Infertility

Three Failed Transfers (all kinds of TWs)

Hello, ladies
I am writing this in tears after learning yesterday that my beta came back at 6.6 after my FET#2. This is my second CP in the last 6 month. They told me to repeat the beta tomorrow  but I know it is just protocol at this point. 
I have tubal infertility and we did our first IVF in September. We retrieved 7 eggs. Not much but my right ovary is not responding properly- they think we damaged it's blood supply when my right tube was removed spring 2017. Anyway from 7 eggs we got 4 blasts! Great percentage and RE was super happy about that! We transferred one fresh and ended in CP ( First beta 147 but second beta only 49). Onto FET#1 which did not work at all and we got a BFN . RE assured us that it is just bad luck, we adjusted the protocol ( added endo scratch and Medrol) FET #2 started very well, the embie was beautiful, the lining was great and I started feeling all my pregnancy symptoms ( cramps and super sore boobs) by 4dpt. I was on cloud nine for 3 days! I just knew I was pregnant! Then on Monday 7dpt the symptoms just started fading away and beta on Wednesday was 6.6. 

I only have one day 6 blast left, it is the worst blast out of the bunch. Is it even worth transferring it at this point if better quality embies failed? Is it my uterus killing embryos? What is wrong with me?

I am mentally prepping for IVF round 2 but I am losing hope at this point. Please talk me into hoping again.

Me 30, DH 39
TTC since Aug 2015, 
BFP Apr 2017 - late diagnosed EP, right tube removed, left tube scarred.
Dx: tubal IF
IVF Sept 2017, 7 R, 6M, 6F- 4 blasts, 1 transferred fresh - CP
FET #1 Dec 2017- BFN
FET #2 Jan 2018- CP
FET #3 BFP!!! EDD 12/15/2018!

Re: Three Failed Transfers (all kinds of TWs)

  • Oh no!  I’m SO sorry to hear this :(. Have you done an ERA?  I took this past cycle off (and mostly off of the bump) to do one because I want to do a natural cycle FET next time.  I’m probably not the most encouraging case as I’ve just started stimming for IVF #5.  I know you’re younger, but has he RE mentioned PGS testing (I don’t think you’d mentioned)?  I’m so sorry you’re going through this.  >>>hugs<<<
    About me:
    Married 6/18/16 (Me 42, DH 44), TTC #2
    ***TW***
    Natural BFP 8/10/16 --> mc our NIPT-normal little girl at 11w5d on 10/1/16 :(
    As of 12/2016:  AMH 1.42, FSH 6.1, AFC ~10
    Self-benched Nov-Dec 2016 for
    IVF #1 Jan-Feb 2017 (OCP, testosterone primed antagonist w/HGH - ER 2/2/17 - 12R, 7M ICSI'd, 3F, 0B)
    IVF #2 Mar-Apr 2017 (testosterone primed agonist/luteal lupron w/HGH - ER 4/8/17 - 10R, 8M, 8F, 5B, 1 PGS normal)
    IVF #3 May-Jun 2017 (testosterone primed agonist/luteal lupron w/HGH - ER 6/4/17 - 14R, 5F, 3B, 0 normal)
    **New RE**
    IVF #4 Sept 2017 (natural start microdose lupron flare w/HGH - ER 9/28/17 - 33R, 18F, 10B, 4 PGS normals!)
    FET #1 (medicated) of one PGS normal 4AA XX 11/2/17 - Beta #1 11/11/17 (153), Beta #2 11/13/17 (324), mc at 5w1d on 11/19/17 :(
    IVF #5 Dec 2017 - Insemination of 9 frozen eggs from 2012 (8F, 1B, 0 normal)
    Jan 2018 - Natural cycle ERA (normal/receptive) & stimming for
    IVF #6 Jan-Feb 2018 (natural start microdose lupron flare w/HGH - ER 2/3/18 - 17R, 6M, 4F, 0 blasts)
    IVF #7 Feb 2018 (natural start microdose lupron flare w/HGH - ER 2/26/18 - 19R, 9M, 9F, 4B, 2 PGS normals)
    FET #2 Apr 2018 (natural cycle w/o trigger, w/P4 support) of one PGS normal 4AA- XX 4/5/18 - Beta #1 4/14/18 (67), Beta #2 4/16/18 (231)
    Rainbow baby girl born 12/16/2018 (via c-section, induced at 39 weeks)

    -----
    TFAS!
    FET #3 Dec 2019 (natural cycle w/o trigger, w/P4 support) of one PGS normal 3BB XY 12/16/19 - Beta #1 12/24/19 (139), Beta #2 12/27/19 (482)

    Lilypie Maternity tickers
  • @artemis618 oh no, I am so sorry for your loss. ERA is going to be my next step probably. My RE thinks we are not there yet for PGS but I am thinking about it too. I am just so bummed and want to make sure it is not my body killing all those "perfect" embryos
    Me 30, DH 39
    TTC since Aug 2015, 
    BFP Apr 2017 - late diagnosed EP, right tube removed, left tube scarred.
    Dx: tubal IF
    IVF Sept 2017, 7 R, 6M, 6F- 4 blasts, 1 transferred fresh - CP
    FET #1 Dec 2017- BFN
    FET #2 Jan 2018- CP
    FET #3 BFP!!! EDD 12/15/2018!
  • Loading the player...
  • I agree with @JamieH2000 4 out of 7 made it to blast must indicate a really good quality!!! 

    Im still not sure if the ERA tweak will make any difference for me. But it definitely gave me hope coming into this cycle. So I def think you should try it before your next transfer. 
    TTC history in spoiler box:
    Me: 42, single
    Hysteroscopy: 2013
    IUI #1-2: 2013 BFN
    Surgery 10/2015: Planned to start trying again but had a surgery. (Not related to fertility)
    Surgery 5/2016: Planned to start trying again but had another surgery. (Not related to fertility)
    IUI  #3-5 (with Clomid): summer 2016 BFN
    IVF #1: 11/2016. 30R; 21M; 20F; 8B (6 day5 & 2 day6); 4 normal after PGS
    Medicated FET #1: 1/31/2017 transferred 1 embryo 3AA. BFP. Embryo stopped growing at 6w 1d. MUA at 9w 3d.
    Medicated FET #2June 2017 - cancelled...
    Hysteroscopy #2: June 2017
    Medicated FET #2: 8/7/2017 transferred 1 embryo 5BB. BFP. Ended in CP.
    Medicated FET #3: 10/11/2017 transferred 1 embryo 3AA. BFN
    ERA: December 2017 - need an extra 12 hours of PIO
    Medicated FET #4: 1/24/2018 transferred 1 embryo 4AA. BFN
    Out of embryos.  :'(
    IVF #2: 03/2018.

  • Wow! Great article!! @JamieH2000 thanks for sharing!!
    TTC history in spoiler box:
    Me: 42, single
    Hysteroscopy: 2013
    IUI #1-2: 2013 BFN
    Surgery 10/2015: Planned to start trying again but had a surgery. (Not related to fertility)
    Surgery 5/2016: Planned to start trying again but had another surgery. (Not related to fertility)
    IUI  #3-5 (with Clomid): summer 2016 BFN
    IVF #1: 11/2016. 30R; 21M; 20F; 8B (6 day5 & 2 day6); 4 normal after PGS
    Medicated FET #1: 1/31/2017 transferred 1 embryo 3AA. BFP. Embryo stopped growing at 6w 1d. MUA at 9w 3d.
    Medicated FET #2June 2017 - cancelled...
    Hysteroscopy #2: June 2017
    Medicated FET #2: 8/7/2017 transferred 1 embryo 5BB. BFP. Ended in CP.
    Medicated FET #3: 10/11/2017 transferred 1 embryo 3AA. BFN
    ERA: December 2017 - need an extra 12 hours of PIO
    Medicated FET #4: 1/24/2018 transferred 1 embryo 4AA. BFN
    Out of embryos.  :'(
    IVF #2: 03/2018.

  • Thank you @prudence9-2

    @JamieH2000 I was on baby aspirin every cycle and we had Medrol (steroid I think...) for 4 days before this last transfer. I really want to do an ERA next. Did you get your's done yet? 

    I am just trying to stay sane at this point. Will talk to RE after my blood work tomorrow.

    The most annoying thing is the message the nurse left me yesterday about beta being 6.6. She said "let's be cautiously optimistic" WTF?! They are supposed to know what they are doing! 6.6 is not cautiously optimistic! IT is "hey you got one in a million shot at viable pregnancy"! I don't need this sugar coated! 

    My RE also thinks that my CP's are potential ectopics and is pushing me to remove my left tube as well. I am not sure how I feel about this whole thing. It is a surgery that I would rather avoid because I need something more than his hunch to go ahead and do it. And what if they damage my left good ovary in the process?

    AHHHHH... I am just so angry, lost and confused at the whole situation!

    Me 30, DH 39
    TTC since Aug 2015, 
    BFP Apr 2017 - late diagnosed EP, right tube removed, left tube scarred.
    Dx: tubal IF
    IVF Sept 2017, 7 R, 6M, 6F- 4 blasts, 1 transferred fresh - CP
    FET #1 Dec 2017- BFN
    FET #2 Jan 2018- CP
    FET #3 BFP!!! EDD 12/15/2018!
  • If you do have to do another round of IVF (hopefully not, praying for success), is there another RE office you could try?

    TW - I had 4 blasts that were frozen. Neither of the *optimal* ones made it.. one was a CP and the other was just a BFN. The third was of lower quality but it successfully stuck and I had great numbers/BFP. I am waiting on genetic testing but so far it looks like the baby is doing great.

    I know all situations are different, but the medications my RE had me on at the time of transfer were pio shots (3cc or whatever), estriadol, 2 minivelle patches every 3 days, baby aspirin, steroids 1 day before and 4 days after transfer, daily lovenox shots, plaqueinil, folic acid, vitamin D. Also he had me do a hyseroscopy prior to starting the FETs. His next step if these last two embryos failed was PGS with IVF because he seems to think I may have "abnormal" eggs.
  • @cseley321 Congrats on the pregnancy! I already switched clinics ones, we have the best RE in the area. I don't have blood clotting issues ( more of the opposite- I am a super bleeder) It is interesting that you had steroids after transfer rather than before, I will ask my RE about that.
    PGS is definitely something to consider for me. Thank you for responding
    Me 30, DH 39
    TTC since Aug 2015, 
    BFP Apr 2017 - late diagnosed EP, right tube removed, left tube scarred.
    Dx: tubal IF
    IVF Sept 2017, 7 R, 6M, 6F- 4 blasts, 1 transferred fresh - CP
    FET #1 Dec 2017- BFN
    FET #2 Jan 2018- CP
    FET #3 BFP!!! EDD 12/15/2018!
  • @DecemberDoll27 it's really easy to get discouraged. On the transfer that worked I even tried eating pineapples, pomegranate juice (yuck). I was desparate. I am not sure if any of that helped, but I figured it couldn't hurt.

    I really do hope this next round works. Try not to stress out about the quality. My RE is very straightforward with me, and he basically said even though they aren't as favorable as the other two were, the chances were still very good.
  • thank you @cseley321. I found a story on the internet it is called "Not Suitable For Transfer" ( here is a link https://www.fertilityfriends.co.uk/forum/index.php?topic=181289.0 ). It appears on many fertility forums and  I don't know how true the story is but it gave me the whole new prospective on hope. ( I cried like a crazy lady at work in my cube and trying not to sob loudly) So I will still be hopeful for my last embie. Out of 4 one should be a take home baby, right?
    Me 30, DH 39
    TTC since Aug 2015, 
    BFP Apr 2017 - late diagnosed EP, right tube removed, left tube scarred.
    Dx: tubal IF
    IVF Sept 2017, 7 R, 6M, 6F- 4 blasts, 1 transferred fresh - CP
    FET #1 Dec 2017- BFN
    FET #2 Jan 2018- CP
    FET #3 BFP!!! EDD 12/15/2018!
  • Try not to get discouraged, I know it's not easy though. Most of the times with CPs, BFNs and MCs the issue is with the embryo, not the uterus. Depending on your age, stats say half or more embryos are not genetically normal. Have you tried a natural FET with Femara, steroids and trigger shot that induces your own progesterone?
  • @decemberdoll27 oh friend I am so sorry to see you post this. 
    I think you have some great advice already.
    Especially love to see the support from @artemis618 and @jamieh2000 - true warriors.

    I would also say, if you want more than one child, get another round of IVF in now and add in PGS (but make sure it’s next gen). Then do ERA and a fresh HSG with a saline sono too. Then back to FETs with all the bells and whistles on the protocol.

    If there are polyps get them removed before more transfers. If the Saline Sono shows any issues with your remaining tube you might need to think about it... as it could be leaking stuff into your Ute which affects implantation etc. But at least you’d have had another ER first.

    If in doubt. Get another opinion. You can get free Skype consults from a number of other top clinics but they tend to have a waiting list. I’ve just taken the first date from each and if I have a solution before will cancel them. Just call, book it and then you have it as a backup plan in a few months time if you’re not comfortable to do it with just the “hunch”.

    Sending you huge hugs and you know where I am if you need someone  <3
    Me 43 DH 45
    Married 12/2016
    TTC #1 since 04/2015
    AMA, DOR (AMH 0.65, AFC 2-4) and autoimmune issues (RA, APS), low TSH, adenomyosis
    7 retrievals, 3 transfers
    Jun19 FET BFP, due date 7th March 2020, DD born Feb20
    Sep17 IVF1 - 1ER, 1F, 1ET, BFN
    Nov17 IVF2 - 1ER, 0F
    Jan18 IVF3 - 3ER, 1F, 1ET, BFN
    Feb18 - second opinion and additional testing
    Apr18 IVF4 - cancelled (E2 too high)
    May/Jun18 IVF4 - 4ER, 0M, 1F, 1 frozen day 3 (not best quality)
    Jun/Jul18 IVF5 - 5 ER, 3M, 2F, 2 frozen day 3 (not best quality)
    Jul/Aug18 IVF6 - 4ER, 3M, 2F, 2 frozen day 3 (good quality)
    Aug/Sep18 IVF7 - cancelled (cyst)
    Sep/Oct18 IVF7 - 3ER, 3M, 2F, 2 frozen Day 3 (excellent quality)
    Oct18 IVF8 - Cancelled (cyst and too low TSH)
    Oct18-Jan19 bringing TSH under control
    Feb19 ERA and hysteroscopy
    Mar19 Investigation for fibroid and adenomyosis
    Apr19 adenomyosis confirmed, polyps removed
    Jun19 FET after 2 months Lupron, autoimmune protocol, transferred two day 3 frozen embryos
    Sep17 - Pergoveris 10-17 Sep, Orgalutran 15-18 Sep, Ovitrelle 18 Sep, ER 20 Sep for 2 follies, 1 mature egg, fertilized, ET 1x 2d 4-cell embryo 22/09, 05/10 BFN
    Nov17 IVF2 - Pergoveris 2-14 Nov, Orgalutran 5-14 Nov, Ovitrelle 15 Nov, ER 17 Nov for 3 follies, 1 mature egg, did not fertilize
    Jan18 IVF3 - Pergoveris 30 Dec - 8 Jan, Orgalutran 5-8 Jan, Ovitrelle 9 Jan, ER 11 Jan 3 eggs, 2 mature, 1 fertilized, ET 1x 4d 12-cell embryo 15/01, 24/01 BFN
    May/Jun18 IVF4 - Rekovelle 25-29 May, Menogon 30May - 2Jun, Zomacton 25 27 29 31 May and 2Jun, Cetrotide 30May - 3Jun, Gonasi 3Jun, ER 5Jun 4 eggs, none mature, two matured overnight, 1 fertilized with ICSI, Frozen day 3 but not good quality
    Jun/Jul18 IVF5 - Rekovelle 21-24 June, Menogon 25Jun-3Jul, Puregon 4-5Jul, Zomacton 21 23 25 27 29 Jun, Cetrotide 25Jun-5Jul, Gonasi 6Jul, ER 8Jul 5 eggs, 3 mature, 2 fertilized with ICSI, 2 frozen day 3 but not good quality
    Jul/Aug18 IVF6 - Rekovelle 26-29 Jul, Menogon 30Jul-7Aug, Buserelin 26Jul-7Aug, Zomacton 26 28 30 Jul 1 3 Aug, Gonasi 7Aug, ER 9Aug 4 eggs, 3 mature, 2 fertilized (normal IVF), 2 frozen day 3 good quality
    Sep/Oct18 IVF7 - Menogon 19-30Sep, Buserelin 19-30Sep, Zomacton 19 21 23 25 27 Sep, Ovitrelle 1 Oct, ER 3 eggs, 3 mature, 2 fertilized with ICSI, 2 frozen day 3 excellent quality 

    Fav Quote: The greatest thing you'll ever learn is just to love and be loved in return

  • @DecemberDoll27 (((hugs))) to you friend. 
  • @decemberdoll27- my ERA should be on Wed, so happy to share my experience/results once I get them. It sounds like only 20% of ladies have a window that is off of the standard 5 day transfer, but its not too expensive ($1k-2k depending on insurance) so it may be worth it just to check it off the list... That is crazy about your nurse... while i am praying for you to be that miracle, i think she could have been hopeful but a little more realistic. I would also be concerned about removing the tube if you don't need to. Unless its causing a hyrdosalphinx (sp?), it shouldn't impact anything... I would definitely question her about the risks of removing it and how it could impact your remaining good ovary. A skilled surgeon should be able to take it without damaging your ovary, but there are always risks. I have one damaged/dead ovary as well (confirmed during my lap) and it is possible that it got damaged during my appendectomy when I was 18, but we will never know for sure of course.
    History in Spoiler

    Age: 32 (same with DH). Together since 2006, Married June 2013 and TTC since August 2015
    Diagnosis: Mild Endo, DOR (AMH of 1.5), Poor Quality Eggs/embryos, Displaced Window of Implantation (ERA Post Receptive)
    March-May 2016: 1 TI and 2 IUIs- BFN 
    June 2016- Laproscopy- found/removed mild endo and confirmed only 1 normal healthy ovary.
    August 2016- IVF #1 with Antagonist Protocol- Cancelled (2 lead follies), converted to IUI- BFN
    Oct-Nov 2016- IVF #2 with Estrogen Priming Micro Lupron Protocol, 2 eggs retrieved, day 3 transfer of 1- BFN
    January 2017- New RE, IVF#3 with Estrogen Priming Antagonist Protocol, 12 eggs, 8 mature, 6 fertilized, 2 day 5 early blasts transferred (none to freeze :(), BFN
    May 2017- Sept 2017- Starting Donor Egg process! Waiting for donor to be available... and then she is pregnant at baseline :(
    Oct 2017- Donor #2: 25R, 22M,18F, 12 blasts frozen! Fresh transfer cancelled due to thin lining with fluid :(
    Nov 2017- Hysterscopy to remove polyp
    Dec 2017- DE FET #1 on 12/8 on 2 perfect blasts- BFN and devastated
    Jan-Mar 2018- ERA #1- Post receptive by 24 hours, ERA #2 RECEPTIVE with 4 days of Progesterone
    Apr 2018- DE FET cancelled for lining issues :(
    Jun 2018- DE FET #2 of two 1AA blasts- first BFP ever! Beta 10dp5dt- 378, Beta 14dp5dt- 2840, Beta 16dp5dt- 4035, beta 18dp5dt- 10916. Due on 2/20 with one baby after a vanishing twin
    Baby Born born early @ 33.5 weeks due to Pre-e
    Back for # 2!
  • @decemberdoll27 Oh friend, I'm so sorry to see this. I'm heartbroken for you. After my fet failed I was looking for answers and what I saw across the board is that embryo problems are the number one cause. PGS may be a good option for a future retrieval if you do one, but I agree with PPs that an ERA may help as well. 

    Another thing I've read about is intralipids infusion (my RE doesn't do this so I don't know much about it). A hysteroscopy to look for new polyps or fibroids may also be an option. 

    I hope you can get to the bottom of this and get your take home baby. Hugs friend.



  • @DecemberDoll27 I'm so sorry about your low beta.  I've had a bunch of chemical pregnancies too and those are so so painful.  You go from being super excited and mentally planning a baby to absolutely crushed.  I agree with the others that PGS testing may be the way to go to first ensure that the embryos are chromosomally normal and then if that doesn't work, ERA.  
    It's amazed me throughout my infertility journey has truly insensitive nurses and doctors can be.  Don't give up hope!
    TTC since August 2014 
    Me: 41, Him: 43 

    DX: Unexplained secondary infertility 

    History:
    Multiple months of Clomid/Femara
    End of March 2015: BFP with Femara! Saw heartbeat at 5.5 weeks. M/C at 11 weeks
    Multiple more months of Femara
    IUI #1 with Femara and Follistem 75 units: BFN
    IUI #2 with Follistem 150 units: BFN
    Dec 2015: 1st IVF. 10 eggs retrieved with 8 eggs fertilized.  5 day transfer of two embryos with 2 frozen embies. BFN
    January 2016: FET #1 2 embryos: BFN
    March 2016: 2nd IVF cycle. 4 eggs retrieved with 2 fertilized. Quick two day transfer of both embryos: BFN
    April/May 2016 IVF #3. 11 eggs retrieved. 10 mature.  7 fertilized.  2 5AA blasts transferred 5/11/2016 BFN
    September 2016 IVF #4: 17 follicles growing, premature ovulation through Cetrotide. Retrieval cancelled. 
    April 2017 IVF #5: 9 follicles growing, 6 eggs retrieved with 5 fertilized. Transfer of three blasts. BFN
    June 2017: IVF #6: 2 follicles growing, 5 eggs retrieved with 5 fertilized. Transfer of 5 3-day embryos. Chemical pregnancy. BFN
    Nov/Dec 2017: Donor egg cycle. 33 eggs retrieved, 26 mature. 26 fertilized. 
  • Thank you everyone! Second beta went down to 1.2 so we are stopping PIO and it is officially my second CP! I feel relieved that at least I don't have to deal with beta hell. Next step is WTF appointment with the RE. Will have a plan after that! 
    I can't express to you how much your kind words mean to me. This community is my wall, my rock, my virtual shoulder to cry on!
    Me 30, DH 39
    TTC since Aug 2015, 
    BFP Apr 2017 - late diagnosed EP, right tube removed, left tube scarred.
    Dx: tubal IF
    IVF Sept 2017, 7 R, 6M, 6F- 4 blasts, 1 transferred fresh - CP
    FET #1 Dec 2017- BFN
    FET #2 Jan 2018- CP
    FET #3 BFP!!! EDD 12/15/2018!
  • So many hugs to you.  It is so painful, I know.  And I know you have so many hopes riding on your last little embryo.  There's a lot that goes into any treatment decision, but I know if you search your heart, you will find the best path for you and your family. ❤❤❤
  • @DecemberDoll27 I'm SO sorry to hear this news. That is just unfair and awful.  I was watching this vlog recently (phil and alex if you watch youtube) and she has a very similar story to you. They did blood work and found out she has a clotting disorder.  Maybe they can do some additional testing. I'm heartbroken for you and know you have an army of people behind you.
    • Me: 36 DH: 33
    • TTC since June 2016
    • Me: PCOS DH: Morphology 1%
    • 3 TI with Famera and trigger shots-BFN
    • 3 IUI's with Famera and trigger shots- BFN
    • IVF August 2017 25 eggs retrieved, 19 mature, 13 fertilized (ICSI), 5 frozen, 3 PGS normal 
    • FET November 2017 Transferred one 6 day blast (a little GIRL) BFP EDD 8/4/18

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