E-tegrity results and a question
Sophistikitty
member
So my biopsy came back negative for Beta-3 Integrin and out of phase (histologically delayed). The biopsy was timed correctly so therefore the results point to a luteal phase defect. My question is, I know if you test negative and the endometrium is “in phase” treatment is two months of Depot Lupron. My RE says he does not treat with Lupron though when the results are “out of phase”. He says that what it is critical is that I have adequate progesterone (my numbers have always been good post transfer though). The physician info section on the E-tegrity website doesn’t really say too much about the recommended course of treatment for my particular situation. Does anyone have any first hand experience with this?
***SIGNATURE WARNING***
TTC #1
Me 42, DH 47
Dx = AMA/DOR, MFI
IVF/ICSI #1 = BFN
IVF/ICSI #2 = BFP; early loss
IVF/ICSI #3 (DE) = BFP; early loss
FET = BFN
IVF/ICSI #4 (DE w/ CCS) = BFP
Beta #1 @ 10dp6dt = 265; Beta #2 @ 14dp6dt = 1251.
1st U/S @ 6w2d showed one perfect little heartbeat!
2nd U/S @ 7w2d. HB 132 & everything measuring on track.
Our beautiful little girl arrived January 2015!
Re: E-tegrity results and a question
10/11: after 2 years, saw a RE, FSH 5.4
11/11: BFP! (surprise after thyroid & normal hsg),
12/11: missed m/c after 7 week u/s, 1/12: D&C
6/12 IUI#1-IUI #3: clomid = BFP!, C/P
IVF #1(10/12) FSH 5.4, AFC: 16 long Lupron, 5R/5M/4F, all 4 made it to 5dt, 1 blast/1-8 cell transferred=BFN
IVF #2(12/12)AFC 21, MD lupron, 4R/4M/3F, 5dt of 1 blast and 2-8cell. BFN.
IVF#3(4/13) Natural start antagon protocol, 12R,11F. one PGS normal at day 6 transfer. BFN.
IVF#4 (11/13) C.CRM (ODW.U normal 8/13 Still no Diagnosis) EPP/antagonist. ER 13R/7M/6F. Only 1 made it to freeze. Abnormal. Looking into options of DE, Fresh vs frozen.
10/14 new local RE to look into what's next. CD3 FSH 4.7, AMH 0.9. Met with DE agencies and exploring options for feb/march 2015.
Surprise natural bfp (4 days before donor is signed). Beta #1 at 9dpo: 51.8, 2nd beta: 195 (25 hours doubling) @11dpo. 3rd beta (12/15): 516 (35 hrs doubling) 4th beta(12/17): 895 (58 hours doubling) 5th beta(12/19): 2120. U/S at 5w0d(12/22): one gestational sac with yolk sac. U/S #2 (6w0d)12/29. One little bean measuring 6w0d with HR 124. 3rd u/s(1/4)7w0d: baby measuring 7w2d. HR 134. 3/30: A/S at MFM went great except for low lying placenta. Verifi results are normal! Team Blue! Please send any positive thoughts our way! EDD:8/24/2015
Baby Will born 8/18. He's perfect.
I have done some more research online and it seems that C.CRM treats for two months with Lupron if you test negative regardless if you are in or out of phase. I have another consult with my RE tomorrow to go over some other test results so I’ll discuss it with him again.
It is nice to see you back J&D!
***SIGNATURE WARNING***
TTC #1
Me 42, DH 47
Dx = AMA/DOR, MFI
IVF/ICSI #1 = BFN
IVF/ICSI #2 = BFP; early loss
IVF/ICSI #3 (DE) = BFP; early loss
FET = BFN
IVF/ICSI #4 (DE w/ CCS) = BFP
Beta #1 @ 10dp6dt = 265; Beta #2 @ 14dp6dt = 1251.
1st U/S @ 6w2d showed one perfect little heartbeat!
2nd U/S @ 7w2d. HB 132 & everything measuring on track.
Our beautiful little girl arrived January 2015!
I had my follow up appointment today and my RE said that he does not treat Beta-3 Integrin negative patients that are “out of phase” with Depot Lupron unless they are histologically delayed by greater then three days (I was two days).
I’ll be interested to hear what your RE’s thoughts are when you have the test. Good luck!
***SIGNATURE WARNING***
TTC #1
Me 42, DH 47
Dx = AMA/DOR, MFI
IVF/ICSI #1 = BFN
IVF/ICSI #2 = BFP; early loss
IVF/ICSI #3 (DE) = BFP; early loss
FET = BFN
IVF/ICSI #4 (DE w/ CCS) = BFP
Beta #1 @ 10dp6dt = 265; Beta #2 @ 14dp6dt = 1251.
1st U/S @ 6w2d showed one perfect little heartbeat!
2nd U/S @ 7w2d. HB 132 & everything measuring on track.
Our beautiful little girl arrived January 2015!