MTHFR gene mutation and pregnant — The Bump
Pregnant after IF

MTHFR gene mutation and pregnant

Hi all! Recently, I found out that I am positive for the MTHFR gene mutation. I know that it means I will struggle with infertility (no shock here lol), and that I have a higher risk of miscarriage (both early and late). I was wondering if there are any ladies who are currently pregnant or have been pregnant that also has the MTHFR gene mutation? I am trying to learn a little bit more about it. I want to know my chances of being pregnant with a healthy and safe pregnancy. 

Thanks for your help!
Me 30 || DH 36
Unexplained Infertility- Postive for MTHFR Gene Mutation

Natural cycles with 1 miscarriage
-3 IUI's w/ Clomid= BFN 
-IVF #1-Follistim and Menopur= BFN
***11 Eggs, 10 mature, 8 fertilized, transferred 1 (day 5) 2 made it to freeze
-FET #1- Transferred 2, day 5 embryos =BFN
-IVF #2- Follistim and Menopur = BFN
***11 retrieved, 8 mature, 6 fertilized, transferred 2 (day 3), 4 made it to freeze (Follistim and Menopur) = BFN
-FET #2- Transferred 2, day 3 embryos = BFN
**Changed doctor**
-IUI #4- natural cycle = BFN
-IUI #5- Follistim (5 eggs) BFP- lead to Miscarriage  :'(
-Laproscopic Surgery for Endometriosis, Polyp removal and Cyst removal. 
-IVF #3- Menopur, Follistim, Lupron, Ganirellex- BFP lead to Eptopic Pregnancy  :'(
***11 Eggs retrieved, 10 Mature, 8 fertilized, transferred 3 embryos (day 3), 0 made it to freeze
-Lapropscopic surgery- Removal of Fallopian Tube
-IVF #4- Estrogen Priming with Vivelle dot, Menopur, Follistim, Ganirellex- BFP  :)
***15 Eggs retreived, 11 mature, 11 fertilized, 2 embryos transferred (day 3), 2 made it to freeze
Found out I was positive for MTHFR Gene Mutation during TWW of IVF #4

Re: MTHFR gene mutation and pregnant

  • edited October 2016
    Hi! I am homozygous for the MTHFR c677t mutation. First off and most importantly, you need to know if you are heterozygous (1 copy), homozygous (2 copies), or 1 of each (I think it's called compound). If you are heterozygous, My RE (and I believe this is pretty standard), they will recommend methyl folate instead of folic acid and that's about it (maybe also baby aspirin) Research speculates that at least 50% of the population is heterozygous and there's really no need to worry/have much medical intervention.

    Homozygous is different, the standard is usually at minimum methyl folate in conjunction with blood thinner injections. I have to take blood thinner injections the whole pregnancy and 6 weeks after I deliver.

    Compound (1 copy of each) I don't know much about.

    Also, it's my understanding that being homozygous doesn't cause too many issues in regards to getting pregnant-it's staying pregnant (so often this is looked at when women have reoccurrent loss) and preventing a baby with neural tubal defects etc...Also, to prevent mommy from clotting and/or having a worn placenta. My RE didn't even start me on blood thinners until after I was clinically confirmed as pregnant.

    Lastly, what copy do you have? I have c677t .
    Me 30 Hubby 32
    TTC#1
    1.) IUI Cycle 1 April 2015- 50mg clomid days 5-9, U/S cycle day 12 at 9:30am showed two follicles (17mm and 19mm), Ovidrel trigger shot cycle day 13 at 9:30pm, IUI cycle day 15 at 10:30 am. BFN
    2.) IUI Cycle 2 May 2015-50mg clomid days 5-9, U/S cycle day 12 at 3:30pm showed three follicles!!! (17mm, 20mm and 22mm), Ovidrel trigger shot cycle day 13 at 9:30pm, IUI cycle day 15 at 10:30 am. BFN
    3.) IUI Cycle 3 June 2015-50mg clomid days 5-9, U/S cycle day 12 showed one follicle, Ovidrel trigger shot cycle day 13 at 9:30pm, IUI cycle day 15 at 10:30 am. BFN
    Month break and switched RE's.
    4.) IUI Cycle 4 July 2015-5mg letrozole/femara days 3-7, U/S day 12 showed one follicle (18mm), Ovidrel trigger shot cycle day 12 10:00pm, IUI cycle day 14 10:30 am. BFN
    5.) IUI Cycle 5 August 2015-100mg clomid days 3-7, U/S day 12 showed 2 follicles (18mm each), Ovidrel trigger shot cycle day 12 10:00pm, IUI cycle day 14 10:30 am. BFN
    Taking a break and trying acupuncture before continuing another 3 IUI/clomid cycles. I also went back to my original RE; because of my age and normal tests, RE wants to try another 3 IUI and Clomid cycles before considering injectables or IVF. 
    6.) IUI Cycle 6 October 2015-100mg clomid days 3-7, U/S day 12 showed 3 follicles!!!( 18mm, 19mm, and 20mm), Ovidrel trigger shot cycle day 13 at 9:30pm, IUI cycle day 15 at 9:30 am. Did acupuncture with this cycle too. BFN
    Took a break and ttc naturally
    7.) IUI Cycle 7 February 2016-100mg clomid days 3-7, U/S day 12 showed 2 follicles (22mm and 24mm), Ovidrel trigger shot day 12 at 9:00pm, IUI cycle day 14 at 10:00am. BFN
    Meeting scheduled for 2/29/2016 to discuss iui with injectables vs. IVF
    8.) IUI Cycle 8 March 2016-Injectables (Gonal F), U/S showed 2 mature follicles, Ovidrel Trigger BFN
    April-May I lost my mind.
    IVF#1 July 2016-Transferred 2 fair blasts. 9dp5dt BFP 129 BETA, 13dp5dt 944 BETA, 20dp5dpt 8776 BETA, 8/19/2016-1 beautiful heartbeat  of 100 BPM at 6 weeks 1 day! Growing baby grow!! 8/25/2016-another ultrasound at 7 weeks and baby has a heart beat of 129 BPM and is 10mm/1cm! Grow baby grow some more!! Graduated from RE at 10 weeks and had ObGyn appointment at 13 weeks. It's a girl (found out via panorama test)  EDD 4/13/2017


    Lilypie Maternity tickers
  • Colleen0516Colleen0516
    1000 Comments 500 Love Its Second Anniversary First Answer
    member
    edited October 2016
    Thank for answering! At the current moment, I only know I'm postive- I'm not exactly sure if I'm Heterogeneous, homogeneous or compound. I also don't know the specific type. Just was told I'm positive and to start baby asprin. She said if I get a postive beta result I will need lovanex. 
    Im going to find out more on friday when I go to the doctor, I only spoke to the PA on the phone for a few minutes. My head was spinning from hearing the results so I didn't think to ask too many questions. 

    I really appreciate you taking the time to explain it. I have have 3 miscarriages, we have been assuming they were bad embryos but now learning this, I'm wondering if it wasn't bad embryos at all. 

    Were you considered to be a high high risk pregnancy due to potential to clot and miscarry? Or were they not too concerned since you were n the lovanex? 
    Me 30 || DH 36
    Unexplained Infertility- Postive for MTHFR Gene Mutation

    Natural cycles with 1 miscarriage
    -3 IUI's w/ Clomid= BFN 
    -IVF #1-Follistim and Menopur= BFN
    ***11 Eggs, 10 mature, 8 fertilized, transferred 1 (day 5) 2 made it to freeze
    -FET #1- Transferred 2, day 5 embryos =BFN
    -IVF #2- Follistim and Menopur = BFN
    ***11 retrieved, 8 mature, 6 fertilized, transferred 2 (day 3), 4 made it to freeze (Follistim and Menopur) = BFN
    -FET #2- Transferred 2, day 3 embryos = BFN
    **Changed doctor**
    -IUI #4- natural cycle = BFN
    -IUI #5- Follistim (5 eggs) BFP- lead to Miscarriage  :'(
    -Laproscopic Surgery for Endometriosis, Polyp removal and Cyst removal. 
    -IVF #3- Menopur, Follistim, Lupron, Ganirellex- BFP lead to Eptopic Pregnancy  :'(
    ***11 Eggs retrieved, 10 Mature, 8 fertilized, transferred 3 embryos (day 3), 0 made it to freeze
    -Lapropscopic surgery- Removal of Fallopian Tube
    -IVF #4- Estrogen Priming with Vivelle dot, Menopur, Follistim, Ganirellex- BFP  :)
    ***15 Eggs retreived, 11 mature, 11 fertilized, 2 embryos transferred (day 3), 2 made it to freeze
    Found out I was positive for MTHFR Gene Mutation during TWW of IVF #4

  • Loading the player...
  • I'm so sorry you have had 3 miscarriages. I think regardless of heterozygous vs. homozygous it would make sense to have you on lovenux. I didn't know you already had miscarriages before diagnosis so that's definitely a game changer. I had never been pregnant and I assumed you were in the same boat.

    I am not considered high risk as far as I'm aware, but I had never been pregnant. I do get scans monthly though and after 32 weeks I'm getting seen every 2 weeks for some testing.
    Me 30 Hubby 32
    TTC#1
    1.) IUI Cycle 1 April 2015- 50mg clomid days 5-9, U/S cycle day 12 at 9:30am showed two follicles (17mm and 19mm), Ovidrel trigger shot cycle day 13 at 9:30pm, IUI cycle day 15 at 10:30 am. BFN
    2.) IUI Cycle 2 May 2015-50mg clomid days 5-9, U/S cycle day 12 at 3:30pm showed three follicles!!! (17mm, 20mm and 22mm), Ovidrel trigger shot cycle day 13 at 9:30pm, IUI cycle day 15 at 10:30 am. BFN
    3.) IUI Cycle 3 June 2015-50mg clomid days 5-9, U/S cycle day 12 showed one follicle, Ovidrel trigger shot cycle day 13 at 9:30pm, IUI cycle day 15 at 10:30 am. BFN
    Month break and switched RE's.
    4.) IUI Cycle 4 July 2015-5mg letrozole/femara days 3-7, U/S day 12 showed one follicle (18mm), Ovidrel trigger shot cycle day 12 10:00pm, IUI cycle day 14 10:30 am. BFN
    5.) IUI Cycle 5 August 2015-100mg clomid days 3-7, U/S day 12 showed 2 follicles (18mm each), Ovidrel trigger shot cycle day 12 10:00pm, IUI cycle day 14 10:30 am. BFN
    Taking a break and trying acupuncture before continuing another 3 IUI/clomid cycles. I also went back to my original RE; because of my age and normal tests, RE wants to try another 3 IUI and Clomid cycles before considering injectables or IVF. 
    6.) IUI Cycle 6 October 2015-100mg clomid days 3-7, U/S day 12 showed 3 follicles!!!( 18mm, 19mm, and 20mm), Ovidrel trigger shot cycle day 13 at 9:30pm, IUI cycle day 15 at 9:30 am. Did acupuncture with this cycle too. BFN
    Took a break and ttc naturally
    7.) IUI Cycle 7 February 2016-100mg clomid days 3-7, U/S day 12 showed 2 follicles (22mm and 24mm), Ovidrel trigger shot day 12 at 9:00pm, IUI cycle day 14 at 10:00am. BFN
    Meeting scheduled for 2/29/2016 to discuss iui with injectables vs. IVF
    8.) IUI Cycle 8 March 2016-Injectables (Gonal F), U/S showed 2 mature follicles, Ovidrel Trigger BFN
    April-May I lost my mind.
    IVF#1 July 2016-Transferred 2 fair blasts. 9dp5dt BFP 129 BETA, 13dp5dt 944 BETA, 20dp5dpt 8776 BETA, 8/19/2016-1 beautiful heartbeat  of 100 BPM at 6 weeks 1 day! Growing baby grow!! 8/25/2016-another ultrasound at 7 weeks and baby has a heart beat of 129 BPM and is 10mm/1cm! Grow baby grow some more!! Graduated from RE at 10 weeks and had ObGyn appointment at 13 weeks. It's a girl (found out via panorama test)  EDD 4/13/2017


    Lilypie Maternity tickers
Sign In or Register to comment.
Choose Another Board
Search Boards