IUI and possibility of twins?

fletch1414 · July 2020

Hi all - we are likely going to try IUI in the next couple of months. Do most people use medication to help with the IUI? I am 40 and recently had a pregnancy loss. I am worried about the potential of twins with medication - do you know how likely this could be? I want the IUI to work... but twins would be nuts given all we have going on in our lives! Thank you!!

inthewoods23 · July 2020

It depends on the medication and dosage. If you're using an oral medication like Letrozole, you won't grow too many follicles. I only ever had 1 follicle reach maturity during my IUIs.

If it's injectables, you're likely to get many more, but that's only used with IUIs of you are a poor responder to meds and/or you do not have the best egg quality.

mbradfo2 · July 2020

It depends on whether your doctor uses medication to stimulate and induce ovulation prior to the insemination (usually depends on the patient - most IUI's I've seen use either oral or injectable meds but it's possible to do it without meds in what's called a 'natural' cycle). Your doctor will likely make the choice of what meds to use (if any) based on your testing -- AMH, AFC, ovulation indicators - during your natural cycle. You should also be monitored, especially if they give you injectables, to keep track of how many follicles are developing. To avoid high risk of multiple pregnancies, if you have too many mature follicles, they may cancel the IUI.

(I've done 3 IUI's with injections, but none of them were successful. The protocol was called a 'mini' stim by my clinic. I rarely had more than one or two mature follicles during the cycles. My AMH and AFC were normal during the testing I had prior to the IUI's but prior to my IVF cycle - two years after we did IUI's - my AMH was very low, so I don't know if that had any impact.).

ivfmeerut · July 2022

While IUI alone will not increase the risk of twin babies, the use of fertility medication does make it more likely that patients will have multiples pregnancy. If a woman releases many mature eggs at ovulation, it is more likely that more than 1 egg will be fertilized, thus resulting in twins or multiples. While the procedure of IUI treatment itself doesn't increase your chances of having twins, certain drugs associated with it might.

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