High-Risk Pregnancy
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New here - MTHFR and IUGR

Hi all, my name is Elizabeth.  I am due November 29th.  I'm currently 26w3d with a little girl.  I had two miscarriages within a year, so she is my miracle baby.  After the second miscarriage, my doctor started the Recurrent Pregnancy Loss testing.  It came back (right before my BFP) that I have the homozygous C677T MTHFR gene mutation.  My baby girl was diagnosed with IUGR.  I'm wondering if there's any other moms out there with the same two issues.  I've read that the two could quite possibly be related.  I have an appointment with an MFM tomorrow, and I'm just wondering what sorts of questions I should be asking, or if you have any advice that could help me out.  I know that MTHFR is still a relatively new and controversial diagnosis.  I'm wondering if you've found some good, unbiased information.  Everything I find is one extreme or another.

Thanks ladies!
~Elizabeth ~

Angel Baby # 1 : EDD 9/11/12,  Missed m/c at just over 13 weeks

Angel Baby # 2 : EDD 9/9/13, m/c at 6 weeks

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Re: New here - MTHFR and IUGR

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    What is the cause of the iugr?
    What goal week should we shoot for?
    Is there anything eating wise I need to do to help things?
    6 m/c
    Anovulatory cycles, increased Synthroid Diagnosed Sep 2010
    Natural cycle Dec 2010 BFP M/C 6 1/2 Weeks, D&E Jan 2011
    1 Clomid/Ovidrel BFN May 2011
    Natural cycle Aug 2011 BFP M/C 4 Weeks
    1 IUI Sept 2011 BFP M/c 7 weeks
    Provera Dec 2011 BFP M/C 3 Weeks
    DQ ALPHA HLA MATCH, High NK Cells Diagnosed Dec 2011
    IVF March 2012 BFP m/c 4weeks 5 days (IL, Prednisone)
    IVF#2w/DS July 2012 MEGA FAILURE BFN (IL, Dexamethasone)
    Diagnosed No real HLA Match, DQ Beta Triad, High TNF, Low NK Cells
    Oct 2012 Natural Cycle m/c 4wks (Lovenox, Prednisone) 
    Went to Beer Center- high tnf, low lad, implantation failure
    Nov/Dec 2012 LIT Treatment
    Dec 12 Humira
    Jan 2013 BFP
    Humira,LIT,Prednisone, Lovenox, IVIG, Baby Aspirin
    Miracle Born August 2013 Premature

    Yours doesn't have to be a sad story



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    Lilypie - (ugiy)


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    Are you being treated for MTHFR?  L-methylfolate? Aspirin? Possibly Lovenox?

    I believe that MTHFR could potentially contribute to placental insufficiency, which could in turn cause IUGR (probably only if you are prone to clotting).  I also think abnormal folate metabolism could possibly affect development, but usually would be worried about major issues w/ spine or heart anatomy, not IUGR.   
    TTC #1 12/2009
    BFP #1 1/2010, M/C 6 weeks
    BFP #2 6/2010, DD lost to
    congenital heart diseasewe are heartbroken.

    TTC #2 4/2011, diagnosed MTHFR, FVL
    Four natural cycles BFN; Clomid IUI BFN; Follistim IUI BFN;
    1/2012 IVF #1 BFN
    4/2012 FET BFP #3
    5/2012 7w1d u/s: anembryonic demise; M/C @ 8w.
    6/2012 found Stage II/III endo on laparoscopy, removed w/ laser.
    8/2012 IVF #2 epic fail: no viable embryos.

    Vacation, break, second opinions, on to new RE.
    1/2013 Surprise chemical pregnancy BFP #4 (break cycle), IVF #3 postponed.
    2/2013 TI w/ hormonal support, prednisone, aspirin, Lovenox, acupuncture gave us a miracle BFP #5!
    Heartbeat on U/S at 6w1d!
    Baby,please stay!!
    Our miracle baby boy arrived 10/2013!  We are so in love!!

    10/2014 Surprise BFP #6
    Our second daughter arrived in May 2015!  We are so grateful!  

    Lilypie Angel and Memorial tickers


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    I don't know anything about the gene mutation, but my DD was diagnosed with IUGR and delivered by c-section at 37 weeks. She weighed 5 lb 8 oz but was perfectly healthy. Now she is 20 months and beginning to catch up a little on the growth charts, but has always met or exceeded every developmental milestone. I'm 29 weeks now and my dr just put me on a folate supplement to try to prevent a recurrence of IUGR this time.
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