@mvt2003 Yay, good job follies!! And nice that there is a good reason you're feeling uncomfy.
So AMH results are back and ultrasound results came in really fast...both good. AMH was 7.31 with ref range of 0.36-10.07 if that means anything to anyone? *shrug emoji*. Anyway two more normal tests which is good but is making me question our plan to do IUI before HSG so I may rethink that. I like to have as much info as possible plus I was reading last night that HSG can possibly make IUI more successful b/c it can clear out blockages like @begging4abump mentioned? Not totally sure yet but reconsidering...we have a few weeks to decide though. SO didn't seem toootally dead-set against spending the money for the HSG when we talked last night.
*** Lurker with lots of progesterone experience ***
@nitnat007 first of all sending you lots of love old friend
By pearls I assume you mean the suppositories?
The good thing about them is no injections, you can easily increase and decrease the dose as needed, and in case you get irritation or bleeding using them vaginally you can use most brands rectally. I used them each time and went up to 2 pearls 4 times a day, split between both options for insertion. Most brands are relatively inexpensive in case you need to pay yourself. Downside is you will need to wear a liner also at night (and a long one if you insert in both places) and some people do get irritation which can cause bleeding from your cervix which is of course enough to cause lots of panic!
The progesterone is absorbed directly locally through the tissues to where it is needed to sustain the pregnancy (as direct as you can get) and does not really go through your bloodstream - but this also means there is little point in testing blood progesterone levels so you’re only guessing if your dose is high enough. Its difficult to know if you are one of the small % who don’t absorb the progesterone well this way.
PIO does go through your bloodstream to get to where it is needed so you can test levels in your blood to make sure your dose is enough. But the painful IM shots are, well, a pain. They seem to cause some people more discomfort than others though. You don’t get the irritation and thus bleeding risk. Dosage is more difficult to alter. Most Drs will only do once per day but some will go up to twice if your blood test results come back very low. Or they will add in the pearls on top of the PIO. Depending on supply and what it is mixed with (you can get it mixed in different oils!) it can be really expensive if you have to pay yourself.
If I remember right you’re in Canada? You could ask or look up if Lubion (also sometimes licenced as Prolutex) is available in Canada now? This is an injectible progesterone but only needs to be given subcutaneously so you avoid the painful part of PIO but get all the other benefits. I used this on my last transfer and it was great as I did have to do two injections per day (as my body doesn’t seem to like to make any progesterone on its own, lazy devil!) which would quite literally have been a pain in the butt with PIO!
Price wise I found it to be slightly less than PIO, but still more than the pearls.
Any points I didn’t don’t be shy to ask!
Me 43 DH 45 Married 12/2016 TTC #1 since 04/2015 AMA, DOR (AMH 0.65, AFC 2-4) and autoimmune issues (RA, APS), low TSH, adenomyosis 7 retrievals, 3 transfers
Jun19 FET BFP, due date 7th March 2020, DD born Feb20
Sep17 IVF1 - 1ER, 1F, 1ET, BFN Nov17 IVF2 - 1ER, 0F Jan18 IVF3 - 3ER, 1F, 1ET, BFN Feb18 - second opinion and additional testing Apr18 IVF4 - cancelled (E2 too high) May/Jun18 IVF4 - 4ER, 0M, 1F, 1 frozen day 3 (not best quality) Jun/Jul18 IVF5 - 5 ER, 3M, 2F, 2 frozen day 3 (not best quality) Jul/Aug18 IVF6 - 4ER, 3M, 2F, 2 frozen day 3 (good quality) Aug/Sep18 IVF7 - cancelled (cyst) Sep/Oct18 IVF7 - 3ER, 3M, 2F, 2 frozen Day 3 (excellent quality) Oct18 IVF8 - Cancelled (cyst and too low TSH) Oct18-Jan19 bringing TSH under control Feb19 ERA and hysteroscopy Mar19 Investigation for fibroid and adenomyosis Apr19 adenomyosis confirmed, polyps removed Jun19 FET after 2 months Lupron, autoimmune protocol, transferred two day 3 frozen embryos
Sep17 - Pergoveris 10-17 Sep, Orgalutran 15-18 Sep, Ovitrelle 18 Sep, ER 20 Sep for 2 follies, 1 mature egg, fertilized, ET 1x 2d 4-cell embryo 22/09, 05/10 BFN Nov17 IVF2 - Pergoveris 2-14 Nov, Orgalutran 5-14 Nov, Ovitrelle 15 Nov, ER 17 Nov for 3 follies, 1 mature egg, did not fertilize Jan18 IVF3 - Pergoveris 30 Dec - 8 Jan, Orgalutran 5-8 Jan, Ovitrelle 9 Jan, ER 11 Jan 3 eggs, 2 mature, 1 fertilized, ET 1x 4d 12-cell embryo 15/01, 24/01 BFN May/Jun18 IVF4 - Rekovelle 25-29 May, Menogon 30May - 2Jun, Zomacton 25 27 29 31 May and 2Jun, Cetrotide 30May - 3Jun, Gonasi 3Jun, ER 5Jun 4 eggs, none mature, two matured overnight, 1 fertilized with ICSI, Frozen day 3 but not good quality Jun/Jul18 IVF5 - Rekovelle 21-24 June, Menogon 25Jun-3Jul, Puregon 4-5Jul, Zomacton 21 23 25 27 29 Jun, Cetrotide 25Jun-5Jul, Gonasi 6Jul, ER 8Jul 5 eggs, 3 mature, 2 fertilized with ICSI, 2 frozen day 3 but not good quality Jul/Aug18 IVF6 - Rekovelle 26-29 Jul, Menogon 30Jul-7Aug, Buserelin 26Jul-7Aug, Zomacton 26 28 30 Jul 1 3 Aug, Gonasi 7Aug, ER 9Aug 4 eggs, 3 mature, 2 fertilized (normal IVF), 2 frozen day 3 good quality Sep/Oct18 IVF7 - Menogon 19-30Sep, Buserelin 19-30Sep, Zomacton 19 21 23 25 27 Sep, Ovitrelle 1 Oct, ER 3 eggs, 3 mature, 2 fertilized with ICSI, 2 frozen day 3 excellent quality
Fav Quote: The greatest thing you'll ever learn is just to love and be loved in return
@emmasemm Hi friend! I was hoping that you would weigh in on this. Thank you! I miss you on the boards, but have been following your journey, and so excited for you!
Unfortunately it doesn't look like we get Lubion in Canada as yet (wouldn't that have been convenient). And it appears that the supply of PIO up here is depleting rapidly, so I am not even sure if that will still be an option for me by the time March rolls around. Even with sourcing through a compounding pharmacy.
I have done the suppositories/pearls with both of my fresh transfers. I didn't find them bad to deal with. But both of them failed, so obviously there is that little piece of doubt that sits with me going "what if". I just didn't want to have any regrets as this is our only frozen embryo we have. If that meant dealing with a little pain in the butt, then so be it.
I have not read the study personally, but have heard there is one that was done recently indicating the success rates of the combination of PIO and suppositories. PIO until week 6, I believe, then switching to suppositories. I will have to see if I can source it and share here.
@nitnat007 personally with one embryo I would say go with both PIO and suppositories from the start, then let the PIO be the first one you stop (but not before seeing the HB). The PIO I had didn’t have too short a shelf life, so you could probably already source it now for March. I’m keeping everything crossed for you!!!
Me 43 DH 45 Married 12/2016 TTC #1 since 04/2015 AMA, DOR (AMH 0.65, AFC 2-4) and autoimmune issues (RA, APS), low TSH, adenomyosis 7 retrievals, 3 transfers
Jun19 FET BFP, due date 7th March 2020, DD born Feb20
Sep17 IVF1 - 1ER, 1F, 1ET, BFN Nov17 IVF2 - 1ER, 0F Jan18 IVF3 - 3ER, 1F, 1ET, BFN Feb18 - second opinion and additional testing Apr18 IVF4 - cancelled (E2 too high) May/Jun18 IVF4 - 4ER, 0M, 1F, 1 frozen day 3 (not best quality) Jun/Jul18 IVF5 - 5 ER, 3M, 2F, 2 frozen day 3 (not best quality) Jul/Aug18 IVF6 - 4ER, 3M, 2F, 2 frozen day 3 (good quality) Aug/Sep18 IVF7 - cancelled (cyst) Sep/Oct18 IVF7 - 3ER, 3M, 2F, 2 frozen Day 3 (excellent quality) Oct18 IVF8 - Cancelled (cyst and too low TSH) Oct18-Jan19 bringing TSH under control Feb19 ERA and hysteroscopy Mar19 Investigation for fibroid and adenomyosis Apr19 adenomyosis confirmed, polyps removed Jun19 FET after 2 months Lupron, autoimmune protocol, transferred two day 3 frozen embryos
Sep17 - Pergoveris 10-17 Sep, Orgalutran 15-18 Sep, Ovitrelle 18 Sep, ER 20 Sep for 2 follies, 1 mature egg, fertilized, ET 1x 2d 4-cell embryo 22/09, 05/10 BFN Nov17 IVF2 - Pergoveris 2-14 Nov, Orgalutran 5-14 Nov, Ovitrelle 15 Nov, ER 17 Nov for 3 follies, 1 mature egg, did not fertilize Jan18 IVF3 - Pergoveris 30 Dec - 8 Jan, Orgalutran 5-8 Jan, Ovitrelle 9 Jan, ER 11 Jan 3 eggs, 2 mature, 1 fertilized, ET 1x 4d 12-cell embryo 15/01, 24/01 BFN May/Jun18 IVF4 - Rekovelle 25-29 May, Menogon 30May - 2Jun, Zomacton 25 27 29 31 May and 2Jun, Cetrotide 30May - 3Jun, Gonasi 3Jun, ER 5Jun 4 eggs, none mature, two matured overnight, 1 fertilized with ICSI, Frozen day 3 but not good quality Jun/Jul18 IVF5 - Rekovelle 21-24 June, Menogon 25Jun-3Jul, Puregon 4-5Jul, Zomacton 21 23 25 27 29 Jun, Cetrotide 25Jun-5Jul, Gonasi 6Jul, ER 8Jul 5 eggs, 3 mature, 2 fertilized with ICSI, 2 frozen day 3 but not good quality Jul/Aug18 IVF6 - Rekovelle 26-29 Jul, Menogon 30Jul-7Aug, Buserelin 26Jul-7Aug, Zomacton 26 28 30 Jul 1 3 Aug, Gonasi 7Aug, ER 9Aug 4 eggs, 3 mature, 2 fertilized (normal IVF), 2 frozen day 3 good quality Sep/Oct18 IVF7 - Menogon 19-30Sep, Buserelin 19-30Sep, Zomacton 19 21 23 25 27 Sep, Ovitrelle 1 Oct, ER 3 eggs, 3 mature, 2 fertilized with ICSI, 2 frozen day 3 excellent quality
Fav Quote: The greatest thing you'll ever learn is just to love and be loved in return
@nitnat007 I used a compounding pharmacy when there was the PIO shortage of 2017, and it was nbd. I had mine compounded in olive oil instead of sesame, since the sesame was giving me a reaction.
*TWs* IVF success / failure <div class=" Spoiler">Ffwd to 2019 and we tried to switch up the protocol, and sadly our first natural cycle (with pearls!) Failed. 😓 So we went back to the proven medicated course with PIO and this time my body didn't respond. No idea why! But eventually the natural cycle worked. Just took us several goes. If you feel more comfortable upping the ante and doing the PIO+pearls, I say reach out to the compounding pharmacy and try that route. But that said, if your levels were rising appropriately on the pearls before with your fresh transfers, I'm not sure there's any reason to think that would have been the cause of the unsuccessful cycles. :/ (((Hugs)))</div> fx you get your hands on what you need, and your THB is on his/her way to you, friend! ❤️❤️❤️
Me: 34 DH: 36 | Together since 2007 | Married July 2016
TTC #1 since 7.2017 Dx: low morph (1%), ANA positive, low decidualization score, high TSH and testosterone, histone antibodies
IUI #1-3| all BFN IVF #1 | 6.11.19 | 24R, 17M, 15F, 6B, PGT-A tested - 5 normal, 3 girls & 2 boys FET #1 | 9.10.19 | BFN "I know you, but we've never met. I'm with you, but I don't know your name" RPL, Receptiva, & ERA testing | all normal/negative, recommended going on gluten and dairy free diet for next FET FET #2 | 3.31.20 | Opted to cancelled due to pandemic, continued diet and tried naturally over the summer 2nd Opinion with another RE | 8.20.20 | Not immune to measles (received 1 dose); SA results similar to 2 years ago; decided to move forward with FET #2 redo at start of next cycle Surprise natural BFP! | 9.22.20 | MC 10.23.20 at 8 weeks TTCAL naturally | starting 11.22.20 Initial consultation with Reproductive Immunologist | 9.14.21 Decidualization score biopsy | 10.1.21 | abnormal - low score of 1; endometrial scratch recommended and progesterone supplementation Saline sono | 10.15.21 | normal Bloodwork | 10.21.21 | high TSH, high testosterone, positive for anti-nuclear antibodies and histone antibodies, high protein S, multiple genetic mutations BFP! | 11.3.21 | EDD 7.14.22 | biopsy provided same effect as endometrial scratch; added supplemental progesterone and estrogen, prednisone, levothyroxine, and MTX Support to maintain pregnancy DS born 7.19.22 after induction
TTC #2 begins 6.2023 Consultation with RI | 6.6.23 Saline sono, endometritis biopsy, skin & eye check | all normal Labs | high TSH, Factor XIII mutation, high %CD56 Follow up | 8.8.23 | prescribed metformin, prednisone, plaquenil, and levothyroxine Repeat labs after 3 weeks on meds Follow up | 11.9.23 | Green light!, increase in prednisone, added lovenox Repeat labs in 8 weeks Follow up | 1.16.24 | Green light continues TTC put on pause
TTC #1: May 2011 BFP: 10/27/2011 | EDD: 6/30/12 DS born 6/28/12 via C/S
TTC #2: September 2018 Me: 36 | DH: 39 Mirena removed 9/13/2018 after 6 years BFP 11/11/2018 | MC @ 5.5 weeks on Thanksgiving July 2019 - Diagnosed with Secondary Unexplained IF August 2019 - 2.5 mg of Letrozole = Never Ovulated so Trigger and IUI were cancelled 9/30/2019 - IUI #1 (5 mg of Letrozole + Trigger) = BFP but Betas showed CP @ 4 weeks 10/28/2019 - IUI #2 (7.5mg of Letrozole + Trigger) = BFN 11/25/2019 - IUI #3 (7.5mg of Letrozole, Trigger + Crinone after IUI) = BFN 12/24/2019 - IUI #4 (7.5mg of Letrozole + Crinone after IUI) = BFN 1/24/2020 - IUI #5 (50mg of Clomid + Trigger + Crinone after IUI) = BFN and an Ovarian Cyst 3/2/2020 - Taking a break to reset/NTNP 11/1/2020 - At peace with where things are in life and are no long actively TTC. Whatever happens will happen and it will all be okay.
Random question for my IVF ladies - I go back for monitoring tomorrow morning, and obviously I'll ask the question and get clarification from the nurse, but just for my own knowledge now - if they tell me to trigger tomorrow night, do I still do my regular stim shots of Gonal-F and Cetrotide along with the trigger?
Also, they only gave me 6 days worth of Cetrotide, so I have 3 days of that left after tonight, and 3 days of Gonal-F left after tonight, but I have refills on my RXs, how long did you ladies stay on stims once you introduced your antagonist?
me: 35 / so: 34 | ttc #1 since 9/2018
DX: MFI IVF Cycle #1 February 2020 4 embryos frozen, 1 fresh transfer = CP FET #1 Natural Cycle March 2020 CXL'd due to Covid-19 FET #1 Natural Cycle June 2020 - CP #2 FET #2 Natural Cycle July 2020 - BFP!!!!!! Beta #1 = 273
@mvt2003 WSS^. Weirdly in my original protocol my trigger was to be the day before the retrieval but it was 2 days before. Cue panic that I'd release ALL the eggs. 😆
@abarr723 I didn't join TB community until after we had gotten back my HSG and DH's SA results after trying for just over a year at that point. We were waiting for his urology appointment when I first joined and I was the only one that I knew personally who was dealing with these issues (my sides of the family seem to be fertile AF). This group has been a BLESSING both in helping navigate the newness of IF and being a major bright spot in my life.
*TW* History:
Me: 34 DH: 36 | Together since 2007 | Married July 2016
TTC #1 since 7.2017 Dx: low morph (1%), ANA positive, low decidualization score, high TSH and testosterone, histone antibodies
IUI #1-3| all BFN IVF #1 | 6.11.19 | 24R, 17M, 15F, 6B, PGT-A tested - 5 normal, 3 girls & 2 boys FET #1 | 9.10.19 | BFN "I know you, but we've never met. I'm with you, but I don't know your name" RPL, Receptiva, & ERA testing | all normal/negative, recommended going on gluten and dairy free diet for next FET FET #2 | 3.31.20 | Opted to cancelled due to pandemic, continued diet and tried naturally over the summer 2nd Opinion with another RE | 8.20.20 | Not immune to measles (received 1 dose); SA results similar to 2 years ago; decided to move forward with FET #2 redo at start of next cycle Surprise natural BFP! | 9.22.20 | MC 10.23.20 at 8 weeks TTCAL naturally | starting 11.22.20 Initial consultation with Reproductive Immunologist | 9.14.21 Decidualization score biopsy | 10.1.21 | abnormal - low score of 1; endometrial scratch recommended and progesterone supplementation Saline sono | 10.15.21 | normal Bloodwork | 10.21.21 | high TSH, high testosterone, positive for anti-nuclear antibodies and histone antibodies, high protein S, multiple genetic mutations BFP! | 11.3.21 | EDD 7.14.22 | biopsy provided same effect as endometrial scratch; added supplemental progesterone and estrogen, prednisone, levothyroxine, and MTX Support to maintain pregnancy DS born 7.19.22 after induction
TTC #2 begins 6.2023 Consultation with RI | 6.6.23 Saline sono, endometritis biopsy, skin & eye check | all normal Labs | high TSH, Factor XIII mutation, high %CD56 Follow up | 8.8.23 | prescribed metformin, prednisone, plaquenil, and levothyroxine Repeat labs after 3 weeks on meds Follow up | 11.9.23 | Green light!, increase in prednisone, added lovenox Repeat labs in 8 weeks Follow up | 1.16.24 | Green light continues TTC put on pause
@abarr723 that is so very true!! Thank you for sharing It's actually something I've been thinking about a lot lately.
AFM - Sorry to report bad news, my dear friends, but the beta was negative...again. Sigh. I will say that I am very proud of myself, though, for the way I am handling it. Thankfully DH was with me when I got the call this time, we work around the corner from one another and were meeting up for lunch, so that helped ease the blow. I was taken back a little bit when she told me my progesterone was still elevated and so they were thinking I O'd later than they originally thought. I had to remind them I was on progesterone and then it all made sense again for them. DH was not amused that they didn't remember what meds they had me on... annnnnyway... DH and I decided we are going to take a break from the meds and the tracking and just reset for a month. So we are going to NTNP this cycle and see how we feel at the end of it before jumping back into the meds and IUIs. We both really need a break to reset, as I can really see things have been effecting DH lately which then effects his ability to produce (the samples). He really wants to just take a break from "trying" and just enjoy each other and our lives again and basically be able to HIO whenever we want to. Which in all honesty, I think will be good for us and I think it's exactly what we need.
Thank you all for always being there, not just for me but for one another. This community, and all of you (including you, lurkers!!) mean so much me and I would not be able to get through month after month after month of this heartache without being able to lean on you amazing women. And I am beyond grateful that you get to lean on me too, when you need to.
Our TTC Journey
TTC #1: May 2011 BFP: 10/27/2011 | EDD: 6/30/12 DS born 6/28/12 via C/S
TTC #2: September 2018 Me: 36 | DH: 39 Mirena removed 9/13/2018 after 6 years BFP 11/11/2018 | MC @ 5.5 weeks on Thanksgiving July 2019 - Diagnosed with Secondary Unexplained IF August 2019 - 2.5 mg of Letrozole = Never Ovulated so Trigger and IUI were cancelled 9/30/2019 - IUI #1 (5 mg of Letrozole + Trigger) = BFP but Betas showed CP @ 4 weeks 10/28/2019 - IUI #2 (7.5mg of Letrozole + Trigger) = BFN 11/25/2019 - IUI #3 (7.5mg of Letrozole, Trigger + Crinone after IUI) = BFN 12/24/2019 - IUI #4 (7.5mg of Letrozole + Crinone after IUI) = BFN 1/24/2020 - IUI #5 (50mg of Clomid + Trigger + Crinone after IUI) = BFN and an Ovarian Cyst 3/2/2020 - Taking a break to reset/NTNP 11/1/2020 - At peace with where things are in life and are no long actively TTC. Whatever happens will happen and it will all be okay.
Thank you @feather_heather@inthewoods23 It makes me oddly nervous to see how much EWCM I have - my body is clearly like OK LADY I'M READY I also get a little nervous because weekends make me nervous with medical stuff in general!
Also, @inthewoods23 speaking of fertile family members, did I tell you my Fertile Myrtle SiL thought that my monitoring appointments were checking on my embryos?!
me: 35 / so: 34 | ttc #1 since 9/2018
DX: MFI IVF Cycle #1 February 2020 4 embryos frozen, 1 fresh transfer = CP FET #1 Natural Cycle March 2020 CXL'd due to Covid-19 FET #1 Natural Cycle June 2020 - CP #2 FET #2 Natural Cycle July 2020 - BFP!!!!!! Beta #1 = 273
Oh @kpearse99 I'm so sorry it was bad news! I've been refreshing all day to see what would happen. I'm thinking of you! A month-long break does sound good for both of you, it will be a good temporary weight off your shoulders while you regroup I'm sure. I'm glad you were with H and didn't have to get the news alone! You can relax a bit (as much as possible) this month and we'll be here when you need to talk!
@mvt2003 well when you're priming your body for LOTS of eggs it happens. Haha. I've noticed with the estradiol valerate injections I seem much more lubricated than normal. Thanks estrogen 😆
*TW* History:
Me: 34 DH: 36 | Together since 2007 | Married July 2016
TTC #1 since 7.2017 Dx: low morph (1%), ANA positive, low decidualization score, high TSH and testosterone, histone antibodies
IUI #1-3| all BFN IVF #1 | 6.11.19 | 24R, 17M, 15F, 6B, PGT-A tested - 5 normal, 3 girls & 2 boys FET #1 | 9.10.19 | BFN "I know you, but we've never met. I'm with you, but I don't know your name" RPL, Receptiva, & ERA testing | all normal/negative, recommended going on gluten and dairy free diet for next FET FET #2 | 3.31.20 | Opted to cancelled due to pandemic, continued diet and tried naturally over the summer 2nd Opinion with another RE | 8.20.20 | Not immune to measles (received 1 dose); SA results similar to 2 years ago; decided to move forward with FET #2 redo at start of next cycle Surprise natural BFP! | 9.22.20 | MC 10.23.20 at 8 weeks TTCAL naturally | starting 11.22.20 Initial consultation with Reproductive Immunologist | 9.14.21 Decidualization score biopsy | 10.1.21 | abnormal - low score of 1; endometrial scratch recommended and progesterone supplementation Saline sono | 10.15.21 | normal Bloodwork | 10.21.21 | high TSH, high testosterone, positive for anti-nuclear antibodies and histone antibodies, high protein S, multiple genetic mutations BFP! | 11.3.21 | EDD 7.14.22 | biopsy provided same effect as endometrial scratch; added supplemental progesterone and estrogen, prednisone, levothyroxine, and MTX Support to maintain pregnancy DS born 7.19.22 after induction
TTC #2 begins 6.2023 Consultation with RI | 6.6.23 Saline sono, endometritis biopsy, skin & eye check | all normal Labs | high TSH, Factor XIII mutation, high %CD56 Follow up | 8.8.23 | prescribed metformin, prednisone, plaquenil, and levothyroxine Repeat labs after 3 weeks on meds Follow up | 11.9.23 | Green light!, increase in prednisone, added lovenox Repeat labs in 8 weeks Follow up | 1.16.24 | Green light continues TTC put on pause
@kpearse99 I am so so so sorry you are having a rough day. I am glad that you are handling it well though! I think it is a great idea for you and hubs to take a break this month. It will be good for you both mentally to reset and go back to it refreshed if you so desire! Thinking of you!!
@inthewoods23 how long have you been TTC if you dont mind me asking?? I also have super fertile family members, so none of them would understand what I am going through. I have a few friends that I share my struggle with, but they all also have kids. Hence why I sought out some people who could understand what I am dealing with. This group has been the greatest find I could ever make! I was thinking the other day what I'm going to do if we end up pregnant, like it would probably be weird for me to continue to hang out here. lol
AFM: So I have spent a lot of time on the phone today with Avella (fertility pharmacy) getting my order for Ovidrel squared away. I had an issue with my FSA processing my payment, annoying. Also, they gave me a total of $197 for the Ovidrel! Does that seem right?! Do you ladies pay that much for trigger shots? I almost passed out when she told me the price.
May Siggy Challenge: It's Gonna be N*SYNC!
TTC #1: 1/2019 Dx: 1/2020 Borderline PCOS Rx: Femara &Trigger with IUI IUI#1 2/26/2020- BETA 3/11 (AF arrived 3/11) 3/20/2020- Benched due to COVID-19
@emmasemm@BusinessWife Thank you both for the advice and info! I think my gut is telling me to go with the PIO if possible. Wish that I could pre-order it now, but our clinic waits another couple weeks. FX! Sending you both love.
@kpearse99 Aw friend! My heart just breaks for you right now. Getting that news is gut wrenching. Do all the things you need to in order to heal your heart. Take the break for you and YH. Enjoy each other, laugh, cry, whatever you need to do. And know that we are here for you always.
@abarr723 feels like forever 😆 since the cycle that started in July 2017. I don't think I've paid more than $100 or so for my trigger shot and that actually was without insurance. With insurance I think I pay maybe 60? Definitely double check that the price is with insurance! That seems way high.
*TW* History:
Me: 34 DH: 36 | Together since 2007 | Married July 2016
TTC #1 since 7.2017 Dx: low morph (1%), ANA positive, low decidualization score, high TSH and testosterone, histone antibodies
IUI #1-3| all BFN IVF #1 | 6.11.19 | 24R, 17M, 15F, 6B, PGT-A tested - 5 normal, 3 girls & 2 boys FET #1 | 9.10.19 | BFN "I know you, but we've never met. I'm with you, but I don't know your name" RPL, Receptiva, & ERA testing | all normal/negative, recommended going on gluten and dairy free diet for next FET FET #2 | 3.31.20 | Opted to cancelled due to pandemic, continued diet and tried naturally over the summer 2nd Opinion with another RE | 8.20.20 | Not immune to measles (received 1 dose); SA results similar to 2 years ago; decided to move forward with FET #2 redo at start of next cycle Surprise natural BFP! | 9.22.20 | MC 10.23.20 at 8 weeks TTCAL naturally | starting 11.22.20 Initial consultation with Reproductive Immunologist | 9.14.21 Decidualization score biopsy | 10.1.21 | abnormal - low score of 1; endometrial scratch recommended and progesterone supplementation Saline sono | 10.15.21 | normal Bloodwork | 10.21.21 | high TSH, high testosterone, positive for anti-nuclear antibodies and histone antibodies, high protein S, multiple genetic mutations BFP! | 11.3.21 | EDD 7.14.22 | biopsy provided same effect as endometrial scratch; added supplemental progesterone and estrogen, prednisone, levothyroxine, and MTX Support to maintain pregnancy DS born 7.19.22 after induction
TTC #2 begins 6.2023 Consultation with RI | 6.6.23 Saline sono, endometritis biopsy, skin & eye check | all normal Labs | high TSH, Factor XIII mutation, high %CD56 Follow up | 8.8.23 | prescribed metformin, prednisone, plaquenil, and levothyroxine Repeat labs after 3 weeks on meds Follow up | 11.9.23 | Green light!, increase in prednisone, added lovenox Repeat labs in 8 weeks Follow up | 1.16.24 | Green light continues TTC put on pause
I've been in all-day development sessions at our head office this week so haven't had a chance to sneak onto TB at all but spent a few mins this aft trying to catch up a little.
@keikilove that's interesting that after all the time they spend looking at your insides with all the tests they've done, nobody has noticed you have a bicornate ute until now? Interesting. I'm sorry to hear that it's just another hurdle in your journey, but sometimes having some answers is better than none, and I've heard a few success stories over the years with people who have gone on to get KU after having the surgery. Trying to remember who it was now. If I remember I'll PM you. @kpearse99 no words, just sending so much love to you and YH. Taking some time off sounds like it's just what you need to regroup and allow yourselves to heal a little from the toll IF takes on all of us. @nitnat007 another fellow Cdn here with an upcoming FET who is affected by the PIO shortage. We weren't given the option of looking for a compounding pharmacy to try to order the PIO but if you do find out anything about that pls let me know because I'm very interested. I was given what feels like a lifetime supply of the suppositories (like 300+ of them @ a starting dose of 2 pearls 2x a day for potentially 12wks). My RE does PIO and suppositories anyway, so they're compensating by doubling up on the pearls. As much as I was dreading the PIO shots, I'm worried that might affect the outcome.
AFM, I'm still in limbo. Currently on my longest cycle since June and based on my very non-scientific calculations based on the few signs I was tracking (just CM and occasionally CP, and O pain) I'm currently 4-5 days late with BFNs on 13dpo and 15dpo. So who really knows wtf is going on. I'm starting to slightly freak out because the longer this cycle is, the further we push our FET back next month, and we went ahead and booked Portugal for mid-April plus we have a whole bunch of other stuff going on at the end of March so this is really stressing MH and I out. But trying to just take it one day at a time.
TTC History:
Me: 36 MH: 39, TTC since Dec 2017
Aug '18: PCOS dx
Nov '18: MH SA - 19mil
Dec '18-Mar '19: Letrozole + TI - all BFN
Apr '19: Letrozole + TI, - BFN. Repeat SA (27mil) & DNA fragmentation test (17%)
@inthewoods23 so apparently the first person I was dealing with neglected to add my insurance! 😒 with the insurance, the trigger is only $35, Thank god!
May Siggy Challenge: It's Gonna be N*SYNC!
TTC #1: 1/2019 Dx: 1/2020 Borderline PCOS Rx: Femara &Trigger with IUI IUI#1 2/26/2020- BETA 3/11 (AF arrived 3/11) 3/20/2020- Benched due to COVID-19
@abarr723 without insurance my trigger shot was around that price but with my insurance, and through one pharmacy in particular that’s about 40 minutes away, it’s only $50.00.
Our TTC Journey
TTC #1: May 2011 BFP: 10/27/2011 | EDD: 6/30/12 DS born 6/28/12 via C/S
TTC #2: September 2018 Me: 36 | DH: 39 Mirena removed 9/13/2018 after 6 years BFP 11/11/2018 | MC @ 5.5 weeks on Thanksgiving July 2019 - Diagnosed with Secondary Unexplained IF August 2019 - 2.5 mg of Letrozole = Never Ovulated so Trigger and IUI were cancelled 9/30/2019 - IUI #1 (5 mg of Letrozole + Trigger) = BFP but Betas showed CP @ 4 weeks 10/28/2019 - IUI #2 (7.5mg of Letrozole + Trigger) = BFN 11/25/2019 - IUI #3 (7.5mg of Letrozole, Trigger + Crinone after IUI) = BFN 12/24/2019 - IUI #4 (7.5mg of Letrozole + Crinone after IUI) = BFN 1/24/2020 - IUI #5 (50mg of Clomid + Trigger + Crinone after IUI) = BFN and an Ovarian Cyst 3/2/2020 - Taking a break to reset/NTNP 11/1/2020 - At peace with where things are in life and are no long actively TTC. Whatever happens will happen and it will all be okay.
@keikilove Will absolutely keep you posted. I was given two options to call, one I know has already run out. So I am starting to panic about it slightly. For both of my fresh transfers I did 2 pearls x 3 times a day. The dosage you have been given seems low? Do they come in different strengths? I assumed they were generic. Everything crossed for your cycle starting soon and not interfering with any of your current plans. Sending positive vibes!
@nitnat007 it seems really low to me too. They’re only 100mg each. For my IUIs I was on 2 pearls once a day already so that really doesn’t seem like enough.
TTC History:
Me: 36 MH: 39, TTC since Dec 2017
Aug '18: PCOS dx
Nov '18: MH SA - 19mil
Dec '18-Mar '19: Letrozole + TI - all BFN
Apr '19: Letrozole + TI, - BFN. Repeat SA (27mil) & DNA fragmentation test (17%)
@kpearse99 Sorry about the news today! I hope this month break helps you find new hope, relieves the stress of IF, and let’s you refocus. Many creepy internet hugs to you.
@kiki047 Hope you get answers soon so all the timing isn’t off for the other plans!
@abarr723 Glad they got your insurance applied to that!
@kiki047 Checked and mine are 100mg as well. I am fairly certain that that is the standard dose as well, as I did not get my progesterone levels checked after we started IVF. And from prior testing my progesterone level had always been normal.
*lurking* @kpearse99 I’m so sorry about the negative beta. You’ve been on my mind this week. I hope you and DH feel refreshed after a break. *creepy internet hugs*
Morning monitoring done, and they’ve already called me! My numbers are good - I’m up to 5 follies on the left, and 8 on the right, and my estrogen is rising.
I’m going back tomorrow morning for another check, they want to give some smaller ones a chance to catch up. My best guess is I trigger tomorrow and go for retrieval Tuesday! (Which is the one day MH has a huge work thing but he said screw it, this is more important 😭💕)
me: 35 / so: 34 | ttc #1 since 9/2018
DX: MFI IVF Cycle #1 February 2020 4 embryos frozen, 1 fresh transfer = CP FET #1 Natural Cycle March 2020 CXL'd due to Covid-19 FET #1 Natural Cycle June 2020 - CP #2 FET #2 Natural Cycle July 2020 - BFP!!!!!! Beta #1 = 273
Re: IF Testing & Treatment w/o 2/3
So AMH results are back and ultrasound results came in really fast...both good. AMH was 7.31 with ref range of 0.36-10.07 if that means anything to anyone? *shrug emoji*. Anyway two more normal tests which is good but is making me question our plan to do IUI before HSG so I may rethink that. I like to have as much info as possible plus I was reading last night that HSG can possibly make IUI more successful b/c it can clear out blockages like @begging4abump mentioned? Not totally sure yet but reconsidering...we have a few weeks to decide though. SO didn't seem toootally dead-set against spending the money for the HSG when we talked last night.
By pearls I assume you mean the suppositories?
Downside is you will need to wear a liner also at night (and a long one if you insert in both places) and some people do get irritation which can cause bleeding from your cervix which is of course enough to cause lots of panic!
Its difficult to know if you are one of the small % who don’t absorb the progesterone well this way.
PIO does go through your bloodstream to get to where it is needed so you can test levels in your blood to make sure your dose is enough. But the painful IM shots are, well, a pain. They seem to cause some people more discomfort than others though. You don’t get the irritation and thus bleeding risk. Dosage is more difficult to alter. Most Drs will only do once per day but some will go up to twice if your blood test results come back very low. Or they will add in the pearls on top of the PIO.
Depending on supply and what it is mixed with (you can get it mixed in different oils!) it can be really expensive if you have to pay yourself.
If I remember right you’re in Canada? You could ask or look up if Lubion (also sometimes licenced as Prolutex) is available in Canada now? This is an injectible progesterone but only needs to be given subcutaneously so you avoid the painful part of PIO but get all the other benefits. I used this on my last transfer and it was great as I did have to do two injections per day (as my body doesn’t seem to like to make any progesterone on its own, lazy devil!) which would quite literally have been a pain in the butt with PIO!
Married 12/2016
TTC #1 since 04/2015
AMA, DOR (AMH 0.65, AFC 2-4) and autoimmune issues (RA, APS), low TSH, adenomyosis
7 retrievals, 3 transfers
Nov17 IVF2 - 1ER, 0F
Jan18 IVF3 - 3ER, 1F, 1ET, BFN
Feb18 - second opinion and additional testing
Apr18 IVF4 - cancelled (E2 too high)
May/Jun18 IVF4 - 4ER, 0M, 1F, 1 frozen day 3 (not best quality)
Jun/Jul18 IVF5 - 5 ER, 3M, 2F, 2 frozen day 3 (not best quality)
Jul/Aug18 IVF6 - 4ER, 3M, 2F, 2 frozen day 3 (good quality)
Aug/Sep18 IVF7 - cancelled (cyst)
Sep/Oct18 IVF7 - 3ER, 3M, 2F, 2 frozen Day 3 (excellent quality)
Oct18 IVF8 - Cancelled (cyst and too low TSH)
Oct18-Jan19 bringing TSH under control
Feb19 ERA and hysteroscopy
Mar19 Investigation for fibroid and adenomyosis
Apr19 adenomyosis confirmed, polyps removed
Jun19 FET after 2 months Lupron, autoimmune protocol, transferred two day 3 frozen embryos
Nov17 IVF2 - Pergoveris 2-14 Nov, Orgalutran 5-14 Nov, Ovitrelle 15 Nov, ER 17 Nov for 3 follies, 1 mature egg, did not fertilize
Jan18 IVF3 - Pergoveris 30 Dec - 8 Jan, Orgalutran 5-8 Jan, Ovitrelle 9 Jan, ER 11 Jan 3 eggs, 2 mature, 1 fertilized, ET 1x 4d 12-cell embryo 15/01, 24/01 BFN
May/Jun18 IVF4 - Rekovelle 25-29 May, Menogon 30May - 2Jun, Zomacton 25 27 29 31 May and 2Jun, Cetrotide 30May - 3Jun, Gonasi 3Jun, ER 5Jun 4 eggs, none mature, two matured overnight, 1 fertilized with ICSI, Frozen day 3 but not good quality
Jun/Jul18 IVF5 - Rekovelle 21-24 June, Menogon 25Jun-3Jul, Puregon 4-5Jul, Zomacton 21 23 25 27 29 Jun, Cetrotide 25Jun-5Jul, Gonasi 6Jul, ER 8Jul 5 eggs, 3 mature, 2 fertilized with ICSI, 2 frozen day 3 but not good quality
Jul/Aug18 IVF6 - Rekovelle 26-29 Jul, Menogon 30Jul-7Aug, Buserelin 26Jul-7Aug, Zomacton 26 28 30 Jul 1 3 Aug, Gonasi 7Aug, ER 9Aug 4 eggs, 3 mature, 2 fertilized (normal IVF), 2 frozen day 3 good quality
Sep/Oct18 IVF7 - Menogon 19-30Sep, Buserelin 19-30Sep, Zomacton 19 21 23 25 27 Sep, Ovitrelle 1 Oct, ER 3 eggs, 3 mature, 2 fertilized with ICSI, 2 frozen day 3 excellent quality
Fav Quote: The greatest thing you'll ever learn is just to love and be loved in return
Unfortunately it doesn't look like we get Lubion in Canada as yet (wouldn't that have been convenient). And it appears that the supply of PIO up here is depleting rapidly, so I am not even sure if that will still be an option for me by the time March rolls around. Even with sourcing through a compounding pharmacy.
I have done the suppositories/pearls with both of my fresh transfers. I didn't find them bad to deal with. But both of them failed, so obviously there is that little piece of doubt that sits with me going "what if". I just didn't want to have any regrets as this is our only frozen embryo we have. If that meant dealing with a little pain in the butt, then so be it.
I have not read the study personally, but have heard there is one that was done recently indicating the success rates of the combination of PIO and suppositories. PIO until week 6, I believe, then switching to suppositories. I will have to see if I can source it and share here.
The PIO I had didn’t have too short a shelf life, so you could probably already source it now for March.
I’m keeping everything crossed for you!!!
Married 12/2016
TTC #1 since 04/2015
AMA, DOR (AMH 0.65, AFC 2-4) and autoimmune issues (RA, APS), low TSH, adenomyosis
7 retrievals, 3 transfers
Nov17 IVF2 - 1ER, 0F
Jan18 IVF3 - 3ER, 1F, 1ET, BFN
Feb18 - second opinion and additional testing
Apr18 IVF4 - cancelled (E2 too high)
May/Jun18 IVF4 - 4ER, 0M, 1F, 1 frozen day 3 (not best quality)
Jun/Jul18 IVF5 - 5 ER, 3M, 2F, 2 frozen day 3 (not best quality)
Jul/Aug18 IVF6 - 4ER, 3M, 2F, 2 frozen day 3 (good quality)
Aug/Sep18 IVF7 - cancelled (cyst)
Sep/Oct18 IVF7 - 3ER, 3M, 2F, 2 frozen Day 3 (excellent quality)
Oct18 IVF8 - Cancelled (cyst and too low TSH)
Oct18-Jan19 bringing TSH under control
Feb19 ERA and hysteroscopy
Mar19 Investigation for fibroid and adenomyosis
Apr19 adenomyosis confirmed, polyps removed
Jun19 FET after 2 months Lupron, autoimmune protocol, transferred two day 3 frozen embryos
Nov17 IVF2 - Pergoveris 2-14 Nov, Orgalutran 5-14 Nov, Ovitrelle 15 Nov, ER 17 Nov for 3 follies, 1 mature egg, did not fertilize
Jan18 IVF3 - Pergoveris 30 Dec - 8 Jan, Orgalutran 5-8 Jan, Ovitrelle 9 Jan, ER 11 Jan 3 eggs, 2 mature, 1 fertilized, ET 1x 4d 12-cell embryo 15/01, 24/01 BFN
May/Jun18 IVF4 - Rekovelle 25-29 May, Menogon 30May - 2Jun, Zomacton 25 27 29 31 May and 2Jun, Cetrotide 30May - 3Jun, Gonasi 3Jun, ER 5Jun 4 eggs, none mature, two matured overnight, 1 fertilized with ICSI, Frozen day 3 but not good quality
Jun/Jul18 IVF5 - Rekovelle 21-24 June, Menogon 25Jun-3Jul, Puregon 4-5Jul, Zomacton 21 23 25 27 29 Jun, Cetrotide 25Jun-5Jul, Gonasi 6Jul, ER 8Jul 5 eggs, 3 mature, 2 fertilized with ICSI, 2 frozen day 3 but not good quality
Jul/Aug18 IVF6 - Rekovelle 26-29 Jul, Menogon 30Jul-7Aug, Buserelin 26Jul-7Aug, Zomacton 26 28 30 Jul 1 3 Aug, Gonasi 7Aug, ER 9Aug 4 eggs, 3 mature, 2 fertilized (normal IVF), 2 frozen day 3 good quality
Sep/Oct18 IVF7 - Menogon 19-30Sep, Buserelin 19-30Sep, Zomacton 19 21 23 25 27 Sep, Ovitrelle 1 Oct, ER 3 eggs, 3 mature, 2 fertilized with ICSI, 2 frozen day 3 excellent quality
Fav Quote: The greatest thing you'll ever learn is just to love and be loved in return
@nitnat007 I used a compounding pharmacy when there was the PIO shortage of 2017, and it was nbd. I had mine compounded in olive oil instead of sesame, since the sesame was giving me a reaction.
*TWs* IVF success / failure
<div class=" Spoiler">Ffwd to 2019 and we tried to switch up the protocol, and sadly our first natural cycle (with pearls!) Failed. 😓 So we went back to the proven medicated course with PIO and this time my body didn't respond. No idea why! But eventually the natural cycle worked. Just took us several goes. If you feel more comfortable upping the ante and doing the PIO+pearls, I say reach out to the compounding pharmacy and try that route. But that said, if your levels were rising appropriately on the pearls before with your fresh transfers, I'm not sure there's any reason to think that would have been the cause of the unsuccessful cycles. :/ (((Hugs)))</div>
fx you get your hands on what you need, and your THB is on his/her way to you, friend! ❤️❤️❤️
@keikilove YGPM
TTC #1 since 7.2017
Dx: low morph (1%), ANA positive, low decidualization score, high TSH and testosterone, histone antibodies
IUI #1-3 | all BFN
IVF #1 | 6.11.19 | 24R, 17M, 15F, 6B, PGT-A tested - 5 normal, 3 girls & 2 boys
FET #1 | 9.10.19 | BFN "I know you, but we've never met. I'm with you, but I don't know your name"
RPL, Receptiva, & ERA testing | all normal/negative, recommended going on gluten and dairy free diet for next FET
FET #2 | 3.31.20 | Opted to cancelled due to pandemic, continued diet and tried naturally over the summer
2nd Opinion with another RE | 8.20.20 | Not immune to measles (received 1 dose); SA results similar to 2 years ago; decided to move forward with FET #2 redo at start of next cycle
Surprise natural BFP! | 9.22.20 | MC 10.23.20 at 8 weeks
TTCAL naturally | starting 11.22.20
Initial consultation with Reproductive Immunologist | 9.14.21
Decidualization score biopsy | 10.1.21 | abnormal - low score of 1; endometrial scratch recommended and progesterone supplementation
Saline sono | 10.15.21 | normal
Bloodwork | 10.21.21 | high TSH, high testosterone, positive for anti-nuclear antibodies and histone antibodies, high protein S, multiple genetic mutations
BFP! | 11.3.21 | EDD 7.14.22
DS born 7.19.22 after induction
TTC #2 begins 6.2023
Consultation with RI | 6.6.23
Saline sono, endometritis biopsy, skin & eye check | all normal
Labs | high TSH, Factor XIII mutation, high %CD56
Follow up | 8.8.23 | prescribed metformin, prednisone, plaquenil, and levothyroxine
Repeat labs after 3 weeks on meds
Follow up | 11.9.23 | Green light!, increase in prednisone, added lovenox
Repeat labs in 8 weeks
Follow up | 1.16.24 | Green light continues
TTC put on pause
BFP: 10/27/2011 | EDD: 6/30/12
DS born 6/28/12 via C/S
TTC #2: September 2018
Me: 36 | DH: 39
Mirena removed 9/13/2018 after 6 years
BFP 11/11/2018 | MC @ 5.5 weeks on Thanksgiving
July 2019 - Diagnosed with Secondary Unexplained IF
August 2019 - 2.5 mg of Letrozole = Never Ovulated so Trigger and IUI were cancelled
9/30/2019 - IUI #1 (5 mg of Letrozole + Trigger) = BFP but Betas showed CP @ 4 weeks
10/28/2019 - IUI #2 (7.5mg of Letrozole + Trigger) = BFN
11/25/2019 - IUI #3 (7.5mg of Letrozole, Trigger + Crinone after IUI) = BFN
12/24/2019 - IUI #4 (7.5mg of Letrozole + Crinone after IUI) = BFN
1/24/2020 - IUI #5 (50mg of Clomid + Trigger + Crinone after IUI) = BFN and an Ovarian Cyst
3/2/2020 - Taking a break to reset/NTNP
11/1/2020 - At peace with where things are in life and are no long actively TTC. Whatever happens will happen and it will all be okay.
I know I have only been a part of the Bump community for a short time, but you ladies have definitely helped me emotionally and to remain positive!
Dx: 1/2020 Borderline PCOS
Rx: Femara &Trigger with IUI
IUI#1 2/26/2020- BETA 3/11 (AF arrived 3/11)
3/20/2020- Benched due to COVID-19
Random question for my IVF ladies - I go back for monitoring tomorrow morning, and obviously I'll ask the question and get clarification from the nurse, but just for my own knowledge now - if they tell me to trigger tomorrow night, do I still do my regular stim shots of Gonal-F and Cetrotide along with the trigger?
Also, they only gave me 6 days worth of Cetrotide, so I have 3 days of that left after tonight, and 3 days of Gonal-F left after tonight, but I have refills on my RXs, how long did you ladies stay on stims once you introduced your antagonist?
IVF Cycle #1 February 2020 4 embryos frozen, 1 fresh transfer = CP
FET #1 Natural Cycle March 2020 CXL'd due to Covid-19
FET #1 Natural Cycle June 2020 - CP #2
FET #2 Natural Cycle July 2020 - BFP!!!!!! Beta #1 = 273
June Signature Challenge - Favorite TV Quotes
@abarr723 - Love that!
@abarr723 I didn't join TB community until after we had gotten back my HSG and DH's SA results after trying for just over a year at that point. We were waiting for his urology appointment when I first joined and I was the only one that I knew personally who was dealing with these issues (my sides of the family seem to be fertile AF). This group has been a BLESSING both in helping navigate the newness of IF and being a major bright spot in my life.
TTC #1 since 7.2017
Dx: low morph (1%), ANA positive, low decidualization score, high TSH and testosterone, histone antibodies
IUI #1-3 | all BFN
IVF #1 | 6.11.19 | 24R, 17M, 15F, 6B, PGT-A tested - 5 normal, 3 girls & 2 boys
FET #1 | 9.10.19 | BFN "I know you, but we've never met. I'm with you, but I don't know your name"
RPL, Receptiva, & ERA testing | all normal/negative, recommended going on gluten and dairy free diet for next FET
FET #2 | 3.31.20 | Opted to cancelled due to pandemic, continued diet and tried naturally over the summer
2nd Opinion with another RE | 8.20.20 | Not immune to measles (received 1 dose); SA results similar to 2 years ago; decided to move forward with FET #2 redo at start of next cycle
Surprise natural BFP! | 9.22.20 | MC 10.23.20 at 8 weeks
TTCAL naturally | starting 11.22.20
Initial consultation with Reproductive Immunologist | 9.14.21
Decidualization score biopsy | 10.1.21 | abnormal - low score of 1; endometrial scratch recommended and progesterone supplementation
Saline sono | 10.15.21 | normal
Bloodwork | 10.21.21 | high TSH, high testosterone, positive for anti-nuclear antibodies and histone antibodies, high protein S, multiple genetic mutations
BFP! | 11.3.21 | EDD 7.14.22
DS born 7.19.22 after induction
TTC #2 begins 6.2023
Consultation with RI | 6.6.23
Saline sono, endometritis biopsy, skin & eye check | all normal
Labs | high TSH, Factor XIII mutation, high %CD56
Follow up | 8.8.23 | prescribed metformin, prednisone, plaquenil, and levothyroxine
Repeat labs after 3 weeks on meds
Follow up | 11.9.23 | Green light!, increase in prednisone, added lovenox
Repeat labs in 8 weeks
Follow up | 1.16.24 | Green light continues
TTC put on pause
AFM - Sorry to report bad news, my dear friends, but the beta was negative...again. Sigh. I will say that I am very proud of myself, though, for the way I am handling it. Thankfully DH was with me when I got the call this time, we work around the corner from one another and were meeting up for lunch, so that helped ease the blow. I was taken back a little bit when she told me my progesterone was still elevated and so they were thinking I O'd later than they originally thought. I had to remind them I was on progesterone
Thank you all for always being there, not just for me but for one another. This community, and all of you (including you, lurkers!!) mean so much me and I would not be able to get through month after month after month of this heartache without being able to lean on you amazing women. And I am beyond grateful that you get to lean on me too, when you need to.
BFP: 10/27/2011 | EDD: 6/30/12
DS born 6/28/12 via C/S
TTC #2: September 2018
Me: 36 | DH: 39
Mirena removed 9/13/2018 after 6 years
BFP 11/11/2018 | MC @ 5.5 weeks on Thanksgiving
July 2019 - Diagnosed with Secondary Unexplained IF
August 2019 - 2.5 mg of Letrozole = Never Ovulated so Trigger and IUI were cancelled
9/30/2019 - IUI #1 (5 mg of Letrozole + Trigger) = BFP but Betas showed CP @ 4 weeks
10/28/2019 - IUI #2 (7.5mg of Letrozole + Trigger) = BFN
11/25/2019 - IUI #3 (7.5mg of Letrozole, Trigger + Crinone after IUI) = BFN
12/24/2019 - IUI #4 (7.5mg of Letrozole + Crinone after IUI) = BFN
1/24/2020 - IUI #5 (50mg of Clomid + Trigger + Crinone after IUI) = BFN and an Ovarian Cyst
3/2/2020 - Taking a break to reset/NTNP
11/1/2020 - At peace with where things are in life and are no long actively TTC. Whatever happens will happen and it will all be okay.
Also, @inthewoods23 speaking of fertile family members, did I tell you my Fertile Myrtle SiL thought that my monitoring appointments were checking on my embryos?!
IVF Cycle #1 February 2020 4 embryos frozen, 1 fresh transfer = CP
FET #1 Natural Cycle March 2020 CXL'd due to Covid-19
FET #1 Natural Cycle June 2020 - CP #2
FET #2 Natural Cycle July 2020 - BFP!!!!!! Beta #1 = 273
June Signature Challenge - Favorite TV Quotes
@mvt2003 well when you're priming your body for LOTS of eggs it happens. Haha. I've noticed with the estradiol valerate injections I seem much more lubricated than normal. Thanks estrogen 😆
TTC #1 since 7.2017
Dx: low morph (1%), ANA positive, low decidualization score, high TSH and testosterone, histone antibodies
IUI #1-3 | all BFN
IVF #1 | 6.11.19 | 24R, 17M, 15F, 6B, PGT-A tested - 5 normal, 3 girls & 2 boys
FET #1 | 9.10.19 | BFN "I know you, but we've never met. I'm with you, but I don't know your name"
RPL, Receptiva, & ERA testing | all normal/negative, recommended going on gluten and dairy free diet for next FET
FET #2 | 3.31.20 | Opted to cancelled due to pandemic, continued diet and tried naturally over the summer
2nd Opinion with another RE | 8.20.20 | Not immune to measles (received 1 dose); SA results similar to 2 years ago; decided to move forward with FET #2 redo at start of next cycle
Surprise natural BFP! | 9.22.20 | MC 10.23.20 at 8 weeks
TTCAL naturally | starting 11.22.20
Initial consultation with Reproductive Immunologist | 9.14.21
Decidualization score biopsy | 10.1.21 | abnormal - low score of 1; endometrial scratch recommended and progesterone supplementation
Saline sono | 10.15.21 | normal
Bloodwork | 10.21.21 | high TSH, high testosterone, positive for anti-nuclear antibodies and histone antibodies, high protein S, multiple genetic mutations
BFP! | 11.3.21 | EDD 7.14.22
DS born 7.19.22 after induction
TTC #2 begins 6.2023
Consultation with RI | 6.6.23
Saline sono, endometritis biopsy, skin & eye check | all normal
Labs | high TSH, Factor XIII mutation, high %CD56
Follow up | 8.8.23 | prescribed metformin, prednisone, plaquenil, and levothyroxine
Repeat labs after 3 weeks on meds
Follow up | 11.9.23 | Green light!, increase in prednisone, added lovenox
Repeat labs in 8 weeks
Follow up | 1.16.24 | Green light continues
TTC put on pause
@inthewoods23 how long have you been TTC if you dont mind me asking?? I also have super fertile family members, so none of them would understand what I am going through. I have a few friends that I share my struggle with, but they all also have kids. Hence why I sought out some people who could understand what I am dealing with. This group has been the greatest find I could ever make! I was thinking the other day what I'm going to do if we end up pregnant, like it would probably be weird for me to continue to hang out here. lol
AFM: So I have spent a lot of time on the phone today with Avella (fertility pharmacy) getting my order for Ovidrel squared away. I had an issue with my FSA processing my payment, annoying. Also, they gave me a total of $197 for the Ovidrel! Does that seem right?! Do you ladies pay that much for trigger shots? I almost passed out when she told me the price.
Dx: 1/2020 Borderline PCOS
Rx: Femara &Trigger with IUI
IUI#1 2/26/2020- BETA 3/11 (AF arrived 3/11)
3/20/2020- Benched due to COVID-19
@kpearse99 Aw friend! My heart just breaks for you right now. Getting that news is gut wrenching. Do all the things you need to in order to heal your heart. Take the break for you and YH. Enjoy each other, laugh, cry, whatever you need to do. And know that we are here for you always.
TTC #1 since 7.2017
Dx: low morph (1%), ANA positive, low decidualization score, high TSH and testosterone, histone antibodies
IUI #1-3 | all BFN
IVF #1 | 6.11.19 | 24R, 17M, 15F, 6B, PGT-A tested - 5 normal, 3 girls & 2 boys
FET #1 | 9.10.19 | BFN "I know you, but we've never met. I'm with you, but I don't know your name"
RPL, Receptiva, & ERA testing | all normal/negative, recommended going on gluten and dairy free diet for next FET
FET #2 | 3.31.20 | Opted to cancelled due to pandemic, continued diet and tried naturally over the summer
2nd Opinion with another RE | 8.20.20 | Not immune to measles (received 1 dose); SA results similar to 2 years ago; decided to move forward with FET #2 redo at start of next cycle
Surprise natural BFP! | 9.22.20 | MC 10.23.20 at 8 weeks
TTCAL naturally | starting 11.22.20
Initial consultation with Reproductive Immunologist | 9.14.21
Decidualization score biopsy | 10.1.21 | abnormal - low score of 1; endometrial scratch recommended and progesterone supplementation
Saline sono | 10.15.21 | normal
Bloodwork | 10.21.21 | high TSH, high testosterone, positive for anti-nuclear antibodies and histone antibodies, high protein S, multiple genetic mutations
BFP! | 11.3.21 | EDD 7.14.22
DS born 7.19.22 after induction
TTC #2 begins 6.2023
Consultation with RI | 6.6.23
Saline sono, endometritis biopsy, skin & eye check | all normal
Labs | high TSH, Factor XIII mutation, high %CD56
Follow up | 8.8.23 | prescribed metformin, prednisone, plaquenil, and levothyroxine
Repeat labs after 3 weeks on meds
Follow up | 11.9.23 | Green light!, increase in prednisone, added lovenox
Repeat labs in 8 weeks
Follow up | 1.16.24 | Green light continues
TTC put on pause
I've been in all-day development sessions at our head office this week so haven't had a chance to sneak onto TB at all but spent a few mins this aft trying to catch up a little.
@keikilove
@kpearse99
@nitnat007 another fellow Cdn here with an upcoming FET who is affected by the PIO shortage. We weren't given the option of looking for a compounding pharmacy to try to order the PIO but if you do find out anything about that pls let me know because I'm very interested. I was given what feels like a lifetime supply of the suppositories (like 300+ of them @ a starting dose of 2 pearls 2x a day for potentially 12wks). My RE does PIO and suppositories anyway, so they're compensating by doubling up on the pearls. As much as I was dreading the PIO shots, I'm worried that might affect the outcome.
AFM, I'm still in limbo. Currently on my longest cycle since June and based on my very non-scientific calculations based on the few signs I was tracking (just CM and occasionally CP, and O pain) I'm currently 4-5 days late with BFNs on 13dpo and 15dpo. So who really knows wtf is going on. I'm starting to slightly freak out because the longer this cycle is, the further we push our FET back next month, and we went ahead and booked Portugal for mid-April plus we have a whole bunch of other stuff going on at the end of March so this is really stressing MH and I out. But trying to just take it one day at a time.
TTC History:
Me: 36 MH: 39, TTC since Dec 2017
Aug '18: PCOS dx
Nov '18: MH SA - 19mil
Dec '18-Mar '19: Letrozole + TI - all BFN
Apr '19: Letrozole + TI, - BFN. Repeat SA (27mil) & DNA fragmentation test (17%)
Aug '19: Letrozole + HCG trigger + IUI + prog supp - BFN (MH: 16mil)
Sep '19: 2nd IUI, same protocol - BFN (MH: 16mil)
Dec '19: IVF #1 w/ICSI, PGT. 5 retrieved, 4 fertilized, 3 blasts, 3 PGT-A normal.
Mar '20: FET #1, perfect 5AA blast transferred. BFN.
Sept '20: FET #2, 5BB tsf. 9/18/20 BFP!! EDD: 5/27/21. MMC 11w
Feb ‘21: FET #3, last 6BB blast transferred. BFP, EDD 11/2/21. MC 5w3d.
May '21: IVF #2 w/ICSI, PGT. 8R, 7M, 6F, 6 blasts - 3AB, 3AB, 3BB, 4BB, 5BB, 6BA. Fresh tsf 5/13/21 - BFN.
June '21: PGT-A results = 3 abnormal, 1 low level mosaic. Referred to new REI, had consult with 2nd RE in between.
Sept '21: RPL, immune testing normal
Oct '21: IVF #3 w/IMSI, PGT. 33R, 26M, 23F, 9 blasts (7 day 6, 2 day 7). PGT-A = 5 normal, 1 mosaic
Dec '21: Positive for endometritis, RX Flagyl & Keflex
Jan '22: FET #5 - Kitchen sink immune/RIF protocol incl. PRP, intralipids, prednisone, medrol, nivestym, fragmin - CP
Feb '22: FET #6 - Kitchen sink immune/RIF protocol w/higher doses of pred & fragmin - BFN
Mar '22: Mock cycle for ERA - cancelled, repeat endometrial biopsy instead. Still positive for endometritis. RX ciprofloxacin & amoxicillin.
Apr '22: IVF #4 w/IMSI, PGT. 28R, 23M, 16F, 11 blasts. PGT-A = 6 normal.
June '22: FET #7 - Microdose lupron downreg w/kitchen sink immune/RIF protocol - double embryo transfer. BFN.
July '22: FET #8 - Mini stim w/Puregon + trigger, kitchen sink immune/RIF protocol. BFN.
Sep '22: Taking a break
Dec '22: Attempted abdominal myomectomy, fibroid too close to cervix and major blood vessels. Wasn't removed.
Feb '23: FET #9 - Modified natural w/baby asp, HCG trigger, PIO, PRP, Medrol, HCG wash, embryo glue - BFP!! EDD 11/11/23
Dx: 1/2020 Borderline PCOS
Rx: Femara &Trigger with IUI
IUI#1 2/26/2020- BETA 3/11 (AF arrived 3/11)
3/20/2020- Benched due to COVID-19
BFP: 10/27/2011 | EDD: 6/30/12
DS born 6/28/12 via C/S
TTC #2: September 2018
Me: 36 | DH: 39
Mirena removed 9/13/2018 after 6 years
BFP 11/11/2018 | MC @ 5.5 weeks on Thanksgiving
July 2019 - Diagnosed with Secondary Unexplained IF
August 2019 - 2.5 mg of Letrozole = Never Ovulated so Trigger and IUI were cancelled
9/30/2019 - IUI #1 (5 mg of Letrozole + Trigger) = BFP but Betas showed CP @ 4 weeks
10/28/2019 - IUI #2 (7.5mg of Letrozole + Trigger) = BFN
11/25/2019 - IUI #3 (7.5mg of Letrozole, Trigger + Crinone after IUI) = BFN
12/24/2019 - IUI #4 (7.5mg of Letrozole + Crinone after IUI) = BFN
1/24/2020 - IUI #5 (50mg of Clomid + Trigger + Crinone after IUI) = BFN and an Ovarian Cyst
3/2/2020 - Taking a break to reset/NTNP
11/1/2020 - At peace with where things are in life and are no long actively TTC. Whatever happens will happen and it will all be okay.
@keikilove sending you love. 💜 I agree that it's interesting they haven't noticed your bicornate uterus before. I would have so many questions.
Everything crossed for your cycle starting soon and not interfering with any of your current plans. Sending positive vibes!
TTC History:
Me: 36 MH: 39, TTC since Dec 2017
Aug '18: PCOS dx
Nov '18: MH SA - 19mil
Dec '18-Mar '19: Letrozole + TI - all BFN
Apr '19: Letrozole + TI, - BFN. Repeat SA (27mil) & DNA fragmentation test (17%)
Aug '19: Letrozole + HCG trigger + IUI + prog supp - BFN (MH: 16mil)
Sep '19: 2nd IUI, same protocol - BFN (MH: 16mil)
Dec '19: IVF #1 w/ICSI, PGT. 5 retrieved, 4 fertilized, 3 blasts, 3 PGT-A normal.
Mar '20: FET #1, perfect 5AA blast transferred. BFN.
Sept '20: FET #2, 5BB tsf. 9/18/20 BFP!! EDD: 5/27/21. MMC 11w
Feb ‘21: FET #3, last 6BB blast transferred. BFP, EDD 11/2/21. MC 5w3d.
May '21: IVF #2 w/ICSI, PGT. 8R, 7M, 6F, 6 blasts - 3AB, 3AB, 3BB, 4BB, 5BB, 6BA. Fresh tsf 5/13/21 - BFN.
June '21: PGT-A results = 3 abnormal, 1 low level mosaic. Referred to new REI, had consult with 2nd RE in between.
Sept '21: RPL, immune testing normal
Oct '21: IVF #3 w/IMSI, PGT. 33R, 26M, 23F, 9 blasts (7 day 6, 2 day 7). PGT-A = 5 normal, 1 mosaic
Dec '21: Positive for endometritis, RX Flagyl & Keflex
Jan '22: FET #5 - Kitchen sink immune/RIF protocol incl. PRP, intralipids, prednisone, medrol, nivestym, fragmin - CP
Feb '22: FET #6 - Kitchen sink immune/RIF protocol w/higher doses of pred & fragmin - BFN
Mar '22: Mock cycle for ERA - cancelled, repeat endometrial biopsy instead. Still positive for endometritis. RX ciprofloxacin & amoxicillin.
Apr '22: IVF #4 w/IMSI, PGT. 28R, 23M, 16F, 11 blasts. PGT-A = 6 normal.
June '22: FET #7 - Microdose lupron downreg w/kitchen sink immune/RIF protocol - double embryo transfer. BFN.
July '22: FET #8 - Mini stim w/Puregon + trigger, kitchen sink immune/RIF protocol. BFN.
Sep '22: Taking a break
Dec '22: Attempted abdominal myomectomy, fibroid too close to cervix and major blood vessels. Wasn't removed.
Feb '23: FET #9 - Modified natural w/baby asp, HCG trigger, PIO, PRP, Medrol, HCG wash, embryo glue - BFP!! EDD 11/11/23
@kpearse99 I’m so sorry about the negative beta. You’ve been on my mind this week. I hope you and DH feel refreshed after a break. *creepy internet hugs*
IVF Cycle #1 February 2020 4 embryos frozen, 1 fresh transfer = CP
FET #1 Natural Cycle March 2020 CXL'd due to Covid-19
FET #1 Natural Cycle June 2020 - CP #2
FET #2 Natural Cycle July 2020 - BFP!!!!!! Beta #1 = 273
June Signature Challenge - Favorite TV Quotes