PGS and failed cycle?

ktrabing · March 2019

Questions for anyone going through it. Has anyone gone through an IVF cycle, had PGS done, transferred blasts with no abnormalities and still had a failed cycle? We are just starting bcp this month with ER scheduled for any time between 3/30 and 4/3. Just wondering how much having PCS testing helps?!

Cossab89 · March 2019

I have read that many people have had success with PGS. Unfortunately I have not. My first transfer didn’t take but we did find out I needed an additional 24 hours of progesterone so I want to believe that was why. My second FET took but I lost it at 6 weeks. I don’t know what the answer is but I do want to believe that it does more good than harm.

makana11 · March 2019

I’m sorry this happened to you. I’m at the beginning of my journey but do plan to PGS test, just to find the golden egg. I would feel so sad too, knowing the normal one didn’t take. What are you going to do?

Cossab89 · March 2019

We still have 3 “normal” PGS embryos frozen so I feel like I have to follow through. My loss was on Friday so it’s very fresh. I have a consult on the 26th. I’m hoping they are able to do some more testing before we move forward and there are some additional things I am hoping they will add to my protocol.

makana11 · March 2019

I still believe it’s the right choice. I’m so happy to hear you have three more! Don’t give up.

Tulips29 · March 2019

I had both - a success and a failure of normal PGS tested embryos. When the failed one didn't take, my RE said it could have been a number of factors affecting the result. Just did my third retrieval and planning to do PGS testing again. I think for me personally, it saves time and heartache transferring possibly abnormal embryos that may result in a miscarriage/birth defects/etc.

makana11 · March 2019

Agreed. Our PGS fee is the same for 1-10 embryos so I’m going to try my hardest to get up to 10 with a few banking rounds of mini IVF. I just don’t have that many follicles. After all of this time, money, effort and emotional stress-I agree that testing will help us emotionally in the long run.

mackorori · March 2019

I love that we had the option of PGS. For our circumstances with multiple known chromosomal losses, it made sense and we hope for the best when we use our one tested embryo next month. Unfortunately, PGS is not a perfect solution, it can only test the number of chromosomes are correct, but it cannot test for all the other reasons why a FET doesn’t work, miscarriages happen, or god forbid other non life-compatible issues come up during pregnancy. We all just have to decide if the testing is right for us, take it one day at a time, and hope for the best.

@ktrabing all the best for your journey and that it’s successful.

ktrabing · March 2019

Thanks ladies! I feel like its definitely the right choice for us to do the PGS testing. Helps have a piece of mind that we are doing everything we can to make this a success as soon as possible.

hchill0209 · March 2019

I just went through this, I had three losses at around 7-8 weeks plus numerous chemical pregnancies over 3 years so decided to go the PGS route. I ended up with five normal embryos (from 23 eggs retrieved) and transferred the first one on Feb 21st. Currently 6 weeks pregnant and anxiously awaiting my first ultrasound on the 25th. I was like you, this was our last shot at becoming parents so I wanted to know we had tried everything before giving up. Really hoping this one is our long-awaited rainbow. Good luck!

knottie0c1886994ffec556 · March 2019

What about PGD? Does that help too since PGS only checks for chromosomes

inthewoods23 · March 2019

I have the same question about PGD! I just had my consultation for IVF and while I'm soon turning 30, my clinic basically pulls out all the stops and said they do the PGD testing to make sure we're transferring the best embyros.

I know the difference a little bit, but not really sure I understand. Is PGD testing more conclusive than PGS?

mbradfo2 · March 2019

My clinic does not recommend PGS testing for under 35s with no RPL (I had 1 prior m/c so didn't qualify). We transferred two untested blasts, both stuck, but only one made it out of the first trimester (vanishing twin @ 8 weeks). PGS testing basically just looks to see that you are transferring embryos with normal numbers of chromosomes and it is not a guarantee -- I have had friends transfer PGS embies which stuck but still miscarried prior to 12 weeks. They are currently looking to see if there are more issues. Currently research is probing whether or not PGS testing is even really accurate.

PGD testing generally looks for specific genetic issues and is used commonly by people who are known carriers for specific defects. We have at least one lady on the forums here who is specifically using PGD to find embryos that do not carry a certain defect so she might be able to provide more insight -- I just don't remember her name :-(

pgdwivf · March 2019

Hello Ladies I had all my embryos PGD tested for the chromosome I carry for Hemophilia. For PGD testing they take a cheek swab from me and my husband as well as my parents to create a specialized test for our embryos. I also had a genetics test initially to confirm I was a carrier. I have heard this can be done for other genetic diseases. While PGS is looking for abnormalities PGD is looking for that 1 chromosome carrying a disease.
Currently I am awaiting FET. I had a fibroid show up in my pre FET hysteroscopy so I will undergo surgery to remove it early April.
We do have one "unaffected" which was PGD/PGS tested. Hoping to transfer in May. We also have one "no result" meaning it will need to be re-tested. One female carrier (like me) which does not have Hemophilia but carries the gene. Three PGS abnormals one of which was PGD affected,

Any other questions, Feel free to ask away! Prayers and positive thoughts to All of you on this journey.

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