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PGD testing: risks to embryo?

emgem819emgem819 member
in Infertility
My re is strongly recommending PGD testing with our ivf but the extra cost of $4500 is certainly a big addition to total costs.  Also I just read this about side effects that may be caused to the embryo: "In a mouse model study, PGD has been attributed to various long term risks including a weight gain and memory decline; a proteomic analysis of adult mouse brains showed significant differences between the biopsied and the control groups, of which many are closely associated with neurodegenerative disorders like Alzheimers and Down Syndrome."(https://en.m.wikipedia.org/wiki/Preimplantation_genetic_diagnosis)  Does anyone know if these are valid studies?  We were going to go with PGD testing since we wanted the best chance possible and since I have pcos and am 37 it also seemed like a good choice.  But now I'm worried about it causing harm to the embryo.  Anyone heard this?  Have opinions either way?
Married to DH since 8/15
TTC since 5/15
PCOS, 35+, diagnosed with pre-diabetes
TI for 4 cycles: 1 round of femara; 2 rounds femara/ injectables: all ended in BFN. 
3 IUI Cycles: letrozole/Follistim with HCG Trigger,all resulted in BFN.
FET #1: Baseline appt 4/28/16, Gonal-F/Menopur stims, Centrotide 5/4/16, ER 5/11/16; 6/8/16 ET, BFN
FET #2: Baseline appt 6/22/16, Estrace/PIO shots: 7/12/16 ET, 1st beta 7/21/16: 83 BFP, 2nd beta 7/23/16: 315. 1st U/S: 8/4/16 empty sac.  2nd U/S: 8/10/16 yolk sac appeared, everything stopped growing. Office D&C: 8/11/16, MC.
FET #3: Baseline appt 12/28/16, Estrace/PIO shots: 1/17/17 ET, 1st beta 1/27/17: 146 BFP, 2nd beta 1/29/17: 336, 1st U/S: 2/16/17, 2 healthy twin babies measuring 7w0d.  EDD: 10/5/17
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Re: PGD testing: risks to embryo?

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    laurenlalaplaurenlalap member
    Sorry, I don't have any advice, but I'm following this as I'm sure the women on here will have good insight for you. My doctor also recommended it but we opted against it mainly due to the costs and potential side effects. I'm also young and we have no confirmed chromosomal issues - our secondary IF is unexplained so we decided against it.
    DS#1: born Dec 29, 2013 
    TTC#2 since Sept 2014 - unexplained secondary IF
    BFP #2: 11.7.14  M/C: 11.27.14 @ 6w3days
    BFP #3: 04.19.2015 M/C 04.27.15 @ 4w3days
    BFP #4: 10.05.2015 C/P @ 3w4days
    Oct 11, 2015: Cycle 13. Starting Femara (2.5mg). HSG this cycle (all clear) - BFN
    Nov 12, 2015: Cyle 14. Femara 5mg + IUI - BFN
    Dec 10, 2015: Cycle 15. Femara 5mg + IUI #2 - BFP #5! C/P 4w4d
    Jan 10, 2016: Cycle 16. Femara 5mg + IUI #3 - BFN.
    Feb 10, 2016: Cycle 17.  No IUI or meds. Taking a break - Natural BFP Mar 5, 2016!!!! EDD Nov 16, 2016
    Moving to IVF March 2016
    Beta at 10dpo: 21, Beta at 12dpo: 98, Beta at 14dpo: 264, Beta at 16dpo: 745
    U/S 6w6d: single beautiful heartbeat of 121bpm - It's a boy!!!!
    Nov 3, 2016: Our family became complete. Welcome DS #2.
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    emgem819emgem819 member
    Thanks @laurenlalap sounds like you made the right decision as the extra cost is pretty big and you are young still.  I also went through pre-genetic screening and was cleared for no issues but I realize the chromosome abnormalities cannot be detected without PGS testing.  Hopefully some others will weigh in!
    Married to DH since 8/15
    TTC since 5/15
    PCOS, 35+, diagnosed with pre-diabetes
    TI for 4 cycles: 1 round of femara; 2 rounds femara/ injectables: all ended in BFN. 
    3 IUI Cycles: letrozole/Follistim with HCG Trigger,all resulted in BFN.
    FET #1: Baseline appt 4/28/16, Gonal-F/Menopur stims, Centrotide 5/4/16, ER 5/11/16; 6/8/16 ET, BFN
    FET #2: Baseline appt 6/22/16, Estrace/PIO shots: 7/12/16 ET, 1st beta 7/21/16: 83 BFP, 2nd beta 7/23/16: 315. 1st U/S: 8/4/16 empty sac.  2nd U/S: 8/10/16 yolk sac appeared, everything stopped growing. Office D&C: 8/11/16, MC.
    FET #3: Baseline appt 12/28/16, Estrace/PIO shots: 1/17/17 ET, 1st beta 1/27/17: 146 BFP, 2nd beta 1/29/17: 336, 1st U/S: 2/16/17, 2 healthy twin babies measuring 7w0d.  EDD: 10/5/17
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    cmm012cmm012 member
    I am also watching this thread. DH wants to move to IVF if this IUI is unsuccessful. He is very interested in PGS testing as well. I've been reading up on it, but have not found much.
    *******
    Married Jan. 2014
    Me:36 DH: 39
    TTC since August 2014, Mild PCOS + uterine fibroids
    Myomectomy June 2015- 18 fibroids removed
    IVF #1, May 2016 = 32 eggs retrieved, 12 fertilized, 7 frozen, 3 PGS normal
    FET#2, July 2016 = one embryo transferred 
    TRIGGER
    BFP! Beta = 617
    Due date = 4/9/17
    Delivery date = 3/20/17
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    emgem819emgem819 member
    This board might also help give some advice from others: https://forums.thebump.com/discussion/comment/88535582#Comment_88535582
    still wondering about the embryo risks however.
    Married to DH since 8/15
    TTC since 5/15
    PCOS, 35+, diagnosed with pre-diabetes
    TI for 4 cycles: 1 round of femara; 2 rounds femara/ injectables: all ended in BFN. 
    3 IUI Cycles: letrozole/Follistim with HCG Trigger,all resulted in BFN.
    FET #1: Baseline appt 4/28/16, Gonal-F/Menopur stims, Centrotide 5/4/16, ER 5/11/16; 6/8/16 ET, BFN
    FET #2: Baseline appt 6/22/16, Estrace/PIO shots: 7/12/16 ET, 1st beta 7/21/16: 83 BFP, 2nd beta 7/23/16: 315. 1st U/S: 8/4/16 empty sac.  2nd U/S: 8/10/16 yolk sac appeared, everything stopped growing. Office D&C: 8/11/16, MC.
    FET #3: Baseline appt 12/28/16, Estrace/PIO shots: 1/17/17 ET, 1st beta 1/27/17: 146 BFP, 2nd beta 1/29/17: 336, 1st U/S: 2/16/17, 2 healthy twin babies measuring 7w0d.  EDD: 10/5/17
    Pregnancy Ticker
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    dragonfaeriedragonfaerie member
    My understanding of PGS testing is that they are taking cells from outside the grouping that will actually become the baby, (more from the placenta than the little cells, can't remember the official name) so the risk is fairly low. I think it's just like anything else with IVF. Let's say twins occur naturally in 3% of births, in IVF they occur in 4% (I know that's not right, but just for example.) The increase in defects in IVF/PGS embryos is negligible. Our doc showed us numbers that looked like it was such a small increase of risk, if any.

    ---Trigger warning---

    Me: 31 DH: 27
    TTC since April 2013
    Two cancelled IUIs in Aug and Sept '15 due to low motility/count
    IVF round 1: January 2016
    ER: February 17, 2016; 9 retrieved, 7 mature, 7 fertilized
    Day 5 Blastocysts: 5 BB, 1 AB, all normal from PGS
    FET date: May 11, '16; transferred 1 AB embryo
    First beta: May 23, '16: 998!!  Second: May 25, '16: 1648
    EDD: January 27, 2017
    BabyFruit Ticker
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    wifeinraleigh28wifeinraleigh28 member
    Also wanted to jump in here and follow this thread now that we're moving to IVF.  I want to do all the testing that is recommended as well so we have the best chance of success.  Thank you for weighing in @dragonfaerie.
    ***BFP & Child Warning***

    Me: 34, DH: 38 ~ TTC since 2014
    IUI #1-3 (Nov 2015, Feb 2016, May 2016) = BFNs
    IVF ER (July 2016) = 7 PGS normal embryos
    FET #1 (Sept 2016) = BFP! DD born 5/30/17
    FET #2 (April 2019) = BFN
    FET #3 (July 2019) = BFP! DS born 3/27/20
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    flanners1flanners1 member
    I am 35 and my RE also recommended to do PGS due to age. I also have PCOS and had a whooping 18 embryos to test - it was extremely expensive because our IVF 'package' only included 8 embryos for testing. After testing, 7 out of 18 had abnormal chromosomes, apparently it can be up to 50% even. I'm really glad we did the testing because I wouldn't have wanted to try out 7 transfers and get my heart broken every time... That's why I personally think PGS is worth it, but again my age is a huge factor here. If you are younger with no family history, I think the stats completely change. Good luck  
    Me: 38, DH: 40 living in Asia
    TTC since March 2015 with known PCOS and MIF
    IVF in 2015. FET nr 3 in 2016 - BFP. Healthy baby girl born in April 2017.
    Trying for nr 2

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