This is a place for those of us who have already started TTC, but have started infertility testing and/or treatments. You can express your thoughts, feelings, and frustrations on infertility. TTC can be a long journey naturally, then add in the difficulties associated with infertility, and it becomes a whole new ball game. The road to infertility can be lonely, frustrating, and complicated, so let's make this a place where we can vent, ask questions, and support one another. Feel free to resurrect this thread at any point in the week if you have something to say. Treat this as an ongoing conversation.
Diagnosis (if you've been):
Status (WTO/TWW/TTA):
What are you doing this cycle? (Testing? Treatment?):
How are things going?:
Any questions?:
GTKY: What do you enjoy most at carnivals or amusement parks, (like a specific game or ride or food)?
Re: IF testing and treatment w/o 5/27
Status (WTO/TWW/TTA): WFAF
What are you doing this cycle? (Testing? Treatment?): Fingers crossed, FET
How are things going?:
Well AF should be today - but it’s already after 12 here so I guess she’s taking her own sweet time. I’ve felt her coming since Saturday, but even after more than 4 years she still likes to keep me guessing from time to time!
We have just got back from a long weekend away with family - which was nice but also tough as we were the only ones without kids. It was mostly ok except Saturday afternoon I don’t know if it was AF coming or the Lupron I’m on, but I was really ready to explode or cry so we took ourselves off for some alone time. Now we have two days before we head off for another long weekend with the other half of the family. Trying to get ourselves up to date with all family before the FET!
Any questions?: Nope
GTKY: What do you enjoy most at carnivals or amusement parks, (like a specific game or ride or food)?
Mmmm candy floss and caramelized cashews... nougat, rock... all the sugary carnival foods!
I used to love all the rides but these days I get injured too easily so avoiding them.
Married 12/2016
TTC #1 since 04/2015
AMA, DOR (AMH 0.65, AFC 2-4) and autoimmune issues (RA, APS), low TSH, adenomyosis
7 retrievals, 3 transfers
Nov17 IVF2 - 1ER, 0F
Jan18 IVF3 - 3ER, 1F, 1ET, BFN
Feb18 - second opinion and additional testing
Apr18 IVF4 - cancelled (E2 too high)
May/Jun18 IVF4 - 4ER, 0M, 1F, 1 frozen day 3 (not best quality)
Jun/Jul18 IVF5 - 5 ER, 3M, 2F, 2 frozen day 3 (not best quality)
Jul/Aug18 IVF6 - 4ER, 3M, 2F, 2 frozen day 3 (good quality)
Aug/Sep18 IVF7 - cancelled (cyst)
Sep/Oct18 IVF7 - 3ER, 3M, 2F, 2 frozen Day 3 (excellent quality)
Oct18 IVF8 - Cancelled (cyst and too low TSH)
Oct18-Jan19 bringing TSH under control
Feb19 ERA and hysteroscopy
Mar19 Investigation for fibroid and adenomyosis
Apr19 adenomyosis confirmed, polyps removed
Jun19 FET after 2 months Lupron, autoimmune protocol, transferred two day 3 frozen embryos
Nov17 IVF2 - Pergoveris 2-14 Nov, Orgalutran 5-14 Nov, Ovitrelle 15 Nov, ER 17 Nov for 3 follies, 1 mature egg, did not fertilize
Jan18 IVF3 - Pergoveris 30 Dec - 8 Jan, Orgalutran 5-8 Jan, Ovitrelle 9 Jan, ER 11 Jan 3 eggs, 2 mature, 1 fertilized, ET 1x 4d 12-cell embryo 15/01, 24/01 BFN
May/Jun18 IVF4 - Rekovelle 25-29 May, Menogon 30May - 2Jun, Zomacton 25 27 29 31 May and 2Jun, Cetrotide 30May - 3Jun, Gonasi 3Jun, ER 5Jun 4 eggs, none mature, two matured overnight, 1 fertilized with ICSI, Frozen day 3 but not good quality
Jun/Jul18 IVF5 - Rekovelle 21-24 June, Menogon 25Jun-3Jul, Puregon 4-5Jul, Zomacton 21 23 25 27 29 Jun, Cetrotide 25Jun-5Jul, Gonasi 6Jul, ER 8Jul 5 eggs, 3 mature, 2 fertilized with ICSI, 2 frozen day 3 but not good quality
Jul/Aug18 IVF6 - Rekovelle 26-29 Jul, Menogon 30Jul-7Aug, Buserelin 26Jul-7Aug, Zomacton 26 28 30 Jul 1 3 Aug, Gonasi 7Aug, ER 9Aug 4 eggs, 3 mature, 2 fertilized (normal IVF), 2 frozen day 3 good quality
Sep/Oct18 IVF7 - Menogon 19-30Sep, Buserelin 19-30Sep, Zomacton 19 21 23 25 27 Sep, Ovitrelle 1 Oct, ER 3 eggs, 3 mature, 2 fertilized with ICSI, 2 frozen day 3 excellent quality
Fav Quote: The greatest thing you'll ever learn is just to love and be loved in return
Diagnosis (if you've been): AMA. MFI
Status (WTO/TWW/TTA): WFAF
What are you doing this cycle? (Testing? Treatment?): Waiting on SA results
How are things going?: Doing ok. We are just waiting on SA results before we even discuss what our next moves will be. For now, we are just taking it easy and trying to find our 'normal' again.
Oh, and we had our first day of summer this weekend. And guess where we spent it...volunteering at the school fair. Sigh. Thanks DH for signing us up for that one.
Any questions?:
GTKY: What do you enjoy most at carnivals or amusement parks, (like a specific game or ride or food)? Cotton candy for sure! Not huge on the rides at amusement parks. But I will spend hours at a water park.
Status (WTO/TWW/TTA): TWW but temp dropped this morning and I have some spotting. I assume I am out.
What are you doing this cycle? (Testing? Treatment?): Just testing. I will go for CD3 bloodwork and DH is supposed to do his SA this week. I won't be able to do the saline ultrasound until next cycle unless I can schedule it for a Saturday. Our clinic doesn't do them so we have to go into the city.
How are things going?: I am really overwhelmed right now and don't really know what to think/do/feel.
Any questions?: Typically how long does it take to get bloodwork and SA results? They didn't really say at our appointment. Or maybe they did and it didn't register. Next time I am taking notes.
GTKY: What do you enjoy most at carnivals or amusement parks, (like a specific game or ride or food)? The Haunted Mansion at WDW is my favorite, but I also love Thunder Mountain and Soarin'. I am a big fan of Dole Whip, fried dough and popcorn. There is also an amazing brioche ice cream sandwich in the France pavilion at Epcot!
Diagnosis (if you've been): unexplained but some MF
Status (WTO/TWW/TTA): WFAF I think? And WFIVF
What are you doing this cycle? (Testing? Treatment?): Making my way through the IVF process
How are things going?: So far so good. Finished the last BCP on Saturday so I'm just on Lupron now. Baseline appt on Thursday to determine if my estradiol is good to move on to stims! The number has gotten lower every time they've tested it over the course of my IUIs to now so I doubt there will be a problem having low enough estradiol being on the Lupron.
Any questions?: I'm going to have a withdrawal bleed coming up right? Or will the lupron prevent that?
GTKY: What do you enjoy most at carnivals or amusement parks, (like a specific game or ride or food)? I love roller coasters in general. Haven't been to an amusement park in so long though! I definitely love funnel cakes and cream puffs!
Dx: low morph (1%), ANA positive, low decidualization score, high TSH and testosterone, histone antibodies
IUI #1-3 | all BFN
IVF #1 | 6.11.19 | 24R, 17M, 15F, 6B, PGT-A tested - 5 normal, 3 girls & 2 boys
FET #1 | 9.10.19 | BFN "I know you, but we've never met. I'm with you, but I don't know your name"
RPL, Receptiva, & ERA testing | all normal/negative, recommended going on gluten and dairy free diet for next FET
FET #2 | 3.31.20 | Opted to cancelled due to pandemic, continued diet and tried naturally over the summer
2nd Opinion with another RE | 8.20.20 | Not immune to measles (received 1 dose); SA results similar to 2 years ago; decided to move forward with FET #2 redo at start of next cycle
Surprise natural BFP! | 9.22.20 | MC 10.23.20 at 8 weeks
TTCAL naturally | starting 11.22.20
Initial consultation with Reproductive Immunologist | 9.14.21
Decidualization score biopsy | 10.1.21 | abnormal - low score of 1; endometrial scratch recommended and progesterone supplementation
Saline sono | 10.15.21 | normal
Bloodwork | 10.21.21 | high TSH, high testosterone, positive for anti-nuclear antibodies and histone antibodies, high protein S, multiple genetic mutations
BFP! | 11.3.21 | EDD 7.14.22
DS born 7.19.22 after induction
TTC #2 begins 6.2023
Consultation with RI | 6.6.23
Saline sono, endometritis biopsy, skin & eye check | all normal
Labs | high TSH, Factor XIII mutation, high %CD56
Follow up | 8.8.23 | prescribed metformin, prednisone, plaquenil, and levothyroxine
Repeat labs after 3 weeks on meds
Follow up | 11.9.23 | Green light!, increase in prednisone, added lovenox
Repeat labs in 8 weeks
Follow up | 1.16.24 | Green light continues
TTC ended due to filing divorce
**New relationship starting May 2024**
Surprise BFP!! | 9.7.25 | EDD 5.11.26
Status (WTO/TWW/TTA): WFIVF
What are you doing this cycle? (Testing? Treatment?): IVF
How are things going?: I'm going to come back tomorrow and tag everybody but I'm completely wiped out right now. I just had 3 days of different wedding activities and then I got home and discovered my fridge is broken with about $2,000 + of my IVF meds inside of it so I had to rush to the store and buy ice packs to put in a cooler and I got a mini fridge that is now plugged in and cooling to store them in until I can get my fridge back up and running or replaced. Today is my last day of bcp and then I have my baseline tomorrow and should be starting meds within the next few days. AHHH!
Any questions?: none right now.
GTKY: What do you enjoy most at carnivals or amusement parks, (like a specific game or ride or food)? DISNEY! I hate roller coasters but I love the rides and atmosphere at the Disney parks.
Since you posted about the pain you had during your saline sono last week and how the doc commented that sometimes it’s painful for women who’ve had endo, I have been wondering if you’ve been treated for inflammation before your IVF procedure? Sorry if this is way too in your business or an obviously stupid question. I’ve just been curious.
Status (WTO/TWW/TTA): FET
What are you doing this cycle? (Testing? Treatment?): prepping for FET so currently on Estrace
How are things going?: So far so good but I'm on the low dose of Estrace right now. I'm just happy to finally be moving forward after so many set-backs.
Any questions?:
GTKY: What do you enjoy most at carnivals or amusement parks, (like a specific game or ride or food)? I grew up about 30-45 minutes away from Cedar Point and love roller coasters. I can't ride them any longer but I use to think the scarier the better!
@emmasemm I hope AF shows up soon so that you can move on to the next step! I hope you enjoy the next fam gathering coming up! I’ve found alone time during those kinds of events really helps me to enjoy the rest of it; otherwise, I feel like I’m “on” too much, especially with all the hidden ttc drama being shoved down.
@nitnat007 GL with those SA results. Are you and YH both teachers? I hope you get to enjoy summer your way tonight!
@inthewoods23 I hope your numbers confirm that you’re good to go!
@littleredm oh my! I’m so glad you were around to remedy the fridge problem! What a save! Sorry about the refrigerator!
@celticknotfire Glad to hear everything is on track!
Diagnosis (if you've been): stage 3 endometriosis
Status (WTO/TWW/TTA): benched.
What are you doing this cycle? (Testing? Treatment?): taking Orilissa to calm down Endo flare up. And mh better get his SA this week or I’m going to lose it. He at least has the referral taken care of, I think.
How are things going?: ok. I’m trying to make this a time where I’m doing things that seem productive, like stripping paint off the front door. I’m still bummed about waiting, but trying to make the most out of taking these months off.
Any questions?: I guess similar to inthewoods, I’m curious how coming off the medication works, if it triggers a period immediately after or not. My med says to avoid trying to get pregnant for a week after stopping usage, so I’m hoping that’ll just coincide with menstruation so that I know where I am in the process and don’t need to wait even longer to regulate everything.
GTKY: What do you enjoy most at carnivals or amusement parks, (like a specific game or ride or food)? Probably roller coasters. 🙂 especially the ones where your feet dangle.
@emeraldduchess apart from AMH I have always got blood test results same day if we go in early - next working day if the doctor has to review them before releasing them. SA was back in 2 days each time (prelim results same day - only the infectious cultures took the extra day). Genetic blood test results took around 2 weeks (karyotyping).
Its not the speed of the tests but more the protocol for releasing results that your doctor uses that can take time.
@inthewoods23 if you’re on low levels of Lupron (daily injections, in the range 0.05ml to 1ml - yes the range can be that wide!) then yes you should bleed as per normal - so if you get a bleed 5 days after stopping BCP without Lupron you should roughly get it the same now. However we all know we are normal until we’re not ;-)
@littleredm oh no! What a nightmare with your fridge! Hope baseline goes well today
@celticknotfire are you just on estrace or also on patches? I only do patches (or have so far in all rounds). When is your next lining check?
@begging4abump if the meds stop you having a period whilst you’re on them, then yes after stopping you should get a withdrawal bleed (not a true period per se if you didn’t ovulate first). “Normally” your cycles should go back to how they were before, so worth to start tracking again after the withdrawal bleed. Of course there are always a few people who ovulate through these medications - hence why they advise to still prevent for the first week after until the meds are out of your body and once you’ve had a withdrawal bleed.
Married 12/2016
TTC #1 since 04/2015
AMA, DOR (AMH 0.65, AFC 2-4) and autoimmune issues (RA, APS), low TSH, adenomyosis
7 retrievals, 3 transfers
Nov17 IVF2 - 1ER, 0F
Jan18 IVF3 - 3ER, 1F, 1ET, BFN
Feb18 - second opinion and additional testing
Apr18 IVF4 - cancelled (E2 too high)
May/Jun18 IVF4 - 4ER, 0M, 1F, 1 frozen day 3 (not best quality)
Jun/Jul18 IVF5 - 5 ER, 3M, 2F, 2 frozen day 3 (not best quality)
Jul/Aug18 IVF6 - 4ER, 3M, 2F, 2 frozen day 3 (good quality)
Aug/Sep18 IVF7 - cancelled (cyst)
Sep/Oct18 IVF7 - 3ER, 3M, 2F, 2 frozen Day 3 (excellent quality)
Oct18 IVF8 - Cancelled (cyst and too low TSH)
Oct18-Jan19 bringing TSH under control
Feb19 ERA and hysteroscopy
Mar19 Investigation for fibroid and adenomyosis
Apr19 adenomyosis confirmed, polyps removed
Jun19 FET after 2 months Lupron, autoimmune protocol, transferred two day 3 frozen embryos
Nov17 IVF2 - Pergoveris 2-14 Nov, Orgalutran 5-14 Nov, Ovitrelle 15 Nov, ER 17 Nov for 3 follies, 1 mature egg, did not fertilize
Jan18 IVF3 - Pergoveris 30 Dec - 8 Jan, Orgalutran 5-8 Jan, Ovitrelle 9 Jan, ER 11 Jan 3 eggs, 2 mature, 1 fertilized, ET 1x 4d 12-cell embryo 15/01, 24/01 BFN
May/Jun18 IVF4 - Rekovelle 25-29 May, Menogon 30May - 2Jun, Zomacton 25 27 29 31 May and 2Jun, Cetrotide 30May - 3Jun, Gonasi 3Jun, ER 5Jun 4 eggs, none mature, two matured overnight, 1 fertilized with ICSI, Frozen day 3 but not good quality
Jun/Jul18 IVF5 - Rekovelle 21-24 June, Menogon 25Jun-3Jul, Puregon 4-5Jul, Zomacton 21 23 25 27 29 Jun, Cetrotide 25Jun-5Jul, Gonasi 6Jul, ER 8Jul 5 eggs, 3 mature, 2 fertilized with ICSI, 2 frozen day 3 but not good quality
Jul/Aug18 IVF6 - Rekovelle 26-29 Jul, Menogon 30Jul-7Aug, Buserelin 26Jul-7Aug, Zomacton 26 28 30 Jul 1 3 Aug, Gonasi 7Aug, ER 9Aug 4 eggs, 3 mature, 2 fertilized (normal IVF), 2 frozen day 3 good quality
Sep/Oct18 IVF7 - Menogon 19-30Sep, Buserelin 19-30Sep, Zomacton 19 21 23 25 27 Sep, Ovitrelle 1 Oct, ER 3 eggs, 3 mature, 2 fertilized with ICSI, 2 frozen day 3 excellent quality
Fav Quote: The greatest thing you'll ever learn is just to love and be loved in return
My RE said she & many other docs treat everyone (male & female) with doxycycline in the lead-up to ER/IVF to clear any hidden infections and/or inflammation. There are other treatments too but I don’t have Endo so am not well-versed in this. Maybe our resident guru @emmasemm knows more about this?
Anyway, along with everyone else here, I wish you the best with everything that’s upcoming! I hope I didn’t make you nervous & feel free to send me a PM if you want anymore info on that FB group.
@nitnat007 hope you get some good results! Omg that's so like MH too to sign us up for something like that. But I'm sure the kiddos loved it and now you can really get down to the summer business!
@emeraldduchess sincerely sorry to see you here, friend. 💜 I personally got my lab results back on Monday (with draw on Saturday) but our SA took longer (a week-ish). I'm guessing it varies a lot but hopefully not too long for some answers! Is it summer for you too?
@inthewoods23 funnel cakes here too! Although it's been so long now maybe I wouldn't even like them anymore... Maybe I'm gonna have to find myself a fair this summer!
@littleredm sorry about all the expenses all at once... That just really sucks. We'll all have fx that IVF goes just as planned for you.
@celticknotfire Omg I've always wanted to go to Cedar Point but still haven't! Def on my bucket list! Good luck with FET! (I feel like I'm saying that a lot today... It's open season on FETs right now and hopefully open season on IFs graduating right outta here!)
@begging4abump I somehow read your SA sentence as "my hubby better make it happen this week or I'm taking care of it" and I was like Dang, girl! But seriously, I hope he does too. I've been in my hubby hard too lately, but it's really just over Vitamins for him (which he just refuses) and honestly I'm going to lose it soon too.
@keikilove still thinking good thoughts on your IUI!! ♥️ ♥️
Diagnosis: still awaiting one, possible minor MF
Status: TWW and waiting for more testing next cycle
What are you doing this cycle? Still just SMEP, and got my progesterone draw today. Hopefully ultrasound/HSG in the next couple weeks. Oh, and trying desperately to get MH to man up and take some pre-conception vitamins. (see above)
How are things going? At the moment, okay. But I'm going to get desperate again when AF shows her ugly face. And struggling with accepting my current situation compared to how I had imagined this past year going...
Any questions? Not at the moment!
GTKY: okay I love all carnival food (which is why I stay away) but also I looove roller coasters!! I haven't been on one in years though...
He's using the Smarty Pants brand which has CoQ10 and 1 or 2 other things that aren't typically in a regular multivitamin but I believe they are known to be helpful for sperm! (Don't quote me on that because I haven't looked into that for some time!)
Dx: low morph (1%), ANA positive, low decidualization score, high TSH and testosterone, histone antibodies
IUI #1-3 | all BFN
IVF #1 | 6.11.19 | 24R, 17M, 15F, 6B, PGT-A tested - 5 normal, 3 girls & 2 boys
FET #1 | 9.10.19 | BFN "I know you, but we've never met. I'm with you, but I don't know your name"
RPL, Receptiva, & ERA testing | all normal/negative, recommended going on gluten and dairy free diet for next FET
FET #2 | 3.31.20 | Opted to cancelled due to pandemic, continued diet and tried naturally over the summer
2nd Opinion with another RE | 8.20.20 | Not immune to measles (received 1 dose); SA results similar to 2 years ago; decided to move forward with FET #2 redo at start of next cycle
Surprise natural BFP! | 9.22.20 | MC 10.23.20 at 8 weeks
TTCAL naturally | starting 11.22.20
Initial consultation with Reproductive Immunologist | 9.14.21
Decidualization score biopsy | 10.1.21 | abnormal - low score of 1; endometrial scratch recommended and progesterone supplementation
Saline sono | 10.15.21 | normal
Bloodwork | 10.21.21 | high TSH, high testosterone, positive for anti-nuclear antibodies and histone antibodies, high protein S, multiple genetic mutations
BFP! | 11.3.21 | EDD 7.14.22
DS born 7.19.22 after induction
TTC #2 begins 6.2023
Consultation with RI | 6.6.23
Saline sono, endometritis biopsy, skin & eye check | all normal
Labs | high TSH, Factor XIII mutation, high %CD56
Follow up | 8.8.23 | prescribed metformin, prednisone, plaquenil, and levothyroxine
Repeat labs after 3 weeks on meds
Follow up | 11.9.23 | Green light!, increase in prednisone, added lovenox
Repeat labs in 8 weeks
Follow up | 1.16.24 | Green light continues
TTC ended due to filing divorce
**New relationship starting May 2024**
Surprise BFP!! | 9.7.25 | EDD 5.11.26
You just know I love an evening summarizing bits of my research :-)
OK - so first of all antibiotics would be for either endometritis (either having a biopsy of the uterine lining that fond it or taking it just in case if you’ve had some recent invasive procedures). However antibiotics in themselves can actually change the expression of the genes in the uterine lining needed for successful implantation - if you do an ERA having had antibiotics in the last 3 months you either need to wait until after 3 months to do it or repeat the same dose of antibiotics at the same time before your real transfer cycle... doxycycline is a common one used by clinics.
If the clinic thinks they might have to go through the uterine wall to reach ovaries (not the vaginal wall) or if they expect contamination (eg from puncturing an endometrioma or cyst) then I can see they would want to use it to try to avoid an infection.
Antibiotics are not normally given for just normal endometriosis. If for example it had caused damage to another organ and then caused an infection I could understand it. Though as mentioned they do change the expression of genes in uterine lining tissue - which would also work when that tissue is outside the uterus like in endo!
All the autoimmune stuff in a spoiler purely for space reasons! I’ve only covered the main ones - there are lots more less common options.
Autoimmune protocols, or bits of them, are quite common to be used by some REs, whereas others will not use them without specifically testing positive for something that needs treating and even if you test positive there are no large scale studies which can really be relied upon for most autoimmune treatments for IF.
If any autoimmune issues are suspected, it is generally it advised NOT to do a fresh transfer as you want to know you’ve got embryos to transfer and not all the meds would be good for getting healthy eggs during the retrieval part.
Dont also forget diet and exercise as crucial triggers of inflammation - neither of those needs a prescription! Typically avoid hard exercise (muscle growth is via inflammatory processes) and move to an anti inflammatory diet (there are several to choose from - I use SCD).
You might come across the following treatments:
Lupron before FET prep - Lupron is seen in some endo (and adenomyosis) patients to “calm” it down. This would make sense as it basically stops the development of the lining at a high enough dose - and as both endo and adeno are just the lining growing in the wrong place it does make some logical sense. Some REs will only offer the depot Lupron shots which come with severe side effects and normally you need to do 3 months with no way to back out if you can’t handle it. However using a high enough dose of the daily Lupron injections can help to get good calming but balance out reducing the side effects - and allow you to stop at any time. It’s not expensive, and if you can work with a few headaches and hot flushes it can be an option worth trying. Even 3-4 weeks could give a benefit. No big reliable studies that I could trust - but a crazy amount of DOR and endo ladies using this approach with success after years of failure. Could be coincidence... but also might be something. As you stop the Lupron before transfer no risk to the embryo.
Baby Aspirin - 75mg dose per day. Some clotting disorders would indicate this - but many REs will allow it even without testing or with a negative result. Used over a short time with no contraindications it should not do any harm - but not clear if really helps without a clear diagnosis requiring it.
Clexane/Heparin/Lovenox etc blood thinners - these act on different clotting mechanisms to the aspirin so can be taken alone or in combination. Theses are daily injections. Some continue until 8-13 weeks, some right through into 3rd trimester or even beyond. If you’ve tested positive for any known clotting disorder they would be prescribed - if not for repeated implantation failure or miscarriage they can also be prescribed as they certainly don’t everything about clotting mechanisms in the uterus yet. For you they do come with the risk of heavy bleeding eg in case of an accident, but I found no overall patterns of risk for the baby. Not cheap if you need them long term.
Low dose steroids - prednisone, prednisolone, medrol etc - if your blood test results show inflammation eg with an elevated CRP level then using these could be indicated. Not all inflammation in all people might show up in those blood levels at the moment of testing of course, so again they can be prescribed as a prophylactic. If the dose is low and you are well monitored and come of slowly in steps it should not cause you harm for a short period of time. However taking steroids during pregnancy is associated with a higher risk of miscarriage, early births, still births and birth defects. Though normally the doses in the studies are much higher that you would be prescribed. Even so, I would recommend to think if the pros outweigh the cons in each case.
Intralipids - these are infusions of basically fats. Need to be done before transfer, after a positive test and then some weeks later again. Administered by a medical professional as intravenous. Quite expensive (I’ve seen people pay from $350-$1000!). No serious research proving they work or don't. But too many anecdotal cases in “last hope” cases to ignore if you’ve tried everything else. Supposed to help calm the immune system and prevent an over reaction to the “foreign body”. Not however seen to be effective for anti cardiolipin antibodies. But others it could work for potentially (including the kind I have). Limited risk for you and the pregnancy. It’s the stuff they give people on life support to give their body some nourishment.
IVIG - super expensive and typically not available for IF in the USA, most people seem to go to Mexico for it. Can be around $3500 per treatment. It is a mix of immunoglobulins donated from different people and given intravenously again. You can also get it done with your partner’s own immunoglobulin mix. It is well known for treating lupus, APL syndrome etc - but if you don’t have something like this then normally a doctor won’t prescribe this. There’s also limited evidence as to whether it works or not as it is not a common treatment.
Neupogen - this is originally a drug often given to those undergoing chemotherapy which has led to them having a low white blood cell count. You don’t tend to feel great on it - it can cause low platelets and the thing most people will tell you about is the bone pain. Normally for short term use you would have it done at the clinic, but can inject it yourself if shown how. It is super expensive. Those who have done this who I know spent $7000-$10,000 per FET just on this! If you read the label it explicitly says don’t get pregnant whilst on it... and I don’t know of any studies on miscarriage, early/still birth or birth defect rates. It’s really known as a last Hail Mary - and most doctors will not prescribe it unless you really have low white blood cell count.
As always, please remember I’m not a doctor - just spent 4 years studying the hell out of all this stuff. Especially this autoimmune stuff as this is one of my problem areas.
edit - NOT to do a fresh transfer
Married 12/2016
TTC #1 since 04/2015
AMA, DOR (AMH 0.65, AFC 2-4) and autoimmune issues (RA, APS), low TSH, adenomyosis
7 retrievals, 3 transfers
Nov17 IVF2 - 1ER, 0F
Jan18 IVF3 - 3ER, 1F, 1ET, BFN
Feb18 - second opinion and additional testing
Apr18 IVF4 - cancelled (E2 too high)
May/Jun18 IVF4 - 4ER, 0M, 1F, 1 frozen day 3 (not best quality)
Jun/Jul18 IVF5 - 5 ER, 3M, 2F, 2 frozen day 3 (not best quality)
Jul/Aug18 IVF6 - 4ER, 3M, 2F, 2 frozen day 3 (good quality)
Aug/Sep18 IVF7 - cancelled (cyst)
Sep/Oct18 IVF7 - 3ER, 3M, 2F, 2 frozen Day 3 (excellent quality)
Oct18 IVF8 - Cancelled (cyst and too low TSH)
Oct18-Jan19 bringing TSH under control
Feb19 ERA and hysteroscopy
Mar19 Investigation for fibroid and adenomyosis
Apr19 adenomyosis confirmed, polyps removed
Jun19 FET after 2 months Lupron, autoimmune protocol, transferred two day 3 frozen embryos
Nov17 IVF2 - Pergoveris 2-14 Nov, Orgalutran 5-14 Nov, Ovitrelle 15 Nov, ER 17 Nov for 3 follies, 1 mature egg, did not fertilize
Jan18 IVF3 - Pergoveris 30 Dec - 8 Jan, Orgalutran 5-8 Jan, Ovitrelle 9 Jan, ER 11 Jan 3 eggs, 2 mature, 1 fertilized, ET 1x 4d 12-cell embryo 15/01, 24/01 BFN
May/Jun18 IVF4 - Rekovelle 25-29 May, Menogon 30May - 2Jun, Zomacton 25 27 29 31 May and 2Jun, Cetrotide 30May - 3Jun, Gonasi 3Jun, ER 5Jun 4 eggs, none mature, two matured overnight, 1 fertilized with ICSI, Frozen day 3 but not good quality
Jun/Jul18 IVF5 - Rekovelle 21-24 June, Menogon 25Jun-3Jul, Puregon 4-5Jul, Zomacton 21 23 25 27 29 Jun, Cetrotide 25Jun-5Jul, Gonasi 6Jul, ER 8Jul 5 eggs, 3 mature, 2 fertilized with ICSI, 2 frozen day 3 but not good quality
Jul/Aug18 IVF6 - Rekovelle 26-29 Jul, Menogon 30Jul-7Aug, Buserelin 26Jul-7Aug, Zomacton 26 28 30 Jul 1 3 Aug, Gonasi 7Aug, ER 9Aug 4 eggs, 3 mature, 2 fertilized (normal IVF), 2 frozen day 3 good quality
Sep/Oct18 IVF7 - Menogon 19-30Sep, Buserelin 19-30Sep, Zomacton 19 21 23 25 27 Sep, Ovitrelle 1 Oct, ER 3 eggs, 3 mature, 2 fertilized with ICSI, 2 frozen day 3 excellent quality
Fav Quote: The greatest thing you'll ever learn is just to love and be loved in return
It is more rare in an FET cycle - there nothing is punctured, but of course they are putting a catheter into your uterus which could introduce bacteria if it’s not completely sterile - which it should absolutely be!
Married 12/2016
TTC #1 since 04/2015
AMA, DOR (AMH 0.65, AFC 2-4) and autoimmune issues (RA, APS), low TSH, adenomyosis
7 retrievals, 3 transfers
Nov17 IVF2 - 1ER, 0F
Jan18 IVF3 - 3ER, 1F, 1ET, BFN
Feb18 - second opinion and additional testing
Apr18 IVF4 - cancelled (E2 too high)
May/Jun18 IVF4 - 4ER, 0M, 1F, 1 frozen day 3 (not best quality)
Jun/Jul18 IVF5 - 5 ER, 3M, 2F, 2 frozen day 3 (not best quality)
Jul/Aug18 IVF6 - 4ER, 3M, 2F, 2 frozen day 3 (good quality)
Aug/Sep18 IVF7 - cancelled (cyst)
Sep/Oct18 IVF7 - 3ER, 3M, 2F, 2 frozen Day 3 (excellent quality)
Oct18 IVF8 - Cancelled (cyst and too low TSH)
Oct18-Jan19 bringing TSH under control
Feb19 ERA and hysteroscopy
Mar19 Investigation for fibroid and adenomyosis
Apr19 adenomyosis confirmed, polyps removed
Jun19 FET after 2 months Lupron, autoimmune protocol, transferred two day 3 frozen embryos
Nov17 IVF2 - Pergoveris 2-14 Nov, Orgalutran 5-14 Nov, Ovitrelle 15 Nov, ER 17 Nov for 3 follies, 1 mature egg, did not fertilize
Jan18 IVF3 - Pergoveris 30 Dec - 8 Jan, Orgalutran 5-8 Jan, Ovitrelle 9 Jan, ER 11 Jan 3 eggs, 2 mature, 1 fertilized, ET 1x 4d 12-cell embryo 15/01, 24/01 BFN
May/Jun18 IVF4 - Rekovelle 25-29 May, Menogon 30May - 2Jun, Zomacton 25 27 29 31 May and 2Jun, Cetrotide 30May - 3Jun, Gonasi 3Jun, ER 5Jun 4 eggs, none mature, two matured overnight, 1 fertilized with ICSI, Frozen day 3 but not good quality
Jun/Jul18 IVF5 - Rekovelle 21-24 June, Menogon 25Jun-3Jul, Puregon 4-5Jul, Zomacton 21 23 25 27 29 Jun, Cetrotide 25Jun-5Jul, Gonasi 6Jul, ER 8Jul 5 eggs, 3 mature, 2 fertilized with ICSI, 2 frozen day 3 but not good quality
Jul/Aug18 IVF6 - Rekovelle 26-29 Jul, Menogon 30Jul-7Aug, Buserelin 26Jul-7Aug, Zomacton 26 28 30 Jul 1 3 Aug, Gonasi 7Aug, ER 9Aug 4 eggs, 3 mature, 2 fertilized (normal IVF), 2 frozen day 3 good quality
Sep/Oct18 IVF7 - Menogon 19-30Sep, Buserelin 19-30Sep, Zomacton 19 21 23 25 27 Sep, Ovitrelle 1 Oct, ER 3 eggs, 3 mature, 2 fertilized with ICSI, 2 frozen day 3 excellent quality
Fav Quote: The greatest thing you'll ever learn is just to love and be loved in return
Hope I get the go ahead soon!
Dx: low morph (1%), ANA positive, low decidualization score, high TSH and testosterone, histone antibodies
IUI #1-3 | all BFN
IVF #1 | 6.11.19 | 24R, 17M, 15F, 6B, PGT-A tested - 5 normal, 3 girls & 2 boys
FET #1 | 9.10.19 | BFN "I know you, but we've never met. I'm with you, but I don't know your name"
RPL, Receptiva, & ERA testing | all normal/negative, recommended going on gluten and dairy free diet for next FET
FET #2 | 3.31.20 | Opted to cancelled due to pandemic, continued diet and tried naturally over the summer
2nd Opinion with another RE | 8.20.20 | Not immune to measles (received 1 dose); SA results similar to 2 years ago; decided to move forward with FET #2 redo at start of next cycle
Surprise natural BFP! | 9.22.20 | MC 10.23.20 at 8 weeks
TTCAL naturally | starting 11.22.20
Initial consultation with Reproductive Immunologist | 9.14.21
Decidualization score biopsy | 10.1.21 | abnormal - low score of 1; endometrial scratch recommended and progesterone supplementation
Saline sono | 10.15.21 | normal
Bloodwork | 10.21.21 | high TSH, high testosterone, positive for anti-nuclear antibodies and histone antibodies, high protein S, multiple genetic mutations
BFP! | 11.3.21 | EDD 7.14.22
DS born 7.19.22 after induction
TTC #2 begins 6.2023
Consultation with RI | 6.6.23
Saline sono, endometritis biopsy, skin & eye check | all normal
Labs | high TSH, Factor XIII mutation, high %CD56
Follow up | 8.8.23 | prescribed metformin, prednisone, plaquenil, and levothyroxine
Repeat labs after 3 weeks on meds
Follow up | 11.9.23 | Green light!, increase in prednisone, added lovenox
Repeat labs in 8 weeks
Follow up | 1.16.24 | Green light continues
TTC ended due to filing divorce
**New relationship starting May 2024**
Surprise BFP!! | 9.7.25 | EDD 5.11.26
My estrogen is higher than they would like (they like below 60) but looking at all my baselines, including today have been around 75 so that's just my normal and they're fine with that.
Dx: low morph (1%), ANA positive, low decidualization score, high TSH and testosterone, histone antibodies
IUI #1-3 | all BFN
IVF #1 | 6.11.19 | 24R, 17M, 15F, 6B, PGT-A tested - 5 normal, 3 girls & 2 boys
FET #1 | 9.10.19 | BFN "I know you, but we've never met. I'm with you, but I don't know your name"
RPL, Receptiva, & ERA testing | all normal/negative, recommended going on gluten and dairy free diet for next FET
FET #2 | 3.31.20 | Opted to cancelled due to pandemic, continued diet and tried naturally over the summer
2nd Opinion with another RE | 8.20.20 | Not immune to measles (received 1 dose); SA results similar to 2 years ago; decided to move forward with FET #2 redo at start of next cycle
Surprise natural BFP! | 9.22.20 | MC 10.23.20 at 8 weeks
TTCAL naturally | starting 11.22.20
Initial consultation with Reproductive Immunologist | 9.14.21
Decidualization score biopsy | 10.1.21 | abnormal - low score of 1; endometrial scratch recommended and progesterone supplementation
Saline sono | 10.15.21 | normal
Bloodwork | 10.21.21 | high TSH, high testosterone, positive for anti-nuclear antibodies and histone antibodies, high protein S, multiple genetic mutations
BFP! | 11.3.21 | EDD 7.14.22
DS born 7.19.22 after induction
TTC #2 begins 6.2023
Consultation with RI | 6.6.23
Saline sono, endometritis biopsy, skin & eye check | all normal
Labs | high TSH, Factor XIII mutation, high %CD56
Follow up | 8.8.23 | prescribed metformin, prednisone, plaquenil, and levothyroxine
Repeat labs after 3 weeks on meds
Follow up | 11.9.23 | Green light!, increase in prednisone, added lovenox
Repeat labs in 8 weeks
Follow up | 1.16.24 | Green light continues
TTC ended due to filing divorce
**New relationship starting May 2024**
Surprise BFP!! | 9.7.25 | EDD 5.11.26
@littleredm that's awful about the fridge! WTF, universe?
@celticknotfire I think it's a basic SA. DH can't go until next week though, I guess the lab is closed for a few days. Glad you are moving forward! (All these meds you ladies are mentioning are making my head spin!)
@begging4abump thank you for reminding me that I am not alone. Hope your DH gets his SA done, I know that's been a struggle.
@jennifer_louise I'm sorry to find you over here too, friend. 💚 Not summer for me yet...8 more days left of school, though! Hope your H listens and starts on his vitamins (seriously, what is it with men and vitamins?)
@keikilove and @emmasemm you ladies are amazing with all your knowledge!
Thank you ladies for all your answers, advice, and kind words. 💚 I am still trying to wrap my mind around all this. "Overwhelmed" is an understatement. No results yet, I think they are waiting to have all the tests done before meeting again to go over results and treatment options.
I go in for CD3 blood work tomorrow morning, but have to postpone the saline ultrasound until next cycle. It's the last full week of school so any time off isn't really possible.
Diagnosis (if you've been): No diagnosis as of yet
Status (WTO/TWW/TTA): Benched until AF shows up
What are you doing this cycle? (Testing? Treatment?): Nothing
How are things going?: Things are going.....My new job- as some of you may know- has been incredibly demanding, which has been challenging. On top of that- we've had a "roommmate" for the last few months- which has been oh so much fun, especially since he broke his foot about a month and a half ago.....And on top of that #######loss mentioned: we've had a chemical pregnancy in Feb and we just had a miscarriage (D & C) at almost 10 wks######## I'm going to be 39 in August, and my DH will be 47 in October- and we are just too old ( I know that lots of people have their first at age 40- but that's not for us). We went back to the RE we saw 3 years ago. He said the good news was for the most part, all of the testing and things we did then, had great levels, numbers, etc and my HSG was good/clean. He also said that he didn't feel doing another SA on hubby was necessary given the circumstances of the last few months, and that was sufficient enough evidence that hubby's swimmers were good and strong. So at this point, we wait until my next period. We will either re-do some of the tests from 3 years ago to see if things have changed or there are maybe other tests we will do at that point? But he said there was nothing to do at this point in time. Also- he said if/when we get pregnant again, they would monitor me more closely for the 1st few weeks to make sure everything was looking good. Which has made me feel significantly better about everything.
Any questions?: What does everyone know about Vitex???? ( I did use the search bar and didn't see much mention of it) A friend of mine from high school started using it at one point- although she had Hasimoto's- and I think that's the primary reason she was taking it.
GTKY: What do you enjoy most at carnivals or amusement parks, (like a specific game or ride or food)? I am no longer a ride person- although I used to love roller coasters. So it would be the food- although that too has it's down falls- too salty or not that good- (not hot enough or over cooked or under done) and WAY too expensive!!!
Sorry for not "participating" and commenting on everyone's posts......life has been crazy here and my personal time is VERY limited. I am sorry to see some of the ladies that I do recognize here though....I will hope and pray for all of you that your stay here is short!!! This journey is a tough one- it's nice to have the support from others who can relate.
My first stims meds was a sanitation nightmare with being at Relay for Life and having only hand sanitizer as a one time use and doing it all in a tent while also watching the injection videos for the first time in dusk light. Why didn't I think to bring extra alcohol swabs to wipe/"clean" my hands that way?? 😅
Anyway, obligatory cheering on the ovaries gif now that there's no turning back!
Dx: low morph (1%), ANA positive, low decidualization score, high TSH and testosterone, histone antibodies
IUI #1-3 | all BFN
IVF #1 | 6.11.19 | 24R, 17M, 15F, 6B, PGT-A tested - 5 normal, 3 girls & 2 boys
FET #1 | 9.10.19 | BFN "I know you, but we've never met. I'm with you, but I don't know your name"
RPL, Receptiva, & ERA testing | all normal/negative, recommended going on gluten and dairy free diet for next FET
FET #2 | 3.31.20 | Opted to cancelled due to pandemic, continued diet and tried naturally over the summer
2nd Opinion with another RE | 8.20.20 | Not immune to measles (received 1 dose); SA results similar to 2 years ago; decided to move forward with FET #2 redo at start of next cycle
Surprise natural BFP! | 9.22.20 | MC 10.23.20 at 8 weeks
TTCAL naturally | starting 11.22.20
Initial consultation with Reproductive Immunologist | 9.14.21
Decidualization score biopsy | 10.1.21 | abnormal - low score of 1; endometrial scratch recommended and progesterone supplementation
Saline sono | 10.15.21 | normal
Bloodwork | 10.21.21 | high TSH, high testosterone, positive for anti-nuclear antibodies and histone antibodies, high protein S, multiple genetic mutations
BFP! | 11.3.21 | EDD 7.14.22
DS born 7.19.22 after induction
TTC #2 begins 6.2023
Consultation with RI | 6.6.23
Saline sono, endometritis biopsy, skin & eye check | all normal
Labs | high TSH, Factor XIII mutation, high %CD56
Follow up | 8.8.23 | prescribed metformin, prednisone, plaquenil, and levothyroxine
Repeat labs after 3 weeks on meds
Follow up | 11.9.23 | Green light!, increase in prednisone, added lovenox
Repeat labs in 8 weeks
Follow up | 1.16.24 | Green light continues
TTC ended due to filing divorce
**New relationship starting May 2024**
Surprise BFP!! | 9.7.25 | EDD 5.11.26
@emmasemm @littleredm @keikilove Re: Neupogen - there was a recent study done on a G-CSF drug referred to by the study as NT100 (Neupogen is a brand of G-CSF drug) to determine if administering G-CSF to women with recurrent loss reduced miscarriage rates. It apparently did not reduce mc’s (earlier, smaller studies had been encouraging I think). However it also did not increase mc rates or other bad outcome rates. Summary here: https://www.miscarriageassociation.org.uk/research/the-response-trial/
@inthwoods23 omg what an adventure! Lol my mom always carried facial type wipes everywhere she went. You never know when you might need to freshen up / inject yourself in a tent!!! 😂 great job.