Infertility

Prometrium and excessive tiredness?

Hi everyone,
     Any of you ladies have tiredness after starting prometrium? I'm on PIO but the doc wanted me to raise my levels a little. I'm feeling exhausted. 

Re: Prometrium and excessive tiredness?

  • vssbrmvssbrm member
    edited May 2016
    I'm just exhausted from all of them... The estrogen kicked my butt, throw the PIO on top and I am done. I am not a nap person (I hate naps). With all these meds I nap like I have been doing it for years. 
    Married May 2009, TTC since November 2012 (Together since 2006 ish - had my eyes on him since 2001)
    Me: 32 (33 in May), Him: 37 (January)

    DX: Me: High Prolactin, Possible Autoimmune Disease Issues, though RE not concerned (?)  New RE has a plan!!
           Him: Minor Varicocele, low morphology, slightly low count

    History:

    Beta 5/9/2016 BFP!!
    Embryo transfer scheduled for April 28, 2016 and beta test May 9, 2016 (day after Mother's Day!)
    Transfer Meds include: Lupron Depot (4/1), Minivelle Patch (every 3rd day), Estradiol (3x daily), Amoxicillin, Progesterone in Oil, Methylprednisonlone. Lovenox and baby asprin added after transfer. 

    3/22/16 - Sono Saline ultrasound cyst to be aspirated on 4/1/16 if not cleared up by 3/29 US - It cleared on its own
    Retrieval 3/4/16 - 26 eggs retrieved, 23 mature, 20 fertilized, 14 embryos currently frozen
    Starting IVF Stims on +/- Feb 22, 2016
    HSG scheduled for 1-26-16 - All clear "beautiful uterus" (though inverted)

    Switched clinics and now prepping for IVF in February / March

    Fourth IUI -  CD3-7 100 Clomid w/ Ovidrel Trigger - December, 2015 - BFN
    Third IUI -  CD3-7 100 Clomid w/ Ovidrel Trigger - November, 2015 - BFN
    Second IUI - CD3-7 100 Clomid w/ Ovidrel Trigger - September, 2015 - BFN
    Started Prolactin Medication October 15 - Levels quickly regulated to with in normal range
    First IUI - CD3-7 100 Clomid w/ Ovidrel Trigger - August, 2015 - BFN
    After no BFPs (ever) First RE/Urologist visit in Feb 2015
    HSG w/ OB, 2014 = all clear
    Trying to conceive since November 2012
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  • LizzieJ13LizzieJ13 member
    edited May 2016
    Prometrium (via suppositories) is making me exhausted this cycle. I want to lie down all the time!
    Me: 33, PCOS with anovulation
    DH: 36, No known issues
    TTC since 11/2014
    1000mg Metformin daily

    Oct-Dec 2015: Letrozole 5mg, Ovidrel, TI = BFN x 2
    Feb-May 2016: Letrozole 5mg, Ovidrel, TI, Prometrium = BFN x 3
    August 2016: Clomid 100mg no response, Letrozole 5mg, Ovidrel, TI, Prometrium = BFN

  • Me too @LizzieJ13 I hope it passes!
  • srh18srh18 member
    I'm always super tired and nauseated when I'm on prometrium, especially for the first few days. Ugh. Hopefully you feel better!!
  • Prometrium makes me tired as well.
  • Same here, I've been extra tired lately. I usually don't nap during my commute to and from work, but I've been sleeping almost the whole way there and back every single day. I'm also feeling like a slug at work, I'm ready ti hibernate until this process is over. 
    ***History & TW in Spoiler***

    ***bfp & child warning***
    TTC - since 2014
    7 rounds of Clomid - BFN
    IUI #1 - October 2015 - BFN
    IUI #2 - November 2015 - BFN
    IUI #3 - December 2015 - BFN
    IVF #1 - March 2016
    Retrieval #1 - April 2016
    FET #1 - May 2016 - BFP!!! DS - Born January 2017
    Trying for baby #2...
    FET #2 - January 2018 - BFN  
    No more embryos left; switched to a new RE
    IVF/Retrieval #2 - January 2019
    IVF/Retrieval #3 - March 2019
    FET #3 - April 2019 - BFP!!! - DD: Born December 2019
    Trying for baby #3...
    FET #4 - October 2021 - BFP!!! - Due June 2022


  • Last cycle I was so tired on the Prometrium (suppositories). No matter what I did all I wanted to do was sleep.
    Daisypath Anniversary tickers

    Diagnosed with PCOS March '10 - Started 1000mg of Metformin
    After 3 unsuccessful Clomid cycles, FSH+Ovidril+IUI+Progesterone=BFP!
    Lilypie Kids Birthday tickers

    Time to make Emilie a big sister!

    May '16 2.0: Letrozole+FSH+Menopur+Ovidril+IUI+Progesterone=BFP! first beta-45.44, second beta-148

    BabyFruit Ticker

  • I'll chime in and say that it makes me extremely tired too!  I sleep so hard when I'm on the progesterone suppositories, and I'm still tired all day long!
    ***BFP & Child Warning***

    Me: 34, DH: 38 ~ TTC since 2014
    IUI #1-3 (Nov 2015, Feb 2016, May 2016) = BFNs
    IVF ER (July 2016) = 7 PGS normal embryos
    FET #1 (Sept 2016) = BFP! DD born 5/30/17
    FET #2 (April 2019) = BFN
    FET #3 (July 2019) = BFP! DS born 3/27/20
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