Infertility

pio allergy or bad batch?

I am taking progesterone in ethyl oleate. Since sunday (when I opened up a new vial) I have had huge red splotches around my injection sites that develop hours later and have not gone away. One is as big as my palm. The edges are turning black and blue now. Its been way more painful than when I have done it in the past. I could barely walk on Sunday but I figured I just hit a sensitive spot and injected it a little too low. But it keeps happening. Last night I was really hot and sweaty. I have been really tired the last few days and have had a runny nose and sinus pain off and on. Today I have been feeling very warm but my temp was normal. I am also incredibly moody.
Googling revealed that some people experience flu like symptoms with ethyl oleate. But that info was all on forums. I couldn't find any reliable websites. I have a call in to my doc. Maybe I am just getting the flu? I thought my seasonal allergies were to blame.
The prior week of PIO and last cycle caused me some soreness and deep bruising but nothing like this. No bruises I could see, no redness.
Any ideas? Thanks.!

 

IF, 5 losses, 1 son, 1 on the way.
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Lilypie Pregnancy tickers

Re: pio allergy or bad batch?

  • *****siggy*****









    I started having a red, spotchy, itchy, raised rash about 3 weeks into taking the PIO.  My RE said it was a delayed reaction to the sesame oil that it is mixed it.  It was miserable for a couple weeks.  I tried to find a pharmacy that would provide me the kind mixed with ethyl oleate, but I was told it was on a national backorder.  I would contact your RE and see if maybe they think its the same reaction situtation and try the kind mixed with sesame oil instead.  I had to power through and take benadryl.  I'm several weeks in and still have horrible black and blue spots and pain still.  I hope it gets better for you soon (((hugs)))
    CafeMom Tickers
     Anniversary
    TTC since July 2011
    BFP #1: 2/15/12-Ectopic/Mtx at 6 wks

    BFP #2: 10/12/12-m/c at 5 wks. 
    BFP #3: 8/27/13
    Me: MTHFR, Low AMH (1.1), High NK cells and Antiphospholipid Antibodies.
    DH:MFI-Low morph (1%), DNA fragmentation: Excellent!
    5 rounds of clomid, 3 IUIs, and multiple non-medicated cycles- BFFN                                                      
    IVF with ICSI in August 2013 brought us our babies.  ER-9R, 7M, 4F w/ICSI  ET of 2-Grade 2 blasts. 
    + HPT at 6dp5dt. #1 (8dp5dt)- 105    #2 (13dp5dt)- 510  #3 (15dp5dt)- 960  #4 (17dp5dt)- 1889
    Dx shortened cervix, PTL, and preeclampsia during pregnancy.  Lots of medications and 13 weeks of bedrest, babies were born healthy at 34w4d!


    imagehttp://oi44.tinypic.com/10dwifm.jpg
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  • Thanks ladies!  Doctor thinks it's a reaction to the oil.  Seems odd since I've done these shots before with no problem.  I will switch to crinone tomorrow since I have some at home and then he'll order me progesterone in a different type of oil. I also reported it to the pharmacy and they said they had no complaints about it being a bad batch.
    I have been having major hot flashes all day too.  Hope I am not also getting the flu!

     

    IF, 5 losses, 1 son, 1 on the way.
    fall in love with someone Pictures Images and Photos  photo turtlejpg
       

    Lilypie Pregnancy tickers
  • monimu13 said:
    *****siggy*****









    I started having a red, spotchy, itchy, raised rash about 3 weeks into taking the PIO.  My RE said it was a delayed reaction to the sesame oil that it is mixed it.  It was miserable for a couple weeks.  I tried to find a pharmacy that would provide me the kind mixed with ethyl oleate, but I was told it was on a national backorder.  I would contact your RE and see if maybe they think its the same reaction situtation and try the kind mixed with sesame oil instead.  I had to power through and take benadryl.  I'm several weeks in and still have horrible black and blue spots and pain still.  I hope it gets better for you soon (((hugs)))

    Huh, I'm 99% sure my PIO is ethyl oleate.

    imageimageimageimageimage

     

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    TTC #1 since August 2011

    My Blog

    September 2012: Start IF testing

    DH (32): SA is ok, slightly low morph, normal SCSA  Me (32): Slightly low progesterone, hostile CM, carrier for CF, Moderately high NKC, High TNFa, heterozyogous mutated Factor XIII, and +APA

    October 2012-May 2014: 4 failed IUIs, 3 failed IVFs, and 1 failed FETw/donor embryos

    November 2014: IVF w/ICSI #4 Agonist/Antagonist with EPP and Prednisone, Baby Aspirin, Lovenox, and IVIG for immune issues.  Converted to freeze all due to lining issues.  2 blasts frozen on day 6!

    January 2015: FET #2 Cancelled due to lining issues

    April 2015: FET #2.1


    PAIF/SAIF Welcome!

  • monimu13 said:
    *****siggy*****









    I started having a red, spotchy, itchy, raised rash about 3 weeks into taking the PIO.  My RE said it was a delayed reaction to the sesame oil that it is mixed it.  It was miserable for a couple weeks.  I tried to find a pharmacy that would provide me the kind mixed with ethyl oleate, but I was told it was on a national backorder.  I would contact your RE and see if maybe they think its the same reaction situtation and try the kind mixed with sesame oil instead.  I had to power through and take benadryl.  I'm several weeks in and still have horrible black and blue spots and pain still.  I hope it gets better for you soon (((hugs)))

    Huh, I'm 99% sure my PIO is ethyl oleate.
    What?!? Didn't you use Avella?  I called them a couple weeks ago and they told me they were out!
    CafeMom Tickers
     Anniversary
    TTC since July 2011
    BFP #1: 2/15/12-Ectopic/Mtx at 6 wks

    BFP #2: 10/12/12-m/c at 5 wks. 
    BFP #3: 8/27/13
    Me: MTHFR, Low AMH (1.1), High NK cells and Antiphospholipid Antibodies.
    DH:MFI-Low morph (1%), DNA fragmentation: Excellent!
    5 rounds of clomid, 3 IUIs, and multiple non-medicated cycles- BFFN                                                      
    IVF with ICSI in August 2013 brought us our babies.  ER-9R, 7M, 4F w/ICSI  ET of 2-Grade 2 blasts. 
    + HPT at 6dp5dt. #1 (8dp5dt)- 105    #2 (13dp5dt)- 510  #3 (15dp5dt)- 960  #4 (17dp5dt)- 1889
    Dx shortened cervix, PTL, and preeclampsia during pregnancy.  Lots of medications and 13 weeks of bedrest, babies were born healthy at 34w4d!


    imagehttp://oi44.tinypic.com/10dwifm.jpg
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