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prometrium anyone??

rachlee2010rachlee2010 member
in Infertility
I had my 3rd IUI yesterday and for the past two I have been given crinone gel to take afterwards until my pregnancy test.  We switched to the other dr in the same practice and he told me he really prefers prometrium over crinone..he thinks it is less messy.  So I am trying it this time.  

It is so strange to put a capsule, (coated pill) up your lady parts.  I have been taking estrace vaginally before which I thought was so weird as it's a pill but that was a more standard, pill (not coated in anything)  

ANyone, has anyone taken both prometrium and crinone and can tell me the differences?  OR if you just have taken prometrium, anything I should expect???

Thanks
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Re: prometrium anyone??

  • PCOSbabyPCOSbaby member
    I haven't taken Crinone so I can't provide insight on that one.

    With Prometrium I experience extremely tender breast. Mine were for oral use only though and to induce AF. I'm not sure if that makes a difference. I agree that inserting a coated capsule into your vagina is a bit odd.

    I'm interested in what others have to say.
    Me {32} DH {34}
    Married 05/2014

    PCOS baby due October 09, 2016
    Beta #1: 22.5
    Beta #2: 74

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  • Wicked4589Wicked4589 member
    edited November 2015
    I took prometrium orally but the only side effects I had was trouble sleeping.
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  • riveridgionalriveridgional member
    I have only taken prometrium orally. It just makes me really tired after my PM dose. I'm actually switching to crinone this time.
    Married to DH 10/6/12
    TTC since 5/14
    Unexplained with (controlled) hypothyroidism and suspected ovulatory dysfunction (but, I do ovulate on my own)
    Clomid 50 mg 3/15 (unmonitored) - BFN
    Clomid 50 mg + metformin 4/15 (unmonitored) - BFN 
    First RE appt. 5/15; Natural cycle 5/15 monitored with 2 mature follicles and Pregnyl Trigger (full dose) + prometrium - BFN
    6/15 HSG - clear tubes & normal uterus; great PCT test results
    TI - 100 mg Clomid + prometrium (AM & PM) + vaginal estrace (AM & PM) 6-7/15 (monitored) --> no additional response and thinned lining - BFN
    TI - Injectables (follistim + Gonal-F, Ganirelix, & 1/2 dose Pregnyl) + prometrium (AM & PM) 9/15 --> 3-7 mature follicles (3 definites and 4+ that could have matured due to trigger) @ O -->BFN + 5 large cysts
    BC for 2 weeks due to cysts
    TI - Injectables (Gonal-F, Ganirelix & full dose Pregnyl) + prometrium (AM & PM) 10/15 --> 1 mature follicle --> BFN 
    TI - Last attempt at injectables (Gonal-F, Ganirelix & 1/2 dose Pregnyl) + crinone (AM only) + vaginal estrace (AM & PM) 11/15 --> 3-4 mature follicles --> BFP!! 11/27/15 @ 13dpo (shockingly, actually waited until then to test)

    Beta #1 @ 16dpo (11/30/15) = 1,075
    Beta #2 @ 19dpo (12/3/15) = 3,150
    One baby: Saw heartbeat @ 5w5d (114 bpm; baby measuring 2.3mm)

    "Great Things are Happening"
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  • KidShrinkKidShrink member
    I took prometrium vaginally (2 capsules twice/day). Won't lie: it's gross. Not sure how it could be less messy than Crinone, but I've never used it so can't compare. It made me a little irritated and dry down there, but it did the job it had to do (and contrary to what some people say, the increased progesterone could be measured in my bloodwork). Taking it vaginally is supposed to lead to less symptoms. I typically was exhausted the first day or two and then that was it.
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  • rachlee2010rachlee2010 member
    @KidShrink was it a yellow capsule that you just shoved up there??
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  • KidShrinkKidShrink member
    It was white/light beige, definitely not a bright yellow. But if yours are yellow, expect that to come back out...
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  • mskeenanmskeenan member
    I took the yellow prometrium vaginally for all of my previous cycles . It is really gross ! The first two times I ended up getting a minor yeast infection . The last 2 times I haven't gotten infections thank god !!! The side effects for me are not fun : I bloat , I'm moody , tender boobs. Ive sucked it up and continue to do it in hopes of a BFP and a pregnancy that lasts !!

    **BFP and loss warning**

    Me: 29
    DH: 29
    Us: Married Valentine's Day, 2015
    DH: No issues.
    Me: PCOS, unexplained infertility (whatever that means!!)
    June 2015 Medicated TI cycle: BFN
    July 2015:  Medicated TI cycle: BFN
    August 2015: IUI: BFP. Chemical pregnancy :(
    October 2015: IUI: BFN
    January 2016: Egg retrieval: 10 frozen embryos!
    March 2016: FET Cycle- 2 embryos transferred!: BFP !
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  • rachlee2010rachlee2010 member
    I can't remember the color. It's either light yellow or white. I started it this morning. It's just so weird that it's a capsule that I feel like I should take orally. Not shove up there
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  • smdrodgerssmdrodgers member
    I've done the prometrium vaginally as well (2x a day), I didn't have any negative side effects from it, but it was a dark brownish pill, so that was lovely on the way back out.  The only notable difference for me was when I did get AF, my cycle was significantly shortened the following month, although I was told with all the meds, that wasn't unusual.
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  • lovelifewifelovelifewife member
    I've taken both and preferred crinone. Good luck! I had more side effects w prometrium vaginally but think I was allergic to something in the coating.
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