Should I be having additional testing? *losses mentioned*

Re: Should I be having additional testing? *losses mentioned*

• cmm012 member

  January 2016

  I think you should seek additional testing. Have you had a work up for blood clotting disorders? An undiagnosed clotting issue could cause repeat miscarriages. I'm sure other ladies might have some suggestions.

  *******
  Married Jan. 2014
  Me:36 DH: 39
  TTC since August 2014, Mild PCOS + uterine fibroids
  Myomectomy June 2015- 18 fibroids removed
  IVF #1, May 2016 = 32 eggs retrieved, 12 fertilized, 7 frozen, 3 PGS normal
  FET#2, July 2016 = one embryo transferred 
  TRIGGER
  BFP! Beta = 617
  Due date = 4/9/17
  Delivery date = 3/20/17
  

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• oxinfree member

  January 2016

  @cmm012 - absolutely agree with the above. I had a friend who dealt with repeated miscarriages and they put her on blood thinning shots (I believe, I'd have to ask specifics). 
  After multiple MCs I'd certainly feel like I was beating my head against the wall and want more answers. Also an option to talk to a different RE, get a second opinion. I know my new one believes in immune related factors and my previous did NOT. Have you had a uterine biopsy done at all to look at receptivity issues? 
  Wishing you all the best on this rollercoaster!

  ---
  Started TTC April 2011
  Me: 32, DH: 32
  Diagnosis: Endometriosis
  
  

  • 2012 - 3 Rounds clomid - all BFN
  • 2013 - 1 Fresh IVF with 2 day 3 embryos - BFN
  • 2014 - 1 Frozen IVF with 2 day 5 embryos - BFN
  • Took a long break, continuing trying naturally
  • Feb 2016 - Biopsy = Endo, DH sperm improved from 1% to 6% morphology
  • March 2016 - Fresh IVF cycle with acupuncture & intralipids: 20 eggs retrieved (17 mature), 7 ICSI'd fertilized, 9 naturally fertilized. 16 total embryos!
  • April 8th - 2 embryos (1ICSI and 1 Natural) transferred. (7 blastocysts frozen), April 18th - Beta = BFN
  • Sept 23rd - Lupron Depot Injection for Endo control
  • Nov 15th 2016 - Started daily Lupron Injections for upcoming FET
  • Nov 22 - Baseline US/BW - Intralipid Infusion - Start Meds for FET with immune protocol
  • Dec 16th FET transfer of 3 embryos (1 - AA, 2 - BB)
  • TW below
  • Dec 22nd - first ever bfp (very faint lines FRER & cheapie)
  • Dec 27th Beta = 192, Dec 29th Beta = 379
  • EDD - Sept 5th 2017

  
  - - -
  I'm a YouTube vlogger who talks about Infertility, IVF and Endometriosis. Check it out here!
  Follow along at http://liv4today.blog
  Instagram @liv4todayvlog 
  

  
  

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• TheLabyrinth member

  January 2016

  Have they done any genetic/kereotype testing on you and your husband? Our clinic mentioned that sometimes this can cause infertility and miscarriages when you and your SO genes are combined.

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• laurenlalap member

  January 2016

  Thanks so much everyone. We are still waiting on the karotype testing results. I will ask about clotting disorders 

  

  DS#1: born Dec 29, 2013 

  TTC#2 since Sept 2014 - unexplained secondary IF

  BFP #2: 11.7.14  M/C: 11.27.14 @ 6w3days

  BFP #3: 04.19.2015 M/C 04.27.15 @ 4w3days

  BFP #4: 10.05.2015 C/P @ 3w4days

  Oct 11, 2015: Cycle 13. Starting Femara (2.5mg). HSG this cycle (all clear) - BFN

  Nov 12, 2015: Cyle 14. Femara 5mg + IUI - BFN

  Dec 10, 2015: Cycle 15. Femara 5mg + IUI #2 - BFP #5! C/P 4w4d
  Jan 10, 2016: Cycle 16. Femara 5mg + IUI #3 - BFN.
  Feb 10, 2016: Cycle 17.  No IUI or meds. Taking a break - Natural BFP Mar 5, 2016!!!! EDD Nov 16, 2016
  Moving to IVF March 2016
  Beta at 10dpo: 21, Beta at 12dpo: 98, Beta at 14dpo: 264, Beta at 16dpo: 745
  U/S 6w6d: single beautiful heartbeat of 121bpm - It's a boy!!!!
  Nov 3, 2016: Our family became complete. Welcome DS #2.

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• 2015dee member

  January 2016

  Yes, I would definitely ask if you've been checked for clotting disorders, but I think those are usually part of a repeated loss panel. I can't imagine how difficult this must be for you. Would IVF with PGD be a possible option? That would (I think) eliminate any chromosomal issues which might be causing the m/cs. (someone correct me if I am wrong).

  *Loss & bfp mentioned*

  me 28 (Lean PCOS, hypothyroid) dh 33
  TTC #1 since early 2011
  May 2011- natural pregnancy (metformin only); m/c @ 9 weeks + D&C
  July 2011- lap to remove dermoid cyst
  August 2012-current- 9 rounds of Clomid, 1 cycle of Femara, several cycles of soy isos, 1 IUI, O'd every cycle, BFN
  August 2014- lap to remove uterine septum. Everything else looking good.
  Moving onto IVF Feb/March 2016 Just kidding. Natural bfp 1/30/16. 1st beta 2/1 = 110. 2nd beta 2/3 = 332.

  First ultrasound 2/19 - one baby with a heart rate of 127! EDD 10/11/2016

  
  

  

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• suchaglencoco member

  January 2016

  ***Children mentioned***
  
  We requested additional testing on me following a m/c after ivf and our RE reluctantly agreed. Turned out I have a blood disorder, mthfr mutation to be exact. We were told the medical community is split about whether or not it can cause or be a leading factor in miscarriages and infertility.
  
  My RE said she had no concrete opinion so she put me on folic acid and baby aspirin just in case. My next pregnancy (through frozen transfer) was successful and now I'm blessed with newborn twins. This was the only thing that really changed ve
  
  It was such an easy, over the counter fix. I looked it up after the results came back and had a few of the other problem the mutation can cause and since I started taking those pills, the other issues have mostly dissipated. Whenever I hear of a woman who has suffered several losses and is struggling, I always suggest they get the blood test for this.
  
  Good luck on your journey.

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• PCOSat25 member

  January 2016

  Does your physician have you on progesterone suppositories? I know a women who has recurrent miscarriages and was eventually placed on progesterone for the first 10 weeks of her most recent pregnancy. She is about to deliver! My RE has me go on progesterone suppositories starting the day after my IUIs to continue through 10 weeks of pregnancy occurs.

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• knklein10 member

  January 2016

  @laurenlalapHello! I'm so sorry to hear about your losses. I've had three losses in about 16 months. They surely don't get any easier. Have you had an RPL panel? If not, I'd request one. Also, did your husband have a semen analysis done? If not, definitely ask for one even though many will say his sperm isn't a factor since you have gotten pregnant. 
  
  I wanted to invite you to my blog about IVF and repeat pregnancy loss. Feel free to check it out, drop a comment where you might have some expertise, or follow via email if you'd like. Check out my blog post (My Road to IVF) regarding my husband's morphology and how that might be factoring into our losses. 
  
  Blog: Threelittlebeans.com  
  Twitter: @ThreeLittleBean (no S!) 
  
  Sending positive vibes your way!
  Kelly 

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• pmnf26 member

  January 2016

  **pregnancy mentioned**
  
  @laurenlalap I am so sorry for your reoccurring miscarriages. I just wanted to let you know I was in the same situation of habitual miscarriages. After all of my D&Cs the fetus showed no sign of chromosomal abnormalities so I knew something was wrong with me and it wasn't just a fluke..Fortunately my RE found the problem after the third loss and found through testing for blood clotting disorders through my blood panel I do have a rare blood clotting disorder called Antiphosolipid syndrome. Make sure they tested your for this disorder along with other blood clotting disorders. I have been on baby aspirin since trying to conceive - and currently am 12 weeks 5 days pregnant and do blood thinner injections one time a day as well as took progesterone until week 10 of pregnancy and a few other medications. So far everything seems to be progressing as it should be. I will be praying for you for a healthy pregnancy.

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