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Chemical pregnancy and ERA question m

IlkyIlky member
in Infertility
Hello ladies,

I had my first baby a couple years ago with my first frozen transfer cycle. We just had another transfer for baby #2, and I had a chemical pregnancy. The doctor is recommending ERA cycle. I don’t want to go thru all those shots if I don’t have to. And also waste more time. But also I only one one embryo left. Also as I understand if the results are not optimal
then they need to do more cycles to find the exact date/time. Has any of you had a successful first time transfer but dealt with chemical with the second transfer? Have you chosen to do ERA and did it make a positive difference? Or chosen to just go ahead with the regular transfer and has success? Thank you! 
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Re: Chemical pregnancy and ERA question m

  • andreamm31andreamm31 member
    My doctor wanted to avoid the possibility of transferring at the wrong time to eliminate a reason why a cycle would fail as I was using donor eggs in another country at the time.  I was happy I did it because it showed I needed 24 extra hours of progesterone.  That cycle ultimately failed (fresh transfer of an untested embryo) but 2 other transfers did initially work with using that timing.  Sadly both ended in miscarriages.  As much as it sucks to do the extra step, sometimes its worth it to avoid more loss, and wasting precious embryos...esp if you only have one left.


    39 years old   DH 41.  Sperm looks great.  We live in San Diego  
    Me:  ****TW loss mentioned***
    MTHFR Homozygous 677TT (dx 2016)
    hypothyroid
    8/2018           Off birth control
    11/29/2018    CP
    2/10/2019.    CP
    3/8/2019        Saw fertility doctor, AFC 5, labs drawn
    3/14/2019      Pregnant
    4/18/2019      9 week ultrasound  MM , stopped growing at 6 weeks, no HB.  D&C 
    5/2/2019       Return to fertility doctor, labs show AMH 0.27. Diminished Ovarian Reserve
                         1st of 3 Egg retrievals planned tentatively for July
    6/29/2019     started Antagonist Protocol 
    7/12/2019     First egg retrieval, only retrieved one egg and fell apart immediately, poor quality.
    8/7/2019.      Second cycle (follicular antagonist) canceled on day 5 of stims when a very large lead follicle grew out of nowhere.
    11/8/2019.    Second Egg retrieval with Lupron Flare Protocol.  2 eggs retrieved, fertilized with ICSI but no reaction occurred at all.                       Told I will never have my own babies with my eggs.
    12/20/2019    ERA - pre-receptive.  Needed 24 hours more of progesterone
    2/2020          CP
     3/2/2020     Egg donor cycle in Prague at Unica Clinic, 2 AA embryos, 1 transfer, 1 on ice. BFN.  Due to pandemic, we could not return to Prague and will abandon our remaining embryo.
    4/20/2020.  BFP trying on our own! 
    06/04/2020   After HBs at 7 and 9 weeks, MM at 10 weeks 3 days.  D&C, Hemorrhaged out 1 liter of blood from uterine artery rupture during procedure.     Spent 1 night in the hospital with a balloon tamponade in my uterus. Baby was mosaic Trisomy 21.
    8/2020.  Moving forward with Donor Egg cycle at Utah Fertility Center and sharing a cycle with ladypOtter (Gina) I met on the Bump who was also supposed to go to Prague but couldn't.  
    9/26/2020 Donor retrieval of 26 eggs, 24 mature.  Split cycle so I have 12 eggs with all 12 fertilizing. 6 PGS normal 3 boys, 3 girls
    10/29/2020 Transfer day of  girl donor egg embryo.     BFP! First HCG 92.9. Then inappropriate rise, plateau and falling.  Possibly ectopic pregnancy.  ER visit with diagnosis of "pregnancy location unknown". CP
    1/19/2021 Embryos shipped from Utah to my local clinic, starting prednisone for anti-histamine protocol. 
    2/26/2021 FET girl embryo BFP. Betas 62, 139, 386! HB at 6 weeks, then baby stopped growing at 8 week check up with weak HB measuring 6 weeks 4 days.  MM at 9 weeks. D&C 4/15/21
    7/13/2021 FET boy and girl embryos. First beta 10dp5dt 177, 14dp5dt 1631, 16dp5dt 6809. Pregnant with Identical triplets.  At 9 weeks, Baby C no longer had a heart beat. Identical Twin Girls.   Pregnancy complicated by TRAP Sequence with baby C an Acardiac fetus still receiving blood flow being pumped to it by other girls.  Referred to UCSF at 18 weeks for consultation.  No intervention needed at this time
    2/18/22 After a failed NST, at 34 weeks 1 day, Charlotte born 4lb 4oz and Lily born 4lbs 10 oz.  Our hearts are complete.  Baby girls in NICU to grow and learn to eat.
    History in Spoiler
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  • Kp214Kp214 member
    I did an ERA and a test on my endometrial lining to check for inflammation. My RE had difficulty the first time retrieving enough of a biopsy for both and tried to convince me to just send it in for the inflammation test. I asked him to try again that day and he was able to get enough for both. I’m glad I did. It confirmed that we were transferring at the correct time but also showed that I had developed inflammation in my lining, I suspect that’s the cause of a failed transfer two years ago. 

    It’s tough to know what to do. Good luck to you. 
    Me:32 DH:36
    Me: DOR, poor egg quality, MTHFR
    DH: MFI
    TTC since 3/2014
    2015: 3 IUI's-BFN
    12/2015: 1st IVF cycle-(9 follicles retrieved, 5 mature, 3 fertilized w/ICSI, transferred 1 excellent and 1 good embryo on day 3)-chemical pregnancy
    3/2016: 2nd IVF cycle- canceled (3 follicles retrieved, 3 mature, all fertilized w/ICSI, 1 fragmented, 2 arrested) 
    3/2016: RE suggested donor eggs- taking an ivf break and to supplement 
    9/2016: 3rd ivf cycle-cancelled due to early ovulation
    Oct./Nov 2016: 4th ivf cycle- EPP-AFC:5, retrieved 10, 10 mature, 8 fertilized with ICSI, 6 blastocysts biopsied and frozen. 3 CCS normal embryos
    1/9/17: transferred 1 embryo-BFP 1/16
    1/18/17: beta #1-104
    1/20/17: beta #2-174
    2/2/17: first u/s, heartbeat of 107 at 6w1d
    7/20/17: baby boy born at 30+3 via emergency c-section 


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  • sfield21sfield21 member
    @Kp214 did you have any other symptoms or issues for wanting the lining checked for inflammation? 
    What was the treatment and did it help you become successful in transferring? TIA :blush:
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