is going on.

Any success stories after this many changes in doses?  I need some inspiration, it is exhausting getting up at 2 AM and driving 3 hours each way for labs/sono!  TIA :)


Me – 33 (no diagnosis), DH – 41 (MFI)

IVF #1/ICSI 2008 – 22 ER, 21 F, Day 3 transfer (8A and 8B) - BFP, 3 Frosties

Surprise BFP 2010

Surprise BFP 2011

Shipped frosties from TX to VA in 2012

FET #1 May 2013, single blast – BFN

FET #2 August 2013 2 blasts – BFN

IVF #2/ICSI/AH Jan 2014 – 8 ER, 7M, 6 F Day 3 transfer (grade 2 & 3), no frosties - BFP!



Re: low estradiol - good outcome possible?

  • First, hugs! We had an initial count on day 4 maybe? Of only 5 follies. This was a shock after AFCs of 20 on my clomid cycles. We ramped up the gonal-f and menopur to double (gf of 300, mp of 150). This coaxed 11 at retrieval, but only the original 5 were mature. We had great fertilization and transferred 2 on day 3. 

    Sadly, we didn't get any frosties (the only embie that made it to day 5 wasn't good enough to freeze), however, I did gof my sweet baby J! 

    I don't the you are out! Good luck!
    TTC Since 3/2010
    Me-36, Unexplained Infertility, DH-35, all clear
    Clomid 50mg 12/2011 = BFN
    Clomid 100mg 1/2012 = BFN, with Cyst
    IVF #1 Lupron/Menopur/Gonal-f/HCG Trigger
    ER 4/19/12 = 11 retrieved, 6 fertilized,
    ET 4/22/12 = 2 transfered (day 3), remaining 3 weren't good enough to freeze
    Beta 5/3 = BFP, 87 Beta #2 5/7 560.9 Beta #3 5/9 1376.5 First u/s One Baby, 125bpm!
    Second u/s, 176bmp! Kicked over to the OB by the RE at 8w. Team Green!! 
    Baby girl J arrived two weeks early! Born into water, med-free. Hooray for Team Pink!

    TTC #2 - back to the RE, treatment started 12/2014. 

    image
  • I had an AFC of 13 for IVF #1 and had 5 retrieved (4 mature). Gonal-F was increased twice that cycle, up to 450 and Menopur went up to 150 (from 75). That cycle brought us DS1 after a 3dt of 2 embryos.

    My AFC for IVF 2 was 10 and I had 6 eggs retrieved 5 mature). Gonal-F was at 450 and Menopur was at 150 throughout this cycle (this one was a Microdose Lupron Flare protocol). That cycle brought us our twins (and 1 frosty) after a 5dt of 2 embryos.

    Good luck!

     

     

    DX: DOR and MFI 

     

    IVF w/ICSI brought us our 1st precious miracle

    V born via induction 4.29.11

    TTC #2: IVF (MDLF) August/September 2012

    ER 9/7: 6R, 5M, 4F ET 9/12: 5dt of 2 blasts 

    +HPT 9/17! Beta #1 (9/25) = 1,000 Beta #2 (9/27) = 1,860 U/S #1 (10/11)...TWINS!

    1/8/13 - It's a..boy and a girl!!   

     

    S&B born via induction 5.8.13

     

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  • Thank you, I am really stressing about this!



    Me – 33 (no diagnosis), DH – 41 (MFI)

    IVF #1/ICSI 2008 – 22 ER, 21 F, Day 3 transfer (8A and 8B) - BFP, 3 Frosties

    Surprise BFP 2010

    Surprise BFP 2011

    Shipped frosties from TX to VA in 2012

    FET #1 May 2013, single blast – BFN

    FET #2 August 2013 2 blasts – BFN

    IVF #2/ICSI/AH Jan 2014 – 8 ER, 7M, 6 F Day 3 transfer (grade 2 & 3), no frosties - BFP!



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