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Is there life after 3 failed IVFs?

Hi ladies, I'm sorry I've been sort of distant lately. I was trying to do the whole "don't think about it and it will happen" . It didn't happen. My third ET of 2 perfect little embies started with a tentative BFP, but ended with a beta of 69 then 23. The fat lady has sung. What on earth am I supposed to do from here? I can't stop crying long enough to carry on a conversation. And my RE hasn't called me, not that I could probably talk to him without sobbing like a complete idiot. I thought that IVF was pretty much the end of the line. What do you do when you reach the end on that line?? Fall of the cliff? Sorry for being so depressing, I'm lost.
Me- 35 Dx endo; DH- 33 no probs.
BFP#1 (totally a wonderful surprise)- 3/10/11. IUFD 6/25/11. 
TTC since 8/2011.
BFP#2- 11/1/11. EDD 7/6/12. Blighted ovum 12/1/11.

New OBGYN 12/2012- CD3 labs, SA, HSG normal. 
First RE appt 1/16/2013. Unexplained infertility. Lap planned. 

12/2012- Clomid 50mg + TI= BFN 
1/2013- Clomid 50mg + TI= BFN.

 Lap 2/11/2013- Removed endo. 

3/2013- Clomid + IUI= BFN
4/2013- Clomid + IUI= BFN
5/2013- Clomid + IUI= BFN

June 2013- Time for a new RE!

July 2013- We're in Shared Risk! Love my new RE!
August 2013- IVF#1- 14 R, 11F, transferred 1 perfect blast, 5 day 5 frosties= BFN.
Sept 2013- Let's get ready for FET October 7th ish!< transfer 2 embies 10/11/13.......BFP 10/18/13!!!!/div>

PAIF/SAIF and everyone is welcome. If I can make even one person's journey less painful, I will consider my experience here successful. Thank you to all for sharing their stories, the intimate details of their lives, their knowledge, and their hearts. I hope this experience changes me, always for the better.

Re: Is there life after 3 failed IVFs?

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    I'm so sorry.  This whole process is so emotional.  I'm right there with you (2 failed IVFs, and 1 failed FET) and I have no idea what to do from here.  It really doesn't make any sense. I swore IVF would work for us since we have no major issues but nope.  As for me, I have an appointment with a new RE in February and will be doing immune testing.  I really love my RE but I have been going to him for a year and nothing.  We are going to try IVF one more time with a new RE and if it doesn't work then I have no idea what we will do.  

    I hope you speak to your RE and get some answers.  Maybe get some second opinions and more testing.  Hang in there- this sucks so bad but something has to work for us.  
    ***SIGGY WARNING***

    DX: Unexplained
    6 Failed IUIs (Clomid and Gonal F).  
    IVF #1 began August 2013- BC, 4 days of Estrace, stimmed with Gonal F and Menopur, Ganirelix, 9R 5M 5F, Medrol and Doxycycline, 5 day transfer of 2 early blastocysts- good quality, Progesterone, Estrace, and baby aspirin, BETA on 9/20 BFN,   IVF #2 began September 2013, stimming with Gonal F (higher dose) and Menopur, Ganirelix, 18R 14M 9F with ICSI, 5 day transfer of 2 BBs one was starting to hatch, 2 frosties: 1  BB and 1 AC, BETA on 10/21, BFN BETA was a 5- chemical 
    Getting some more testing and trying to figure out what the issue is before FET in December, started acupuncture on 11/10, RLP and some other BW nothing major to report except slightly high Prolactin. Prolactin was slightly high when I started with my RE and I already had an MRI which was Neg.  Endo biopsy=negative.  WTF is wrong with us???
    12/18/13 FET of 1 BB and 1 AC.  Hoping for a miracle.  Beta 12/26 Low BETA-8 2nd BETA 5- chemical
    After 3 failed transfers IDK where to go from here.  Still no real answers as to why this isn't working.  Getting a second opinion in February and looking into immune testing.  
    2/14- NEW RE- Immune testing showed a partial dq alpha match with DH- On prednisone and did intralipids prior to transfer.  3/14 Lupron, gonal f, menopur, HGH.  ER 15 mature all 15 fertilized!  5dt of an early blast grade 1 and an expanded blast grade 2.  BETA on 4/21.  1 grade 2 embryo frozen
    BETA #1 59 BETA #2 148 BETA #3 283 BETA #4 2,783! US at 6w2d shows 1 bean measuring right on track! HR 121.  US at 8w3d measuring on track HR 177. Released form my RE.  EDD 12/28


    All Welcome
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    I'm so sorry. I'm also right there with you - I'm in the 2WW for FET #3. If this cycle fails, our options in terms of what's next are not looking good. It's truly an empty and awful feeling.

    After our last FET failed, our RE had DH and I both do the genetic karyotyping test to rule out chromosome issues. I also had the uterine scratch procedure done with this FET (it supposedly helps with implantation). Our karyotyping was normal & the verdict isn't in yet on if the scratch helped, but maybe those are things to ask about?

    Know that you aren't alone & if you ever need to vent, feel free to PM me. Sending you hugs!

    It's twin girls!! Born on 11-2-14!
    image
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    poohnikipoohniki member
    edited December 2013
    I'm so, so sorry. I've been at the end of my line a few times but I realized I don't want to be child-free. So I changed the plan- and quite a few times. Sometimes when you change plans you have to go completely out of your comfort zone.  It may mean trying a new RE. Possibly more testing is needed to find a correct diagnosis. You may want to look into a RPL panel if you haven't already had one.   
    My RE is pretty good about having a back up plan if what we are doing doesn't work. At this point in the game I need to know its not the end and there is something else to try. It helps when things don't turn out.
    ((hugs))
    ***WARNING***

    TTC Since 12/2008;  DH: 32, Azoospermia     me: 33, DX during IVF #4: Low AMH (Normal FSH) / SER due 
    to IVF Meds (causing failure to fertilize) Recent DX: Hashimoto's, Lupus Anticoagulant, White Blood Cell Disorder 
    High ANA, ATA, & APA, PAI-1 Heterozygous= blood clotting disorder; connective tissue disorder 
    IVF w/ ICSI #1 2/2011     IVF w/ ICSI #2 5/2011    IVF w/ ICSI #3 12/2012   *New RE* IVF w/ ICSI #4  5/2013
    IVF w/ ICSI #5 8/2013 (Natural Cycle- No drugs)- One follicle->one blast. CCS normal. FET 9/10- 6BB blast. m/c @ 5w
    IUI #1 12/23- BFN  IUI #2 Cancelled (ovulated during AF)  Prep:CoQ10 (300 mg); DHEA (25 mg); Melatonin (3 mg), Folgard 2.2, Metformin 500 2x, Levothyroxine 50mcg, Aspirin 81mg w/ calcium, B12,  Vit. D 4000 & Prenate Elite Daily; Cabergoline 1/2 pill 2x week-  Cycling: Estrace Priming; Prednisone 10mg, Lovenox 40mg 2x,  Femera & Menopur   
    IUI #2.1 6/30 & 7/1. 1st Beta: 90 (7/15); 2nd Beta: 226 (7/17); 3rd Beta: 766   EDD: 3/23/2015

       **ALL WELCOME**                                    My Blog 
    image
    image


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    McIrish wrote exactly what I was thinking. I'm going to do ivf #5 and possibly #6 starting in March. I think seeing a new RE and immune testing are good steps to take.

    TTC#1 since April 2011
    IVF#1 July 2012 5R, 3 made it to blast, sET c/p
    FET#1 Aug 2012 2 blasts transferred BFN
    IVF#2 Oct 2012
    16R/6M/6F/2-8 cell grade 1 transfer
    Beta 1-237.9, Beta 2-566, Beta 3-8657
    US 6w3d shows one baby w/ HB 115
    US 7w1d no more heartbeat/ D&C 11/30/12 normal karyotype
    IVF#3 Mar 2013
    6R/4M/4F 1 compacting and 2-8 cell transfer
    ectopic pg MTX given 3 month break from TTC

    IVF#4 Sept 2013--BFN
    IVF#5-7 Apr 2014, Jun 2014 and Aug 2014 banking embryos for CCS testing. Praying for normals! Image and video hosting by TinyPic imageimage

    http://i61.tinypic.com/34zll06
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    Ugg... Yes, there is life, but it's hard.

    I'm sorry for your loss.

    I totally get it. It feels like the end of the world, but you still have options.

    We are about to start IVF #7 in a few months...I still can't believe it.

    Take some time to do some things just for you. Even if you don't feel like it, take care of yourself.

    Go to your wtf appt, listen to what your RE says. If it doesn't sit well with you, get a 2nd opinion. Try to be open minded. Hang in there, you're down but definitely not out!!

    Me (32) DOR, elevated NK Cells/ 2 copies of MTHFR mutation/ MH (35) azoo/high DFI   (TTC#1 since 2009)

    IVFs#1-4: (4/10-2/12) all BFN

    Surprise Bfp (9/11) - c/p

    DS IUI#1-2 (9/12, 10/12) - BFN

    DS IVF: (11/12) - BFN

    DE/DS IVF#1: (10/13) - 2 day 3 embies transferred-BFFN

    FET of 2 day 6 blasts: (12/13) - c/p

    DE/DS IVF #2: (4/14) - 1 day 5 blast transferred...BFFN...again.

    FET 5/14: 1 day 5 hatching blast transferred...another BFFN

    Repeat SHG 6/14-normal / Endometrial Receptivity Array biopsy 7/14-Receptive Uterus

    New RE, additional testing reveals elevated NK Cells

    FET of 1 day 5 blast (RE recommends transferring 1 due to elevated NK cells) with lovenox, steroids & intralipids in October

     

     

     

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    its never over until you decide it is. i am so sorry you have to go through this again and i wish we can all say it gets easier because you get used to the routine of it all but its not. i agree with the PP, definitely look into either a second opinion or see if your RE is open to doing further testing and trying something different next time. T&P are with you! *hugs*
    **SIGGY TICKER WARNING**
    Me: 27 High FSH (POF?) DH: 33 Slightly Low Morphology / Married Aug '08 TTC since 7/2009
    6 rounds of clomid = no luck
    IVF w/ ICSI & AZH #1 - Jan/2011 = ET cancelled OHSS
    FET #1 & #2 - March/2011 & June/2011 = Chemical Preg.
    IVF w/ Half ICSI #2 New RE - May/2012 = BFN!
    May '12 - Sep '13 - Took A Break
    Dec '13 IVF w/ Half ICSI #3!!!!! Switched RE
    Protocol - Lupron trigger/Follistim/Ganirelix/Estrace/Vivelle/Crinone
    12/27 - BFP! TWINS! EDD 9/3/14 ...Team PURPLE!
    6/27/14 - Emergency C/S @ 30w2d - Baby A 2lb 14oz, Baby B 2lb 11 oz
    image
    ALL WELCOME :)
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    So sorry For your loss. This journey is so rough.

    DH 38- Low Everything
    Me 33- AMH .9
    Married 11 years
    2002-current IUIs, meds, natural = All BFN

    Aug. '13  Attempt at IVF #1 with Lurpon Flare- Canceled due to ovulation through Lupron.
    Sept. '13 - We will try again with EPP.

    October '13 Started BCP for December IVF. Long Lupron protocol. Canceled due to ovulation through Lupron.

    April '14 Planning IVF attempt #3. Adding Cetrotide. Doc consult at the end of this month. 

    imageimage                                                   


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    (((((hugs))))) I'm so sorry you're going through this... it is absolutely the worst feeling in the world. PPs have already made excellent points and pretty much said it all. I know it's hard to imagine, but eventually the tears will stop flowing long enough for you to be able to think it out and figure out your next steps... whatever they may be... there is no right or wrong decision in all of this. The only thing that is certain is that it is incredibly hard, but somehow you and your husband will find your way through it. (((((((hugs)))))))
    **SIGGY WARNING**

    Me: 32 DH: 35  TTC#1 since March 2012
    Dx: Poor Embryo Quality, Arcuate Uterus, Poor Uterine Blood Flow, Mild Endo, 
           Protein S Deficiency, Sjorgen's Syndrome 

    IUI #1-5: BFN
    Laparoscopy & Hysteroscopy: minimal endo, partial septoplasty
    IVF #1: 10R/6M/6F ~ Day 3 ET = BFN
    IVF #2: 14R/9M/5F ~ transfer canceled ~ all embryos arrested at 1-2 cell stage
    IVF #3: 9R/5M/5F ~ 1 frosty!
    IVF #4 (FET #1): BFN

    IVF #5 (DE IVF #1 with Dr. KK protocol): Currently PREGNANT!!!!!!
    Synthroid + Prednisone + Metformin + Baby Aspirin + Supplements Galore = 15+ pills a day
    Lupron + Lovenox + Delestrogen + IVIG + B/W = 2-5 pokes a day
    19R, 17M, 17F - transferred two Grade A blasts 11/16, four frosties!!!
    Beta #1 11/24 (13dpo/8dp5dt) = 367 ~ Beta #2 11/26 (15dpo/10dp5dt) = 709
    Beta #3 11/29 (18dpo/13dp5dt) = 1,997 ~ Beta #4 12/1 (20dpo/15dp5dt) = 3,403

    imageimageimage

    My Blog: Running and Dreaming for Two ~ All are Welcome!
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    What McIrish said... I felt the same way wafted my 4th embryo transfer resulted in a negative. We took a break to regroup, made plans for donor cycles or adoption and then gave ivf one last shot. We are so glad we did. Big hugs to you. Hope the path becomes more clear as you press forward.

    Age: 35 TTC since 2005, MFI & DOR 

    IVF #1 Sep '11 - canceled poor response

     IVF #2 Nov '11  8R/8M/4F 3dt x2 - chemical

    IVF #3 April '12  11R/6M/4F 3dt x2 - m/c

    FET #1 Aug 2012  3dt x2 - BFN

    **new RE**

     IVF #4 Jan '13 BFN 11R/6M/6F 5dt x2 - BFN

     IVF #5 July '13 16R/10M/10F 5dt x2 + 1 frostie

    9dp5dt Beta 1 = 344!! 16dp5dt. Beta 2 = 4822 7wk u/s= 2 heartbeats!

    Twin girls! 3/6/14

     

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    I'm so sorry...we too are trying to pick up our pieces and figure out our next steps. If we move fwd with IVF we will definitely be getting a second opinion. Goodluck
    2013- 2 IVF cycles with PGD to prevent genetic disorder from being passed on. Both BFFN :(
    2/2014 pregnant!  EDD 10/17/2014

    All always welcome! :)
     Image and video hosting by TinyPic Image and video hosting by TinyPic  Image and video hosting by TinyPic Image and video hosting by TinyPic 
    BabyFruit Ticker
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    ((Hugs)) so glad you have a plan to move forward. T&P are with you!
    Me: 35  low AMH, normal FSH
    DH: 31 Fair DNA fragmentation test :( Normal SA
    TTC: since March 2012

    09-21-13 start IVF #1
    10-04-13 ER 6 eggs, 6 mature, all 6 fertilized. 3 frozen
    10-08-13 fresh transfer canceled due to high progesterone
    waiting for FET
    10-18 started BCP
    10-29 baseline appt scheduled
    11-20 scheduled date of FET #1
    12-2 BFN :(

    3-1-14 moving on to the next step. Switched RE. going to plan 3 IUI cycles while saving for IVF#2

    April 2014- IUI#1  BFN
    May 2014- IUI#2 BFN
    June 2014 IUI#3 BFN

    Taking a break for a while, focusing on our wedding.

    Sept 24th missed period! Surprise natural BFP
    10-15-14 first ultrasound
    06-05-15 EDD

    imageimage

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    We will be doing IVF #5 in June, I feel your pain! :(  GOOD LUCK!
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    I just wanted to say that you ladies are all so brave and an inspiration to me as I look forward from a failed first IVF cycle. Hugs to you all.
    *** TW ***
    2013: BFP #1 - M/C 3/13
    2014: IVF #1-4 = BFFN
    2015: Dance break = got healthy
    7/2016: IVF #5 = BFP!!!
    Babysizer Cravings Pregnancy Tracker
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    I'm glad your RE called and you're feeling better. I've been thinking a lot about a child free life mainly because we are becoming financially tapped out, but coming here makes me realize I'm not alone. I hope your bfp is coming soon

     


    imageimageimageimage

     
     

    *******siggy/ticker warning***** 

     Me(31). DH (31)

    DH SA normal count and motility, 1% morphology
    Me .72 AMH, Fragile X premutation carrier
    IVF #1 (6/12/13) BFN

    IVF #2 (8/16/13) BFN

    FET 10/4/13 Chemical

    IVF #3 MC 5 weeks 5 days

    IVF #4 DE 11/7 BFP, edd 7/28/15

    All Welcome

    BabyFruit Ticker

  • Options
    I'm so sorry you're having oto go through this. I felt the same way after our 2nd FET failed. DH told me "I will do this next cycle if you want but after that I'm DONE seeing you got hrough this!" We switched RE's and are trying a new protocol, intralipids, steriods, CGH testing... AS MUCH AS POSSIBLE. You have to try until you feell you are ready to move on. If you don't feelt hat way, you're not there yet. Hang in there!
    Me (28) DH (32)  Endometriosis                                                                                   IVF  #1 (1/2013) - 17 Retrieved, 16 Mature, 14 Fertilized- 2 transferred- BFN
    FET #1 (7/2013) - 2 embryos - BFN
    FET #2 (9/2013) - 2 emrbyos - BFN
    New RE. Fresh Start
    IVF  #2 (2/2014) - 25 Retrieved, 19 Mature, 16 Fertilized, 9 blasts.
                                 CGH Testing: 6 Normal
    FET #3 (4/2014) -1 embryo -  BFP! Beta#1: 35 Beta #2: 16 :(
    FET #4 (5/2014) -1 embryo -  BFP! Beta#1: 321!!! Beta #2: 727.9!
    6/5/2014 Heartbeat! 144bpm It's a girl!
    Due January!
     
     

  • Options
    hi!
    i understand you and feel your pain bcz was in your situation. i could'nt get pregnant by myself and my doctor suggested me to do IVF. but i've done 3 and no results. and then my doctor tell that my ovaries might produce bad eggs. so the only option for me were donated eggs. my result now is having my beautiful baby  :)

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