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genetic testing+++Update :(

PPoppy2010PPoppy2010 member
edited August 2013 in TTC after 35
I have been through every test these last few weeks... just had my blood drawn for Genetic testing.... and it is the first time I am really worried about the results... If I am a mutant... and my hubby is a mutant... then there is no going forward... it hit me on the way home .. that this one test may decide everything.... 
anyone else get freaked out about knowing everything you probably didnt ever want to know about your DNA make-up?

Me:38 DH:40 TTC for over 3 yrs~
Every test known to man- comes out that we are both perfectly capable of conceiving- 

Officially diagnosed with "unexplained infertility"

7/17/13-1st try with 100mg Clomid+Novarel+Prog.
7/25/13 Mid-cycle U/S- 4 Follicles! 17, 16,L 16,15 R
7/25/13 Trigger shot
8/6/13 Beta Blood Drawn... Big fat Neg. 
New RE:- 101 tests done during break cycle.. All look great! green light to hit the deck running!
9/18/13- Cd 1- FINALLY! 100 mg clomid CD3-7- 75iu Bravelle 7-10   
9/30/13 Follie count.. 3 on right. 2 on left-- trigger today
10/2/13- IUI #1
10/15/13 Beta #1- BFN.. :(


 


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Re: genetic testing+++Update :(

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    ksgsmuksgsmu member
    just breathe :)  I know it is hard and the waiting is horrible. 
    ***siggy/ticker warning***

    Me:36 DH:38 TTC#1 since 4/2012
    Me DX: Hashimotos,Hypothyroid, DOR, MTHFR,  DH: normal

     IUI #1-#4 BFNs and a few cancelled cycles in the mix.
    - poor responder
    ***Suprise BFP on 6/13/13. Natural MC @6wks 3days
    IVF#1 and 2- Cancelled due to no response on max stimms
    FET 5/20- BFP
    1st Beta- 641
    2nd beta- 2166
    Sono- TWINS!!!!
    Two Boys! Born January 2015 @36 weeks.  Healthy and no NICU!  So blessed!



    image 

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    BeckyP005BeckyP005 member
    Fx that that the results are ok.

    ME:46 MH:44 DE IVF 2014
    Met with RE 4/11. 2 IUI's BFN. DE best option. Switched clinics to do "shared" program. Had to retake all tests and a mamm that put me behind and then on a DE waiting list for 12 months. Picked a donor!! (10/13/13) Got matched. Estimated transfer in December. After 2.5 years of patiently waiting I will finally cycle....can hardly believe it. DE cycle got cancelled. One of her tests came back positive.  Waiting for another donor. Donor picked!! (1/18/14)

    DE IVF #1 (4/26) BFN  DE FET #1 (6/4) BFP! Beta 1=339 Beta 2=852 Beta 3=9957 EDD 2/22/15!!


     

     

         imageimage 
         image   imageimage



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    PPoppy2010PPoppy2010 member
    thanks ladies.... I guess its just that if there is a hormone imbalance... or a blocked this.. or a low count here... 
    all of that is workable and still has hope.... if our DNA isnt good for one another... then that is the end of the game... just seems scary to me... :} 
    How many of you have done genetic testing... 



    Me:38 DH:40 TTC for over 3 yrs~
    Every test known to man- comes out that we are both perfectly capable of conceiving- 

    Officially diagnosed with "unexplained infertility"

    7/17/13-1st try with 100mg Clomid+Novarel+Prog.
    7/25/13 Mid-cycle U/S- 4 Follicles! 17, 16,L 16,15 R
    7/25/13 Trigger shot
    8/6/13 Beta Blood Drawn... Big fat Neg. 
    New RE:- 101 tests done during break cycle.. All look great! green light to hit the deck running!
    9/18/13- Cd 1- FINALLY! 100 mg clomid CD3-7- 75iu Bravelle 7-10   
    9/30/13 Follie count.. 3 on right. 2 on left-- trigger today
    10/2/13- IUI #1
    10/15/13 Beta #1- BFN.. :(


     


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    MarylandWedMarylandWed member
    Sorry you have that worry :-( we elected not to do it. Sometimes I wondered if we should have but I assumed it was cost prohibitive.
    Me:39 Dx LPD, Fibroid, AMA and all that goes with that. H:37 Dx low motility and low morphology. TTC since 3/12. Clomid 8/12 and 9/12: BFN. 11/12 on a break for Myomectomy sched. 11/26. Resume TTC early 2013.
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    hydrangeagirlhydrangeagirl member
    PPoppy2010 said:
    thanks ladies.... I guess its just that if there is a hormone imbalance... or a blocked this.. or a low count here... 
    all of that is workable and still has hope.... if our DNA isnt good for one another... then that is the end of the game... just seems scary to me... :} 
    How many of you have done genetic testing... 

    Hi PPoppy2010,

    We've had two miscarriages so RE did the genetic karotyping on both of us, and ran every other test under the sun to see what might be the cause.  I was horrified by the 16 vials of blood taken from me for my testing- thank goodness the results were negative all the way around, but I agree that the waiting can be very stressful and scary.  Thankfully, we had all of our test results within one week- we were initially told to expect a 2-3 week wait.   FX for you and your DH that your results will be negative too.  


    Me, 41; DH 38; TTC since July 2012, 1st round of Clomid, BFP on 10/19, what an incredible blessing!  M/c on 7w3d; D&C on 11/30; 4th round of Clomid 100mg = BFP on 04/19!!! M/c #2 at 7w; D&C on 5/30, then repeat D&C on 7/1.  Saline u/s on 8/2, uterus looks great!  Will start TTC in 09/13 w/ Clomid 100mg. Surprise natural BFP on 8/25!!! Beta #1=95, #2=182, #3=404!  EDD 5/4/13...Grow baby grow!


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    PPoppy2010PPoppy2010 member
    hydrangeagirl said:


    PPoppy2010 said:

    thanks ladies.... I guess its just that if there is a hormone imbalance... or a blocked this.. or a low count here... 
    all of that is workable and still has hope.... if our DNA isnt good for one another... then that is the end of the game... just seems scary to me... :} 
    How many of you have done genetic testing... 

    Hi PPoppy2010,

    We've had two miscarriages so RE did the genetic karotyping on both of us, and ran every other test under the sun to see what might be the cause.  I was horrified by the 16 vials of blood taken from me for my testing- thank goodness the results were negative all the way around, but I agree that the waiting can be very stressful and scary.  Thankfully, we had all of our test results within one week- we were initially told to expect a 2-3 week wait.   FX for you and your DH that your results will be negative too.  





    That's awesome that it all came back neg!... I can't wait to get the same news.. :)

    Me:38 DH:40 TTC for over 3 yrs~
    Every test known to man- comes out that we are both perfectly capable of conceiving- 

    Officially diagnosed with "unexplained infertility"

    7/17/13-1st try with 100mg Clomid+Novarel+Prog.
    7/25/13 Mid-cycle U/S- 4 Follicles! 17, 16,L 16,15 R
    7/25/13 Trigger shot
    8/6/13 Beta Blood Drawn... Big fat Neg. 
    New RE:- 101 tests done during break cycle.. All look great! green light to hit the deck running!
    9/18/13- Cd 1- FINALLY! 100 mg clomid CD3-7- 75iu Bravelle 7-10   
    9/30/13 Follie count.. 3 on right. 2 on left-- trigger today
    10/2/13- IUI #1
    10/15/13 Beta #1- BFN.. :(


     


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    QOTRQOTR member
    Similar to hydrangeagirl, I had it done after recurrent losses to see if a genetic issue might be a factor.   They did identify some issues with me (which is a weird discovery this late in life), but after meeting with a genetic specialist, they explained that they didn't think it played a role in my miscarriages.  I agree that it is stressful, but hopefully it will give you some peace of mind that offsets this current worry.
    Me-41, Hubby-40.
    1st BFP-8/17/12!  Missed Miscarriage discovered @ 8 week US.  D&C.
    2nd BFP-2/13/13!  Blighted Ovum discovered @ 8 week US. Natural miscarriage.
    3rd BFP-5/22/13!  By early June, progesterone plummeting.  Another loss.
    August 2013 - started Donor Egg process, but surprise BFP with my own eggs.
    Dear Son born 5/28/14
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    amyelise25amyelise25 member

    For whatever reason, this was the one test that didn't get me worried.  I was told that there would only be concern if both parents showed the same abnormality.  We didn't even have my husband tested, and he's adopted and not sure of his background.  It helped that I didn't have anyone in my family that had been diagnosed with any of the conditions listed.  The results came back fine and the doctors didn't say anything about getting DH tested. 

    The cost was also pretty inexpensive.  It would have been about $100 (per person) if insurance didn't cover it.  Our insurance did cover it. 

    Good luck

    ***BFP and Loss Mentioned in Siggy***

    Me: 39 (PCOS)
    DH: 47 (slightly low volume...considered MFI)
    TTC since 11/2012
    10/2013:  IUI#1 BFN - 50mg clomid, two .75mg shots of Bravelle, ovidril trigger...1 follicle
    11/14/13: IUI#2 BFN - 50mg clomid, two .75 mg shots of Bravelle, ovidrill trigger..2 follicles

    IVF #1 w/ICSI:  ER 3/12/14; ET 3/17/14:  BFP!!!  Beta #1 3/31/14=1540;  Beta #2 4/2/14 =2551

    Twin A became an angel on 4/30/14 (8w6d)

    Twin B became an angel on 5/21/14 (11w6d)

    D&C 5/23/14

    FET#1 - 9/2/14 - BFP!!! Beta #1 (9/15): 926.  Beta #2 (9/17): 1946.

    MC -9/20/14
    FET#2 - 4/20/15 - BFP!!! Beta #1 (5/4): 1277.  Beta #2 (5/6): 2817.  US#5 -153 heartbeat.
    Due Date: January 6, 2016
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    hydrangeagirlhydrangeagirl member
    amyelise25 said:

    For whatever reason, this was the one test that didn't get me worried.  I was told that there would only be concern if both parents showed the same abnormality.  We didn't even have my husband tested, and he's adopted and not sure of his background.  It helped that I didn't have anyone in my family that had been diagnosed with any of the conditions listed.  The results came back fine and the doctors didn't say anything about getting DH tested. 

    The cost was also pretty inexpensive.  It would have been about $100 (per person) if insurance didn't cover it.  Our insurance did cover it. 

    Good luck

    For other ladies who might be looking to explore genetic testing, especially if OOP, our karotyping and other panels (I can't remember everything RE tested, but there were quite a few panels) ran about $4,000.  Thankfully our insurance paid all but $190.  
    Me, 41; DH 38; TTC since July 2012, 1st round of Clomid, BFP on 10/19, what an incredible blessing!  M/c on 7w3d; D&C on 11/30; 4th round of Clomid 100mg = BFP on 04/19!!! M/c #2 at 7w; D&C on 5/30, then repeat D&C on 7/1.  Saline u/s on 8/2, uterus looks great!  Will start TTC in 09/13 w/ Clomid 100mg. Surprise natural BFP on 8/25!!! Beta #1=95, #2=182, #3=404!  EDD 5/4/13...Grow baby grow!


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    HeathernStevenHeathernSteven member
    I wasn't worried, As far as we could tell no one in our families had any issues, mental health or physical - other then cancer seems to run in his family heart issues in mine, so I totally wasn't worried about the tests.

    image
    My Ovulation Chart


    Me: 41 DH: 46. We are TTC our 1st, started July '11,
    3 cycles clomid with Ob,
    1 cycle Tamoxifen with Ob,
    Diagnosed PCOS 11/5/12
    clomid, trigger & timed bd 12/12 BFN
    1st clomid IUI 1/4/13 BFN.
    2nd clomid IUI 2/13 cancelled didn't respond to clomid.
    3/15/13 scheduled laparoscopy & on bcp.

    May 10 IUI from injectibles - BFN 

    May 22 done with interventions it will either happen or it won't. 

    February 2014 No longer actively trying, but not preventing. 

    SURPISE BFP 4/2/2015!!!!!!!!!!

    Miscarriage 4/23/15

     

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    PPoppy2010PPoppy2010 member
    WELL.... I got the results back from my genetic testing.. everything was fine and perfect with mine.. except I have one mutant gene.. I have 

    V Leiden thrombophilia

    which is basically a blood clotting issue... BUT after reading more... it may explain a lot more of my history of 3 m/c... 9wks...10wks.. and 19wks...
    The factor V Leiden mutation is associated with a slightly increased risk of pregnancy loss (miscarriage). Women with this mutation are two to three times more likely to have multiple (recurrent) miscarriages or a pregnancy loss during the second or third trimester. Some research suggests that the factor V Leiden mutation may also increase the risk of other complications during pregnancy, including pregnancy-induced high blood pressure (preeclampsia), slow fetal growth, and early separation of the placenta from the uterine wall (placental abruption). 


    ugh...
     

    Me:38 DH:40 TTC for over 3 yrs~
    Every test known to man- comes out that we are both perfectly capable of conceiving- 

    Officially diagnosed with "unexplained infertility"

    7/17/13-1st try with 100mg Clomid+Novarel+Prog.
    7/25/13 Mid-cycle U/S- 4 Follicles! 17, 16,L 16,15 R
    7/25/13 Trigger shot
    8/6/13 Beta Blood Drawn... Big fat Neg. 
    New RE:- 101 tests done during break cycle.. All look great! green light to hit the deck running!
    9/18/13- Cd 1- FINALLY! 100 mg clomid CD3-7- 75iu Bravelle 7-10   
    9/30/13 Follie count.. 3 on right. 2 on left-- trigger today
    10/2/13- IUI #1
    10/15/13 Beta #1- BFN.. :(


     


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    HeathernStevenHeathernSteven member

    So is there anything they can do to counter act that?? I hope so! Now you have some answers lets hope your next one sticks :)

     

    image
    My Ovulation Chart


    Me: 41 DH: 46. We are TTC our 1st, started July '11,
    3 cycles clomid with Ob,
    1 cycle Tamoxifen with Ob,
    Diagnosed PCOS 11/5/12
    clomid, trigger & timed bd 12/12 BFN
    1st clomid IUI 1/4/13 BFN.
    2nd clomid IUI 2/13 cancelled didn't respond to clomid.
    3/15/13 scheduled laparoscopy & on bcp.

    May 10 IUI from injectibles - BFN 

    May 22 done with interventions it will either happen or it won't. 

    February 2014 No longer actively trying, but not preventing. 

    SURPISE BFP 4/2/2015!!!!!!!!!!

    Miscarriage 4/23/15

     

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    PPoppy2010PPoppy2010 member
    Hi H... there is no treatment for this.... other than dealing with it during a blood issue... surgery... injury... etc... it is just what it is... 
    I have my WTF appt on Wed... well see what the RE says.. 

    Me:38 DH:40 TTC for over 3 yrs~
    Every test known to man- comes out that we are both perfectly capable of conceiving- 

    Officially diagnosed with "unexplained infertility"

    7/17/13-1st try with 100mg Clomid+Novarel+Prog.
    7/25/13 Mid-cycle U/S- 4 Follicles! 17, 16,L 16,15 R
    7/25/13 Trigger shot
    8/6/13 Beta Blood Drawn... Big fat Neg. 
    New RE:- 101 tests done during break cycle.. All look great! green light to hit the deck running!
    9/18/13- Cd 1- FINALLY! 100 mg clomid CD3-7- 75iu Bravelle 7-10   
    9/30/13 Follie count.. 3 on right. 2 on left-- trigger today
    10/2/13- IUI #1
    10/15/13 Beta #1- BFN.. :(


     


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    SophistikittySophistikitty member

    I am so sorry you are dealing with this.  You will likely be put on lovenox or heparin during IVF and pregnancy.  It sounds like have a very thorough RE though which is a big plus.  I am so glad that at least you finally have some answers.  Good luck on Wednesday!


    ***SIGNATURE WARNING***


    TTC #1

    Me 42, DH 47

    Dx = AMA/DOR, MFI

    IVF/ICSI #1 = BFN

    IVF/ICSI #2 = BFP; early loss

    IVF/ICSI #3 (DE) = BFP; early loss

    FET = BFN

    IVF/ICSI #4 (DE w/ CCS) = BFP

    Beta #1 @ 10dp6dt = 265; Beta #2 @ 14dp6dt = 1251. 

    1st U/S @ 6w2d showed one perfect little heartbeat! 

    2nd U/S @ 7w2d. HB 132 & everything measuring on track.

    Our beautiful little girl arrived January 2015!


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    MAtoNCMAtoNC member
    PPoppy2010 said:
    Hi H... there is no treatment for this.... other than dealing with it during a blood issue... surgery... injury... etc... it is just what it is... 
    I have my WTF appt on Wed... well see what the RE says.. 

    I am so sorry for your losses. I think there are ways that a person can be prophylactically treated during pregnancy. I have a blood-clotting issue that only affects me during pregnancy, as well. I was placed on lovenox for the duration of my pregnancy. I went to a perinatologist whose specialty is thrombophilia. 
    Married 4/12/08 DS born 11/17/2009 via c-section at 39 weeks. 11/12/2011 BFP #2!! m/c 7w5d. 2/28/2012 BFP #3 Beta #1-12dpo = 18; Beta #2-16dpo = 185; Beta #3-18dpo = 505. EDD 11/10/2012. Ectopic discovered at 5w4d. D&C followed by methotrexate.
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