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Estradiol- estrogen- safe to take?

Krisd6Krisd6 member
in Infertility
i am in the oh so fun 2 week window
Had my IUI on Sunday and Monday this past week. Had blood work drawn today. My progesterone levels were great- my estrogen levels were low. The nurse left a message on my voicemail telling me she was calling in a prescription and that it is safe to take in the first few weeks but not after 12 weeks
I went to the pharmacy and had to speak to the pharmacist who told me it has a black box warning on it for pregnant women. She was very serious about it- it freaked me out!

Has Anyone had to take it? Any thoughts??
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Re: Estradiol- estrogen- safe to take?

  • rachlee2010rachlee2010 member
    I have been put on estrogen a few days before both my IUI's and continued through the 2week wait. I got  BFN both times which is when I stopped but was told that if I got a BFP I would continue both the estrogen and progesterone for a few weeks.  That's my only experience with it and i'm not expert 
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  • riveridgionalriveridgional member
    I had the same experience as @rachlee2010. I had a similar question a few months ago and people told me they took it through week 8 of pregnancy
    Married to DH 10/6/12
    TTC since 5/14
    Unexplained with (controlled) hypothyroidism and suspected ovulatory dysfunction (but, I do ovulate on my own)
    Clomid 50 mg 3/15 (unmonitored) - BFN
    Clomid 50 mg + metformin 4/15 (unmonitored) - BFN 
    First RE appt. 5/15; Natural cycle 5/15 monitored with 2 mature follicles and Pregnyl Trigger (full dose) + prometrium - BFN
    6/15 HSG - clear tubes & normal uterus; great PCT test results
    TI - 100 mg Clomid + prometrium (AM & PM) + vaginal estrace (AM & PM) 6-7/15 (monitored) --> no additional response and thinned lining - BFN
    TI - Injectables (follistim + Gonal-F, Ganirelix, & 1/2 dose Pregnyl) + prometrium (AM & PM) 9/15 --> 3-7 mature follicles (3 definites and 4+ that could have matured due to trigger) @ O -->BFN + 5 large cysts
    BC for 2 weeks due to cysts
    TI - Injectables (Gonal-F, Ganirelix & full dose Pregnyl) + prometrium (AM & PM) 10/15 --> 1 mature follicle --> BFN 
    TI - Last attempt at injectables (Gonal-F, Ganirelix & 1/2 dose Pregnyl) + crinone (AM only) + vaginal estrace (AM & PM) 11/15 --> 3-4 mature follicles --> BFP!! 11/27/15 @ 13dpo (shockingly, actually waited until then to test)

    Beta #1 @ 16dpo (11/30/15) = 1,075
    Beta #2 @ 19dpo (12/3/15) = 3,150
    One baby: Saw heartbeat @ 5w5d (114 bpm; baby measuring 2.3mm)

    "Great Things are Happening"
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  • rachlee2010rachlee2010 member
    I think I noticed on the bottle it said something about pregnancy and not taking it so I asked the nurse at my RE's office and she said it was fine.  I could be thinking of something else I was asking about but i think it was estrogen.  I am assuming I will be starting it again shortly with this cycle as that has been my trend..it helps thicken my lining but we will see when I go for my first follicle check tomorrow
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  • MrsBwIVFMrsBwIVF member
    I took estradiol until I was 11 weeks along. The pharmacist asked my husband when he picked up a refill, if I was pregnant, and he said "yes". The pharmacist argued until my husband explained it was through a fertility specialist.
    It is not normally a medication for pregnant women however, it is very commonly used and needed for those who have had infertility struggles. I know it's hard not to over analyze every after the long journey you've been on but this medication should be perfectly fine. I'm now 25w and both my babies are doing just fine.
    ***Trying to conceive since 9/12- m/c 2/13 from natural conception.
    IVF success 10/14 with m/c 11/14. FET success 4/15***

    Pregnancy Ticker
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  • gkamerman78gkamerman78 member
    ***BFP MENTIONED***
    Yes both estrogen and progesterone are catigory x drugs. However they are category x drugs because they used to be completely synthetic. And synthetic estrogen had caused birth defects. They are safe to take and they will tell you when to stop them I got my BFP last week a.nd they still have me on 3 MG of Estrace and 10 MG of progesterone. They are considered pregnancy support for usually 8 to 10 wks. Some long er some shorter that depends on your re.
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  • Krisd6Krisd6 member
    Thanks everyone! I appreciate the feedback and support!!
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