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Manufacturer's Shortage on Progesterone in Oil- 2 vial limit

greenhillgirlgreenhillgirl member
in Infertility
Just a heads up for everyone- there is currently a shortage of PIO again (this happened before, apparently) so each pharmacy can only give each patient two vials at one time. I looked it up and apparently its actually the pharmaceutical grade sesame oil that is in shortage. This applies to all pharmacies since it is coming from the manufacturer. Just be sure to plan ahead and know that no matter how long you take it, you will only be given two vials at once. I hope this is helpful. 

https://www.goodrx.com/blog/the-national-shortage-in-progesterone-in-oil-what-you-can-do/ 
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Re: Manufacturer's Shortage on Progesterone in Oil- 2 vial limit

  • greenhillgirlgreenhillgirl member
    https://www.accessdata.fda.gov/scripts/drugshortages/dsp_ActiveIngredientDetails.cfm?AI=Progesterone Injection, USP&st=c&tab=tabs-1

    PresentationAvailability and Estimated Shortage DurationRelated InformationShortage Reason (per FDASIA)
    50MG 1X10ML (NDC 0591-3128-79)Product is currently on backorder. Next forecasted supply date is by end of April 2018.Teva is working to improve forecasted supply date.Demand increase for the drug
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  • dragonette505dragonette505 member
    I guess I was lucky and my pharmacy gave me the 3 my doc ordered (last week) glad I got my hands on it
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  • prudence9-2prudence9-2 member
    @greenhillgirl did you try Freedom? 
    TTC history in spoiler box:
    Me: 42, single
    Hysteroscopy: 2013
    IUI #1-2: 2013 BFN
    Surgery 10/2015: Planned to start trying again but had a surgery. (Not related to fertility)
    Surgery 5/2016: Planned to start trying again but had another surgery. (Not related to fertility)
    IUI  #3-5 (with Clomid): summer 2016 BFN
    IVF #1: 11/2016. 30R; 21M; 20F; 8B (6 day5 & 2 day6); 4 normal after PGS
    Medicated FET #1: 1/31/2017 transferred 1 embryo 3AA. BFP. Embryo stopped growing at 6w 1d. MUA at 9w 3d.
    Medicated FET #2: June 2017 - cancelled...
    Hysteroscopy #2: June 2017
    Medicated FET #2: 8/7/2017 transferred 1 embryo 5BB. BFP. Ended in CP.
    Medicated FET #3: 10/11/2017 transferred 1 embryo 3AA. BFN
    ERA: December 2017 - need an extra 12 hours of PIO
    Medicated FET #4: 1/24/2018 transferred 1 embryo 4AA. BFN
    Out of embryos.  :'(
    IVF #2: 03/2018.

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  • mayflower513mayflower513 member
    Yikes!
    Pregnancy TickerAbout me: *TW*

    Me: 34, DH: 38                                                                                                                                                                                
    TTC #1 June of 2014  9/14 BFP, baby boy EDD 5/18/15. Elias (Eli) born 5/13/15 7lb0oz, 19 inches.                                      
    Surprise BFP 10/15, live ectopic, lost ruptured tube on 11/5/15 at 8 weeks                                                                              
    Started TTC #2 2/16                                                                                                                                                                   
    HSG 1/18 after no BFPs- diagnosed w/ tubal infertility and referred to RE                                                                     
    3/28/18 remaining tube removed                                                                                                                                              
    IVF 5/18: 15 retrieved, 11 fertilized, 8 blasts -- (3) 4aa, (2) 5aa (2) 4ba frozen -- fresh transfer of 1 day-5 4aa blast, BFP, EDD 2/4/19

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  • mcgeevamcgeeva member
    Wow that’s crZy!!

    Married: 5/09 ~ TTC Since: 10/10 ~ PCOS ~ Progesterone from 10/10 - 2/11 ~ HSG on 3/18 - Clear ~ Started Metformin 1000mg & Clomid 50mg 2/11 ~ Metformin upped to 1500mg 4/6 ~ 6/7 Now going to SG and put on Clomid, Ovidrel, Gonal F, Prometrium, Estrace ~ IUI #1 7/2 = BFP!!!!!! March 6th our little man was born. 

    6/17/13 - Ovidrel, Follistim, Prometrium ~ IUI #1 7/2 = BFP! March 17th our St. Pattys day baby arrived

    10/29/17 - Started process for IVF, got pregnant & miscarried a 2nd time since summer. 2/22 started stims - Menopur, Gonal F, Cetrotide - retrieval 3/6 - , PIO, estrace 3xday - FET 4/18 = Beta 1: 616; Beta 2: 1342 = BFP 

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  • stephanienjstephanienj member
    I believe Glen Rock Pharmacy in NJ makes their own in olive oil. I'm not 100% on this though this i don't take pio and I'm on Crinone instead...but this is what I've heard in case anyone needs it and wants to check into this
    Me 33, DH 39
    Poor Ovulation & MFI (very low for all counts)
    TTC #1 12/2006.
    Clomid for ovulation- 10/2007 & 11/2007- no effect- Told we'd never conceive naturally.
    Natural BFP- 10/2008, Miracle Boy born 6/18/2009

    TTC #2- Since 6/2011
    1st RE apt- 2/2014
    TTC put on back burner 6/2014-1/2016
    Diagnosed w/ Thyroid Cancer- 3/2016, Radiation 9/2016 (no ttc x 1 yr)
    Resume RE- 9/2017- Myomectomy 6 Fibroids- 12/2017
    IVF w/ICSI #1- 8r,5m,5f, Transferred 1 5d blast, 0 made freeze. Bets #1-8dp= 7 :(


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  • adiratadirat member
    I remember this from last time :( Some local compounding pharmacies can make this for you, in a different oil, too. It's worth asking. 


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  • [Deleted User][Deleted User] member
    I was able to get mine compounded in olive oil, no problem.  It was still just the difference between getting 2 or 3 vials at a time, and they deliver next day, if needed (though I recommend calling a few days before you know you're going to run out.)
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  • greenhillgirlgreenhillgirl member
    edited March 2018
    prudence9-2  this is with Freedom, who my RE and my insurance requires. I got my two vials today and its a different brand, but it looks like different manufacturers all have shortages and are enforcing the two vial limit with the sesame. 

    Two vials was fine for me for now, just surprised. 
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  • prudence9-2prudence9-2 member
    @greenhillgirl oh wow! I remember the last time that there was a shortage and I was able to easily get PIO from Freedom!!! 

    Ill keep that in mind. I’m on PIO now. And if I get a BFP I’ll need more!  :)
    TTC history in spoiler box:
    Me: 42, single
    Hysteroscopy: 2013
    IUI #1-2: 2013 BFN
    Surgery 10/2015: Planned to start trying again but had a surgery. (Not related to fertility)
    Surgery 5/2016: Planned to start trying again but had another surgery. (Not related to fertility)
    IUI  #3-5 (with Clomid): summer 2016 BFN
    IVF #1: 11/2016. 30R; 21M; 20F; 8B (6 day5 & 2 day6); 4 normal after PGS
    Medicated FET #1: 1/31/2017 transferred 1 embryo 3AA. BFP. Embryo stopped growing at 6w 1d. MUA at 9w 3d.
    Medicated FET #2: June 2017 - cancelled...
    Hysteroscopy #2: June 2017
    Medicated FET #2: 8/7/2017 transferred 1 embryo 5BB. BFP. Ended in CP.
    Medicated FET #3: 10/11/2017 transferred 1 embryo 3AA. BFN
    ERA: December 2017 - need an extra 12 hours of PIO
    Medicated FET #4: 1/24/2018 transferred 1 embryo 4AA. BFN
    Out of embryos.  :'(
    IVF #2: 03/2018.

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  • mcgeevamcgeeva member
    Shoot now I’m all worried since I use freedom and need all my crap by next Friday. 

    Married: 5/09 ~ TTC Since: 10/10 ~ PCOS ~ Progesterone from 10/10 - 2/11 ~ HSG on 3/18 - Clear ~ Started Metformin 1000mg & Clomid 50mg 2/11 ~ Metformin upped to 1500mg 4/6 ~ 6/7 Now going to SG and put on Clomid, Ovidrel, Gonal F, Prometrium, Estrace ~ IUI #1 7/2 = BFP!!!!!! March 6th our little man was born. 

    6/17/13 - Ovidrel, Follistim, Prometrium ~ IUI #1 7/2 = BFP! March 17th our St. Pattys day baby arrived

    10/29/17 - Started process for IVF, got pregnant & miscarried a 2nd time since summer. 2/22 started stims - Menopur, Gonal F, Cetrotide - retrieval 3/6 - , PIO, estrace 3xday - FET 4/18 = Beta 1: 616; Beta 2: 1342 = BFP 

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  • kristimh80kristimh80 member
    Yep! When I talked to the pharmacy about my PIO order, she said there was a shortage but was able to give me 3 vials. Said they usually get 10 vials at a time in here and there, but would be until May she thought till things got better.
    TTC #1 since April 2015
    June 2016 - CP
    2017 - Medicated Cycles & IUI's
    IVF w/ PGS  - January 2018
    FET #1 - April 2018 - BFN
    ERA Cycle May / June 2018
    ERA Biopsy June 2018 ~ Results: receptive (no change)
    FET #2 - July 2018 - BFP <3 Beta #1 - 137 Beta #2 - 410
    U/S #1 7wk1d - HB 144 U/S #2 9w1d HB 166
    Anatomy Scan 1st 11/2/18 2nd AS 11/19
    EDD March 28, 2019
    Baby Girl born 3/26/19  <3



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  • mcgeevamcgeeva member
    @kristimh80 well I guess I’ll find out this week when mine gets ordered

    Married: 5/09 ~ TTC Since: 10/10 ~ PCOS ~ Progesterone from 10/10 - 2/11 ~ HSG on 3/18 - Clear ~ Started Metformin 1000mg & Clomid 50mg 2/11 ~ Metformin upped to 1500mg 4/6 ~ 6/7 Now going to SG and put on Clomid, Ovidrel, Gonal F, Prometrium, Estrace ~ IUI #1 7/2 = BFP!!!!!! March 6th our little man was born. 

    6/17/13 - Ovidrel, Follistim, Prometrium ~ IUI #1 7/2 = BFP! March 17th our St. Pattys day baby arrived

    10/29/17 - Started process for IVF, got pregnant & miscarried a 2nd time since summer. 2/22 started stims - Menopur, Gonal F, Cetrotide - retrieval 3/6 - , PIO, estrace 3xday - FET 4/18 = Beta 1: 616; Beta 2: 1342 = BFP 

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  • kristimh80kristimh80 member
    @mcgeeva Maybe your doctor has someone local to your area. Mine had a local pharmacy fill it. Thinking maybe one's that aren't super big may have more supply on hand since they aren't a main source everyone goes to :) Or they can order you a PIO that isn't in sesame, but another oil that is just as good, just not as much of a popular choice. 
    TTC #1 since April 2015
    June 2016 - CP
    2017 - Medicated Cycles & IUI's
    IVF w/ PGS  - January 2018
    FET #1 - April 2018 - BFN
    ERA Cycle May / June 2018
    ERA Biopsy June 2018 ~ Results: receptive (no change)
    FET #2 - July 2018 - BFP <3 Beta #1 - 137 Beta #2 - 410
    U/S #1 7wk1d - HB 144 U/S #2 9w1d HB 166
    Anatomy Scan 1st 11/2/18 2nd AS 11/19
    EDD March 28, 2019
    Baby Girl born 3/26/19  <3



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  • mcgeevamcgeeva member
    There is a specialty fertility pharmacy but not sure about the prices. I used to go here before because I had no coverage and they offered discounts. I’ll def have to ask about that.

    Married: 5/09 ~ TTC Since: 10/10 ~ PCOS ~ Progesterone from 10/10 - 2/11 ~ HSG on 3/18 - Clear ~ Started Metformin 1000mg & Clomid 50mg 2/11 ~ Metformin upped to 1500mg 4/6 ~ 6/7 Now going to SG and put on Clomid, Ovidrel, Gonal F, Prometrium, Estrace ~ IUI #1 7/2 = BFP!!!!!! March 6th our little man was born. 

    6/17/13 - Ovidrel, Follistim, Prometrium ~ IUI #1 7/2 = BFP! March 17th our St. Pattys day baby arrived

    10/29/17 - Started process for IVF, got pregnant & miscarried a 2nd time since summer. 2/22 started stims - Menopur, Gonal F, Cetrotide - retrieval 3/6 - , PIO, estrace 3xday - FET 4/18 = Beta 1: 616; Beta 2: 1342 = BFP 

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  • J1006J1006 member
    I go through Mandells and got five vials, but I’m not sure what oil it’s in. This was about a month ago before my first cycle was cancelled. So glad I got the extra vials! 
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  • ndz2018ndz2018 member
    I got my PIO (sesame oil) weeks ago from Schraft Pharmacy in NJ( it’s local) in prep for my April FET  but I only Got 2 vials they said nothing about a 2 vial limit. That being said my SIL who stopped her PIO in Feb had to get hers in olive oil because of the shortage.  I will definitely ask because I’m REALLY hoping to need more  :)
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  • greenhillgirlgreenhillgirl member
    mcgeeva don't worry, I just got mine through Freedom from a refill order I called in on Thursday by noon Friday next day delivery. It's just annoying that they will only give two vials at a time. I'm on 1.5 ml a day right now so that means calling in for refill less than every 2 weeks. Oh well.
    Report Reply
  • mcgeevamcgeeva member
    @greenhillgirl well it’s good to know they have it!!

    Married: 5/09 ~ TTC Since: 10/10 ~ PCOS ~ Progesterone from 10/10 - 2/11 ~ HSG on 3/18 - Clear ~ Started Metformin 1000mg & Clomid 50mg 2/11 ~ Metformin upped to 1500mg 4/6 ~ 6/7 Now going to SG and put on Clomid, Ovidrel, Gonal F, Prometrium, Estrace ~ IUI #1 7/2 = BFP!!!!!! March 6th our little man was born. 

    6/17/13 - Ovidrel, Follistim, Prometrium ~ IUI #1 7/2 = BFP! March 17th our St. Pattys day baby arrived

    10/29/17 - Started process for IVF, got pregnant & miscarried a 2nd time since summer. 2/22 started stims - Menopur, Gonal F, Cetrotide - retrieval 3/6 - , PIO, estrace 3xday - FET 4/18 = Beta 1: 616; Beta 2: 1342 = BFP 

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  • ChristenMA83ChristenMA83 member
    Still available from Glen Rock Pharmacy with no issues - just reordered.
    December FET Spreadsheet
    TTC History in spoiler  Instagram
    Me 35 - DH 42
    Married Oct 2007
    TTC Since Oct 2010 - MFI Diagnosis 2012 (Morphology 1% + High DNA Frag)
    IUI x2 in 2012 - BFN
    IVF #1 Feb 2018 - 9 Retrieved - 8 Mature - 5 Fertilized - 2 Snowbabies - no testing
    FET#1 March 2018 - BFP - MMC May @ 10w4d
    FET#2 July 2018 - BFN
    IVF #2 Nov 2018 - 10 Retrieved - 10 Mature - 8 Fertilized - 2 Snowbabies - no testing
    “Never give up on something that you can't go a day without thinking about.”― Winston Churchill
    Report Reply
  • mcgeevamcgeeva member
    I just got mine from freedom no issues here!!

    Married: 5/09 ~ TTC Since: 10/10 ~ PCOS ~ Progesterone from 10/10 - 2/11 ~ HSG on 3/18 - Clear ~ Started Metformin 1000mg & Clomid 50mg 2/11 ~ Metformin upped to 1500mg 4/6 ~ 6/7 Now going to SG and put on Clomid, Ovidrel, Gonal F, Prometrium, Estrace ~ IUI #1 7/2 = BFP!!!!!! March 6th our little man was born. 

    6/17/13 - Ovidrel, Follistim, Prometrium ~ IUI #1 7/2 = BFP! March 17th our St. Pattys day baby arrived

    10/29/17 - Started process for IVF, got pregnant & miscarried a 2nd time since summer. 2/22 started stims - Menopur, Gonal F, Cetrotide - retrieval 3/6 - , PIO, estrace 3xday - FET 4/18 = Beta 1: 616; Beta 2: 1342 = BFP 

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  • greenhillgirlgreenhillgirl member
    Nice! @ChristenMA83 and @mcgeeva ! did you get more than two vials at a time?

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  • mcgeevamcgeeva member
    Yup only two viles :) so just means I’ll be watching it to call back for more earlier if needed.

    Married: 5/09 ~ TTC Since: 10/10 ~ PCOS ~ Progesterone from 10/10 - 2/11 ~ HSG on 3/18 - Clear ~ Started Metformin 1000mg & Clomid 50mg 2/11 ~ Metformin upped to 1500mg 4/6 ~ 6/7 Now going to SG and put on Clomid, Ovidrel, Gonal F, Prometrium, Estrace ~ IUI #1 7/2 = BFP!!!!!! March 6th our little man was born. 

    6/17/13 - Ovidrel, Follistim, Prometrium ~ IUI #1 7/2 = BFP! March 17th our St. Pattys day baby arrived

    10/29/17 - Started process for IVF, got pregnant & miscarried a 2nd time since summer. 2/22 started stims - Menopur, Gonal F, Cetrotide - retrieval 3/6 - , PIO, estrace 3xday - FET 4/18 = Beta 1: 616; Beta 2: 1342 = BFP 

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  • prudence9-2prudence9-2 member
    edited April 2018
    Just ordered 3 vials from Freedom. 

    I actually didn’t need more for at least another week. But because of this thread I got nervous and ordered now. 
    TTC history in spoiler box:
    Me: 42, single
    Hysteroscopy: 2013
    IUI #1-2: 2013 BFN
    Surgery 10/2015: Planned to start trying again but had a surgery. (Not related to fertility)
    Surgery 5/2016: Planned to start trying again but had another surgery. (Not related to fertility)
    IUI  #3-5 (with Clomid): summer 2016 BFN
    IVF #1: 11/2016. 30R; 21M; 20F; 8B (6 day5 & 2 day6); 4 normal after PGS
    Medicated FET #1: 1/31/2017 transferred 1 embryo 3AA. BFP. Embryo stopped growing at 6w 1d. MUA at 9w 3d.
    Medicated FET #2: June 2017 - cancelled...
    Hysteroscopy #2: June 2017
    Medicated FET #2: 8/7/2017 transferred 1 embryo 5BB. BFP. Ended in CP.
    Medicated FET #3: 10/11/2017 transferred 1 embryo 3AA. BFN
    ERA: December 2017 - need an extra 12 hours of PIO
    Medicated FET #4: 1/24/2018 transferred 1 embryo 4AA. BFN
    Out of embryos.  :'(
    IVF #2: 03/2018.

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