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4 failed FETs with Excellent grade PGS Tested Embryos

lauren1310lauren1310 member
in Infertility
We have had 4 failed FETs with PGS tested embryos, of those 4, 3 were excellent grade and one was fair grade. I have done a HSG test that showed my tubes are open and good to go, a miscarriage panel, all types of blood tests, a sonohysterogram that was clear, an ERA test and I’m 34. In the last year of my 4 FETs, I have had one chemical pregnancy and the rest failed completely. The last FET was with a new embryo from my second retrieval and I used 20mg medrol 5 days before the transfer and the day of transfer. The only thing the 5 doctors I have had a consult with, have said it that it could be the embryo and I am redoing the ERA test because the first doctor that performed it was not experienced and did not do an endo scratch before the ERA and I wanted to do an endo scratch before FETs because it's what I did before the only FET that resulted in a pregnancy. Does anyone have any other methods/medications/tests to help withmy next FET? 
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Re: 4 failed FETs with Excellent grade PGS Tested Embryos

  • AlohaKumuAlohaKumu member
    I've had two failed FETs with PGS tested embryos. I went to a new RE after the second transfer (for unrelated reasons) and she discovered I had chronic endometritis, which resulted in micropolyps and plasma. I'm not sure if they've specifically looked for that for you, but I know a few of us have been diagnosed with that after further testing. I know the endo scratch also helps many women.
    Me: 35 DH: 28
    TTC since June 2016
    Azoospermia diagnosis (zero count) Dec 2016
    AZFc chromosome microdeletion discovery March 2017
    Unsuccessful TESE for DH in August 2017
    October 2017 IVF with donor sperm
    29R, 24M, 16F, 2d5, 4d6 (6 embryos total)
    Only 3 could have PGS. 2/3 normal. 5 embies frozen
    12/15/17 FET #1 (1 embryo)--CP
    2/7/17 FET #2 (2 embryos)--BFN
    Chronic endometritis diagnosis May 2018
    ERA Sept 2018--borderline receptive--12 more hours of progesterone
    Abnormal SIS Oct 2018
    Repeat hysteroscopy Nov 1. Treated recurring endometritis.
    12/4/18 FET #3 (2 embryos)--BFN
    Our journey has come to an end.
    ~*~*~Nevertheless, she persisted~*~*~
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  • lauren1310lauren1310 member
    Thank you!!! I’ll be sure ask my doctor about that.
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  • rachelbeth130rachelbeth130 member
    I had 7 embryo transfers, 6 failed and I’m currently 23 weeks pregnant. We did medicated FETs for the first 5 with two ERAs (I had a chemical pregnancy the second transfer before doing any ERA tests). I never got a receptive result, but the test came back that we were close enough to the window, though I really wish we had done another just to get receptive. We were always pre-receptive. After the 5th failed transfer my doctor suggested a d&c to clear out the lining and get a better look at my uterus. I also met with a hematologist that specialized in reproductive health who put me on lovenox, he said it sometimes helps women with implantation failure. During the d&c my doctor found polyps and a uterine septum. We followed up with a natural cycle FET (#6), which failed. Then did two ERAs, first one came back post-receptive, second was receptive. Transfer #7 worked! All of my embryos were PGS tested so we knew it had to be something else. 

    Dont give up! If you have any questions let me know!
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  • embryomanembryoman member
    @lauren1310 Just want to add that sometimes even though you test the embryos and they come back normal, this doesn't guarantee they're normal. You're taking a small piece of a fairly large embryo and sometimes that piece isn't truly representative of the rest of the embryo. However for that to happen four (separate?) times is extremely unlikely! I agree that there may be issues with your lining. 

    You might also want to see if they offer embryo glue (https://www.vitrolife.com/en/products/ivf-media--oil/embryoglue/). It doesn't seem to have an enormous benefit but still can't hurt.

    Good luck!
    I am Embryoman - your friendly neighborhood embryologist!
    **Removed for TOU violation**
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  • NicWalker10NicWalker10 member
    @lauren1310 I am blessed to have my almost two year old son from IVF.  I did 2 stim cycles.  first poor results with only one good pgs embryo,  transfer resulted in a chemical.  second cycle resulted in 15 PGS good embryos.  First transfer from that cycle success.   I've been trying for 10 months to have a second. I have done 3 FETs all failed, all pgs embryos all from the same cycle that produced my son.  I did a ton of blood work, no anomalies.  I did the saline sono before doing the first of the 3 FETs and nothing.   Most recently I had an endo biopsy.  It came back positive for polyp fragments.  I am going to have a hysteroscopy on 9/21 so they can go in and see what's happening in my uterus (I had a c section with my son).   Even tho my RE doesn't think the biopsy results are a big deal, my nurse said it is probably a good idea to go in there and get a better look at my uterus to see if there are polyps, or scar tissue or anything else that the biopsy didn't pick up.   Also, I was told that ultrasounds and the saline sono can miss anomalies in your uterus.   Maybe it doesn't hurt to see if you're RE will biopsy or take a look at what's going on?
    I'm so sorry you are in this place.  I know it's so frustrating.  I know PGS isn't a guarantee but this process is so hard, and exhausting and emotional that I feel like when you PGS you feel like you should get a break somewhere along the way.  I am hoping your break is coming soon!!!  Good luck!
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