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PdG testing

teddybear4eteddybear4e member
in Trying to Get Pregnant
Hi

Anyone uses Mira confirm wands to test the PdG level? I just started testing my PdG for this cycle (usual cycle length - 27/28), however, my PdG graph does not follow the "usual trend". Should I be concerned about this or is this normal?
 
PdG on 26 Oct (CD 6) = 2.7 μg/mL (baseline)
PdG on  7 Nov to 11 Nov (CD 18 - 22) =  >15 μg/mL (Upper limit for the PdG wand is 15 μg/mL)
PdG on 12 Nov (CD 23) = 14.7 μg/mL
PdG on 13 Nov (CD 24) = 12.1 μg/mL
PdG on  14 Nov to 15 Nov (CD 25 - CD26) = >15 μg/mL

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Re: PdG testing

  • optimistgardeneroptimistgardener member
    hi @teddybear4e. just fyi, this is the kind of question we'd usually encourage in our November chart stalk/questions thread, which has admittedly fallen ridiculously far down the forum onto pg 2. there may be folks on this forum who use Mira and will have more insight than i, but since i'm here: are these your numbers listed above the graph? what about them do you find worrying? I don't know a lot about progesterone levels, but i believe through your luteal phase they should ideally be up in the mid teens or higher, as yours apparently are except that minor blip on CD24.
    History
    I am doing this on my own. Left ovary and fallopian tube removed due to cyst/necrosis just after birth. Right ovary and tube still purport to function.
    Began TTC in Aug '18 @ age 35
    5 or 6 (or 7?!) cycles using frozen donor sperm, ICI. All BFN
    Mar-Jun '19 IUIs, all BFN
    Began process of referral for RE in spring of '19, blood tests confirm low AMH (.54) but all else is good.
    May '19 HSG shows open tube, but ultrasound suggests fibroids
    MRI in June '19 confirms two large fibroids, one growing through wall of uterus
    In June '19 I move from California to Oregon, disrupting my insurance, referrals, etc. 5 months spent piecing it all back together.
    Nov. '19 attempted myomectomy (vaginal approach) failed. 2nd surgery using laparoscopic method in Jan '20 is successful.
    April '20 --> June '20, natural IUIs, all BFN.
    July? saline ultrasound and bubble test demonstrate open tube
    July '20 clomid cycle cancelled for thin lining
    Aug-Oct, 3 femara cycles, all BFN
    RE referral. While waiting to set up an appointment Nov-Jan,I continue with natural cycles and ICI, using a known donor, BFN...
    Jan '21 more bloodwork, AMH is worse (.30), FSH high albeit not catastrophic at 13.2. hysteroscopy all good. "looks cozy!" says the RE.
    Feb '21, injectables (menopur, novarel), iui, BFN (doc said the frozen donor sperm sample had the "best numbers she'd ever seen!")
    Mar '21, injectables, iui cancelled due to lack of follicles, converted to at home-insem. BFN
    May '21, first IVF round cancelled due to cyst.
    July '21 IVF: standard antagonist. 225menupur/225gonal-f/cetrotide/5000u trigger, AFC 7; 6 days of stims. 8 eggs retrieved, 7 mature, 5 fertilize, 4 made it to blast. 3 are 4AB, 1 is 4BB. PGT-A results all abnormal.
    Oct '21 somewhat improved AMH (.51) and significantly improved FSH (8.9). Maybe it's all the pills I swallow.
    Dec -21, standard antagonist. 225menupur/225gonal-f/cetrotide/5000u trigger, AFC 5; 11 days of stims. retrieval yields 5, 4M, 2 reach day-6 blast (4AB & 4BB). 1 low-level mosaic (chr. 3 deletion), 1 complex abnormal.
    Feb '22 FET (low-level mosaic): CP.
    May '22 egg retrieval, lupron flare protocol. HGH priming for 1 month before stims; md lupron 20/20u daily; menopur 225, follistim 225, 10k trigger after 8 days of stims; AFC 10; 13 retrieved; 10 mature; 8 fertilized. All frozen at 2PN for later thaw, grow, and biopsy.
    July '22 egg retrieval same protocol: 9 days of stims; AFC 8; 10 retrieved, 8 mature, 4 fertilized and frozen.
    Sept '22 ER same protocol: AFC 10; 12 retrieved, 11 mature, 11 fertilized.
    From the 3 retrievals, 7 survived to day 5-6 blastocyst, from which I have 2 normal embryos!
    Jan 20, Fully medicated FET, baby aspirin, dexamethasone, acupuncture, and as much woo as I can stand (which isn't very much). BFN.
    July 23, Natural FET + baby aspirin. BFN.
    Report Reply
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  • teddybear4eteddybear4e member
    Hi @optimistgardener

    Thanks for informing me about the other thread. 

    These are my readings taken during this period.
    PdG on 26 Oct (CD 6) = 2.7 μg/mL (my baseline)
    PdG on  7 Nov to 11 Nov (CD 18 - 22) =  >15 μg/mL (Upper limit for the PdG wand is 15 μg/mL)
    PdG on 12 Nov (CD 23) = 14.7 μg/mL
    PdG on 13 Nov (CD 24) = 12.1 μg/mL
    PdG on  14 Nov to 15 Nov (CD 25 - CD26) = >15 μg/mL

    Typical PdG chart looks like the graph below, however, my PdG chart seems to be very different from the typical chart. Thus, i am not sure if there is something wrong with my PdG hormone.

    Report Reply
  • keikilovekeikilove member
    edited November 2021
    @teddybear4e This question could be interpreted as if you are asking us if you are pregnant, although you are asking in a roundabout way. It is against forum rules to do this.
     
    If you are tracking your progesterone then you probably know that it will stay elevated after ovulation if you’re pregnant (along with your temperature), and if there was no implantation then your progesterone will drop, leading to your period. If your cycle is 28 days long then you have just a couple of days to find out what’s going on. 
    Also, your chart doesn’t resemble the other charts because you didn’t track from your baseline all the way through to your current high levels. If you had you would likely see a climb from baseline to a peak after ovulation. 
    If you are pregnant then you can move on to your Birth Month Board. If not, feel free to hang out with us and maybe even recruit some folks to research with you why you have this prolonged elevated pattern. 
    Report Reply
  • optimistgardeneroptimistgardener member
    @keikilove she introduced herself a little while back. :)
    @teddybear4e, Keiki is correct about your incomplete data and that you're within the "just be patient or go take a test" window of finding out what's going on with your cycle.
    History
    I am doing this on my own. Left ovary and fallopian tube removed due to cyst/necrosis just after birth. Right ovary and tube still purport to function.
    Began TTC in Aug '18 @ age 35
    5 or 6 (or 7?!) cycles using frozen donor sperm, ICI. All BFN
    Mar-Jun '19 IUIs, all BFN
    Began process of referral for RE in spring of '19, blood tests confirm low AMH (.54) but all else is good.
    May '19 HSG shows open tube, but ultrasound suggests fibroids
    MRI in June '19 confirms two large fibroids, one growing through wall of uterus
    In June '19 I move from California to Oregon, disrupting my insurance, referrals, etc. 5 months spent piecing it all back together.
    Nov. '19 attempted myomectomy (vaginal approach) failed. 2nd surgery using laparoscopic method in Jan '20 is successful.
    April '20 --> June '20, natural IUIs, all BFN.
    July? saline ultrasound and bubble test demonstrate open tube
    July '20 clomid cycle cancelled for thin lining
    Aug-Oct, 3 femara cycles, all BFN
    RE referral. While waiting to set up an appointment Nov-Jan,I continue with natural cycles and ICI, using a known donor, BFN...
    Jan '21 more bloodwork, AMH is worse (.30), FSH high albeit not catastrophic at 13.2. hysteroscopy all good. "looks cozy!" says the RE.
    Feb '21, injectables (menopur, novarel), iui, BFN (doc said the frozen donor sperm sample had the "best numbers she'd ever seen!")
    Mar '21, injectables, iui cancelled due to lack of follicles, converted to at home-insem. BFN
    May '21, first IVF round cancelled due to cyst.
    July '21 IVF: standard antagonist. 225menupur/225gonal-f/cetrotide/5000u trigger, AFC 7; 6 days of stims. 8 eggs retrieved, 7 mature, 5 fertilize, 4 made it to blast. 3 are 4AB, 1 is 4BB. PGT-A results all abnormal.
    Oct '21 somewhat improved AMH (.51) and significantly improved FSH (8.9). Maybe it's all the pills I swallow.
    Dec -21, standard antagonist. 225menupur/225gonal-f/cetrotide/5000u trigger, AFC 5; 11 days of stims. retrieval yields 5, 4M, 2 reach day-6 blast (4AB & 4BB). 1 low-level mosaic (chr. 3 deletion), 1 complex abnormal.
    Feb '22 FET (low-level mosaic): CP.
    May '22 egg retrieval, lupron flare protocol. HGH priming for 1 month before stims; md lupron 20/20u daily; menopur 225, follistim 225, 10k trigger after 8 days of stims; AFC 10; 13 retrieved; 10 mature; 8 fertilized. All frozen at 2PN for later thaw, grow, and biopsy.
    July '22 egg retrieval same protocol: 9 days of stims; AFC 8; 10 retrieved, 8 mature, 4 fertilized and frozen.
    Sept '22 ER same protocol: AFC 10; 12 retrieved, 11 mature, 11 fertilized.
    From the 3 retrievals, 7 survived to day 5-6 blastocyst, from which I have 2 normal embryos!
    Jan 20, Fully medicated FET, baby aspirin, dexamethasone, acupuncture, and as much woo as I can stand (which isn't very much). BFN.
    July 23, Natural FET + baby aspirin. BFN.
    Report Reply
  • keikilovekeikilove member
    edited November 2021
    @optimistgardener Thanks! I didn’t recognize the name. Just edited it. 
    Report Reply
  • teddybear4eteddybear4e member
    @keikilove

    Thanks for the information. Actually I wasn't asking if I'm pregnant, and I'm sure I'm not pregnant since I missed the opportunity to DTD during the fertile period :D 

    Since Mira only launched the PdG confirm wands recently, this is actually my first cycle testing the PdG hormones. I'm worried as my chart does not follow the normal trend during the luteal phase, which might suggest something is wrong with my hormones. Furthermore, my readings hit mostly the upper limit of the test, thus, I'm not sure if this is considered bad?

    However, as the measurement unit is in μg/mL, there isn't much info online about the normal range for PdG. Most of the info available online is mainly for Serum Progesterone and in ng/ml measurement unit. 

    As I have fibroids and also renal AML, I'm worried that these crazy hormones will further accelerate the growth of these benign mass. 

    Thus, I posted the post to see if anyone has similar encounter. 

    Thanks
    Report Reply
  • optimistgardeneroptimistgardener member
    hi @teddybear4e. thanks for the clarification on your situation. I would certainly want to take all this information to your doctor, or perhaps more appropriately a fertility specialist. This seems to me like a fairly specialized concern that you have, and since you're worried about it, the best reassurance will come from a medical professional rather than a hive-mind of internet strangers. As regards fibroids, as far as I know it is usually said to be estrogen that drives fibroid growth, rather than progesterone.
    History
    I am doing this on my own. Left ovary and fallopian tube removed due to cyst/necrosis just after birth. Right ovary and tube still purport to function.
    Began TTC in Aug '18 @ age 35
    5 or 6 (or 7?!) cycles using frozen donor sperm, ICI. All BFN
    Mar-Jun '19 IUIs, all BFN
    Began process of referral for RE in spring of '19, blood tests confirm low AMH (.54) but all else is good.
    May '19 HSG shows open tube, but ultrasound suggests fibroids
    MRI in June '19 confirms two large fibroids, one growing through wall of uterus
    In June '19 I move from California to Oregon, disrupting my insurance, referrals, etc. 5 months spent piecing it all back together.
    Nov. '19 attempted myomectomy (vaginal approach) failed. 2nd surgery using laparoscopic method in Jan '20 is successful.
    April '20 --> June '20, natural IUIs, all BFN.
    July? saline ultrasound and bubble test demonstrate open tube
    July '20 clomid cycle cancelled for thin lining
    Aug-Oct, 3 femara cycles, all BFN
    RE referral. While waiting to set up an appointment Nov-Jan,I continue with natural cycles and ICI, using a known donor, BFN...
    Jan '21 more bloodwork, AMH is worse (.30), FSH high albeit not catastrophic at 13.2. hysteroscopy all good. "looks cozy!" says the RE.
    Feb '21, injectables (menopur, novarel), iui, BFN (doc said the frozen donor sperm sample had the "best numbers she'd ever seen!")
    Mar '21, injectables, iui cancelled due to lack of follicles, converted to at home-insem. BFN
    May '21, first IVF round cancelled due to cyst.
    July '21 IVF: standard antagonist. 225menupur/225gonal-f/cetrotide/5000u trigger, AFC 7; 6 days of stims. 8 eggs retrieved, 7 mature, 5 fertilize, 4 made it to blast. 3 are 4AB, 1 is 4BB. PGT-A results all abnormal.
    Oct '21 somewhat improved AMH (.51) and significantly improved FSH (8.9). Maybe it's all the pills I swallow.
    Dec -21, standard antagonist. 225menupur/225gonal-f/cetrotide/5000u trigger, AFC 5; 11 days of stims. retrieval yields 5, 4M, 2 reach day-6 blast (4AB & 4BB). 1 low-level mosaic (chr. 3 deletion), 1 complex abnormal.
    Feb '22 FET (low-level mosaic): CP.
    May '22 egg retrieval, lupron flare protocol. HGH priming for 1 month before stims; md lupron 20/20u daily; menopur 225, follistim 225, 10k trigger after 8 days of stims; AFC 10; 13 retrieved; 10 mature; 8 fertilized. All frozen at 2PN for later thaw, grow, and biopsy.
    July '22 egg retrieval same protocol: 9 days of stims; AFC 8; 10 retrieved, 8 mature, 4 fertilized and frozen.
    Sept '22 ER same protocol: AFC 10; 12 retrieved, 11 mature, 11 fertilized.
    From the 3 retrievals, 7 survived to day 5-6 blastocyst, from which I have 2 normal embryos!
    Jan 20, Fully medicated FET, baby aspirin, dexamethasone, acupuncture, and as much woo as I can stand (which isn't very much). BFN.
    July 23, Natural FET + baby aspirin. BFN.
    Report Reply
  • keikilovekeikilove member
    edited November 2021
    @teddybear4e Ah, I see. Thanks for the additional background information. We get so many sneaky (and not so sneaky) questions around here basically asking “Am I preggo?” that I made assumptions based on the limited info. I apologize. 

    I agree with @optimistgardener ‘s feedback above. Your situation sounds too specific and rare for any of us to give you solid advice. Also, I think there’s a question of “Are the elevated progesterone levels accelerating the growth of the benign mass, or is the benign mass causing elevated progesterone levels?” A doctor would be your best bet in finding these answers. Good luck! 
    Report Reply
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