Infertility

First round of IVF

Hi everyone! 

I'm new to this forum. I've been in a couple Facebook groups but decided I needed to get off of Facebook because I kept seeing too many pregnancy announcements. 

So here's my story. We've been trying for two years with unexplained infertility. We had a chemical pregnancy after an HSG about a year and a half ago. Since then we've done 4 unsuccessful IUIs. We're now moving on to IVF. I just started taking birth control this week and will start injections in a couple of weeks. Tentative retrieval on May 1st. 

I'm nervous about how many eggs I'll be able to produce because during the medicated IUI cycles I only ever produced 1 sometimes 2 mature follicles, so we'll see. 

Looking forward to having others on this journey with me!

Re: First round of IVF

  • Were you also on injectables for your IUIs? If you were only taking letrozole/clomid it's normal to only get 1-2 mature follicles. The injectables are much stronger and will help produce lots of mature follicles (assuming you don't have a low AMH or other issues that make it difficult for the body to respond to hormones).

    I always ended up with 1 mature follicle during my IUIs with letrozole but was able to retrieve 24 eggs in my 1 IVF cycle from the injectables. YMMV depending on how you respond and what your currently fertility looks like. I have a pretty high AFC for someone my age so retrieving 24 eggs is probably an outlier for what to expect.
    *TW* History
    TTC #1 since 7.2017
    Dx: low morph (1%), ANA positive, low decidualization score, high TSH and testosterone, histone antibodies

    IUI #1-3 all BFN
    IVF #1 | 6.11.19 | 24R, 17M, 15F, 6B, PGT-A tested - 5 normal, 3 girls & 2 boys
    FET #1 | 9.10.19 | BFN "I know you, but we've never met. I'm with you, but I don't know your name"
    RPL, Receptiva, & ERA testing | all normal/negative, recommended going on gluten and dairy free diet for next FET
    FET #2 | 3.31.20 | Opted to cancelled due to pandemic, continued diet and tried naturally over the summer
    2nd Opinion with another RE | 8.20.20 | Not immune to measles (received 1 dose); SA results similar to 2 years ago; decided to move forward with FET #2 redo at start of next cycle
    Surprise natural BFP! | 9.22.20 | MC 10.23.20 at 8 weeks
    TTCAL naturally | starting 11.22.20

    Initial consultation with Reproductive Immunologist | 9.14.21
    Decidualization score biopsy | 10.1.21 | abnormal - low score of 1; endometrial scratch recommended and progesterone supplementation
    Saline sono | 10.15.21 | normal
    Bloodwork | 10.21.21 high TSH, high testosterone, positive for anti-nuclear antibodies and histone antibodies, high protein S, multiple genetic mutations
    BFP! | 11.3.21 | EDD 7.14.22 B) | biopsy provided same effect as endometrial scratch; added supplemental progesterone and estrogen, prednisone, levothyroxine, and MTX Support to maintain pregnancy
    DS born 7.19.22 after induction


    TTC #2 begins 6.2023
    Consultation with RI | 6.6.23
    Saline sono, endometritis biopsy, skin & eye check | all normal
    Labs | high TSH, Factor XIII mutation, high %CD56
    Follow up | 8.8.23 | prescribed metformin, prednisone, plaquenil, and levothyroxine
    Repeat labs after 3 weeks on meds
    Follow up | 11.9.23 | Green light!, increase in prednisone, added lovenox
    Repeat labs in 8 weeks
    Follow up | 1.16.24 | Green light continues
    TTC ended due to filing divorce

    **New relationship starting May 2024**

    Surprise BFP!! | 9.7.25 | EDD 5.11.26
    Its Gonna Be May GIFs  Tenor
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  • @inthewoods23 thanks for letting me know that! I was only on Clomid I wasn't taking any injectables. They told me my AMH was normal at 2.724. 

    They didn't tell me an AFC. Is that something I should ask for? Or maybe they'll do that during my baseline scan in a couple weeks? 
  • @enaids they'll definitely do that at your baseline so they have some idea of potential number of eggs you may get in the end. My AFC was always a bit ridiculous with some 30+ follicles between my 2 ovaries. I think at the first check up they'll look at them all again but after that they will only take note of the ones that are measuring at least a certain size with each subsequent visit. My last check up before my retrieval they counted some 12 or 15 follicles that were at least 18mm. So with me ending up with 24 eggs likely meant that they collected some undermature eggs in the follicles that were slightly smaller. Only 17 ended up being mature enough to attempt fertilization.

    Good luck!
    *TW* History
    TTC #1 since 7.2017
    Dx: low morph (1%), ANA positive, low decidualization score, high TSH and testosterone, histone antibodies

    IUI #1-3 all BFN
    IVF #1 | 6.11.19 | 24R, 17M, 15F, 6B, PGT-A tested - 5 normal, 3 girls & 2 boys
    FET #1 | 9.10.19 | BFN "I know you, but we've never met. I'm with you, but I don't know your name"
    RPL, Receptiva, & ERA testing | all normal/negative, recommended going on gluten and dairy free diet for next FET
    FET #2 | 3.31.20 | Opted to cancelled due to pandemic, continued diet and tried naturally over the summer
    2nd Opinion with another RE | 8.20.20 | Not immune to measles (received 1 dose); SA results similar to 2 years ago; decided to move forward with FET #2 redo at start of next cycle
    Surprise natural BFP! | 9.22.20 | MC 10.23.20 at 8 weeks
    TTCAL naturally | starting 11.22.20

    Initial consultation with Reproductive Immunologist | 9.14.21
    Decidualization score biopsy | 10.1.21 | abnormal - low score of 1; endometrial scratch recommended and progesterone supplementation
    Saline sono | 10.15.21 | normal
    Bloodwork | 10.21.21 high TSH, high testosterone, positive for anti-nuclear antibodies and histone antibodies, high protein S, multiple genetic mutations
    BFP! | 11.3.21 | EDD 7.14.22 B) | biopsy provided same effect as endometrial scratch; added supplemental progesterone and estrogen, prednisone, levothyroxine, and MTX Support to maintain pregnancy
    DS born 7.19.22 after induction


    TTC #2 begins 6.2023
    Consultation with RI | 6.6.23
    Saline sono, endometritis biopsy, skin & eye check | all normal
    Labs | high TSH, Factor XIII mutation, high %CD56
    Follow up | 8.8.23 | prescribed metformin, prednisone, plaquenil, and levothyroxine
    Repeat labs after 3 weeks on meds
    Follow up | 11.9.23 | Green light!, increase in prednisone, added lovenox
    Repeat labs in 8 weeks
    Follow up | 1.16.24 | Green light continues
    TTC ended due to filing divorce

    **New relationship starting May 2024**

    Surprise BFP!! | 9.7.25 | EDD 5.11.26
    Its Gonna Be May GIFs  Tenor
  • Hi! Welcome to the club, I hope you get your baby soon enough Xxx 

    I am 40yo, trying to become a mum via ivf, I'm single, and I've got pcos. Thankfully I have my family's support, they're too excited - a tad too excited if you know what I mean...-. 

    Now I am waiting to take the pregnancy test after my 2nd IVF cycle, but tbh dreading the moment!! 

    Wishing everyone good luck! 
  • @isabelherna sending you all the sticky baby vibes!! When will you go in for betas? 
  • mina-pmina-p member
    Hi there also new here! I'm 34 years old and after 2 years ttc, my DH and I are considering going down the IVF route. Are IUIs common to try first before IVF? Are success rates much lower? 
    Thank you in advance ! Good luck to all <3
  • mina-p said:
    Hi there also new here! I'm 34 years old and after 2 years ttc, my DH and I are considering going down the IVF route. Are IUIs common to try first before IVF? Are success rates much lower? 
    Thank you in advance ! Good luck to all <3
    IUIs are common before IVF for a few reasons - they're significantly cheaper (IUI costs from a few hundred to a few thousand, while IVF is in the tens of thousands), some people find them ethically more palatable, and for some people, insurance covers them. If you're lucky enough to have insurance that covers fertility treatments, you may have to prove that IUIs didn't work before getting any coverage for IVF. But yes, success rates are significantly lower. Success rates vary a lot based on all sorts of factors, but IUI is roughly 10% (you'll see 5-20% usually), and IVF is closer to 50% (places will quote anywhere from 30-75%, but usually 40-50% if you're young and healthy, etc). 
  • This may be important for patients who have concerns about a genetic condition or who have had multiple failed IUI cycles or miscarriages. This process can be used to identify genetic disorders or chromosomal abnormalities in embryos, and can also help identify the best embryo to transfer. IVF is the only best option available after multiple failed IUI. A couple can try a minimum of 3 to 4 cycles of IUI and still fail to conceive it is better to proceed with the IVF as the success rate is higher in IVF procedures as compared to IUI.
  • mina-pmina-p member
    Thank you for your reply! After my consultation it seems that they want me to jump straight into IVF, as they said exactly the same about success rates. Fingers crossed
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