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Let Didnt Work...On to Injectables

pupluv0410pupluv0410 member
edited June 2016 in Trouble TTC
So I just verified that the Letrozole did not work at getting me to ovulate.  :(  So now they want me to do Prometria to induce a period and then injectables (if insurance covers it). Anyone have any experience with Prometria or injectables?

EDIT: They prescribed Follistim, Ovidrel and Progesterone capsules.
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Re: Let Didnt Work...On to Injectables

  • hoffmanr7hoffmanr7 member
    I have no experience but hope it works for you :)
    Me:33, DH:38 Married: 8/2/2014
    TTC #1 Since: April 2015
    Unexplained Infertility

    Cycle 1&2 : Clomid 50mg- BFN
    Cycle 3: Letrozole 2.5mg- BFN
    Cycle 4: Letrozole 5mg- BFN
    Cycle 5: HSG-normal
                  Clomid 100mg+ Estrace- BFN
    Cycle 6: Letrozole 5mg+Trigger shot+IUI+Progestrone- BFN
    Cycle 7: Letrozole 5mg, Cyst found during follicle check
    Cycle 8: Birth control to treat left ovary cyst
    Cycle 9: Letrozole 7.5mg+Trigger shot+IUI+Progesterone- BFN
    Cycle 10: Letrozole 7.5mg, 2 Cysts found during follicle check
    Cycle 11: Clomid 100mg+Estradiol+Trigger shot+IUI+Progesterone- BFN
    Cycle 12: Clomid 100mg- BFN
    Cycle 13-16: Natural attempts while awaiting IVF 
    Cycle 14: IVF-BFN

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  • pupluv0410pupluv0410 member
    Thank you
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  • starlitfaestarlitfae member
    I'm using injectables with IVF - Lupron, Gonal-F, and Menopur.  I have no issues with them, even though the Menopur burns when most people inject it.  For some reason I have no issues with it.

    TTC since 2011

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  • wifeinraleigh28wifeinraleigh28 member
    I used follistim and ovidrel for all 3 of my IUIs.  I'm happy to answer any questions if you have some.  I was also prescribed the progesterone suppositories during my TWW.  I hope you see a better outcome with the follistim!
    ***BFP & Child Warning***

    Me: 34, DH: 38 ~ TTC since 2014
    IUI #1-3 (Nov 2015, Feb 2016, May 2016) = BFNs
    IVF ER (July 2016) = 7 PGS normal embryos
    FET #1 (Sept 2016) = BFP! DD born 5/30/17
    FET #2 (April 2019) = BFN
    FET #3 (July 2019) = BFP! DS born 3/27/20
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  • pupluv0410pupluv0410 member
    Thank you guys. @wifeinraleigh28, Was the Follistim effective at ovulation? Did you have to try multiple levels of the dosing? They have me doing the progesterone too.
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  • wifeinraleigh28wifeinraleigh28 member
    edited June 2016
    @pupluv0410 I had a very quick/strong response to follistim and ended up with over 4 follicles at each cycle and high estrogen levels indicating maturing eggs.  I took 125 iu CD 3-8 for all 3 cycles but on the 3rd, they reduced my dosage to 75 iu for the last day because my follicles were maturing so rapidly.  Ovulation was timed perfectly with ovidrel on CD 9 and IUI on CD 11 (all 3 cycles).  We have MFI though so unfortunately no baby ever resulted from all those follicles :(  We are doing IVF now.
    ***BFP & Child Warning***

    Me: 34, DH: 38 ~ TTC since 2014
    IUI #1-3 (Nov 2015, Feb 2016, May 2016) = BFNs
    IVF ER (July 2016) = 7 PGS normal embryos
    FET #1 (Sept 2016) = BFP! DD born 5/30/17
    FET #2 (April 2019) = BFN
    FET #3 (July 2019) = BFP! DS born 3/27/20
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  • mackenzie07mackenzie07 member
    @pupluv0410 how many times did you try the letrozole?

    Married for 3 years
    Me: 28 DH: 33
    Together for a total of 6 years
    Fur mommy to two rescue dogs
    DX: PCOS and Insulin Resistance

    History:
    Irregular Cycles
    2010: Laproscopy with Hystroscopy ablation. Tubes were clear.
    1/5/2016 : DH sperm analysis is excellent.
    February: Switched to a new RE
    Two failed clomid rounds
    March 2016: New HSG and found tubes are open
    April 2016: Round one Letrozole 2.5 mg. Ultrasounds day 13 &16. No follicle grouth
    May 2016: Had to take a month off
    June 9th 2016: Started Letrozole again but at 5mg
    July 5th: bfp beta 31
    July 7th: Beta 97
    July 9th: Beta 231
    July 11th: Beta 500
    July 13: Beta 1400
    Beautiful son born 3/16/17 @ 1:38pm




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  • pupluv0410pupluv0410 member
    @wifeinraleigh28 I'm so sorry to hear that they did not work. I wish you a lot of luck with the IVF.
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  • pupluv0410pupluv0410 member
    @mackenzie07 We only did Letrozole for 1 month. My RE told me that we would try it for a month and if it didn't work then we would move on. I was on Clomid for 6 months...I ovulated 3 of those months but no BFP. I did not ovulate at all on the Letrozole.
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