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(loss mentioned) Two times PGD tested embryos failed to implant

purepositivitypurepositivity member
edited December 2015 in Infertility
Hello! Original issue was 3 miscarriages due to possible chrom issues, thyroid, and Not so great sperm analysis. TSH has been in normal range for both egg transfers. And in two egg retrievals total of 13 Ferilized Eggs and in the end 7 viable Pgd tested embryos. But both times the PGD tested embryo didn't implant. I did one frozen transfer with acupuncture and one fresh transfer without acupuncture, so now I'm in unexplained infertility category. Now Dr. is redoing SHG (since different dr did it last year) and doing an endometrial biopsy since they weren't expecting this issue with implanting. Any advice?
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Re: (loss mentioned) Two times PGD tested embryos failed to implant

  • ecb3588ecb3588 member
    @purepositivity I don't have any advice per se, but I have just been through a failed fresh transfer and preparing for a fet next month. Are they doing the endometrial biopsy to look for an issue in your lining or as a therapeutic measure to help implantation? I am scheduled for a biopsy like procedure next week, but not for diagnostic reasons, it's to try and assist with implantation next cycle. From what I have read, it is frequently done in women with 2 failed ivf transfers. (I've only done one, but I guess my clinic does them on everyone). If they are doing your biopsy for diagnostic reasons, it may be worth asking about the "endometrial scratch" as a therapeutic treatment.
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  • purepositivitypurepositivity member
    @erinscaren thank you so much for your reply! I read a little about the endometrial scratch awhile ago. I'll definitely bring it up! I think they are just doing it to look if there's an issue but honestly didn't get to talk to anyone yet so not sure. Sorry about your failed transfer. So disappointing after all you go through. I know a few people that had much better luck with frozen since their bodies had a break from stimming. Lots of luck to you!!
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  • purepositivitypurepositivity member
    My nurse told me today that the endometrial biopsy and scratch are the same thing, they are both a disruption. But since I had the biopsy my results can take up to 14 days and I won't get my next steps until the results come.
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  • oxinfreeoxinfree member
    @purepositivity - thanks for sharing that info. I'm going in for a biopsy too, and was curious about the scratch, so question answered ;) When do you get your results?


    ---
    Started TTC April 2011
    Me: 32, DH: 32
    Diagnosis: Endometriosis

    • 2012 - 3 Rounds clomid - all BFN
    • 2013 - 1 Fresh IVF with 2 day 3 embryos - BFN
    • 2014 - 1 Frozen IVF with 2 day 5 embryos - BFN
    • Took a long break, continuing trying naturally
    • Feb 2016 - Biopsy = Endo, DH sperm improved from 1% to 6% morphology
    • March 2016 - Fresh IVF cycle with acupuncture & intralipids: 20 eggs retrieved (17 mature), 7 ICSI'd fertilized, 9 naturally fertilized. 16 total embryos!
    • April 8th - 2 embryos (1ICSI and 1 Natural) transferred. (7 blastocysts frozen), April 18th - Beta = BFN
    • Sept 23rd - Lupron Depot Injection for Endo control
    • Nov 15th 2016 - Started daily Lupron Injections for upcoming FET
    • Nov 22 - Baseline US/BW - Intralipid Infusion - Start Meds for FET with immune protocol
    • Dec 16th FET transfer of 3 embryos (1 - AA, 2 - BB)
    • TW below
    • Dec 22nd - first ever bfp (very faint lines FRER & cheapie)
    • Dec 27th Beta = 192, Dec 29th Beta = 379
    • EDD - Sept 5th 2017

    - - -
    I'm a YouTube vlogger who talks about Infertility, IVF and Endometriosis. Check it out here!
    Follow along at http://liv4today.blog
    Instagram @liv4todayvlog 


    Report Reply
  • purepositivitypurepositivity member
    @oxinfree I got my results 8 days later. They came back normal .. So starting third IVF cycle in Jan.
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  • oxinfreeoxinfree member
    That's excellent news @purepositivity hoping this IVF is it for you! Anything else come up or are you still "unexplained"? Have you done immune testing at all, I can't recall...
    ---
    Started TTC April 2011
    Me: 32, DH: 32
    Diagnosis: Endometriosis

    • 2012 - 3 Rounds clomid - all BFN
    • 2013 - 1 Fresh IVF with 2 day 3 embryos - BFN
    • 2014 - 1 Frozen IVF with 2 day 5 embryos - BFN
    • Took a long break, continuing trying naturally
    • Feb 2016 - Biopsy = Endo, DH sperm improved from 1% to 6% morphology
    • March 2016 - Fresh IVF cycle with acupuncture & intralipids: 20 eggs retrieved (17 mature), 7 ICSI'd fertilized, 9 naturally fertilized. 16 total embryos!
    • April 8th - 2 embryos (1ICSI and 1 Natural) transferred. (7 blastocysts frozen), April 18th - Beta = BFN
    • Sept 23rd - Lupron Depot Injection for Endo control
    • Nov 15th 2016 - Started daily Lupron Injections for upcoming FET
    • Nov 22 - Baseline US/BW - Intralipid Infusion - Start Meds for FET with immune protocol
    • Dec 16th FET transfer of 3 embryos (1 - AA, 2 - BB)
    • TW below
    • Dec 22nd - first ever bfp (very faint lines FRER & cheapie)
    • Dec 27th Beta = 192, Dec 29th Beta = 379
    • EDD - Sept 5th 2017

    - - -
    I'm a YouTube vlogger who talks about Infertility, IVF and Endometriosis. Check it out here!
    Follow along at http://liv4today.blog
    Instagram @liv4todayvlog 


    Report Reply
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