Trouble TTC

"Inflammation labs" & MTHFR genetic variant

@ReesaAnne16 and anyone else who is interested...here is a list of the labs that my new RE has run.  Some of these have come up abnormal so I am anxious to see him next week to discuss.  I had my 23&Me genetic counseling that he requires by his PA and that was sort of mind-blowing. I am still educating myself on the results but they determined I have a MTHFR genetic variant that has been linked to increased miscarriages, birth defects and infertility.  The combination of variants I have make it likely I am not metabolizing folic acid.  So I have about 15 supplements now and instructions to avoid folic acid by eating GF, 100% organic or %100 whole grain. Fingers crossed I am on the right path!

D-Dimer, Quantitative

CD4/CD8 Panel (fasting)

Tumor Necrosis Factor

Lipoprotein (a)

Cortisol PM

Vitamin D, 25-Hydroxy

IGF-I, LC/MS

Herpesvirus 6 (HHV-6) IgG Antibody

CRP, High Sensitivity

Homocysteiene

TSH, High Sensitivity

DHEA Sulfate

Cortisol AM

17-OH Progesterone, LC/MS/MS

Androstenedione, LC/MS/MS

Thyroid Antibody Panel

ANA Screen w/ Reflex to Titer

Testosterone, Free (Dialysis) and Total (LC/MS/MS)

Cytomegalovirus IgG

Epstein-Barr Virus (EBV) Panel

TTC since May 2013
Mild PCOS, Compound Heterozygous MTHFR
No Folic acid/pharmaceuticals/supplements (too many to list- private message me if interested), IVIL infusion

Re: "Inflammation labs" & MTHFR genetic variant

  • wow thats an extensive panel, I hope the supplements work well for you!

    Me 34 DH 36 Married since July 2010 
    MFI (High DNA Fragmentation) & Mild endometriosis
    TTC #1 since June 2015 
    Aug 2016 - May 2017  6 IUI's with letrozole - BFN
    April 2017 - laparoscopy to remove mild endo
    June 2017 - Mini IVF letrozole 12.5mg, Gonal-F 75IU - Cancelled early ovulation, no eggs retrieved. 
    Aug/Sept 2017 - Mini IVF letrozole 12.5mg, Gonal-F 75IU, cetrotide - 13 eggs retrieved, 11 mature
    5 eggs ICSI'd 6 eggs frozen - 1 day 5 blast transfered, 2 expanded blast frozen - BFP!
    May 2018 - Baby girl born - Our Joy

    TTC #2 since July 2019
    July 2019 - FET - BFN
    Jan 2020 - FET - canceled due to family health issues
    Mar 2020 - FET - low beta - chemical pregnancy
    July 2020 - ICSI'd remaining 6 eggs - 3 fertilized - 2 survived to early blast stage, transfered both - Chemical Pregnancy


  • I'm happy your panel was helpful, but sorry that you're going through this.  FX that the supplements work!  Please keep us updated on new developments.  
  • Loading the player...
  • I'm glad you seemed to have gotten some answers from it and hope the supplements and diet work for you!
    Me:33, DH:38 Married: 8/2/2014
    TTC #1 Since: April 2015
    Unexplained Infertility

    Cycle 1&2 : Clomid 50mg- BFN
    Cycle 3: Letrozole 2.5mg- BFN
    Cycle 4: Letrozole 5mg- BFN
    Cycle 5: HSG-normal
                  Clomid 100mg+ Estrace- BFN
    Cycle 6: Letrozole 5mg+Trigger shot+IUI+Progestrone- BFN
    Cycle 7: Letrozole 5mg, Cyst found during follicle check
    Cycle 8: Birth control to treat left ovary cyst
    Cycle 9: Letrozole 7.5mg+Trigger shot+IUI+Progesterone- BFN
    Cycle 10: Letrozole 7.5mg, 2 Cysts found during follicle check
    Cycle 11: Clomid 100mg+Estradiol+Trigger shot+IUI+Progesterone- BFN
    Cycle 12: Clomid 100mg- BFN
    Cycle 13-16: Natural attempts while awaiting IVF 
    Cycle 14: IVF-BFN

  • Thanks ladies! I've been reading a lot about the MTHFR and it is overwhelming and a little scary. I'm anxious to see the dr and get some more questions answered. 
    TTC since May 2013
    Mild PCOS, Compound Heterozygous MTHFR
    No Folic acid/pharmaceuticals/supplements (too many to list- private message me if interested), IVIL infusion
Sign In or Register to comment.
Choose Another Board
Search Boards
"
"