Infertility
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Unexplained Infertility Support

Hi all,
I am new to this site and looking for some support as well as to support others with unexplained infertility. DH and I have been TTC for over a year now, I wasn't worried about it till my gyn saw low progesterone in a blood test he sent me for and recommended me to an RE. My RE gave me every test in the book and drained me of all my blood lol she found hypothyroidism and moderate AMH and DH's swimmers are great therefore coming up with unexplained infertility...ugh! This past cycle CD 1 9/13/13( yes Friday the 13th!) I was given clomid on CD 4 thru 8 had 3 large follicles did a trigger shot on CD 13 with iui on CD 14 and 15. I'm now 2DPO in the 2WW which is so hard to get through. Any others out there in the same boat or have been that want to share their stories?

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Re: Unexplained Infertility Support

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    My offical diagnosis is unexplained infertility, but DH and I have both had tests that show minor issues.  I have slightly low progesterone on natural cycles (never with medicated though), but not enough to worry my RE.  I also have possible hostile CM (I had several bad post coital tests), which "could" be why we have had issues getting pregnant on our own.  I also have slightly high NK cells.  We found out that DH has slightly low morphology after his second SA.

    We have done 4 IUIs (3 with Clomid) and 1 cycle of IVF.  We are currently in the middle of IVF #2.

    imageimageimageimageimage

     

    image

    TTC #1 since August 2011

    My Blog

    September 2012: Start IF testing

    DH (32): SA is ok, slightly low morph, normal SCSA  Me (32): Slightly low progesterone, hostile CM, carrier for CF, Moderately high NKC, High TNFa, heterozyogous mutated Factor XIII, and +APA

    October 2012-May 2014: 4 failed IUIs, 3 failed IVFs, and 1 failed FETw/donor embryos

    November 2014: IVF w/ICSI #4 Agonist/Antagonist with EPP and Prednisone, Baby Aspirin, Lovenox, and IVIG for immune issues.  Converted to freeze all due to lining issues.  2 blasts frozen on day 6!

    January 2015: FET #2 Cancelled due to lining issues

    April 2015: FET #2.1


    PAIF/SAIF Welcome!

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    Hi Twinkie thanks for replying. It's so frustrating having all these tests and them finding small things but nothing that warrants an exact reason for infertility grrr. Good luck with the IVF I'll be thinking of you keep me posted!

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    We are officially unexplained but like others have a couple of minor issues that could have impacted our fertility.  We've been TTC for just over 3 years and have tried just about everything (history in my siggy).  We did IVF in April, got enough eggs to freeze and now I'm on my second frozen transfer.  We've had a few pregnancies along the way but none that lasted.  Unexplained is a very frustrating diagnosis.  Our highest chance of success is with IVF/FET and despite the process going well each time, it's not working.  I hope that science will advance enough in my lifetime that they figure out what our problem is.
    There are a lot of ladies doing IVF on this board.  You might want to check out the Trouble Trying To Conceive board as well.   You will find more ladies on clomid and femara over there.  Best of luck to you! Try to stay sane in the 2ww, I know how hard it is!
    Best of luck to you. 

     

    IF, 5 losses, 1 son, 1 on the way.
    fall in love with someone Pictures Images and Photos  photo turtlejpg
       

    Lilypie Pregnancy tickers
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    ***child mentioned***

    We were unexplained before our we conceived our first. (I also had a LPD at the time.) We were fortunate that the RE was able to help pretty quickly. Through testing with my family doctor, we discovered that I have Hashimotos earlier this year. Once my Synthroid dose was figured out, I have a regular LP! (like, 15 days last cycle, as opposed to 5-6 days before that.) Hopefully getting your thyroid figured out will help you to conceive! Good luck =)
    image imageimage
    image

    ***EVERYONE WELCOME***
    TTC #2 with assistance since 03/11
    Me: 33, Autoimmune (Hashimotos and FMS/CFS)
    Treated with Synthroid, acupuncture, TCM and supplements
    DH: 33, MFI (very low on all counts, high antibodies, hemochromatosis)
    Many treatments tried, none successful

    IVF/ICSI #1 05/14 - EPP/Antagonist, Gonal-F and Luveris, 18R, 14M, 13F - SET of 1BC, all arrested on day 5 - C/P
    Genetic testing = normal, DNA Frag = excellent
    IVF #2 03/15 - Long protocol with Suprefact, Gonal-F, and possibly Luveris, adding in PICSI
     
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    Hi whoberry,
    Thank you for sharing your story, beat of luck with your IVF/FET my thoughts are with you.

    I will definitely check out those other boards still learning where things are around here! I have been warned by other users that some people get territorial about who's posting in what and making people move off certain boards...is that true?

    <a href="http://www.thebump.com/?utm_source=ticker&utm_medium=HTML&utm_campaign=tickers" title="Trying to Conceive"><img src="http://global.thebump.com/tickers/tt193dba.aspx" alt=" BabyFruit Ticker" border="0"  /></a>
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    Shcr said:
    Hi whoberry, Thank you for sharing your story, beat of luck with your IVF/FET my thoughts are with you. I will definitely check out those other boards still learning where things are around here! I have been warned by other users that some people get territorial about who's posting in what and making people move off certain boards...is that true?
    It's tough to gauge a persons tone from responses, so sometimes a poster will feel like they're not welcome, but really it's just about finding where YOU fit in. As long as you're respectful of the board and other posters, you're welcome pretty much anywhere! By saying that there are more people going through the same situation as you on another board, that just means that you might get more answers and more support there, since they're going through the same thing as you =)
    image imageimage
    image

    ***EVERYONE WELCOME***
    TTC #2 with assistance since 03/11
    Me: 33, Autoimmune (Hashimotos and FMS/CFS)
    Treated with Synthroid, acupuncture, TCM and supplements
    DH: 33, MFI (very low on all counts, high antibodies, hemochromatosis)
    Many treatments tried, none successful

    IVF/ICSI #1 05/14 - EPP/Antagonist, Gonal-F and Luveris, 18R, 14M, 13F - SET of 1BC, all arrested on day 5 - C/P
    Genetic testing = normal, DNA Frag = excellent
    IVF #2 03/15 - Long protocol with Suprefact, Gonal-F, and possibly Luveris, adding in PICSI
     
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    Hello!  I also am diagnosed as unexplained IF. During the course of tx (3 rounds Femara, 4 IUIs with Follistim) my RE thinks I may have endometriosis.  I don't have symptoms though (they found what may be endometrial tissue on my ovary during all my US).  Through all of the above plus 1 year trying before that I have never been pregnant.  I am starting BCP shortly for our first IVF.  This whole process sucks!  Good luck to you and hope your 2ww flies by!
                        imageimage

                    image  imageimage
                      imageimage
      

    TTC #1 since November 2011
    Dx: Unexplained Infertility, probable endometriosis
    Feb-April 2013: Femara + TI: BFN
    May - September 2013:  Follistim + Ovidrel + IUI#1-4 = BFN
    IVF # 1 November 2013: transferred 1 perfect blast = BFN
    IVF # 2 April 2014: Endo scrape, transferred 2 blasts = BFP!! (first ever!), CP
    FET #1 June 2014: transferred 2 blasts = BFFN
    New Dx: Repeat Implantation Failure
     IVF # 3 November 2014 = BFP!!  Beta #1 9dp5t 272  Beta # 2 11dp5dt 626
    It's Twins! 
    *everyone welcome*
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    Thanks tbtbabe, that really helps a lot! I hope I find my way around soon.

    Hi Shelbeans82,
    Thank you for sharing. Fingers crossed it's not endometriosis and best of luck with your first IVF!!!

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    We are unexplained too. It is very frustrating! Good luck to you!
    **SIGGY WARNING**

    Me: 32 DH: 35  TTC#1 since March 2012
    Dx: Poor Embryo Quality, Arcuate Uterus, Poor Uterine Blood Flow, Mild Endo, 
           Protein S Deficiency, Sjorgen's Syndrome 

    IUI #1-5: BFN
    Laparoscopy & Hysteroscopy: minimal endo, partial septoplasty
    IVF #1: 10R/6M/6F ~ Day 3 ET = BFN
    IVF #2: 14R/9M/5F ~ transfer canceled ~ all embryos arrested at 1-2 cell stage
    IVF #3: 9R/5M/5F ~ 1 frosty!
    IVF #4 (FET #1): BFN

    IVF #5 (DE IVF #1 with Dr. KK protocol): Currently PREGNANT!!!!!!
    Synthroid + Prednisone + Metformin + Baby Aspirin + Supplements Galore = 15+ pills a day
    Lupron + Lovenox + Delestrogen + IVIG + B/W = 2-5 pokes a day
    19R, 17M, 17F - transferred two Grade A blasts 11/16, four frosties!!!
    Beta #1 11/24 (13dpo/8dp5dt) = 367 ~ Beta #2 11/26 (15dpo/10dp5dt) = 709
    Beta #3 11/29 (18dpo/13dp5dt) = 1,997 ~ Beta #4 12/1 (20dpo/15dp5dt) = 3,403

    imageimageimage

    My Blog: Running and Dreaming for Two ~ All are Welcome!
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    Best of luck to you too RunCC37!

    <a href="http://www.thebump.com/?utm_source=ticker&utm_medium=HTML&utm_campaign=tickers" title="Trying to Conceive"><img src="http://global.thebump.com/tickers/tt193dba.aspx" alt=" BabyFruit Ticker" border="0"  /></a>
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    cachoquecachoque member
    edited September 2013
    We're also unexplained. My history is in my siggy. Headed into transfer #3. I'm having a hysteroscopy & endometrial biopsy tomorrow. We're praying it'll bring more to light, even if it's bad news. Not knowing sux!! My advice is don't be afraid to do your own research & ask your RE anything & everything! GL
    image
    TTC #1 since August 2011 w/ unexplained IF
    09/12-11/13: 3 TIs, 3 IUIs, ICSI/PGS IVF & 2 FETs
    08/14: Our little miracle has FINALLY arrived - 3 years after we started trying!
    Baby Birthday Ticker Ticker
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    Hi cachoque,
    Thanks for sharing! I had a hysteroscopy done last week, warning it's not a fun process and I hope it brings you answers! Thanks for the tips it means a lot. Good luck with everything!

    <a href="http://www.thebump.com/?utm_source=ticker&utm_medium=HTML&utm_campaign=tickers" title="Trying to Conceive"><img src="http://global.thebump.com/tickers/tt193dba.aspx" alt=" BabyFruit Ticker" border="0"  /></a>
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    @Shcr, did you have to go under for yours? I hate going under!
    image
    TTC #1 since August 2011 w/ unexplained IF
    09/12-11/13: 3 TIs, 3 IUIs, ICSI/PGS IVF & 2 FETs
    08/14: Our little miracle has FINALLY arrived - 3 years after we started trying!
    Baby Birthday Ticker Ticker
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    Welcome to the board! I am also unexplained. I've had multiple failed IUI's, a failed IVF and failed FET. Next FET is this Thursday! We are all here to support eachother!
    Me:35,  DH: 39   
    TTC since March 2011. All bloodword, SA & HSG are normal.  
    8/12: Clomid & TI - BFN 
    10/12: Colmid & TI - BFN 
    3/13:  Clomid, Trigger & IUI - BFN 
    4/13: Gonal F, Trigger & IUI: BFN  
    6/13: IVF #1 (1AA blast & 1BB blast) = BFN 
    8/13: FET #1= BFN
    10/13: FET #2= BFP!!!

    BabyFruit Ticker  image
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    My history is in my signature....but we are unexplained too.  The boards are great for support. 

    ************** Siggy Warning************


    Married August 2012 -- Me (40 yrs old) My husband (45 yrs. old) 

    RE referral from ObGYN in late Jan. 2013 -- Testing Confirms Unexplained IF 

    IUI #"s1 - 3 (Femara + IUI) April - June 2013 - all BFN

      Decided to do IVF... Began stimming on September 10th!  Egg Retrieval 9/20/13.  19 eggs: 6 to mature to freeze after 6 fertilized with ICSI

     3 morula stage embryos transferred on 9/25/13.....Beta #1 on 10/4/13/ = 7.5  Beta #2 on 10/6/13 =  negative

      IVF#2 - Lupron plan  (set to begin on 10/28/13)  (Planning on thawing and fertilizing our 6 eggs with ICSI as well as all of the mature eggs they retrieve with this fresh cycle.)

     Late October 2013 - ectopic pregnancy - methotrexate injection....benched 3 months

    CD1 - 12/5/13...Lupron set to start on 12/26/13; CD1 - 1/2/14....Baseline 1/3/14....begin follistim tonight and continue with lupron.  (Got my calendar today!  IVF#2 is a go!)

    ER = 1/14/14  (11 eggs....9 were mature. 9 fertilized.  Of the 6 mature eggs we thawed, only 4 fertilized.  At this time, we have 13 eggs fertilized and growing.  Waiting for news about a 3-day or 5-day transfer.)

    ET = 1/19/14  (5dt).....3 blastocysts transferred!   (All nine embryos didn't make it to freeze.  =(  )

    Beta #1 = 1/28/14   (2 weeks after ER)  BFP! 209 (9dp5dt)   EDD 10/7/14

    Beta #2 - 1/30/14  (11 dp5dt) 302

    Beta #3 - 2/3/14  (15 dp5dt)  1222 

    Ultrasound set for 2/17/14......TWINS!        Twin A - HR 124 bpm; Twin B - HR 126 bpm

    Final Ultrasound with RE 3/10/14 - Twin A - HR 176 bpm; Twin B - HR 177 bpm.

     PAIF/SAIF Welcome! 

     

     

    imageimage 

    imageimageimage

     

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    Welcome!! I am unexplained also and have very low progesterone after ovulation getting ready for ivf..glad you made it through the clomid..it brought out a side I never knew existed lol
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    @cachoque
    No I was not put under they didn't give me that option. They gave me a local anesthetic and my hubby was in there with me so that helped. It was very uncomfortable the saline solution felt like a horrible gas pain and there was a lot of blood (sry for the TMI) it was really cool to see my tube openings and my uterus though. Also I bled for a full week some women dont bleed at all! Good luck tomorrow let me know how it goes!

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    @Ajc&amp;Maggie
    Thanks for the post good luck on Thursday fingers crossed for you!!!

    @prayingforblessing good luck with the IVF! Oh I know clomid made me a blubbering fool along with evil mood swings thank goodness it's over lol

    So great to get all these responses thanks for the support ladies much luck for us all!!!

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    We are unexplained- no issues at all have been found.  While I am glad we have nothing major wrong with us I am frustrated bc we have been TTC for 2 years and have been doing medical treatments since February (see siggy).  Its frustrating but theres nothing you can do but keep on trying and work with a RE.  In my mind I keep on telling myself somethings gotta work eventually.  Good luck!
    ***SIGGY WARNING***

    DX: Unexplained
    6 Failed IUIs (Clomid and Gonal F).  
    IVF #1 began August 2013- BC, 4 days of Estrace, stimmed with Gonal F and Menopur, Ganirelix, 9R 5M 5F, Medrol and Doxycycline, 5 day transfer of 2 early blastocysts- good quality, Progesterone, Estrace, and baby aspirin, BETA on 9/20 BFN,   IVF #2 began September 2013, stimming with Gonal F (higher dose) and Menopur, Ganirelix, 18R 14M 9F with ICSI, 5 day transfer of 2 BBs one was starting to hatch, 2 frosties: 1  BB and 1 AC, BETA on 10/21, BFN BETA was a 5- chemical 
    Getting some more testing and trying to figure out what the issue is before FET in December, started acupuncture on 11/10, RLP and some other BW nothing major to report except slightly high Prolactin. Prolactin was slightly high when I started with my RE and I already had an MRI which was Neg.  Endo biopsy=negative.  WTF is wrong with us???
    12/18/13 FET of 1 BB and 1 AC.  Hoping for a miracle.  Beta 12/26 Low BETA-8 2nd BETA 5- chemical
    After 3 failed transfers IDK where to go from here.  Still no real answers as to why this isn't working.  Getting a second opinion in February and looking into immune testing.  
    2/14- NEW RE- Immune testing showed a partial dq alpha match with DH- On prednisone and did intralipids prior to transfer.  3/14 Lupron, gonal f, menopur, HGH.  ER 15 mature all 15 fertilized!  5dt of an early blast grade 1 and an expanded blast grade 2.  BETA on 4/21.  1 grade 2 embryo frozen
    BETA #1 59 BETA #2 148 BETA #3 283 BETA #4 2,783! US at 6w2d shows 1 bean measuring right on track! HR 121.  US at 8w3d measuring on track HR 177. Released form my RE.  EDD 12/28


    All Welcome
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    We are unexplained as well.  I am taking Synthroid for slight hypothyroidism and the progesterone takes care of a possible LPD.  Other than that we don't have any known problems.  My RE suspects it may be a tubal issue.  It is so frustrating to not be able to "fix" something.  I hope you have great news from your IUI!

    TTC #1 since Feb. 2011/Me 30, DH 37

    Unexplained

    Nov. 2012-IUI #1-Femara 2.5 mg, Ovidrel=BFN

    Jan. 2013-IUI #2-Femara 2.5 mg, Ovidrel, 1 follie=BFN

    Feb. 2013-IUI #3-Clomid 50 mg on CD5 only, 2 follies=BFN

    IVF#1 (4/13)-19 retrieved, 18 mature, 16 fertilized w/ ICSI=lucky #7 frosties

    ET cancelled due to OHSS

    FET #1 June 2013/transferred 2=Chemical

    FET #2 August 2013/transferred 2=Chemical

    FET #3 October 2013=BFN

    IVF#2 (2/14)-17 retrieved, 14 mature, 11 fertilized w/ ICSI, 3 blasts, PGS= all 3 abnormal

    IVF#3 (5/14)-13 retrieved, 11 mature, 9 fertilized w/ ICSI, 2 blasts, PGS=both abnormal

    IVF#4 (8/14)-5-day transfer of 2 embies=BFP! (8/28/14) beta 99

    U/S #1 (6 wks, 2 days)=1 bean, U/S#2 (8 weeks, 2 days)=180 HB, U/S #3 (10 weeks)=measuring 10 wks, 2 days

     


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    Hi Rixx0207,
    I'm on synthroid as well and just stared progesteron suppositories for added support during the 2WW.

    Have you had your tubes checked yet? That was the first thing my RE did plus I insisted because that was my moms issue getting pregnant with me. The procedure is not painful at all and pretty quick.

    I am such a problem solver so it's so hard for me to understand that there really isn't a problem to fix, doesn't make sense!

    Thank you and good luck to you!

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    tptbabe said:
    Shcr said:
    Hi whoberry, Thank you for sharing your story, beat of luck with your IVF/FET my thoughts are with you. I will definitely check out those other boards still learning where things are around here! I have been warned by other users that some people get territorial about who's posting in what and making people move off certain boards...is that true?
    It's tough to gauge a persons tone from responses, so sometimes a poster will feel like they're not welcome, but really it's just about finding where YOU fit in. As long as you're respectful of the board and other posters, you're welcome pretty much anywhere! By saying that there are more people going through the same situation as you on another board, that just means that you might get more answers and more support there, since they're going through the same thing as you =)
    Yes that's exactly what I meant!  Sorry if it didn't come across that way!

     

    IF, 5 losses, 1 son, 1 on the way.
    fall in love with someone Pictures Images and Photos  photo turtlejpg
       

    Lilypie Pregnancy tickers
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    Oh no I understood what you were saying I just wanted to see if that was true or not :)

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