TTCAL week of 2/1

gingermama29 · February 2021

**This is a general trigger warning that CP, miscarriage, selective termination due to medical complications, and/or stillbirth may be mentioned.**

Introduce yourself and anything you think is important: number of loss(es), when you had the loss(es), diagnosis/conditions surrounding loss, etc.

Status:

How are things going? What is something that you are struggling with and/or what is going well?

Any testing coming up/any recent results?

Questions?

GTKY: if you could have any super power, what would it be and why?

rgn12 · February 2021

Introduce yourself and anything you think is important: number of loss(es), when you had the loss(es), diagnosis/conditions surrounding loss, etc. CP on 12/26 at 5 weeks

Status: WTO

How are things going? What is something that you are struggling with and/or what is going well? I have been doing well for the most part. However, last night I actually felt really sad about the CP and anxious about trying again. Not sure where that came from, since it’s been over a month. I feel like there have been a lot of pregnancy announcements with my friends lately, so maybe that is it? I think the pandemic is also just weighing on me, and I wish things could go back to “normal” sooner rather than later. A lot has happened in my personal life recently too. I have had some sick family members, we had to put one of our cats down a couple of weeks ago, the CP, and my parent’s dog passed away suddenly. It just seems like everyone I know is going through a rough time.

Any testing coming up/any recent results? None

Questions? None

GTKY: if you could have any super power, what would it be and why? Hmm... teleportation maybe? I would love to be able to just go where I want in the blink of an eye! I have always lived so far away from my family, so it would be awesome not to have to travel!

gingermama29 · February 2021

@rgn12 I definitely understand the sadness that is seemingly out of nowhere when you think you're doing okay. I've definitely been experiencing that for the last few days. Sorry for all of the difficulties in you've been dealing with. That's definitely a lot all at once.

Introduce yourself and anything you think is important: number of loss(es), when you had the loss(es), diagnosis/conditions surrounding loss, etc.
1 loss discovered at 7.5 week ultrasound - suspected blighted ovum

Status: technically benched?, but likely NTNP

How are things going? What is something that you are struggling with and/or what is going well?
Things are pretty good this week. I met with my doctor today for a check in. He wants us to wait 2 months before we start actively trying again. I'm supposed to call him in May when my period comes. But he talked pretty openly about calling if I get KU before then so he definitely wasn't explicitly telling us to prevent pregnancy? DH wants to prevent until after I get my second COVID shot, which is 2 weeks away. So that's the plan. We're NTNP until May and if I don't get KU on my own, we'll be going back to Letrozole.

Any testing coming up/any recent results?
I had another HCG blood draw on Saturday in anticipation of my appointment today and my levels were at <10. Definitely a good sign that my body is almost completely "reset" from my loss.

Questions? None at the moment

GTKY: if you could have any super power, what would it be and why?
I agree with teleportation! I would love to be able to instantly travel anywhere I wanted.

rgn12 · February 2021

@gingermama29 thank you! I guess that’s just part of it, the ups and downs! Hoping for some sunshine and rainbows for everyone very soon!

inthewoods23 · February 2021

@rgn12 I'm sorry to hear you're having a bit of a rough time. There's nothing wrong with feeling that sadness from your CP even though it's a month later. I'm at a point of accepting my MC, but some things just make me think about it and what that all meant and what I'm now missing out on and that in turn makes me sad. We'll all get through this

@gingermama29 May?!?! That feels forever away! Can you call if it's like late April?

Introduce yourself and anything you think is important: number of loss(es), when you had the loss(es), diagnosis/conditions surrounding loss, etc. 1 loss Oct 2020 at 8 weeks

Status: WTO, should be in TWW in the next few days

How are things going? What is something that you are struggling with and/or what is going well? Between our well pump issue yesterday and being extra busy at work, I feel like there's no time to chill - even though that's literally what we did over the weekend. Had a couple of things we wanted to do last weekend and did none of it.

Any testing coming up/any recent results? Nah, just doing OPKs right now. I might be at 10dpo on Valentine's Day so that could get interesting....

Questions? nope

GTKY: if you could have any super power, what would it be and why? Teleportation definitely sounds nice. Sometimes I wish I could read DH's mind haha but that could be a disaster to know everything he's thinking of.

sienna221 · February 2021

@rgn12 I’m also sorry you are having such a rough few weeks. So sorry about your fur babies...that’s never easy. And as everyone else said, totally okay to not be okay about your MC still. Mine was back in October and while some weeks in okay...I still have my off days where I’m so sad and May 12 (my original due date) will just haunt me.

@gingermama29 May does seem so far away. But I’m sure it’s nice to know your hcg is so low.

@inthewoods23 what day do you typically O on? I know we are same CD but I tend to be closer to CD17-20 for O. Just curious!

Introduce yourself and anything you think is important: number of loss(es), when you had the loss(es), diagnosis/conditions surrounding loss, etc. MMC Oct 2020 & MC or RPOC Dec 2020

Status: WTO...day 5 of flashing smileys on the Cb digital. Waiting for that peak.

How are things going? What is something that you are struggling with and/or what is going well? Good. Had some travel this past weekend. First time flying since the pandemic started. Felt relatively safe but self quarantining for the week just out of abundance of safety.

Any testing coming up/any recent results? No. Deciding if MH will get the karyotype testing. Since all my results (TSH, Lupus, blood clot stuff), including karyotype, came back normal.

Questions? If any of you did the karyotype testing, did your SO do it as well?

GTKY: if you could have any super power, what would it be and why? Definitely invisibility. I’m super nosey and would love to just sneak into places and be a fly on the wall.

inthewoods23 · February 2021

@sienna221 I'm usually around CD16 or 17 but have also gotten CD15 for O. The genetic screening was only done by me. I was found to not be a carrier for anything they screened for so DH did not have to get tested.

I found some great information at this link. I'll put the highlights on the probabilities in the spoiler.
https://www.reproductivefacts.org/resources/educational-videos/videos/genetics-and-fertility/videos/chapter-2---inheritance-and-mutations/

Essentially, I believe in all cases, if you're not carrier for anything, then at most your children could be a carrier if the other parent (YH) is a carrier so that's why they don't automatically test both partner.

Here's what I found on the probabilities with the recessive genes (need 2 copies of mutation to have the disease).

The chance of each outcome breaks down like this:

Affected person plus a non-carrier = All children are carriers, no children have the disease, and no children are without the mutation.

Affected person plus a carrier = Statistically, half the children will have the disease and half will be carriers.

Carrier plus a carrier = Statistically, half the children will be carriers, 1/4 will have the disease, and 1/4 will not have the mutation.

Carrier plus a non-carrier = Statistically, half of children are carriers and half are non-carriers.

And with dominant genes/diseases (only 1 copy needed to have the disease).

It breaks down like this:

If one parent has one mutated copy and the other parent is healthy, there‘s a 50% chance of having a healthy child and a 50% chance of having an affected child with one mutated copy.

If at least one parent has both copies of an affected gene, all children will be affected- this is rare.

If both parents have one mutated copy of the gene, there is a 1 in 4 chance of a healthy child, a 2 in 4 chance of getting a child with one mutated copy (and thus affected), and a 1 in 4 chance of having a child with 2 mutated copies. Because this is autosomal dominant, the overall chance that a child will be affected by the disease is 3 in 4.

There's also probabilities related to X-linked diseases which explains why they start with the female.

The chance of having an affected child with an X-linked recessive disease breaks down like this:

Carrier mother and healthy father: There is an equal chance of having a healthy girl, a healthy boy, an affected boy, or carrier girl. Statistically, this means that half of the children, boys and girls together, will be unaffected. For the other half of the children, the girls will be carriers and the boys will be affected.

Non-carrier healthy mother and affected father: All the girls will be carriers since the father can only pass his mutated X chromosome to the girls, while none of the boys will have the disease since the father passes his Y chromosome.

An affected mother with 2 copies, and affected father with one copy: All children will be affected. This is rare.

Carrier mother with one copy and an affected father: Half of the girls will be carriers and half of the girls will be affected. Half of the boys will be affected and half of the boys will be unaffected.

bumblebee0210 · February 2021

@sienna221 I used to use the CBDA, but I ended up stopping because I would always get one day of low, then high immediately (even if it was like CD8) and then more often than not, I'd never get a peak. It was super annoying. I started using mira this month, and interestingly my estrogen was really high on CD7 and 8 and then dropped down before it started rising again. So maybe that's what used to trip up the CBDAs? I like the mira so far (I love having actual numbers), but it is $$$ and almost surely not necessary. The semi-quantitative cheapies (like premom) might be helpful if you have a surge that doesn't always reach the CBDA threshold.

@rgn12 I'm sorry you're having a rough time. CPs can mess with your head, and it's normal to feel ok and then not ok (at least in my experience).

@gingermama29 I'm surprised your doctor wants you to wait-- are you doing any testing? Usually I thought most modern docs are ok with trying right away.

@inthewoods23 Hopefully you get some time to relax soon. House adulting is the worst. It always feels like extortion to me, like "Nice roof you've got here. Pay $20k or it will fall in".

inthewoods23 · February 2021

@bumblebee0210 no lie that is literally us with our roof 🤣 it's not an immediate need, but one of the valleys in the room has a droop in it so that's going to be a big expense since that means replacing a bunch of the trusses.

bumblebee0210 · February 2021

@inthewoods23 @sienna221 I could be wrong but I think the karyotype is one of the things that doesn't need to be a factor for both parents. My understanding is that you OR YH could have a balanced translocation, in which two of your chromosomes are in the wrong spot (?? this might be wrong?), and it "balances" in you, so you are fine, but when you produce an egg/sperm, it is only half your chromosomes, so becomes aneuploid, and causes miscarriage. This is different than carrier status for other genetic issues. It's pretty rare I think, but also an easy test. So it might be worth checking with your doctor (also I could be misremembering so take this with a grain of salt). My husband did do karyotyping as well.

Introduce yourself and anything you think is important: number of loss(es), when you had the loss(es), diagnosis/conditions surrounding loss, etc. 2 mmcs, most recently in Sep 2020

Status: WTO

How are things going? What is something that you are struggling with and/or what is going well? Honestly doing pretty well. I am waiting to do a follow up with RE once tests come in, and I am kind of making peace with whatever comes next.

Any testing coming up/any recent results? Still waiting on most of the RPL stuff, so far everything is normal with a side of maybe old eggs (or maybe I'm reading too much into it and it's standard-issue normal)

Questions? NATM

GTKY: if you could have any super power, what would it be and why? Teleportation. It would make so many things so much easier!

sienna221 · February 2021

@bumblebee0210 I think you may be right in the testing. Only because when she mentioned I was normal, she still suggested MH come in for testing. We won’t have time for him to test before this O since we’re already in FW. We’ll have to decide after what we want to do.

*edited because I used names. Oops. Brain is not working*😂😂😂

inthewoods23 · February 2021

@bumblebee0210 I wasn't sure if karyotyping and genetic screenings were related or different. I would think if it really mattered with either/or parent that they would always test both. All I know is they're all related to our genes!

fitzfizz · February 2021

**lurking**

For karyotype screening you need to test both potential parents, since chromosomal problems are typically inherited from only one parent. It is typically what is called a balanced translocation (a chromosome where part is broken off and attached to another chromosome, such that the carrier/parent has all chromosomes in equal number and is normal, but any offspring can have a 50 or 100% chance of having a problem) that they are looking for for RPL testing. This is not typically needed if the couple has ever had a baby or embryo with normal karyotype.

For single genes that are inherited in a recessive manner, that is what carrier screenings usually are and that is what @inthewoods23’s explanation is about.

There are also mutations that have dominant inheritance, but they are unlikely if the parent is genetically normal, the only chance of that is the baseline chance of what is called genetic mosaicism. These are often new mutations and they wouldn’t be tested for unless you had a child known to have that mutation. With a prior child with a known dominant mutation, there is a 2-5% risk of recurrence, but as I mentioned those are only tested for if there is a known problem.

inthewoods23 · February 2021

Ok, now I need to know how the PGT-A testing fits into this that they do on embryos. Is that still different from karyotyping?

fitzfizz · February 2021

**lurking

@inthewoods23 My understanding is that it is basically like karyotyping, but the PGT-A may not be adequate to detect small translocations. Basically they can count the chromosomes, but they sometimes don’t have enough cells to do a thorough analysis.

gingermama29 · February 2021

@inthewoods23 I agree that May feels late. I will definitely call if I get my period in late April. I hope you get some time to relax and chill this week.

@sienna221 glad your results came back normal. And glad flying felt safe. Hopefully everyone was good about masking.

@bumblebee0210 nope, no testing between now and then. I was disappointed he rented us to wait so long for actively trying but we definitely won't be preventing in the meantime. When are you expecting your results?

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