Hi ladies.....I posted here a couple weeks ago because I had my 4th miscarriage (well 2 chemicals and 1 D&C and 1 natural miscarriage at 7 weeks. I am waiting for AF and then possibly will try another FET in March. I am so discouraged because this was a "perfect" embryo that had PGD and PGS testing......my lining was excellent at 11.....Progesterone good at 31.....just started bleeding and it got heavier and heavier..
Baby's hb was 113....126....132....everything looked perfect and yet another disappointment.....I thought that the testing would have caught any chromosonal defects but maybe that is not my problem. I have a 3 yr old daughter and had no issue except LPD which didn't stop my pregnancy.
Has anyone had a mis with this testing? My RE said it happens but I am not convinced...and by way I had the RPL in August and all normal...... This really sucks....Thanks for listening....
I'm so sorry. Going the extra lengths and still getting the rug pulled out from under you is just plain awful.
I just had my genetic consultation prior to moving forward with PGS, and the doctor did touch on this possibility. 1 thing she said was sometimes it can be a perfectly healthy embryo, but somewhere in the cell division something goes wrong. The other thing she said is that (someone correct me if I'm explaining this inaccurately) an embryo essentially has two parts - 1 that becomes the baby and 1 that becomes the placenta. When they take the biopsy of the embryo there is no way to know for sure if you are testing what will become the placenta vs. the baby, and it's possible the placenta can be tested and appear fine, but the baby part has abnormalities.
Two DDs 10/08 and 08/10, no primary IF
TTC #3 since 10/2011 - dx unexplained/weak ovulation
3 BFN clomid + TI cycles, 5 BFN clomid/gonal f IUIs, 1 mmc IUI
2/19/2014 IVF #1 Unexpected low E2 (oversuppressed) -> increased to max doses = 3 or 4 follicles, converting to IUI
BFFP Saw 1 beautiful heartbeat at 6w6d, follow up u/s at 9w showed mmc. Eff this.
NTNP 5/2014-9/2014, OPKs and TI 10/2014 - 1/2015.
RPL testing all normal, AFC, AMH, and FSH all normal.
IVF #1, Stimmed for 12 days, ER 8/22/14, 9 retrieved, 7M, 7F!! Freeze all due to fluid in uterus.
FET end of October 2014 cancelled due to fluid in uterus due to possible c-scar defect
Surgery scheduled 12/12/14 to fix possible isthmocele
3/26/15 transferred one 8 cell grade 4 embryo and one 6 cell grade 3 embryo = slow rising betas for 2+ weeks = ectopic MTX shot 4/29/15
Repeat c-scar surgery June 2015
2nd and last IVF cycle August 2015, stimmed for 12 days, 2 egg retrieved, both mature and both fertilized. Transferred both 8-cell embryos on Day 3, beta 9/5/15 = BFFN
I'm so sorry. Going the extra lengths and still getting the rug pulled out from under you is just plain awful.
I just had my genetic consultation prior to moving forward with PGS, and the doctor did touch on this possibility. 1 thing she said was sometimes it can be a perfectly healthy embryo, but somewhere in the cell division something goes wrong. The other thing she said is that (someone correct me if I'm explaining this inaccurately) an embryo essentially has two parts - 1 that becomes the baby and 1 that becomes the placenta. When they take the biopsy of the embryo there is no way to know for sure if you are testing what will become the placenta vs. the baby, and it's possible the placenta can be tested and appear fine, but the baby part has abnormalities.
Yes, this! Our genetic counselor said the same. Also, that sometimes the test comes back normal but there was actually a chromosomal issue that the lab missed. That they are confident they discard only abnormal embryos, but they can't be 100% the deemed normal actually are.
I am sorry, I can't offer adivce, but I wanted to offer my sympathy. I am sorry for your loss.
Kid #1 - 09/03/12
Kid #2 - maybe???
Diagnosed with Severe Ashermans Hysteroscopy #10 - scar tissue grew back reblocking my right tube #11 or IVF with scarring still inside? 1 lone embryo from September 2016 retreival, dx with Trisomy 16, starting fresh
I have no advice. But I wanted to say I'm so sorry for your loss ((hugs))
Me(27)+ DH(30) Married since Sept.2007 BFP #1 DD born 6/1/2009 (no complications) TTC #2 March 2011 BFP# 2 after 4 rounds of clomid (blighted ovum)12/11 BFP# 3 w help of clomid 2/12 DS born 10/24/2012
TTC#3
Stopped preventing when DS was 6 months old (4/13), really started TTC 10/13 Started clomid July 2014, 3 failed rounds of clomid w OB (low pro on CD 21) sent to RE
HSG and blood work all good round 1: clomid and trigger shot~BFN round 2: clomid, trigger and IUI~BFN round 3: clomid, trigger and IUI +4 booster HCG~NOPE
On a break!!! Til April/May
round 4:clomid, trigger (missed IUI window) NO fricking way BFP
I haven't had PGS or PGD testing, but when we had our consultation, our doctor said that there are other problems that can occur, like implantation failure. Part of the problem for me is the APS, so they think I'm throwing mini-clots that prevent a baby from implanting. Have you had all that tested? If yes, maybe it would be worth adding a blood thinner (lovenox and baby aspirin) prophylactically, and maybe a steroid to prevent an inflammatory issue?
I'm so sorry for your loss It's absolutely awful, and I hope you can take time to grieve and heal.
an embryo essentially has two parts - 1 that becomes the baby and 1 that becomes the placenta. When they take the biopsy of the embryo there is no way to know for sure if you are testing what will become the placenta vs. the baby, and it's possible the placenta can be tested and appear fine, but the baby part has abnormalities.
jen#'s is nearly spot-on here. but in PGS/PGD sampling (and someone please chime in here if i am off-base) they are testing the outer trophectoderm of the embroyo. it is the outer ring of the embryo which goes on to become the placenta. there is no technology available right now that can test the inner cell mass, which becomes the baby itself. some REs argue that fact alone should deter women who are doing this test in hopes of preventing m/c, since you're not even testing the baby.
i'm sorry you had the shittiest of luck your last pg. it unfortunately comes down to the plain fact that PGS/PGD is not a guarantee. just like everything else in this fucked up world of infertility.
i hope you are able to find peace with your loss somewhere down the road. having had 4 miscarriages myself, i know how difficult it is grasping at straws for reasons why it happened.
BFP #4 2/18/14. EDD 10/30/14... Ruptured ectopic with L tube removed & D&C 3/7/14.
BFP #5 7/27/14. EDD 4/9/15... m/c @ 5w4d.
IVF #1 Oct 2014 - antagonist protocol: 9R, 7M, 5F. 3dt of 3 Grade 2 embies. BFN.
IVF #2 Jan 2015 cancelled due to dominant follicle. Converted to IUI #1. BFFN
IVF #2.1 March 2015 cancelled due to dominant follicle.
BFP #6 (SUPRISE!) 3/19/15. EDD 11/30/15... CP at 4w2d.
IUI #2: Clomid + Follistim = 3 follies. BFN.
IVF #2.2 May 2015 - horrible response to micro lupron flare protocol: 3R, 3M, 3F. 3dt of 2 Grade 3 embies. BFFN.
BFP #7 (beyond surprised again!) 4/26/16. EDD 1/5/17. beautiful betas!!!! and then near-fatal hemorrhagic corpus luteum. turns out baby was ectopic after all; another lap 5/6 (@24dpo).
the universe can fuck off.
"You are
overly paranoid and delusional that every one is out to get you."
-lastsliverofhope
an embryo essentially has two parts - 1 that becomes the baby and 1 that becomes the placenta. When they take the biopsy of the embryo there is no way to know for sure if you are testing what will become the placenta vs. the baby, and it's possible the placenta can be tested and appear fine, but the baby part has abnormalities.
jen#'s is nearly spot-on here. but in PGS/PGD sampling (and someone please chime in here if i am off-base) they are testing the outer trophectoderm of the embroyo. it is the outer ring of the embryo which goes on to become the placenta. there is no technology available right now that can test the inner cell mass, which becomes the baby itself. some REs argue that fact alone should deter women who are doing this test in hopes of preventing m/c, since you're not even testing the baby.
This is really intriguing me so I did a little research, and wise nurse @jodee37 is correct! No surprise there The cells biopsied ARE future placenta. My genetics doctor must have said that there can be differences between those placenta cells tested (that T word is too hard to type) and the inner fetus cells.
Two DDs 10/08 and 08/10, no primary IF
TTC #3 since 10/2011 - dx unexplained/weak ovulation
3 BFN clomid + TI cycles, 5 BFN clomid/gonal f IUIs, 1 mmc IUI
2/19/2014 IVF #1 Unexpected low E2 (oversuppressed) -> increased to max doses = 3 or 4 follicles, converting to IUI
BFFP Saw 1 beautiful heartbeat at 6w6d, follow up u/s at 9w showed mmc. Eff this.
NTNP 5/2014-9/2014, OPKs and TI 10/2014 - 1/2015.
RPL testing all normal, AFC, AMH, and FSH all normal.
First of all, I am sorry for your losses I am in the same situation now, my pgs/pgd embryo miscarried by 7.5 weeks after seeing 156bpm heart beat.i am waiting for my and the fetus genetic reports.Have you went for second FET or have you found out the reasons. Including this i already had 5 miscarriages and yet to have my first child and in TTC for 8 years.Its very scary now, likely a lonely child in a dark forest.
Hi, I just wanted to say that I am so sorry for your losses and that my story is very similar to yours. I also miscarried after seeing a HB using a pgs tested embryo. I also had an ectopic with a pgs tested embryo but that has to be a fluke. I've also had countless chemical pregnancies that were without ivf. I hope you get answers and wishing you good luck with your next transfer.
Embryologist here. Yes you guys are correct! When embryos are eligible for biopsying they are made up of the inner cell mass (becomes fetus) and the trophectoderm (becomes placenta). Picture a blown up balloon (trophectoderm) with a small ball stuck on the inside at one position (inner cell mass).
When an embryo is tested we use a laser to remove a small (4-6 cell) chunk from the trophectoderm (typically there's about 100 cells in the trophectoderm at the biopsy-eligible stage). We don't want to remove cells from the inner cell mass as this will likely destroy the embryo. The trophectoderm cells are sent for testing and this gives us information on the trophectoderm and not the inner cell mass. Since the biopsied trophectoderm cells originated from parent cells that also made up the inner cell mass, we infer that the status of these cells is the same. However sometimes a mutation occurs in one subset of cells and this creates a mosaic embryo. Here we have an embryo that has 2 (or more) cells that are genetically different and if there is a serious mutation in cells of the inner cell mass this could lead to a miscarriage. Checking just 4-6 cells out of the whole embryo (100+ cells) sometimes doesn't give us the whole story!
Hope that helps.
I am Embryoman - your friendly neighborhood embryologist! **Removed for TOU violation**
Have you ever had a hysteroscopy done? I had 5 miscarriages (and I have 2 healthy children) before they did a hysteroscopy and found all kinds of things in there that could/should explain my miscarriages. I've had every other test under the sun and did PGS on all my embroys (and ALL of them were normal) so I think sometimes it's not the embryos themselves but something else that could be going on. I'm so sorry for your loss, I know how crappy that is.
Re: PGS and PGD testing and still miscarried
I just had my genetic consultation prior to moving forward with PGS, and the doctor did touch on this possibility. 1 thing she said was sometimes it can be a perfectly healthy embryo, but somewhere in the cell division something goes wrong. The other thing she said is that (someone correct me if I'm explaining this inaccurately) an embryo essentially has two parts - 1 that becomes the baby and 1 that becomes the placenta. When they take the biopsy of the embryo there is no way to know for sure if you are testing what will become the placenta vs. the baby, and it's possible the placenta can be tested and appear fine, but the baby part has abnormalities.
TTC #3 since June 2013
BFP #1 7/21/2013--EDD 3/30/14--D&C 9/24/13
BFP #2 1/28/14--MC 2/7/14
IUI #1 5mg Femara + trigger = BFN
IUI #2 5mg Femara + trigger = BFN
IUI #3 5mg Femara + trigger = BFN
Kid #1 - 09/03/12
Hysteroscopy #10 - scar tissue grew back reblocking my right tube
#11 or IVF with scarring still inside?
1 lone embryo from September 2016 retreival, dx with Trisomy 16, starting fresh
Dx: Me: Recurrent Pregnancy Loss; DH: Low Morphology (2%)
BFP#1: MC 3/1/11 at 6w1d - EDD 10/21/11
BFP#3: MC 2/8/14 at 4w5d - EDD 10/13/14
BFP#6: CP 11/6/14 at 4w2d - EDD 7/14/15
IVF #1 with ICSI & PGS: May/June 2015, ER 6/3/15, 17R/17M/15F
IVF #2 with ICSI & PGS: July 2015, ER 7/16/15, 16R/11M/9F
PGS results = 6 normal embryos (4 boys, 2 girls)
FET 9/23/15 = BFFN
((hugs))
Me(27)+ DH(30) Married since Sept.2007
BFP #1 DD born 6/1/2009 (no complications)
TTC #2 March 2011
BFP# 2 after 4 rounds of clomid (blighted ovum)12/11
BFP# 3 w help of clomid 2/12 DS born 10/24/2012
TTC#3
Stopped preventing when DS was 6 months old (4/13), really started TTC 10/13
Started clomid July 2014, 3 failed rounds of clomid w OB (low pro on CD 21) sent to RE
HSG and blood work all good
round 1: clomid and trigger shot~BFN
round 2: clomid, trigger and IUI~BFN
round 3: clomid, trigger and IUI +4 booster HCG~NOPE
On a break!!! Til April/May
round 4:clomid, trigger (missed IUI window) NO fricking way BFP
BFP #7 (beyond surprised again!) 4/26/16. EDD 1/5/17. beautiful betas!!!! and then near-fatal hemorrhagic corpus luteum. turns out baby was ectopic after all; another lap 5/6 (@24dpo).
the universe can fuck off.
"You are overly paranoid and delusional that every one is out to get you." -lastsliverofhope
FET #1 Dec 2013 BFN
FET # 2 Feb 2014 BFN
No more frosties
IVF #2. September 2014
PGD yielded 2 perfect 5d blasts
SET November 9, 2014
Nov 23, 2014. Another BFN
Not sure where to go from here.
First of all, I am sorry for your losses I am in the same situation now, my pgs/pgd embryo miscarried by 7.5 weeks after seeing 156bpm heart beat.i am waiting for my and the fetus genetic reports.Have you went for second FET or have you found out the reasons.
Including this i already had 5 miscarriages and yet to have my first child and in TTC for 8 years.Its very scary now, likely a lonely child in a dark forest.
**Removed for TOU violation**