Clomid and Depression?

Re: Clomid and Depression?

• Starlight811 member

  April 2016 edited April 2016

  I was on 3 cycles of clomid I wouldn't say depressed but it definitely made me very mean and aggravated! Everything my DH did annoyed me and at times I would snap at him for nothing really. He learned quick it is just the meds..Most women on here have also said clomid gave them the "moody" side effects. If you search clomid side effects you will find alot of info on this board. I hope you find some peace I know it is so frustrating but you are not alone .

  Me 28 DH 33 | DX: DOR | HSG: Normal | IUI#1: (Clomid/HCG/Progesterone) BFN | IUI#2: (Clomid/HCG/Progesterone) BFN | IUI#3: (Clomid/HCG/Progesterone) BFN | IUI#4: (Menopur/HCG/Progesterone) BFN | IUI#5: (Menopur/Gonal-F/HCG/Progesterone) BETA 7/2

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• dragonfaerie member

  April 2016

  I'm sorry to hear of your struggles. I have not taken Clomid, but from what I've experienced on many of my meds, I would say it's fairly normal. Your hormones are swinging pretty hard on these medications. Add to that the stress and sadness of IF, the fear, knowing you aren't really yourself, and struggles with hubby, and it's kind of a perfect storm. After our failed IUIs, I was basically depressed for two months. I knew I wasn't myself, and struggled to find that balance. 
  I hope you can find some peace. If you can get in to see a counselor, I would highly recommend it. Having someone outside of the situation that you can vent to and get some clarity is wonderful.

  ---Trigger warning---

  Me: 31 DH: 27
  TTC since April 2013
  Two cancelled IUIs in Aug and Sept '15 due to low motility/count
  IVF round 1: January 2016
  ER: February 17, 2016; 9 retrieved, 7 mature, 7 fertilized
  Day 5 Blastocysts: 5 BB, 1 AB, all normal from PGS
  FET date: May 11, '16; transferred 1 AB embryo
  First beta: May 23, '16: 998!!  Second: May 25, '16: 1648
  EDD: January 27, 2017

  

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• vssbrm member

  April 2016

  When I was on clomid I had an amplified sense of depression. I have diagnosed anxiety as well - so throw all the IF struggles and clomid on top... It was not so fun, but not nearly as terrible as some stories I have read. I, like the previous poster, really recommend seeing a counselor. It helped me a lot. My counselor made a statement that really helped me to understand taking care of ourselves emotionally. With my anxiety I am more susceptible to postpartum depression, but being aware of my emotions and talking to a professional can help me equip myself to be prepared and hopefully to lessen it if it indeed does occur.

  Married May 2009, TTC since November 2012 (Together since 2006 ish - had my eyes on him since 2001)

  Me: 32 (33 in May), Him: 37 (January)
  

  
  

  DX: Me: High Prolactin, Possible Autoimmune Disease Issues, though RE not concerned (?)  New RE has a plan!!

         Him: Minor Varicocele, low morphology, slightly low count

  
  

  History:
  
  Beta 5/9/2016 BFP!!
  Embryo transfer scheduled for April 28, 2016 and beta test May 9, 2016 (day after Mother's Day!)
  Transfer Meds include: Lupron Depot (4/1), Minivelle Patch (every 3rd day), Estradiol (3x daily), Amoxicillin, Progesterone in Oil, Methylprednisonlone. Lovenox and baby asprin added after transfer. 
  
  3/22/16 - Sono Saline ultrasound cyst to be aspirated on 4/1/16 if not cleared up by 3/29 US - It cleared on its own
  Retrieval 3/4/16 - 26 eggs retrieved, 23 mature, 20 fertilized, 14 embryos currently frozen
  Starting IVF Stims on +/- Feb 22, 2016
  HSG scheduled for 1-26-16 - All clear "beautiful uterus" (though inverted)
  
  Switched clinics and now prepping for IVF in February / March
  
  

  Fourth IUI -  CD3-7 100 Clomid w/ Ovidrel Trigger - December, 2015 - BFN
  

  Third IUI -  CD3-7 100 Clomid w/ Ovidrel Trigger - November, 2015 - BFN

  Second IUI - CD3-7 100 Clomid w/ Ovidrel Trigger - September, 2015 - BFN

  Started Prolactin Medication October 15 - Levels quickly regulated to with in normal range

  First IUI - CD3-7 100 Clomid w/ Ovidrel Trigger - August, 2015 - BFN

  After no BFPs (ever) First RE/Urologist visit in Feb 2015
  

  HSG w/ OB, 2014 = all clear
  Trying to conceive since November 2012

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• freudianmamma member

  April 2016

  I had my first cycle using clomid last month and I can completely identify with the depression/anger that you guys are talking about.  My DH was literally scared of me during the days I was on Clomid.  I can just flat out say that I was living in a state of "rage" and everything was setting me off!  By the time I got to the progesterone stage during the two week wait I felt like a new woman.  I had my sanity back!  

  Me (34) & DH (38)
  Married 2014; TTC since 4/2015
  Diagnosed with Stage 3 Endometriosis and possible ovulation dysfunction 
  

  1st TI (clomid/follistim/ovidrel/progesterone)- 3/19/16 - BFN
  2nd TI (clomid/follistim/ovidrel/progesterone)- 5/11/16 - BFN
  
  

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• wifeinraleigh28 member

  April 2016

  I haven't taken clomid but any time you take hormones it can affect your mood.  I had some of my biggest anger outbursts and break downs since starting fertility treatments.  Hang in there!!!

  ***BFP & Child Warning***
  
  Me: 34, DH: 38 ~ TTC since 2014
  IUI #1-3 (Nov 2015, Feb 2016, May 2016) = BFNs
  IVF ER (July 2016) = 7 PGS normal embryos
  FET #1 (Sept 2016) = BFP! DD born 5/30/17
  FET #2 (April 2019) = BFN
  FET #3 (July 2019) = BFP! DS born 3/27/20

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• FatPony member

  April 2016

  For lack of a better word - Clomid will Fuck. You. Up. 
  
  And it it gets better! That shit takes at least a couple months to get out of your system. 
  
  I was was an anxiety-riddled wreck when I was on it. And I am normally just fine emotionally!!! It was a real eye opener to the challenges that people with mental health issues face. I did IVF after clomid and even THOSE drugs were less awful than Clomid. 
  
  Just know that it's the Clomid that's making you this way, and it won't last forever. GL!! 

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• freudianmamma member

  April 2016

  @FatPony at least that would be one "upside" to moving to ivf meds then. I'm glad to hear that!

  Me (34) & DH (38)
  Married 2014; TTC since 4/2015
  Diagnosed with Stage 3 Endometriosis and possible ovulation dysfunction 
  

  1st TI (clomid/follistim/ovidrel/progesterone)- 3/19/16 - BFN
  2nd TI (clomid/follistim/ovidrel/progesterone)- 5/11/16 - BFN
  
  

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• LizzieJ13 member

  April 2016

  I've been following this thread because my RE is suggesting I move from Letrozole to Clomid to switch things up a bit. Letrozole has been fine for me, but I'm on the anxious/moody side in general so I'm terrified of Clomid! Have you all responded well to it? I'm wondering if it's maybe worth it if I get more follicles/higher quality eggs. Also, apparently Letrozole can have a negative effect on progesterone, which I only recently learned.

  Me: 33, PCOS with anovulation
  DH: 36, No known issues
  TTC since 11/2014
  1000mg Metformin daily
  
  Oct-Dec 2015: Letrozole 5mg, Ovidrel, TI = BFN x 2
  Feb-May 2016: Letrozole 5mg, Ovidrel, TI, Prometrium = BFN x 3
  August 2016: Clomid 100mg no response, Letrozole 5mg, Ovidrel, TI, Prometrium = BFN
  
  

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• themuffinman16 member

  April 2016

  Thank you so much, ladies.  I'm feeling a little better, emotionally today, with a visit from AF (when does that happen?) If I feel worse, next month, or even the same, I will talk to a counselor to see if that helps me through the emotional toll fertility drugs take on me. You all have been so supportive, and it helps me stay as level headed as I can be... and even if I'm not, I know that is normal on this journey. Thank you all

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• themuffinman16 member

  April 2016

  @LizzieJ13 I have been on 3 total treatments of Clomid.  So far, nada, but everyone's TTC journey is different.  I hope Clomid works for you. FX

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